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Items: 1 to 50 of 89

1.

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation.

Zhao X, Hamidinia M, Choo JAL, Too CT, Ho ZZ, Ren EC, Bertoletti A, MacAry PA, Gould KG, Brzostek J, Gascoigne NRJ.

J Vis Exp. 2019 Feb 28;(144). doi: 10.3791/59126.

2.

HNF4α Combinatorial Isoform Heterodimers Activate Distinct Gene Targets that Differ from Their Corresponding Homodimers.

Ko HL, Zhuo Z, Ren EC.

Cell Rep. 2019 Mar 5;26(10):2549-2557.e3. doi: 10.1016/j.celrep.2019.02.033.

3.

Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling.

Zhao X, Sankaran S, Yap J, Too CT, Ho ZZ, Dolton G, Legut M, Ren EC, Sewell AK, Bertoletti A, MacAry PA, Brzostek J, Gascoigne NRJ.

Nat Commun. 2018 Jul 13;9(1):2716. doi: 10.1038/s41467-018-05288-0.

4.

Influenza A Virus Facilitates Its Infectivity by Activating p53 to Inhibit the Expression of Interferon-Induced Transmembrane Proteins.

Wang B, Lam TH, Soh MK, Ye Z, Chen J, Ren EC.

Front Immunol. 2018 May 31;9:1193. doi: 10.3389/fimmu.2018.01193. eCollection 2018.

5.

Identification of Slug and SOX7 as transcriptional repressors binding to the hepatitis B virus core promoter.

Ko HL, Lam TH, Ng H, Toh J, Wang LW, Ren EC.

J Hepatol. 2017 Sep 5. pii: S0168-8278(17)32276-6. doi: 10.1016/j.jhep.2017.08.033. [Epub ahead of print]

PMID:
28887167
6.

Dual non-contiguous peptide occupancy of HLA class I evoke antiviral human CD8 T cell response and form neo-epitopes with self-antigens.

Xiao Z, Ye Z, Tadwal VS, Shen M, Ren EC.

Sci Rep. 2017 Jul 11;7(1):5072. doi: 10.1038/s41598-017-05171-w.

7.

Unique Allelic eQTL Clusters in Human MHC Haplotypes.

Lam TH, Shen M, Tay MZ, Ren EC.

G3 (Bethesda). 2017 Aug 7;7(8):2595-2604. doi: 10.1534/g3.117.043828.

8.

Tailoring of recommendations to reduce serious cutaneous adverse drug reactions: a pharmacogenomics approach.

Tan-Koi WC, Sung C, Chong YY, Lateef A, Pang SM, Vasudevan A, Aw D, Lui NL, Lee SX, Ren EC, Koay ES, Tay YK, Lim YL, Lee HY, Dong D, Loke C, Tan L, Limenta M, Lee EJ, Toh D, Chan CL.

Pharmacogenomics. 2017 Jun;18(9):881-890. doi: 10.2217/pgs-2017-0016. Epub 2017 Jun 8.

PMID:
28594314
9.

Facile and phase-defined determination of HLA alleles with morpholino-functionalized nanoparticle probes.

Zu Y, Tan MH, Ren EC, Ying JY.

Nanomedicine. 2017 Feb;13(2):611-618. doi: 10.1016/j.nano.2016.09.009. Epub 2016 Oct 5.

PMID:
27720927
10.

Primary Localized Cutaneous Amyloidosis and Human Leukocyte Antigen A and -B in a Chinese Population.

Cao T, Shen M, Tan V, Ren EC, Tey HL.

Skinmed. 2016 Feb 1;14(1):75-6. eCollection 2016. No abstract available.

PMID:
27072740
11.

Increased risk of strontium ranelate-related SJS/TEN is associated with HLA.

Lee HY, Shen MX, Lim YL, Tay YK, Chan MM, Pang SM, Xiao ZW, Ang SB, Ren EC.

Osteoporos Int. 2016 Aug;27(8):2577-83. doi: 10.1007/s00198-016-3568-9. Epub 2016 Mar 22.

PMID:
27003892
12.

Actinic Prurigo in Singaporean Chinese: A Positive Association with HLA-DRB1*03:01.

Chen Q, Shen M, Heng YK, Theng TSC, Tey HL, Ren EC, Chong WS.

Photochem Photobiol. 2016 Mar;92(2):355-359. doi: 10.1111/php.12569. Epub 2016 Feb 11.

PMID:
26787110
13.

KIR-HLA profiling shows presence of higher frequencies of strong inhibitory KIR-ligands among prognostically poor risk AML patients.

Shen M, Linn YC, Ren EC.

Immunogenetics. 2016 Feb;68(2):133-44. doi: 10.1007/s00251-015-0888-4. Epub 2015 Dec 9.

PMID:
26649563
14.

Intrahaplotypic Variants Differentiate Complex Linkage Disequilibrium within Human MHC Haplotypes.

Lam TH, Tay MZ, Wang B, Xiao Z, Ren EC.

Sci Rep. 2015 Nov 23;5:16972. doi: 10.1038/srep16972.

15.

The immunodominant influenza A virus M158-66 cytotoxic T lymphocyte epitope exhibits degenerate class I major histocompatibility complex restriction in humans.

Choo JA, Liu J, Toh X, Grotenbreg GM, Ren EC.

J Virol. 2014 Sep;88(18):10613-23. doi: 10.1128/JVI.00855-14. Epub 2014 Jul 2.

16.

Activating killer cell immunoglobulin-like receptor 2DS2 binds to HLA-A*11.

Liu J, Xiao Z, Ko HL, Shen M, Ren EC.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2662-7. doi: 10.1073/pnas.1322052111. Epub 2014 Feb 3.

17.

Building pharmacogenetics into a pharmacovigilance program in Singapore: using serious skin rash as a pilot study.

Toh DS, Tan LL, Aw DC, Pang SM, Lim SH, Thirumoorthy T, Lee HY, Tay YK, Tan SK, Vasudevan A, Lateef A, Chong YY, Chan YC, Loke C, Chan CL, Koay ES, Ren EC, Lee EJ, Sung C.

Pharmacogenomics J. 2014 Aug;14(4):316-21. doi: 10.1038/tpj.2013.46. Epub 2014 Jan 7.

PMID:
24394201
18.

Mapping the p53 transcriptome universe using p53 natural polymorphs.

Wang B, Niu D, Lam TH, Xiao Z, Ren EC.

Cell Death Differ. 2014 Apr;21(4):521-32. doi: 10.1038/cdd.2013.132. Epub 2013 Sep 27.

19.

p53 increases MHC class I expression by upregulating the endoplasmic reticulum aminopeptidase ERAP1.

Wang B, Niu D, Lai L, Ren EC.

Nat Commun. 2013;4:2359. doi: 10.1038/ncomms3359.

20.

Reduced ADP-ribosylation by PARP1 natural polymorphism V762A and by PARP1 inhibitors enhance Hepatitis B virus replication.

Ko HL, Ng HJ, Goh EH, Ren EC.

J Viral Hepat. 2013 Sep;20(9):658-65. doi: 10.1111/jvh.12100. Epub 2013 Apr 17.

PMID:
23910651
21.

Population-specific recombination sites within the human MHC region.

Lam TH, Shen M, Chia JM, Chan SH, Ren EC.

Heredity (Edinb). 2013 Aug;111(2):131-8. doi: 10.1038/hdy.2013.27. Epub 2013 May 29.

22.

hnRNP K suppresses apoptosis independent of p53 status by maintaining high levels of endogenous caspase inhibitors.

Xiao Z, Ko HL, Goh EH, Wang B, Ren EC.

Carcinogenesis. 2013 Jul;34(7):1458-67. doi: 10.1093/carcin/bgt085. Epub 2013 Mar 1.

PMID:
23455382
23.

Structural and functional distinctiveness of HLA-A2 allelic variants.

Chen KY, Liu J, Ren EC.

Immunol Res. 2012 Sep;53(1-3):182-90. doi: 10.1007/s12026-012-8295-5. Review.

PMID:
22434516
24.

Functional Aspects of PARP1 in DNA Repair and Transcription.

Ko HL, Ren EC.

Biomolecules. 2012 Nov 12;2(4):524-48. doi: 10.3390/biom2040524.

25.

A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis.

Lin Z, Bei JX, Shen M, Li Q, Liao Z, Zhang Y, Lv Q, Wei Q, Low HQ, Guo YM, Cao S, Yang M, Hu Z, Xu M, Wang X, Wei Y, Li L, Li C, Li T, Huang J, Pan Y, Jin O, Wu Y, Wu J, Guo Z, He P, Hu S, Wu H, Song H, Zhan F, Liu S, Gao G, Liu Z, Li Y, Xiao C, Li J, Ye Z, He W, Liu D, Shen L, Huang A, Wu H, Tao Y, Pan X, Yu B, Tai ES, Zeng YX, Ren EC, Shen Y, Liu J, Gu J.

Nat Genet. 2011 Dec 4;44(1):73-7. doi: 10.1038/ng.1005.

PMID:
22138694
26.

B*13:50, a novel HLA-B*13 allele, identified by sequence-based typing.

Shen M, Loh MF, Zulaimi MN, Chan SH, Ren EC.

Tissue Antigens. 2012 Jan;79(1):74-5. doi: 10.1111/j.1399-0039.2011.01767.x. Epub 2011 Sep 7.

PMID:
21899519
27.

Novel poly (ADP-ribose) polymerase 1 binding motif in hepatitis B virus core promoter impairs DNA damage repair.

Ko HL, Ren EC.

Hepatology. 2011 Oct;54(4):1190-8. doi: 10.1002/hep.24502. Epub 2011 Jul 25.

PMID:
21721027
28.

Structural insights into the binding of hepatitis B virus core peptide to HLA-A2 alleles: towards designing better vaccines.

Liu J, Chen KY, Ren EC.

Eur J Immunol. 2011 Jul;41(7):2097-106. doi: 10.1002/eji.201041370.

29.

TAP Hunter: a SVM-based system for predicting TAP ligands using local description of amino acid sequence.

Lam TH, Mamitsuka H, Ren EC, Tong JC.

Immunome Res. 2010 Sep 27;6 Suppl 1:S6. doi: 10.1186/1745-7580-6-S1-S6.

30.

Identification of a novel HLA-C allele, HLA-C*03:85, in a Singaporean Chinese.

Shen M, Chan SH, Ren EC.

Tissue Antigens. 2011 Jan;77(1):83-4. doi: 10.1111/j.1399-0039.2010.01555.x. Epub 2010 Aug 19.

PMID:
20727113
31.

The p53 response element and transcriptional repression.

Wang B, Xiao Z, Ko HL, Ren EC.

Cell Cycle. 2010 Mar 1;9(5):870-9. Epub 2010 Mar 2. Review.

PMID:
20160511
32.

Redefining the p53 response element.

Wang B, Xiao Z, Ren EC.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14373-8. doi: 10.1073/pnas.0903284106. Epub 2009 Jul 13. Erratum in: Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16890.

33.

Ablation of phosphoinositide-3-kinase class II alpha suppresses hepatoma cell proliferation.

Ng SK, Neo SY, Yap YW, Karuturi RK, Loh ES, Liau KH, Ren EC.

Biochem Biophys Res Commun. 2009 Sep 18;387(2):310-5. doi: 10.1016/j.bbrc.2009.07.013. Epub 2009 Jul 8.

PMID:
19591801
34.

Immunoinformatics: current trends and future directions.

Tong JC, Ren EC.

Drug Discov Today. 2009 Jul;14(13-14):684-9. doi: 10.1016/j.drudis.2009.04.001. Epub 2009 Apr 18. Review.

PMID:
19379830
35.

BEID: database for sequence-structure-function information on antigen-antibody interactions.

Tong JC, Song CM, Tan PT, Ren EC, Sinha AA.

Bioinformation. 2008;3(2):58-60. Epub 2008 Oct 13.

36.

LIM and SH3 protein 1 (Lasp1) is a novel p53 transcriptional target involved in hepatocellular carcinoma.

Wang B, Feng P, Xiao Z, Ren EC.

J Hepatol. 2009 Mar;50(3):528-37. doi: 10.1016/j.jhep.2008.10.025. Epub 2008 Dec 25.

PMID:
19155088
37.

Asian population frequencies and haplotype distribution of killer cell immunoglobulin-like receptor (KIR) genes among Chinese, Malay, and Indian in Singapore.

Lee YC, Chan SH, Ren EC.

Immunogenetics. 2008 Nov;60(11):645-54. doi: 10.1007/s00251-008-0321-3. Epub 2008 Jul 31.

PMID:
18668235
38.

Cyr61/CCN1 is a tumor suppressor in human hepatocellular carcinoma and involved in DNA damage response.

Feng P, Wang B, Ren EC.

Int J Biochem Cell Biol. 2008;40(1):98-109. Epub 2007 Jul 26.

PMID:
17698398
39.

Cellular transcription modulator SMARCE1 binds to HBV core promoter containing naturally occurring deletions and represses viral replication.

Pan H, Niu DD, Feng H, Ng LF, Ren EC, Chen WN.

Biochim Biophys Acta. 2007 Sep;1772(9):1075-84. Epub 2007 Jul 6.

40.

Identification of a new HLA-A*2464 variant in the Singapore Chinese population.

Lim S, Chen SH, Ren EC.

Tissue Antigens. 2006 Sep;68(3):265-7. No abstract available.

PMID:
16948652
41.

Know the enemy.

Ren EC.

Nat Biotechnol. 2006 Mar;24(3):330-1. No abstract available.

PMID:
16525409
42.

Specific detection of H5N1 avian influenza A virus in field specimens by a one-step RT-PCR assay.

Ng LF, Barr I, Nguyen T, Noor SM, Tan RS, Agathe LV, Gupta S, Khalil H, To TL, Hassan SS, Ren EC.

BMC Infect Dis. 2006 Mar 2;6:40.

43.

Identification of two novel HLA-C alleles, HLA-Cw*1217 and HLA-Cw*030404, in Singapore Chinese.

Pang SW, Chan SH, Ren EC.

Tissue Antigens. 2006 Feb;67(2):177-9. No abstract available.

PMID:
16441500
44.

A population-based LD map of the human chromosome 6p.

Yu HX, Chia JM, Bourque G, Wong MV, Chan SH, Ren EC.

Immunogenetics. 2005 Sep;57(8):559-65. Epub 2005 Sep 29.

PMID:
16133449
45.

Host heterogeneous ribonucleoprotein K (hnRNP K) as a potential target to suppress hepatitis B virus replication.

Ng LF, Chan M, Chan SH, Cheng PC, Leung EH, Chen WN, Ren EC.

PLoS Med. 2005 Jul;2(7):e163. Epub 2005 Jul 26.

47.

A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection.

Ng LF, Hibberd ML, Ooi EE, Tang KF, Neo SY, Tan J, Murthy KR, Vega VB, Chia JM, Liu ET, Ren EC.

BMC Infect Dis. 2004 Sep 9;4:34.

48.

Hcc-1 is a novel component of the nuclear matrix with growth inhibitory function.

Leaw CL, Ren EC, Choong ML.

Cell Mol Life Sci. 2004 Sep;61(17):2264-73.

PMID:
15338056
49.

Identification of discriminators of hepatoma by gene expression profiling using a minimal dataset approach.

Neo SY, Leow CK, Vega VB, Long PM, Islam AF, Lai PB, Liu ET, Ren EC.

Hepatology. 2004 Apr;39(4):944-53.

PMID:
15057898
50.

Detection of severe acute respiratory syndrome coronavirus in blood of infected patients.

Ng LF, Wong M, Koh S, Ooi EE, Tang KF, Leong HN, Ling AE, Agathe LV, Tan J, Liu ET, Ren EC, Ng LC, Hibberd ML.

J Clin Microbiol. 2004 Jan;42(1):347-50.

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