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Items: 20


Preclinical Development of a vWF Aptamer to Limit Thrombosis and Engender Arterial Recanalization of Occluded Vessels.

Nimjee SM, Dornbos D 3rd, Pitoc GA, Wheeler DG, Layzer JM, Venetos N, Huttinger A, Talentino SE, Musgrave NJ, Moody H, Rempel RE, Jones C, Carlisle K, Wilson J, Bratton C, Joseph ME, Khan S, Hoffman MR, Sommerville L, Becker RC, Zweier JL, Sullenger BA.

Mol Ther. 2019 Jul 3;27(7):1228-1241. doi: 10.1016/j.ymthe.2019.03.016. Epub 2019 Mar 30.


Polymer-Mediated Inhibition of Pro-invasive Nucleic Acid DAMPs and Microvesicles Limits Pancreatic Cancer Metastasis.

Naqvi I, Gunaratne R, McDade JE, Moreno A, Rempel RE, Rouse DC, Herrera SG, Pisetsky DS, Lee J, White RR, Sullenger BA.

Mol Ther. 2018 Apr 4;26(4):1020-1031. doi: 10.1016/j.ymthe.2018.02.018. Epub 2018 Feb 23.


Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2.

Moffitt AB, Ondrejka SL, McKinney M, Rempel RE, Goodlad JR, Teh CH, Leppa S, Mannisto S, Kovanen PE, Tse E, Au-Yeung RKH, Kwong YL, Srivastava G, Iqbal J, Yu J, Naresh K, Villa D, Gascoyne RD, Said J, Czader MB, Chadburn A, Richards KL, Rajagopalan D, Davis NS, Smith EC, Palus BC, Tzeng TJ, Healy JA, Lugar PL, Datta J, Love C, Levy S, Dunson DB, Zhuang Y, Hsi ED, Dave SS.

J Exp Med. 2017 May 1;214(5):1371-1386. doi: 10.1084/jem.20160894. Epub 2017 Apr 19.


GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo.

Healy JA, Nugent A, Rempel RE, Moffitt AB, Davis NS, Jiang X, Shingleton JR, Zhang J, Love C, Datta J, McKinney ME, Tzeng TJ, Wettschureck N, Offermanns S, Walzer KA, Chi JT, Rasheed SA, Casey PJ, Lossos IS, Dave SS.

Blood. 2016 Jun 2;127(22):2723-31. doi: 10.1182/blood-2015-07-659938. Epub 2016 Mar 17.


Utilization of the Eμ-Myc mouse to model heterogeneity of therapeutic response.

Rempel RE, Jiang X, Fullerton P, Tan TZ, Ye J, Lau JA, Mori S, Chi JT, Nevins JR, Friedman DR.

Mol Cancer Ther. 2014 Dec;13(12):3219-29. doi: 10.1158/1535-7163.MCT-13-0044. Epub 2014 Oct 27.


A role for E2F activities in determining the fate of Myc-induced lymphomagenesis.

Rempel RE, Mori S, Gasparetto M, Glozak MA, Andrechek ER, Adler SB, Laakso NM, Lagoo AS, Storms R, Smith C, Nevins JR.

PLoS Genet. 2009 Sep;5(9):e1000640. doi: 10.1371/journal.pgen.1000640. Epub 2009 Sep 11.


Utilization of pathway signatures to reveal distinct types of B lymphoma in the Emicro-myc model and human diffuse large B-cell lymphoma.

Mori S, Rempel RE, Chang JT, Yao G, Lagoo AS, Potti A, Bild A, Nevins JR.

Cancer Res. 2008 Oct 15;68(20):8525-34. doi: 10.1158/0008-5472.CAN-08-1329.


Patterns of cell signaling pathway activation that characterize mammary development.

Andrechek ER, Mori S, Rempel RE, Chang JT, Nevins JR.

Development. 2008 Aug;135(14):2403-13. doi: 10.1242/dev.019018. Epub 2008 Jun 11.


Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia.

Giangrande PH, Zhang J, Tanner A, Eckhart AD, Rempel RE, Andrechek ER, Layzer JM, Keys JR, Hagen PO, Nevins JR, Koch WJ, Sullenger BA.

Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):12988-93. Epub 2007 Jul 25.


Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras.

McNamara JO 2nd, Andrechek ER, Wang Y, Viles KD, Rempel RE, Gilboa E, Sullenger BA, Giangrande PH.

Nat Biotechnol. 2006 Aug;24(8):1005-15. Epub 2006 Jun 25.


Combinatorial gene control involving E2F and E Box family members.

Giangrande PH, Zhu W, Rempel RE, Laakso N, Nevins JR.

EMBO J. 2004 Mar 24;23(6):1336-47. Epub 2004 Mar 4.


E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control.

Gaubatz S, Lindeman GJ, Ishida S, Jakoi L, Nevins JR, Livingston DM, Rempel RE.

Mol Cell. 2000 Sep;6(3):729-35.


Loss of E2F4 activity leads to abnormal development of multiple cellular lineages.

Rempel RE, Saenz-Robles MT, Storms R, Morham S, Ishida S, Engel A, Jakoi L, Melhem MF, Pipas JM, Smith C, Nevins JR.

Mol Cell. 2000 Aug;6(2):293-306.


Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts.

Strausfeld UP, Howell M, Descombes P, Chevalier S, Rempel RE, Adamczewski J, Maller JL, Hunt T, Blow JJ.

J Cell Sci. 1996 Jun;109 ( Pt 6):1555-63.


In vivo regulation of the early embryonic cell cycle in Xenopus.

Hartley RS, Rempel RE, Maller JL.

Dev Biol. 1996 Feb 1;173(2):408-19.


Cloning and characterization of the Xenopus cyclin-dependent kinase inhibitor p27XIC1.

Su JY, Rempel RE, Erikson E, Maller JL.

Proc Natl Acad Sci U S A. 1995 Oct 24;92(22):10187-91.


Vaccinia virus encodes an essential gene with strong homology to protein kinases.

Traktman P, Anderson MK, Rempel RE.

J Biol Chem. 1989 Dec 25;264(36):21458-61.

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