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Items: 1 to 50 of 97

1.

Non invasive prenatal diagnosis of fetal aneuploidy using cell free fetal DNA.

Renga B.

Eur J Obstet Gynecol Reprod Biol. 2018 Jun;225:5-8. doi: 10.1016/j.ejogrb.2018.03.033. Epub 2018 Mar 20. Review.

PMID:
29626711
2.

Platelets and cardiovascular risk.

Renga B, Scavizzi F.

Acta Cardiol. 2017 Feb;72(1):2-8. doi: 10.1080/00015385.2017.1281560.

PMID:
28597734
3.

Navigation in bile acid chemical space: discovery of novel FXR and GPBAR1 ligands.

Finamore C, Festa C, Renga B, Sepe V, Carino A, Masullo D, Biagioli M, Marchianò S, Capolupo A, Monti MC, Fiorucci S, Zampella A.

Sci Rep. 2016 Jul 6;6:29320. doi: 10.1038/srep29320.

4.

Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists.

Sepe V, Festa C, Renga B, Carino A, Cipriani S, Finamore C, Masullo D, Del Gaudio F, Monti MC, Fiorucci S, Zampella A.

Sci Rep. 2016 Jan 7;6:19008. doi: 10.1038/srep19008.

5.

Investigation on bile acid receptor regulators. Discovery of cholanoic acid derivatives with dual G-protein coupled bile acid receptor 1 (GPBAR1) antagonistic and farnesoid X receptor (FXR) modulatory activity.

Sepe V, Renga B, Festa C, Finamore C, Masullo D, Carino A, Cipriani S, Distrutti E, Fiorucci S, Zampella A.

Steroids. 2016 Jan;105:59-67. doi: 10.1016/j.steroids.2015.11.003. Epub 2015 Dec 1.

PMID:
26607331
6.

Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism.

Di Leva FS, Festa C, Renga B, Sepe V, Novellino E, Fiorucci S, Zampella A, Limongelli V.

Sci Rep. 2015 Nov 16;5:16605. doi: 10.1038/srep16605.

7.

Reversal of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a AKT/FOXOA1 Dependent Regulation of H2S Generation and Endothelin-1.

Renga B, Cipriani S, Carino A, Simonetti M, Zampella A, Fiorucci S.

PLoS One. 2015 Nov 5;10(11):e0141082. doi: 10.1371/journal.pone.0141082. eCollection 2015.

8.

The HIV matrix protein p17 induces hepatic lipid accumulation via modulation of nuclear receptor transcriptoma.

Renga B, Francisci D, Carino A, Marchianò S, Cipriani S, Chiara Monti M, Del Sordo R, Schiaroli E, Distrutti E, Baldelli F, Fiorucci S.

Sci Rep. 2015 Oct 15;5:15403. doi: 10.1038/srep15403.

9.

Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling.

Cipriani S, Renga B, D'Amore C, Simonetti M, De Tursi AA, Carino A, Monti MC, Sepe V, Zampella A, Fiorucci S.

PLoS One. 2015 Jul 15;10(7):e0129866. doi: 10.1371/journal.pone.0129866. eCollection 2015.

10.

Cystathionine γ-lyase, a H2S-generating enzyme, is a GPBAR1-regulated gene and contributes to vasodilation caused by secondary bile acids.

Renga B, Bucci M, Cipriani S, Carino A, Monti MC, Zampella A, Gargiulo A, d'Emmanuele di Villa Bianca R, Distrutti E, Fiorucci S.

Am J Physiol Heart Circ Physiol. 2015 Jul 1;309(1):H114-26. doi: 10.1152/ajpheart.00087.2015. Epub 2015 May 1.

11.

Bile acid activated receptors are targets for regulation of integrity of gastrointestinal mucosa.

Distrutti E, Santucci L, Cipriani S, Renga B, Schiaroli E, Ricci P, Donini A, Fiorucci S.

J Gastroenterol. 2015 Jul;50(7):707-19. doi: 10.1007/s00535-015-1041-8. Epub 2015 Feb 24. Review.

PMID:
25708288
12.

Interactions Between Nuclear Receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice.

Tsuchiya H, da Costa KA, Lee S, Renga B, Jaeschke H, Yang Z, Orena SJ, Goedken MJ, Zhang Y, Kong B, Lebofsky M, Rudraiah S, Smalling R, Guo G, Fiorucci S, Zeisel SH, Wang L.

Gastroenterology. 2015 May;148(5):1012-1023.e14. doi: 10.1053/j.gastro.2015.01.045. Epub 2015 Feb 19.

13.

Molecular decodification of gymnemic acids from Gymnema sylvestre. Discovery of a new class of liver X receptor antagonists.

Renga B, Festa C, De Marino S, Di Micco S, D'Auria MV, Bifulco G, Fiorucci S, Zampella A.

Steroids. 2015 Apr;96:121-31. doi: 10.1016/j.steroids.2015.01.024. Epub 2015 Feb 7.

PMID:
25668616
14.

Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands.

Festa C, Renga B, D'Amore C, Sepe V, Finamore C, De Marino S, Carino A, Cipriani S, Monti MC, Zampella A, Fiorucci S.

J Med Chem. 2014 Oct 23;57(20):8477-95. doi: 10.1021/jm501273r. Epub 2014 Oct 9.

PMID:
25247751
15.

Modulation of intestinal microbiota by the probiotic VSL#3 resets brain gene expression and ameliorates the age-related deficit in LTP.

Distrutti E, O'Reilly JA, McDonald C, Cipriani S, Renga B, Lynch MA, Fiorucci S.

PLoS One. 2014 Sep 9;9(9):e106503. doi: 10.1371/journal.pone.0106503. eCollection 2014.

16.

Modification on ursodeoxycholic acid (UDCA) scaffold. discovery of bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 (GP-BAR1).

Sepe V, Renga B, Festa C, D'Amore C, Masullo D, Cipriani S, Di Leva FS, Monti MC, Novellino E, Limongelli V, Zampella A, Fiorucci S.

J Med Chem. 2014 Sep 25;57(18):7687-701. doi: 10.1021/jm500889f. Epub 2014 Sep 7.

PMID:
25162837
17.

Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane X receptor modulation.

Sepe V, Di Leva FS, D'Amore C, Festa C, De Marino S, Renga B, D'Auria MV, Novellino E, Limongelli V, D'Souza L, Majik M, Zampella A, Fiorucci S.

Mar Drugs. 2014 May 27;12(6):3091-115. doi: 10.3390/md12063091.

18.

The HIV matrix protein p17 promotes the activation of human hepatic stellate cells through interactions with CXCR2 and Syndecan-2.

Renga B, Francisci D, Schiaroli E, Carino A, Cipriani S, D'Amore C, Sidoni A, Sordo RD, Ferri I, Lucattelli M, Lunghi B, Baldelli F, Fiorucci S.

PLoS One. 2014 Apr 15;9(4):e94798. doi: 10.1371/journal.pone.0094798. eCollection 2014.

19.

Incisterols, highly degraded marine sterols, are a new chemotype of PXR agonists.

Chianese G, Sepe V, Limongelli V, Renga B, D'Amore C, Zampella A, Taglialatela-Scafati O, Fiorucci S.

Steroids. 2014 May;83:80-5. doi: 10.1016/j.steroids.2014.02.003. Epub 2014 Feb 28.

PMID:
24582706
20.

CCR5 Antagonism by Maraviroc Reduces the Potential for Gastric Cancer Cell Dissemination.

Mencarelli A, Graziosi L, Renga B, Cipriani S, D'Amore C, Francisci D, Bruno A, Baldelli F, Donini A, Fiorucci S.

Transl Oncol. 2013 Dec 1;6(6):784-93. eCollection 2013 Dec 1.

21.

Insights on pregnane-X-receptor modulation. Natural and semisynthetic steroids from Theonella marine sponges.

Sepe V, D'Amore C, Ummarino R, Renga B, D'Auria MV, Novellino E, Sinisi A, Taglialatela-Scafati O, Nakao Y, Limongelli V, Zampella A, Fiorucci S.

Eur J Med Chem. 2014 Feb 12;73:126-34. doi: 10.1016/j.ejmech.2013.12.005. Epub 2013 Dec 15.

PMID:
24388834
22.

Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors.

D'Amore C, Di Leva FS, Sepe V, Renga B, Del Gaudio C, D'Auria MV, Zampella A, Fiorucci S, Limongelli V.

J Med Chem. 2014 Feb 13;57(3):937-54. doi: 10.1021/jm401873d. Epub 2014 Jan 17.

PMID:
24387325
23.

Solomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis.

Mencarelli A, D'Amore C, Renga B, Cipriani S, Carino A, Sepe V, Perissutti E, D'Auria MV, Zampella A, Distrutti E, Fiorucci S.

Mar Drugs. 2013 Dec 24;12(1):36-53. doi: 10.3390/md12010036.

24.

In vivo administration of ritonavir worsens intestinal damage caused by cyclooxygease inhibitors.

Renga B, Mencarelli A, Cipriani S, D'Amore C, Francisci D, Santucci L, Baldelli F, Distrutti E, Fiorucci S.

Eur J Pharmacol. 2014 Jan 15;723:194-201. doi: 10.1016/j.ejphar.2013.11.035. Epub 2013 Dec 4.

PMID:
24315932
25.

Structural insights into Estrogen Related Receptor-β modulation: 4-methylenesterols from Theonella swinhoei sponge as the first example of marine natural antagonists.

Di Micco S, Renga B, Carino A, D'Auria MV, Zampella A, Riccio R, Fiorucci S, Bifulco G.

Steroids. 2014 Feb;80:51-63. doi: 10.1016/j.steroids.2013.11.017. Epub 2013 Dec 4.

PMID:
24315836
26.

New tridecapeptides of the theonellapeptolide family from the Indonesian sponge Theonella swinhoei.

Sinisi A, Calcinai B, Cerrano C, Dien HA, Zampella A, D'Amore C, Renga B, Fiorucci S, Taglialatela-Scafati O.

Beilstein J Org Chem. 2013 Aug 13;9:1643-51. doi: 10.3762/bjoc.9.188. eCollection 2013.

27.

FXR mediates a chromatin looping in the GR promoter thus promoting the resolution of colitis in rodents.

Renga B, D'Amore C, Cipriani S, Mencarelli A, Carino A, Sepe V, Zampella A, Distrutti E, Fiorucci S.

Pharmacol Res. 2013 Nov;77:1-10. doi: 10.1016/j.phrs.2013.08.008. Epub 2013 Sep 1.

PMID:
24004655
28.

Dissociation of intestinal and hepatic activities of FXR and LXRα supports metabolic effects of terminal ileum interposition in rodents.

Mencarelli A, Renga B, D'Amore C, Santorelli C, Graziosi L, Bruno A, Monti MC, Distrutti E, Cipriani S, Donini A, Fiorucci S.

Diabetes. 2013 Oct;62(10):3384-93. doi: 10.2337/db13-0299. Epub 2013 Jul 8.

29.

Isoswinholide B and swinholide K, potently cytotoxic dimeric macrolides from Theonella swinhoei.

Sinisi A, Calcinai B, Cerrano C, Dien HA, Zampella A, D'Amore C, Renga B, Fiorucci S, Taglialatela-Scafati O.

Bioorg Med Chem. 2013 Sep 1;21(17):5332-8. doi: 10.1016/j.bmc.2013.06.015. Epub 2013 Jun 15.

PMID:
23830699
30.

Oxygenated polyketides from Plakinastrella mamillaris as a new chemotype of PXR agonists.

Festa C, D'Amore C, Renga B, Lauro G, De Marino S, D'Auria MV, Bifulco G, Zampella A, Fiorucci S.

Mar Drugs. 2013 Jul 2;11(7):2314-27. doi: 10.3390/md11072314.

31.

Probiotics VSL#3 protect against development of visceral pain in murine model of irritable bowel syndrome.

Distrutti E, Cipriani S, Mencarelli A, Renga B, Fiorucci S.

PLoS One. 2013 May 15;8(5):e63893. doi: 10.1371/journal.pone.0063893. Print 2013.

32.

Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands.

Di Leva FS, Festa C, D'Amore C, De Marino S, Renga B, D'Auria MV, Novellino E, Limongelli V, Zampella A, Fiorucci S.

J Med Chem. 2013 Jun 13;56(11):4701-17. doi: 10.1021/jm400419e. Epub 2013 May 24.

PMID:
23656455
33.

Efficacy of the CCR5 antagonist maraviroc in reducing early, ritonavir-induced atherogenesis and advanced plaque progression in mice.

Cipriani S, Francisci D, Mencarelli A, Renga B, Schiaroli E, D'Amore C, Baldelli F, Fiorucci S.

Circulation. 2013 May 28;127(21):2114-24. doi: 10.1161/CIRCULATIONAHA.113.001278. Epub 2013 Apr 30.

PMID:
23633271
34.

The bile acid sensor FXR is required for immune-regulatory activities of TLR-9 in intestinal inflammation.

Renga B, Mencarelli A, Cipriani S, D'Amore C, Carino A, Bruno A, Francisci D, Zampella A, Distrutti E, Fiorucci S.

PLoS One. 2013;8(1):e54472. doi: 10.1371/journal.pone.0054472. Epub 2013 Jan 25.

35.

Preliminary structure-activity relationship on theonellasterol, a new chemotype of FXR antagonist, from the marine sponge Theonella swinhoei.

Sepe V, Ummarino R, D'Auria MV, Taglialatela-Scafati O, Marino SD, D'Amore C, Renga B, Chini MG, Bifulco G, Nakao Y, Fusetani N, Fiorucci S, Zampella A.

Mar Drugs. 2012 Nov 5;10(11):2448-66. doi: 10.3390/md10112448.

36.

HIV-1 infection is associated with changes in nuclear receptor transcriptome, pro-inflammatory and lipid profile of monocytes.

Renga B, Francisci D, D'Amore C, Schiaroli E, Carino A, Baldelli F, Fiorucci S.

BMC Infect Dis. 2012 Oct 29;12:274. doi: 10.1186/1471-2334-12-274.

37.

Role of nuclear receptors in lipid dysfunction and obesity-related diseases.

Swanson HI, Wada T, Xie W, Renga B, Zampella A, Distrutti E, Fiorucci S, Kong B, Thomas AM, Guo GL, Narayanan R, Yepuru M, Dalton JT, Chiang JY.

Drug Metab Dispos. 2013 Jan;41(1):1-11. doi: 10.1124/dmd.112.048694. Epub 2012 Oct 4.

38.

VSL#3 resets insulin signaling and protects against NASH and atherosclerosis in a model of genetic dyslipidemia and intestinal inflammation.

Mencarelli A, Cipriani S, Renga B, Bruno A, D'Amore C, Distrutti E, Fiorucci S.

PLoS One. 2012;7(9):e45425. doi: 10.1371/journal.pone.0045425. Epub 2012 Sep 21.

39.

Epigenetic modulation by methionine deficiency attenuates the potential for gastric cancer cell dissemination.

Graziosi L, Mencarelli A, Renga B, D'Amore C, Bruno A, Santorelli C, Cavazzoni E, Cantarella F, Rosati E, Donini A, Fiorucci S.

J Gastrointest Surg. 2013 Jan;17(1):39-49; discussion p. 49. doi: 10.1007/s11605-012-1996-1. Epub 2012 Sep 5.

PMID:
22948834
40.

Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor γ.

Festa C, Lauro G, De Marino S, D'Auria MV, Monti MC, Casapullo A, D'Amore C, Renga B, Mencarelli A, Petek S, Bifulco G, Fiorucci S, Zampella A.

J Med Chem. 2012 Oct 11;55(19):8303-17. doi: 10.1021/jm300911g. Epub 2012 Sep 19.

PMID:
22934537
41.

Activation of the bile acid receptor GPBAR1 protects against gastrointestinal injury caused by non-steroidal anti-inflammatory drugs and aspirin in mice.

Cipriani S, Mencarelli A, Bruno A, Renga B, Distrutti E, Santucci L, Baldelli F, Fiorucci S.

Br J Pharmacol. 2013 Jan;168(1):225-37. doi: 10.1111/j.1476-5381.2012.02128.x.

42.

Chalinulasterol, a chlorinated steroid disulfate from the Caribbean sponge Chalinula molitba. Evaluation of its role as PXR receptor modulator.

Teta R, Della Sala G, Renga B, Mangoni A, Fiorucci S, Costantino V.

Mar Drugs. 2012 Jun;10(6):1383-90. doi: 10.3390/md10061383. Epub 2012 Jun 14.

43.

Modification in the side chain of solomonsterol A: discovery of cholestan disulfate as a potent pregnane-X-receptor agonist.

Sepe V, Ummarino R, D'Auria MV, Lauro G, Bifulco G, D'Amore C, Renga B, Fiorucci S, Zampella A.

Org Biomol Chem. 2012 Aug 21;10(31):6350-62. doi: 10.1039/c2ob25800e. Epub 2012 Jun 26.

PMID:
22733410
44.

The HIV matrix protein p17 subverts nuclear receptors expression and induces a STAT1-dependent proinflammatory phenotype in monocytes.

Renga B, Francisci D, D'Amore C, Schiaroli E, Mencarelli A, Cipriani S, Baldelli F, Fiorucci S.

PLoS One. 2012;7(4):e35924. doi: 10.1371/journal.pone.0035924. Epub 2012 Apr 30.

45.

Glucocorticoid receptor mediates the gluconeogenic activity of the farnesoid X receptor in the fasting condition.

Renga B, Mencarelli A, D'Amore C, Cipriani S, Baldelli F, Zampella A, Distrutti E, Fiorucci S.

FASEB J. 2012 Jul;26(7):3021-31. doi: 10.1096/fj.11-195701. Epub 2012 Mar 23.

PMID:
22447981
46.

Ritonavir-induced lipoatrophy and dyslipidaemia is reversed by the anti-inflammatory drug leflunomide in a PPAR-γ-dependent manner.

Mencarelli A, Francisci D, Renga B, D'Amore C, Cipriani S, Basile F, Schiaroli E, Baldelli F, Fiorucci S.

Antivir Ther. 2012;17(4):669-78. doi: 10.3851/IMP2039. Epub 2012 Jan 25.

PMID:
22297608
47.

Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis.

Renga B, Mencarelli A, D'Amore C, Cipriani S, D'Auria MV, Sepe V, Chini MG, Monti MC, Bifulco G, Zampella A, Fiorucci S.

PLoS One. 2012;7(1):e30443. doi: 10.1371/journal.pone.0030443. Epub 2012 Jan 23.

48.

4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunity.

De Marino S, Ummarino R, D'Auria MV, Chini MG, Bifulco G, D'Amore C, Renga B, Mencarelli A, Petek S, Fiorucci S, Zampella A.

Steroids. 2012 Apr;77(5):484-95. doi: 10.1016/j.steroids.2012.01.006. Epub 2012 Jan 20.

PMID:
22285937
49.

Polyhydroxylated sterols from the Indonesian soft coral Sinularia sp. and their effect on farnesoid X-activated receptor.

Putra MY, Bavestrello G, Cerrano C, Renga B, D'Amore C, Fiorucci S, Fattorusso E, Taglialatela-Scafati O.

Steroids. 2012 Apr;77(5):433-40. doi: 10.1016/j.steroids.2011.12.026. Epub 2012 Jan 10.

PMID:
22252013
50.

Molecular determinants of gastrointestinal and liver cancers: role of bile acid activated nuclear receptors.

Renga B, Mencarelli A, Cipriani S, Distrutti E.

Curr Top Med Chem. 2012;12(6):625-36. Review.

PMID:
22242858

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