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Items: 1 to 50 of 65

1.

Curli Biogenesis: Bacterial Amyloid Assembly by the Type VIII Secretion Pathway.

Bhoite S, van Gerven N, Chapman MR, Remaut H.

EcoSal Plus. 2019 Mar;8(2). doi: 10.1128/ecosalplus.ESP-0037-2018.

PMID:
30892177
2.

Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission.

Rice HC, de Malmazet D, Schreurs A, Frere S, Van Molle I, Volkov AN, Creemers E, Vertkin I, Nys J, Ranaivoson FM, Comoletti D, Savas JN, Remaut H, Balschun D, Wierda KD, Slutsky I, Farrow K, De Strooper B, de Wit J.

Science. 2019 Jan 11;363(6423). pii: eaao4827. doi: 10.1126/science.aao4827.

PMID:
30630900
3.

In silico proteomic and phylogenetic analysis of the outer membrane protein repertoire of gastric Helicobacter species.

Bauwens E, Joosten M, Taganna J, Rossi M, Debraekeleer A, Tay A, Peters F, Backert S, Fox J, Ducatelle R, Remaut H, Haesebrouck F, Smet A.

Sci Rep. 2018 Oct 18;8(1):15453. doi: 10.1038/s41598-018-32476-1.

4.

The Role of Functional Amyloids in Bacterial Virulence.

Van Gerven N, Van der Verren SE, Reiter DM, Remaut H.

J Mol Biol. 2018 Oct 12;430(20):3657-3684. doi: 10.1016/j.jmb.2018.07.010. Epub 2018 Jul 12. Review.

5.

Hop-family Helicobacter outer membrane adhesins form a novel class of Type 5-like secretion proteins with an interrupted β-barrel domain.

Coppens F, Castaldo G, Debraekeleer A, Subedi S, Moonens K, Lo A, Remaut H.

Mol Microbiol. 2018 Oct;110(1):33-46. doi: 10.1111/mmi.14075. Epub 2018 Sep 28.

PMID:
29995350
6.

Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAMs.

Moonens K, Hamway Y, Neddermann M, Reschke M, Tegtmeyer N, Kruse T, Kammerer R, Mejías-Luque R, Singer BB, Backert S, Gerhard M, Remaut H.

EMBO J. 2018 Jul 2;37(13). pii: e98665. doi: 10.15252/embj.201798665. Epub 2018 Jun 1.

PMID:
29858229
7.

Future perspective for potential Helicobacter pylori eradication therapies.

Debraekeleer A, Remaut H.

Future Microbiol. 2018 May;13:671-687. doi: 10.2217/fmb-2017-0115. Epub 2018 May 25.

8.

Nucleation and growth of a bacterial functional amyloid at single-fiber resolution.

Sleutel M, Van den Broeck I, Van Gerven N, Feuillie C, Jonckheere W, Valotteau C, Dufrêne YF, Remaut H.

Nat Chem Biol. 2017 Aug;13(8):902-908. doi: 10.1038/nchembio.2413. Epub 2017 Jun 19.

9.

Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist.

Spaulding CN, Klein RD, Ruer S, Kau AL, Schreiber HL, Cusumano ZT, Dodson KW, Pinkner JS, Fremont DH, Janetka JW, Remaut H, Gordon JI, Hultgren SJ.

Nature. 2017 Jun 22;546(7659):528-532. doi: 10.1038/nature22972. Epub 2017 Jun 14.

10.

Bacterial RadA is a DnaB-type helicase interacting with RecA to promote bidirectional D-loop extension.

Marie L, Rapisarda C, Morales V, Bergé M, Perry T, Soulet AL, Gruget C, Remaut H, Fronzes R, Polard P.

Nat Commun. 2017 May 31;8:15638. doi: 10.1038/ncomms15638.

11.

Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2.

Wohlkönig A, Remaut H, Moune M, Tanina A, Meyer F, Desroses M, Steyaert J, Willand N, Baulard AR, Wintjens R.

Biochem Biophys Res Commun. 2017 May 27;487(2):403-408. doi: 10.1016/j.bbrc.2017.04.074. Epub 2017 Apr 14.

PMID:
28416386
12.

Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence.

Bugaytsova JA, Björnham O, Chernov YA, Gideonsson P, Henriksson S, Mendez M, Sjöström R, Mahdavi J, Shevtsova A, Ilver D, Moonens K, Quintana-Hayashi MP, Moskalenko R, Aisenbrey C, Bylund G, Schmidt A, Åberg A, Brännström K, Königer V, Vikström S, Rakhimova L, Hofer A, Ögren J, Liu H, Goldman MD, Whitmire JM, Ådén J, Younson J, Kelly CG, Gilman RH, Chowdhury A, Mukhopadhyay AK, Nair GB, Papadakos KS, Martinez-Gonzalez B, Sgouras DN, Engstrand L, Unemo M, Danielsson D, Suerbaum S, Oscarson S, Morozova-Roche LA, Olofsson A, Gröbner G, Holgersson J, Esberg A, Strömberg N, Landström M, Eldridge AM, Chromy BA, Hansen LM, Solnick JV, Lindén SK, Haas R, Dubois A, Merrell DS, Schedin S, Remaut H, Arnqvist A, Berg DE, Borén T.

Cell Host Microbe. 2017 Mar 8;21(3):376-389. doi: 10.1016/j.chom.2017.02.013.

13.

Evolution and structural dynamics of bacterial glycan binding adhesins.

Moonens K, Remaut H.

Curr Opin Struct Biol. 2017 Jun;44:48-58. doi: 10.1016/j.sbi.2016.12.003. Epub 2016 Dec 30. Review.

PMID:
28043017
14.

Erratum: Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs.

Javaheri A, Kruse T, Moonens K, Mejías-Luque R, Debraekeleer A, Asche CI, Tegtmeyer N, Kalali B, Bach NC, Sieber SA, Hill DJ, Königer V, Hauck CR, Moskalenko R, Haas R, Busch DH, Klaile E, Slevogt H, Schmidt A, Backert S, Remaut H, Singer BB, Gerhard M.

Nat Microbiol. 2016 Nov 7;2:16243. doi: 10.1038/nmicrobiol.2016.243. No abstract available.

PMID:
27819267
15.

Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs.

Javaheri A, Kruse T, Moonens K, Mejías-Luque R, Debraekeleer A, Asche CI, Tegtmeyer N, Kalali B, Bach NC, Sieber SA, Hill DJ, Königer V, Hauck CR, Moskalenko R, Haas R, Busch DH, Klaile E, Slevogt H, Schmidt A, Backert S, Remaut H, Singer BB, Gerhard M.

Nat Microbiol. 2016 Oct 17;2:16189. doi: 10.1038/nmicrobiol.2016.189. Erratum in: Nat Microbiol. 2016 Nov 07;2:16243.

PMID:
27748768
16.

Inflammation-Induced Adhesin-Receptor Interaction Provides a Fitness Advantage to Uropathogenic E. coli during Chronic Infection.

Conover MS, Ruer S, Taganna J, Kalas V, De Greve H, Pinkner JS, Dodson KW, Remaut H, Hultgren SJ.

Cell Host Microbe. 2016 Oct 12;20(4):482-492. doi: 10.1016/j.chom.2016.08.013. Epub 2016 Sep 22.

17.

Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori.

Moonens K, Gideonsson P, Subedi S, Bugaytsova J, Romaõ E, Mendez M, Nordén J, Fallah M, Rakhimova L, Shevtsova A, Lahmann M, Castaldo G, Brännström K, Coppens F, Lo AW, Ny T, Solnick JV, Vandenbussche G, Oscarson S, Hammarström L, Arnqvist A, Berg DE, Muyldermans S, Borén T, Remaut H.

Cell Host Microbe. 2016 Jan 13;19(1):55-66. doi: 10.1016/j.chom.2015.12.004.

18.

Crystal Structure of the Conserved Amino Terminus of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus Gripped by an Antibody.

Cho KJ, Schepens B, Moonens K, Deng L, Fiers W, Remaut H, Saelens X.

J Virol. 2015 Oct 14;90(1):611-5. doi: 10.1128/JVI.02105-15. Print 2016 Jan 1.

19.

Bacterial amyloid formation: structural insights into curli biogensis.

Van Gerven N, Klein RD, Hultgren SJ, Remaut H.

Trends Microbiol. 2015 Nov;23(11):693-706. doi: 10.1016/j.tim.2015.07.010. Epub 2015 Oct 1. Review.

20.

Structural and adhesive properties of the long polar fimbriae protein LpfD from adherent-invasive Escherichia coli.

Coppens F, Iyyathurai J, Ruer S, Fioravanti A, Taganna J, Vereecke L, De Greve H, Remaut H.

Acta Crystallogr D Biol Crystallogr. 2015 Aug;71(Pt 8):1615-26. doi: 10.1107/S1399004715009803. Epub 2015 Jul 28.

PMID:
26249343
21.

Production, purification and crystallization of a trans-sialidase from Trypanosoma vivax.

Haynes CL, Ameloot P, Remaut H, Callewaert N, Sterckx YG, Magez S.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):577-85. doi: 10.1107/S2053230X15002496. Epub 2015 Apr 21.

22.

Structural insight in the inhibition of adherence of F4 fimbriae producing enterotoxigenic Escherichia coli by llama single domain antibodies.

Moonens K, Van den Broeck I, Okello E, Pardon E, De Kerpel M, Remaut H, De Greve H.

Vet Res. 2015 Feb 24;46:14. doi: 10.1186/s13567-015-0151-x.

23.

Insights in peptide diffusion channels from the bacterial amyloid secretor CsgG.

Van den Broeck I, Goyal P, Remaut H.

Channels (Austin). 2015;9(2):65-7. doi: 10.1080/19336950.2015.1017172. No abstract available.

24.

Structural and functional insight into the carbohydrate receptor binding of F4 fimbriae-producing enterotoxigenic Escherichia coli.

Moonens K, Van den Broeck I, De Kerpel M, Deboeck F, Raymaekers H, Remaut H, De Greve H.

J Biol Chem. 2015 Mar 27;290(13):8409-19. doi: 10.1074/jbc.M114.618595. Epub 2015 Jan 28.

25.

Virulence-targeted Antibacterials: Concept, Promise, and Susceptibility to Resistance Mechanisms.

Ruer S, Pinotsis N, Steadman D, Waksman G, Remaut H.

Chem Biol Drug Des. 2015 Oct;86(4):379-99. doi: 10.1111/cbdd.12517. Epub 2015 Feb 6.

PMID:
25589217
26.

Nanobody mediated inhibition of attachment of F18 Fimbriae expressing Escherichia coli.

Moonens K, De Kerpel M, Coddens A, Cox E, Pardon E, Remaut H, De Greve H.

PLoS One. 2014 Dec 11;9(12):e114691. doi: 10.1371/journal.pone.0114691. eCollection 2014.

27.

Expression, purification and X-ray crystallographic analysis of the Helicobacter pylori blood group antigen-binding adhesin BabA.

Subedi S, Moonens K, Romão E, Lo A, Vandenbussche G, Bugaytsova J, Muyldermans S, Borén T, Remaut H.

Acta Crystallogr F Struct Biol Commun. 2014 Dec 1;70(Pt 12):1631-5. doi: 10.1107/S2053230X14023188. Epub 2014 Nov 14.

28.

Lifting the lid on pilus assembly.

Remaut H, Ben-Tal N.

Elife. 2014 Oct 28;3. doi: 10.7554/eLife.04997.

29.

Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG.

Goyal P, Krasteva PV, Van Gerven N, Gubellini F, Van den Broeck I, Troupiotis-Tsaïlaki A, Jonckheere W, Péhau-Arnaudet G, Pinkner JS, Chapman MR, Hultgren SJ, Howorka S, Fronzes R, Remaut H.

Nature. 2014 Dec 11;516(7530):250-3. doi: 10.1038/nature13768. Epub 2014 Sep 14.

30.

Bacterial surface appendages as targets for novel antibacterial therapeutics.

Steadman D, Lo A, Waksman G, Remaut H.

Future Microbiol. 2014;9(7):887-900. doi: 10.2217/fmb.14.46. Review.

PMID:
25156378
31.

The molecular mechanism of Shiga toxin Stx2e neutralization by a single-domain antibody targeting the cell receptor-binding domain.

Lo AW, Moonens K, De Kerpel M, Brys L, Pardon E, Remaut H, De Greve H.

J Biol Chem. 2014 Sep 5;289(36):25374-81. doi: 10.1074/jbc.M114.566257. Epub 2014 Jul 22.

32.

Secretion and functional display of fusion proteins through the curli biogenesis pathway.

Van Gerven N, Goyal P, Vandenbussche G, De Kerpel M, Jonckheere W, De Greve H, Remaut H.

Mol Microbiol. 2014 Mar;91(5):1022-35. doi: 10.1111/mmi.12515. Epub 2014 Feb 12.

33.

Suppression of type 1 pilus assembly in uropathogenic Escherichia coli by chemical inhibition of subunit polymerization.

Lo AW, Van de Water K, Gane PJ, Chan AW, Steadman D, Stevens K, Selwood DL, Waksman G, Remaut H.

J Antimicrob Chemother. 2014 Apr;69(4):1017-26. doi: 10.1093/jac/dkt467. Epub 2013 Dec 8.

34.

Crystallization and preliminary X-ray crystallographic analysis of the curli transporter CsgG.

Goyal P, Van Gerven N, Jonckheere W, Remaut H.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Dec;69(Pt 12):1349-53. doi: 10.1107/S1744309113028054. Epub 2013 Nov 28.

35.

The crystal structure of the cell division amidase AmiC reveals the fold of the AMIN domain, a new peptidoglycan binding domain.

Rocaboy M, Herman R, Sauvage E, Remaut H, Moonens K, Terrak M, Charlier P, Kerff F.

Mol Microbiol. 2013 Oct;90(2):267-77. doi: 10.1111/mmi.12361. Epub 2013 Aug 23.

36.

Structure of a bacterial type IV secretion core complex at subnanometre resolution.

Rivera-Calzada A, Fronzes R, Savva CG, Chandran V, Lian PW, Laeremans T, Pardon E, Steyaert J, Remaut H, Waksman G, Orlova EV.

EMBO J. 2013 Apr 17;32(8):1195-204. doi: 10.1038/emboj.2013.58. Epub 2013 Mar 19.

37.

Chemical attenuation of pilus function and assembly in Gram-negative bacteria.

Lo AW, Moonens K, Remaut H.

Curr Opin Microbiol. 2013 Feb;16(1):85-92. doi: 10.1016/j.mib.2013.02.003. Epub 2013 Feb 19. Review.

PMID:
23434114
38.

A bacterial glycosidase enables mannose-6-phosphate modification and improved cellular uptake of yeast-produced recombinant human lysosomal enzymes.

Tiels P, Baranova E, Piens K, De Visscher C, Pynaert G, Nerinckx W, Stout J, Fudalej F, Hulpiau P, Tännler S, Geysens S, Van Hecke A, Valevska A, Vervecken W, Remaut H, Callewaert N.

Nat Biotechnol. 2012 Dec;30(12):1225-31. doi: 10.1038/nbt.2427. Epub 2012 Nov 18.

PMID:
23159880
39.

Structural insights into Helicobacter pylori oncoprotein CagA interaction with β1 integrin.

Kaplan-Türköz B, Jiménez-Soto LF, Dian C, Ertl C, Remaut H, Louche A, Tosi T, Haas R, Terradot L.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14640-5. doi: 10.1073/pnas.1206098109. Epub 2012 Aug 20.

40.

SAMBA, a plant-specific anaphase-promoting complex/cyclosome regulator is involved in early development and A-type cyclin stabilization.

Eloy NB, Gonzalez N, Van Leene J, Maleux K, Vanhaeren H, De Milde L, Dhondt S, Vercruysse L, Witters E, Mercier R, Cromer L, Beemster GT, Remaut H, Van Montagu MC, De Jaeger G, Ferreira PC, Inzé D.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13853-8. doi: 10.1073/pnas.1211418109. Epub 2012 Aug 6.

41.

Structural insight in histo-blood group binding by the F18 fimbrial adhesin FedF.

Moonens K, Bouckaert J, Coddens A, Tran T, Panjikar S, De Kerpel M, Cox E, Remaut H, De Greve H.

Mol Microbiol. 2012 Oct;86(1):82-95. doi: 10.1111/j.1365-2958.2012.08174.x. Epub 2012 Aug 13.

42.

SbsB structure and lattice reconstruction unveil Ca2+ triggered S-layer assembly.

Baranova E, Fronzes R, Garcia-Pino A, Van Gerven N, Papapostolou D, Péhau-Arnaudet G, Pardon E, Steyaert J, Howorka S, Remaut H.

Nature. 2012 Jul 5;487(7405):119-22. doi: 10.1038/nature11155.

PMID:
22722836
43.

The tyrosine gate as a potential entropic lever in the receptor-binding site of the bacterial adhesin FimH.

Wellens A, Lahmann M, Touaibia M, Vaucher J, Oscarson S, Roy R, Remaut H, Bouckaert J.

Biochemistry. 2012 Jun 19;51(24):4790-9. doi: 10.1021/bi300251r. Epub 2012 Jun 7.

PMID:
22657089
44.

Small heat-shock protein HSPB1 mutants stabilize microtubules in Charcot-Marie-Tooth neuropathy.

Almeida-Souza L, Asselbergh B, d'Ydewalle C, Moonens K, Goethals S, de Winter V, Azmi A, Irobi J, Timmermans JP, Gevaert K, Remaut H, Van Den Bosch L, Timmerman V, Janssens S.

J Neurosci. 2011 Oct 26;31(43):15320-8. doi: 10.1523/JNEUROSCI.3266-11.2011.

45.

Pili and flagella biology, structure, and biotechnological applications.

Van Gerven N, Waksman G, Remaut H.

Prog Mol Biol Transl Sci. 2011;103:21-72. doi: 10.1016/B978-0-12-415906-8.00005-4. Review.

PMID:
21999994
46.

Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate.

Phan G, Remaut H, Wang T, Allen WJ, Pirker KF, Lebedev A, Henderson NS, Geibel S, Volkan E, Yan J, Kunze MB, Pinkner JS, Ford B, Kay CW, Li H, Hultgren SJ, Thanassi DG, Waksman G.

Nature. 2011 Jun 2;474(7349):49-53. doi: 10.1038/nature10109.

47.

Design and synthesis of C-2 substituted thiazolo and dihydrothiazolo ring-fused 2-pyridones: pilicides with increased antivirulence activity.

Chorell E, Pinkner JS, Phan G, Edvinsson S, Buelens F, Remaut H, Waksman G, Hultgren SJ, Almqvist F.

J Med Chem. 2010 Aug 12;53(15):5690-5. doi: 10.1021/jm100470t.

48.

Protein oligomerization in the bacterial outer membrane (Review).

Meng G, Fronzes R, Chandran V, Remaut H, Waksman G.

Mol Membr Biol. 2009 Apr;26(3):136-45. doi: 10.1080/09687680802712422. Epub 2009 Feb 14. Review.

PMID:
19225986
49.

Structural determinants of polymerization reactivity of the P pilus adaptor subunit PapF.

Verger D, Rose RJ, Paci E, Costakes G, Daviter T, Hultgren S, Remaut H, Ashcroft AE, Radford SE, Waksman G.

Structure. 2008 Nov 12;16(11):1724-31. doi: 10.1016/j.str.2008.08.012.

50.

Unraveling the molecular basis of subunit specificity in P pilus assembly by mass spectrometry.

Rose RJ, Verger D, Daviter T, Remaut H, Paci E, Waksman G, Ashcroft AE, Radford SE.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12873-8. doi: 10.1073/pnas.0802177105. Epub 2008 Aug 26.

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