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Items: 1 to 50 of 101

1.

Effect of acute inflammatory brain injury on accumulation of morphine and morphine 3- and 6-glucuronide in the human brain.

Roberts DJ, Goralski KB, Renton KW, Julien LC, Webber AM, Sleno L, Volmer DA, Hall RI.

Crit Care Med. 2009 Oct;37(10):2767-74. doi: 10.1097/CCM.0b013e3181b755d5.

PMID:
19865006
2.

Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer.

Morgan ET, Goralski KB, Piquette-Miller M, Renton KW, Robertson GR, Chaluvadi MR, Charles KA, Clarke SJ, Kacevska M, Liddle C, Richardson TA, Sharma R, Sinal CJ.

Drug Metab Dispos. 2008 Feb;36(2):205-16. doi: 10.1124/dmd.107.018747.

PMID:
18218849
3.

Evaluation of performance factors affecting two formulations of cyclosporine in pediatric renal transplant patients.

Acott PD, Crocker JF, Renton KW.

Transplant Proc. 2006 Nov;38(9):2835-41.

PMID:
17112843
4.

Pamidronate distribution in pediatric renal and rheumatologic patients.

Acott PD, Wong JA, Crocker JF, Lang B, O'Regan P, Renton KW.

Eur J Clin Pharmacol. 2006 Dec;62(12):1013-9. Epub 2006 Oct 6.

PMID:
17024486
5.

Regulation of drug metabolism and disposition during inflammation and infection.

Renton KW.

Expert Opin Drug Metab Toxicol. 2005 Dec;1(4):629-40. Review.

PMID:
16863429
6.

The regulation of cytochrome P450 2E1 during LPS-induced inflammation in the rat.

Abdulla D, Goralski KB, Renton KW.

Toxicol Appl Pharmacol. 2006 Oct 1;216(1):1-10. Epub 2006 May 18.

PMID:
16712892
7.

The signal transduction pathways involved in hepatic cytochrome P450 regulation in the rat during a lipopolysaccharide-induced model of central nervous system inflammation.

Abdulla D, Goralski KB, Del Busto Cano EG, Renton KW.

Drug Metab Dispos. 2005 Oct;33(10):1521-31. Epub 2005 Jul 8.

PMID:
16006567
8.

Toll-like receptor-4 regulation of hepatic Cyp3a11 metabolism in a mouse model of LPS-induced CNS inflammation.

Goralski KB, Abdulla D, Sinal CJ, Arsenault A, Renton KW.

Am J Physiol Gastrointest Liver Physiol. 2005 Sep;289(3):G434-43. Epub 2005 May 5.

9.

Beta-adrenergic receptor modulation of the LPS-mediated depression in CYP1A activity in astrocytes.

Abdulla D, Renton KW.

Biochem Pharmacol. 2005 Mar 1;69(5):741-50. Epub 2005 Jan 13.

PMID:
15710352
10.

Paradoxical cyclosporine A requirements in pediatric renal transplants receiving high-dose steroids.

Hardy KW, Crocker JF, McLellan H, Goralski KB, Renton KW, Acott PD.

J Clin Pharmacol. 2005 Feb;45(2):161-7.

PMID:
15647408
11.

Nitric oxide mediates an LPS-induced depression of cytochrome P450 (CYP1A) activity in astrocytes.

Nicholson TE, Dibb S, Renton KW.

Brain Res. 2004 Dec 17;1029(2):148-54.

PMID:
15542068
12.

A comparison of the pharmacokinetics of tacrolimus and microemulsified cyclosporin in paediatric renal transplant recipients.

Renton KW, Crocker JF, McLellan H, Acott PD.

Eur J Clin Pharmacol. 2004 Aug;60(6):421-6. Epub 2004 Jul 1.

PMID:
15232662
13.

Cytochrome P450 regulation and drug biotransformation during inflammation and infection.

Renton KW.

Curr Drug Metab. 2004 Jun;5(3):235-43. Review.

PMID:
15180493
14.

Brain inflammation enhances 1-methyl-4-phenylpyridinium-evoked neurotoxicity in rats.

Goralski KB, Renton KW.

Toxicol Appl Pharmacol. 2004 May 1;196(3):381-9.

PMID:
15094308
15.

Determination of pamidronate in human whole blood and urine by reversed-phase HPLC with fluorescence detection.

Wong JA, Renton KW, Crocker JF, O'Regan PA, Acott PD.

Biomed Chromatogr. 2004 Mar;18(2):98-101.

PMID:
15039961
16.

Modulation of hepatic cytochrome P450 during Listeria monocytogenes infection of the brain.

Garcia Del Busto Cano E, Renton KW.

J Pharm Sci. 2003 Sep;92(9):1860-8.

PMID:
12950004
17.

Downregulation of mdr1a expression in the brain and liver during CNS inflammation alters the in vivo disposition of digoxin.

Goralski KB, Hartmann G, Piquette-Miller M, Renton KW.

Br J Pharmacol. 2003 May;139(1):35-48.

18.

Alteration of drug biotransformation and elimination during infection and inflammation.

Renton KW.

Pharmacol Ther. 2001 Nov-Dec;92(2-3):147-63. Review.

PMID:
11916535
19.

Role of cytokines in the lipopolysaccharide-evoked depression of cytochrome P450 in the brain and liver.

Nicholson TE, Renton KW.

Biochem Pharmacol. 2001 Dec 15;62(12):1709-17.

PMID:
11755125
22.
23.

Hepatic drug metabolism and immunostimulation.

Renton KW.

Toxicology. 2000 Jan 17;142(3):173-8. Review.

PMID:
10667888
24.

Lipopolysaccharide evokes the modulation of brain cytochrome P4501A in the rat.

Renton KW, Dibb S, Levatte TL.

Brain Res. 1999 Sep 18;842(1):139-47.

PMID:
10526104
25.

Modulation of cytochrome P450 by inflammation in astrocytes.

Nicholson TE, Renton KW.

Brain Res. 1999 May 8;827(1-2):12-8.

PMID:
10320688
26.

Cytokine-mediated down-regulation of CYP1A1 in Hepa1 cells.

Paton TE, Renton KW.

Biochem Pharmacol. 1998 Jun 1;55(11):1791-6.

PMID:
9714297
27.

Amlodipine inhibits rat microsomal cytochrome P450-mediated drug biotransformation.

Drobitch RK, McLellan RA, Renton KW.

J Pharm Sci. 1997 Dec;86(12):1501-3.

PMID:
9423169
29.

Differential effect of pentoxifylline on lipopolysaccharide-induced downregulation of cytochrome P450.

Monshouwer M, McLellan RA, Delaporte E, Witkamp RF, van Miert AS, Renton KW.

Biochem Pharmacol. 1996 Oct 25;52(8):1195-200.

PMID:
8937426
30.

Fluoroquinolone antibiotics inhibit cytochrome P450-mediated microsomal drug metabolism in rat and human.

McLellan RA, Drobitch RK, Monshouwer M, Renton KW.

Drug Metab Dispos. 1996 Oct;24(10):1134-8.

PMID:
8894516
31.

The role of nitric oxide generation in interferon-evoked cytochrome P450 down-regulation.

Hodgson PD, Renton KW.

Int J Immunopharmacol. 1995 Dec;17(12):995-1000.

PMID:
8964659
32.

Interferon-mediated changes in the expression of CYP1A1 in human B lymphoblastoid (AHH-1 TK +/-) cells.

Delaporte E, Cribb AE, Renton KW.

Can J Physiol Pharmacol. 1995 Dec;73(12):1692-7.

PMID:
8834482
33.

Norfloxacin interferes with cyclosporine disposition in pediatric patients undergoing renal transplantation.

McLellan RA, Drobitch RK, McLellan H, Acott PD, Crocker JF, Renton KW.

Clin Pharmacol Ther. 1995 Sep;58(3):322-7.

PMID:
7554706
35.

Assessment of arylamine N-acetyltransferase (NAT1) activity in mononuclear leukocytes of cystic fibrosis patients.

Cribb AE, Tsui B, Isbrucker R, Michael RT, Gillespie CT, Brown-Bonomo J, Barrett P, Levatte T, Renton KW.

Br J Clin Pharmacol. 1995 Jan;39(1):85-9.

36.

Factors involved in the down-regulation of cytochrome P450 during Listeria monocytogenes infection.

Armstrong SG, Renton KW.

Int J Immunopharmacol. 1994 Sep;16(9):747-54.

PMID:
7806432
37.

The interaction of the calcium channel blockers verapamil and nifedipine with cyclosporin A in pediatric renal transplant patients.

Crocker JF, Renton KW, LeVatte TL, McLellan DH.

Pediatr Nephrol. 1994 Aug;8(4):408-11.

PMID:
7947026
38.

Acetylator phenotyping: the urinary caffeine metabolite ratio in slow acetylators correlates with a marker of systemic NAT1 activity.

Cribb AE, Isbrucker R, Levatte T, Tsui B, Gillespie CT, Renton KW.

Pharmacogenetics. 1994 Jun;4(3):166-70.

PMID:
7920698
39.

Regulation of cytochrome P-4501A and cytochrome P-4502E induction in the rat during the production of interferon alpha/beta.

Cribb AE, Delaporte E, Kim SG, Novak RF, Renton KW.

J Pharmacol Exp Ther. 1994 Jan;268(1):487-94.

PMID:
8301591
40.
41.

Modulatory effect of hyperthermia on hepatic microsomal cytochrome P450 in mice.

Anari MR, Renton KW.

Biochem Pharmacol. 1993 Jul 20;46(2):307-10.

PMID:
8347153
42.

Modulation of rat hepatic CYP3A1 induction by the interferon inducer polyinosinic acid-polycytidylic acid (polyic).

Delaporte E, Cribb AE, Renton KW.

Drug Metab Dispos. 1993 May-Jun;21(3):520-3.

PMID:
7686458
43.

Mechanism of hepatic cytochrome P450 modulation during Listeria monocytogenes infection in mice.

Armstrong SG, Renton KW.

Mol Pharmacol. 1993 Apr;43(4):542-7. Erratum in: Mol Pharmacol 1993 Sep;44(3):677.

PMID:
8379989
44.
45.
46.

Interferons: potential problems.

Cribb AE, Renton KW, Armstrong SG.

JAMA. 1992 Jan 22-29;267(4):508-9. No abstract available.

PMID:
1370333
47.

Role of altered drug metabolism in virus-drug interactions.

Renton KW, Cribb AE, Armstrong S.

Rev Infect Dis. 1991 Nov-Dec;13(6):1256-7. No abstract available.

PMID:
1775871
48.

A role for xanthine oxidase in the loss of cytochrome P-450 evoked by interferon.

Moochhala SM, Renton KW.

Can J Physiol Pharmacol. 1991 Jul;69(7):944-50.

PMID:
1720069
49.
50.

Surfactant-potentiated increases in intracranial pressure in a mouse model of Reye's syndrome.

Crocker JF, Lee SH, Love JA, Malatjalian DA, Renton KW, Rozee KR, Murphy MG.

Exp Neurol. 1991 Jan;111(1):95-7.

PMID:
1984438

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