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Items: 34

1.

Mechanisms of reactivation of latent tuberculosis infection due to SIV co-infection.

Bucşan AN, Chatterjee A, Singh DK, Foreman TW, Lee TH, Threeton B, Kirkpatrick MG, Ahmed M, Golden N, Alvarez X, Hoxie JA, Mehra S, Rengarajan J, Khader SA, Kaushal D.

J Clin Invest. 2019 Sep 3. pii: 125810. doi: 10.1172/JCI125810. [Epub ahead of print]

2.

Immunology of Mycobacterium tuberculosis Infections.

Sia JK, Rengarajan J.

Microbiol Spectr. 2019 Jul;7(4). doi: 10.1128/microbiolspec.GPP3-0022-2018.

3.

Mucosal-activated invariant T cells do not exhibit significant lung recruitment and proliferation profiles in macaques in response to infection with Mycobacterium tuberculosis CDC1551.

Bucsan AN, Rout N, Foreman TW, Khader SA, Rengarajan J, Kaushal D.

Tuberculosis (Edinb). 2019 May;116S:S11-S18. doi: 10.1016/j.tube.2019.04.006. Epub 2019 Apr 26.

PMID:
31072689
4.

Moving toward Tuberculosis Elimination. Critical Issues for Research in Diagnostics and Therapeutics for Tuberculosis Infection.

Keshavjee S, Amanullah F, Cattamanchi A, Chaisson R, Dobos KM, Fox GJ, Gendelman HE, Gordon R, Hesseling A, Le Van H, Kampmann B, Kana B, Khuller G, Lewinsohn DM, Lewinsohn DA, Lin PL, Lu LL, Maartens G, Owen A, Protopopova M, Rengarajan J, Rubin E, Salgame P, Schurr E, Seddon JA, Swindells S, Tobin DM, Udwadia Z, Walzl G, Srinivasan S, Rustomjee R, Nahid P.

Am J Respir Crit Care Med. 2019 Mar 1;199(5):564-571. doi: 10.1164/rccm.201806-1053PP. No abstract available.

5.

High Frequencies of Caspase-3 Expressing Mycobacterium tuberculosis-Specific CD4+ T Cells Are Associated With Active Tuberculosis.

Adekambi T, Ibegbu CC, Cagle S, Ray SM, Rengarajan J.

Front Immunol. 2018 Jun 25;9:1481. doi: 10.3389/fimmu.2018.01481. eCollection 2018.

6.

A High Throughput Whole Blood Assay for Analysis of Multiple Antigen-Specific T Cell Responses in Human Mycobacterium tuberculosis Infection.

Whatney WE, Gandhi NR, Lindestam Arlehamn CS, Nizam A, Wu H, Quezada MJ, Campbell A, Allana S, Kabongo MM, Khayumbi J, Muchiri B, Ongalo J, Tonui J, Sasser LE, Fergus TJ, Ouma GS, Ouma SG, Beck AA, Mulligan MJ, Oladele A, Kaushal D, Cain KP, Waller L, Blumberg HM, Altman JD, Ernst JD, Rengarajan J, Day CL; TBRU-ASTRa Study Group.

J Immunol. 2018 Apr 15;200(8):3008-3019. doi: 10.4049/jimmunol.1701737. Epub 2018 Mar 14.

7.

Deletion of BCG Hip1 protease enhances dendritic cell and CD4 T cell responses.

Bizzell E, Sia JK, Quezada M, Enriquez A, Georgieva M, Rengarajan J.

J Leukoc Biol. 2018 Apr;103(4):739-748. doi: 10.1002/JLB.4A0917-363RR. Epub 2017 Dec 28.

8.

In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis.

Gautam US, Foreman TW, Bucsan AN, Veatch AV, Alvarez X, Adekambi T, Golden NA, Gentry KM, Doyle-Meyers LA, Russell-Lodrigue KE, Didier PJ, Blanchard JL, Kousoulas KG, Lackner AA, Kalman D, Rengarajan J, Khader SA, Kaushal D, Mehra S.

Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):E62-E71. doi: 10.1073/pnas.1711373114. Epub 2017 Dec 18.

9.

Mycobacterium tuberculosis GroEL2 Modulates Dendritic Cell Responses.

Georgieva M, Sia JK, Bizzell E, Madan-Lala R, Rengarajan J.

Infect Immun. 2018 Jan 22;86(2). pii: e00387-17. doi: 10.1128/IAI.00387-17. Print 2018 Feb.

10.

Neutrophil extracellular trap (NET) levels in human plasma are associated with active TB.

Schechter MC, Buac K, Adekambi T, Cagle S, Celli J, Ray SM, Mehta CC, Rada B, Rengarajan J.

PLoS One. 2017 Aug 4;12(8):e0182587. doi: 10.1371/journal.pone.0182587. eCollection 2017.

11.

Engaging the CD40-CD40L pathway augments T-helper cell responses and improves control of Mycobacterium tuberculosis infection.

Sia JK, Bizzell E, Madan-Lala R, Rengarajan J.

PLoS Pathog. 2017 Aug 2;13(8):e1006530. doi: 10.1371/journal.ppat.1006530. eCollection 2017 Aug.

12.

Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c).

Naffin-Olivos JL, Daab A, White A, Goldfarb NE, Milne AC, Liu D, Baikovitz J, Dunn BM, Rengarajan J, Petsko GA, Ringe D.

Biochemistry. 2017 May 2;56(17):2304-2314. doi: 10.1021/acs.biochem.6b01066. Epub 2017 Apr 7.

13.

Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis.

Kaushal D, Foreman TW, Gautam US, Alvarez X, Adekambi T, Rangel-Moreno J, Golden NA, Johnson AM, Phillips BL, Ahsan MH, Russell-Lodrigue KE, Doyle LA, Roy CJ, Didier PJ, Blanchard JL, Rengarajan J, Lackner AA, Khader SA, Mehra S.

Nat Commun. 2015 Oct 13;6:8533. doi: 10.1038/ncomms9533.

14.

Biomarkers on patient T cells diagnose active tuberculosis and monitor treatment response.

Adekambi T, Ibegbu CC, Cagle S, Kalokhe AS, Wang YF, Hu Y, Day CL, Ray SM, Rengarajan J.

J Clin Invest. 2015 Sep;125(9):3723. doi: 10.1172/JCI83279. Epub 2015 Sep 1. No abstract available.

15.

Innate Immune Defenses in Human Tuberculosis: An Overview of the Interactions between Mycobacterium tuberculosis and Innate Immune Cells.

Sia JK, Georgieva M, Rengarajan J.

J Immunol Res. 2015;2015:747543. doi: 10.1155/2015/747543. Epub 2015 Jul 14. Review.

16.

Biomarkers on patient T cells diagnose active tuberculosis and monitor treatment response.

Adekambi T, Ibegbu CC, Cagle S, Kalokhe AS, Wang YF, Hu Y, Day CL, Ray SM, Rengarajan J.

J Clin Invest. 2015 May;125(5):1827-38. doi: 10.1172/JCI77990. Epub 2015 Mar 30. Erratum in: J Clin Invest. 2015 Sep;125(9):3723.

17.

DosS Is required for the complete virulence of mycobacterium tuberculosis in mice with classical granulomatous lesions.

Gautam US, McGillivray A, Mehra S, Didier PJ, Midkiff CC, Kissee RS, Golden NA, Alvarez X, Niu T, Rengarajan J, Sherman DR, Kaushal D.

Am J Respir Cell Mol Biol. 2015 Jun;52(6):708-16. doi: 10.1165/rcmb.2014-0230OC.

18.

Impaired degranulation and proliferative capacity of Mycobacterium tuberculosis-specific CD8+ T cells in HIV-infected individuals with latent tuberculosis.

Kalokhe AS, Adekambi T, Ibegbu CC, Ray SM, Day CL, Rengarajan J.

J Infect Dis. 2015 Feb 15;211(4):635-40. doi: 10.1093/infdis/jiu505. Epub 2014 Sep 9.

19.

Mycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2.

Naffin-Olivos JL, Georgieva M, Goldfarb N, Madan-Lala R, Dong L, Bizzell E, Valinetz E, Brandt GS, Yu S, Shabashvili DE, Ringe D, Dunn BM, Petsko GA, Rengarajan J.

PLoS Pathog. 2014 May 15;10(5):e1004132. doi: 10.1371/journal.ppat.1004132. eCollection 2014 May.

20.

Mycobacterium tuberculosis impairs dendritic cell functions through the serine hydrolase Hip1.

Madan-Lala R, Sia JK, King R, Adekambi T, Monin L, Khader SA, Pulendran B, Rengarajan J.

J Immunol. 2014 May 1;192(9):4263-72. doi: 10.4049/jimmunol.1303185. Epub 2014 Mar 21.

21.

The intracellular environment of human macrophages that produce nitric oxide promotes growth of mycobacteria.

Jung JY, Madan-Lala R, Georgieva M, Rengarajan J, Sohaskey CD, Bange FC, Robinson CM.

Infect Immun. 2013 Sep;81(9):3198-209. doi: 10.1128/IAI.00611-13. Epub 2013 Jun 17.

22.

Meeting report: The International Conference on Human Immunity to Tuberculosis.

Ernst JD, Hanekom W, Hawn T, Kampmann B, Rengarajan J.

Tuberculosis (Edinb). 2012 Sep;92(5):440-4. doi: 10.1016/j.tube.2012.05.003. Epub 2012 Jun 2.

PMID:
22658910
23.

Distinct effector memory CD4+ T cell signatures in latent Mycobacterium tuberculosis infection, BCG vaccination and clinically resolved tuberculosis.

Adekambi T, Ibegbu CC, Kalokhe AS, Yu T, Ray SM, Rengarajan J.

PLoS One. 2012;7(4):e36046. doi: 10.1371/journal.pone.0036046. Epub 2012 Apr 24.

24.

Mycobacterium tuberculosis Hip1 dampens macrophage proinflammatory responses by limiting toll-like receptor 2 activation.

Madan-Lala R, Peixoto KV, Re F, Rengarajan J.

Infect Immun. 2011 Dec;79(12):4828-38. doi: 10.1128/IAI.05574-11. Epub 2011 Sep 26.

25.

Mycobacterium tuberculosis Rv2224c modulates innate immune responses.

Rengarajan J, Murphy E, Park A, Krone CL, Hett EC, Bloom BR, Glimcher LH, Rubin EJ.

Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):264-9. doi: 10.1073/pnas.0710601105. Epub 2008 Jan 2.

26.

Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages.

Rengarajan J, Bloom BR, Rubin EJ.

Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8327-32. Epub 2005 May 31.

27.

The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria.

Rengarajan J, Sassetti CM, Naroditskaya V, Sloutsky A, Bloom BR, Rubin EJ.

Mol Microbiol. 2004 Jul;53(1):275-82.

28.

Bacterial genomics and vaccine design.

Sampson SL, Rengarajan J, Rubin EJ.

Expert Rev Vaccines. 2003 Jun;2(3):437-45. Review.

PMID:
12903808
29.

Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression.

Rengarajan J, Mowen KA, McBride KD, Smith ED, Singh H, Glimcher LH.

J Exp Med. 2002 Apr 15;195(8):1003-12.

30.

NFATc2 and NFATc3 regulate T(H)2 differentiation and modulate TCR-responsiveness of naïve T(H)cells.

Rengarajan J, Tang B, Glimcher LH.

Nat Immunol. 2002 Jan;3(1):48-54. Epub 2001 Dec 10.

PMID:
11740499
31.

Sequential involvement of NFAT and Egr transcription factors in FasL regulation.

Rengarajan J, Mittelstadt PR, Mages HW, Gerth AJ, Kroczek RA, Ashwell JD, Glimcher LH.

Immunity. 2000 Mar;12(3):293-300.

32.

Transcriptional regulation of Th1/Th2 polarization.

Rengarajan J, Szabo SJ, Glimcher LH.

Immunol Today. 2000 Oct;21(10):479-83. Review. No abstract available.

PMID:
11071525
33.

Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.

Ranger AM, Oukka M, Rengarajan J, Glimcher LH.

Immunity. 1998 Nov;9(5):627-35.

34.

NF-AT-Driven interleukin-4 transcription potentiated by NIP45.

Hodge MR, Chun HJ, Rengarajan J, Alt A, Lieberson R, Glimcher LH.

Science. 1996 Dec 13;274(5294):1903-5.

PMID:
8943202

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