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Lupus nephritis: low urinary DNase I levels reflect loss of renal DNase I and may be utilized as a biomarker of disease progression.

Pedersen HL, Horvei KD, Thiyagarajan D, Norby GE, Seredkina N, Moroni G, Eilertsen GØ, Holdaas H, Strøm EH, Bakland G, Meroni PL, Rekvig OP.

J Pathol Clin Res. 2018 Jul;4(3):193-203. doi: 10.1002/cjp2.99. Epub 2018 Apr 6.


Systemic Lupus Erythematosus: Definitions, Contexts, Conflicts, Enigmas.

Rekvig OP.

Front Immunol. 2018 Mar 1;9:387. doi: 10.3389/fimmu.2018.00387. eCollection 2018.


IL-1β Promotes a New Function of DNase I as a Transcription Factor for the Fas Receptor Gene.

Thiyagarajan D, Pedersen HL, Seredkina N, Horvei KD, Arranz L, Sonneveld R, Nijenhuis T, van der Vlag J, Rekvig OP.

Front Cell Dev Biol. 2018 Feb 6;6:7. doi: 10.3389/fcell.2018.00007. eCollection 2018.


Lupus nephritis progression in FcγRIIB-/-yaa mice is associated with early development of glomerular electron dense deposits and loss of renal DNase I in severe disease.

Horvei KD, Pedersen HL, Fismen S, Thiyagarajan D, Schneider A, Rekvig OP, Winkler TH, Seredkina N.

PLoS One. 2017 Nov 30;12(11):e0188863. doi: 10.1371/journal.pone.0188863. eCollection 2017.


B Cell Tolerance to Deiminated Histones in BALB/c, C57BL/6, and Autoimmune-Prone Mouse Strains.

Dwivedi N, Hedberg A, Zheng YY, Neeli I, Satoh M, Morel L, Rekvig OP, Radic M.

Front Immunol. 2017 Mar 30;8:362. doi: 10.3389/fimmu.2017.00362. eCollection 2017.


Lipid degradation promotes prostate cancer cell survival.

Itkonen HM, Brown M, Urbanucci A, Tredwell G, Ho Lau C, Barfeld S, Hart C, Guldvik IJ, Takhar M, Heemers HV, Erho N, Bloch K, Davicioni E, Derua R, Waelkens E, Mohler JL, Clarke N, Swinnen JV, Keun HC, Rekvig OP, Mills IG.

Oncotarget. 2017 Jun 13;8(24):38264-38275. doi: 10.18632/oncotarget.16123.


A framework for remission in SLE: consensus findings from a large international task force on definitions of remission in SLE (DORIS).

van Vollenhoven R, Voskuyl A, Bertsias G, Aranow C, Aringer M, Arnaud L, Askanase A, Balážová P, Bonfa E, Bootsma H, Boumpas D, Bruce I, Cervera R, Clarke A, Coney C, Costedoat-Chalumeau N, Czirják L, Derksen R, Doria A, Dörner T, Fischer-Betz R, Fritsch-Stork R, Gordon C, Graninger W, Györi N, Houssiau F, Isenberg D, Jacobsen S, Jayne D, Kuhn A, Le Guern V, Lerstrøm K, Levy R, Machado-Ribeiro F, Mariette X, Missaykeh J, Morand E, Mosca M, Inanc M, Navarra S, Neumann I, Olesinska M, Petri M, Rahman A, Rekvig OP, Rovensky J, Shoenfeld Y, Smolen J, Tincani A, Urowitz M, van Leeuw B, Vasconcelos C, Voss A, Werth VP, Zakharova H, Zoma A, Schneider M, Ward M.

Ann Rheum Dis. 2017 Mar;76(3):554-561. doi: 10.1136/annrheumdis-2016-209519. Epub 2016 Nov 24. Review.


Future Perspectives on Pathogenesis of Lupus Nephritis: Facts, Problems, and Potential Causal Therapy Modalities.

Rekvig OP, Thiyagarajan D, Pedersen HL, Horvei KD, Seredkina N.

Am J Pathol. 2016 Nov;186(11):2772-2782. doi: 10.1016/j.ajpath.2016.06.026. Epub 2016 Sep 21. Review.


Murine and Human Lupus Nephritis: Pathogenic Mechanisms and Theoretical Strategies for Therapy.

Pedersen HL, Horvei KD, Thiyagarajan D, Seredkina N, Rekvig OP.

Semin Nephrol. 2015 Sep;35(5):427-38. doi: 10.1016/j.semnephrol.2015.08.004. Review.


TNFα Amplifies DNaseI Expression in Renal Tubular Cells while IL-1β Promotes Nuclear DNaseI Translocation in an Endonuclease-Inactive Form.

Thiyagarajan D, Rekvig OP, Seredkina N.

PLoS One. 2015 Jun 11;10(6):e0129485. doi: 10.1371/journal.pone.0129485. eCollection 2015.


The anti-DNA antibody: origin and impact, dogmas and controversies.

Rekvig OP.

Nat Rev Rheumatol. 2015 Sep;11(9):530-40. doi: 10.1038/nrrheum.2015.69. Epub 2015 Jun 2. Review.


Galectin-3 binding protein links circulating microparticles with electron dense glomerular deposits in lupus nephritis.

Nielsen CT, Østergaard O, Rekvig OP, Sturfelt G, Jacobsen S, Heegaard NH.

Lupus. 2015 Oct;24(11):1150-60. doi: 10.1177/0961203315580146. Epub 2015 Apr 2.


Clinical phenotype associations with various types of anti-dsDNA antibodies in patients with recent onset of rheumatic symptoms. Results from a multicentre observational study.

Compagno M, Rekvig OP, Bengtsson AA, Sturfelt G, Heegaard NH, Jönsen A, Jacobsen RS, Eilertsen GØ, Fenton CG, Truedsson L, Nossent JC, Jacobsen S.

Lupus Sci Med. 2014 Apr 1;1(1):e000007. doi: 10.1136/lupus-2013-000007. eCollection 2014.


The pathogenesis and diagnosis of systemic lupus erythematosus: still not resolved.

Rekvig OP, Van der Vlag J.

Semin Immunopathol. 2014 May;36(3):301-11. doi: 10.1007/s00281-014-0428-6. Epub 2014 Apr 25. Review.


Review: antinucleosome antibodies: a critical reflection on their specificities and diagnostic impact.

Rekvig OP, van der Vlag J, Seredkina N.

Arthritis Rheumatol. 2014 May;66(5):1061-9. doi: 10.1002/art.38365. Review. No abstract available.


LMW heparin prevents increased kidney expression of proinflammatory mediators in (NZBxNZW)F1 mice.

Hedberg A, Kanapathippillai P, Rekvig OP, Fenton KA.

Clin Dev Immunol. 2013;2013:791262. doi: 10.1155/2013/791262. Epub 2013 Sep 17.


Lupus nephritis: enigmas, conflicting models and an emerging concept.

Seredkina N, Van Der Vlag J, Berden J, Mortensen E, Rekvig OP.

Mol Med. 2013 Jul 24;19:161-9. doi: 10.2119/molmed.2013.00010. Review.


Low diagnostic and predictive value of anti-dsDNA antibodies in unselected patients with recent onset of rheumatic symptoms: results from a long-term follow-up Scandinavian multicentre study.

Compagno M, Jacobsen S, Rekvig OP, Truedsson L, Heegaard NH, Nossent J, Jönsen A, Jacobsen RS, Eilertsen GØ, Sturfelt G, Bengtsson AA.

Scand J Rheumatol. 2013;42(4):311-6. doi: 10.3109/03009742.2013.765032. Epub 2013 Mar 16.


Impact of the tumor necrosis factor receptor-associated protein 1 (Trap1) on renal DNaseI shutdown and on progression of murine and human lupus nephritis.

Fismen S, Thiyagarajan D, Seredkina N, Nielsen H, Jacobsen S, Elung-Jensen T, Kamper AL, Johansen SD, Mortensen ES, Rekvig OP.

Am J Pathol. 2013 Mar;182(3):688-700. doi: 10.1016/j.ajpath.2012.11.013. Epub 2012 Dec 27.


Immunity and autoimmunity to dsDNA and chromatin--the role of immunogenic DNA-binding proteins and nuclease deficiencies.

Rekvig OP, Mortensen ES.

Autoimmunity. 2012 Dec;45(8):588-92. doi: 10.3109/08916934.2012.719954. Epub 2012 Sep 26. Review.


Silencing of renal DNaseI in murine lupus nephritis imposes exposure of large chromatin fragments and activation of Toll like receptors and the Clec4e.

Thiyagarajan D, Fismen S, Seredkina N, Jacobsen S, Elung-Jensen T, Kamper AL, Fenton CG, Rekvig OP, Mortensen ES.

PLoS One. 2012;7(3):e34080. doi: 10.1371/journal.pone.0034080. Epub 2012 Mar 30.


Autoantibodies in lupus: culprits or passive bystanders?

Rekvig OP, Putterman C, Casu C, Gao HX, Ghirardello A, Mortensen ES, Tincani A, Doria A.

Autoimmun Rev. 2012 Jun;11(8):596-603. doi: 10.1016/j.autrev.2011.10.021. Epub 2011 Oct 25. Review.


Acquired loss of renal nuclease activity is restricted to DNaseI and is an organ-selective feature in murine lupus nephritis.

Seredkina N, Rekvig OP.

Am J Pathol. 2011 Sep;179(3):1120-8. doi: 10.1016/j.ajpath.2011.05.011. Epub 2011 Jun 30.


Chromatin as a target antigen in human and murine lupus nephritis.

Hedberg A, Mortensen ES, Rekvig OP.

Arthritis Res Ther. 2011 Apr 18;13(2):214. doi: 10.1186/ar3281. Review.


Circulating levels of chromatin fragments are inversely correlated with anti-dsDNA antibody levels in human and murine systemic lupus erythematosus.

Jørgensen MH, Rekvig OP, Jacobsen RS, Jacobsen S, Fenton KA.

Immunol Lett. 2011 Aug 30;138(2):179-86. doi: 10.1016/j.imlet.2011.04.006. Epub 2011 Apr 17.


Alterations in Wnt pathway activity in mouse serum and kidneys during lupus development.

Tveita AA, Rekvig OP.

Arthritis Rheum. 2011 Feb;63(2):513-22. doi: 10.1002/art.30116.


Nephritogenic antibodies bind in glomeruli through interaction with exposed chromatin fragments and not with renal cross-reactive antigens.

Mjelle JE, Rekvig OP, Van Der Vlag J, Fenton KA.

Autoimmunity. 2011 Aug;44(5):373-83. doi: 10.3109/08916934.2010.541170. Epub 2011 Jan 19.


Regulatory and pathogenetic mechanisms of autoantibodies in SLE.

Radic M, Herrmann M, van der Vlag J, Rekvig OP.

Autoimmunity. 2011 Aug;44(5):349-56. doi: 10.3109/08916934.2010.536794. Epub 2011 Jan 14. Review.


BCR-ABL isoforms associated with intrinsic or acquired resistance to imatinib: more heterogeneous than just ABL kinase domain point mutations?

Gruber FX, Lundán T, Goll R, Silye A, Mikkola I, Rekvig OP, Knuutila S, Remes K, Gedde-Dahl T, Porkka K, Hjorth-Hansen H.

Med Oncol. 2012 Mar;29(1):219-26. doi: 10.1007/s12032-010-9781-z. Epub 2011 Jan 8.


Heparin exerts a dual effect on murine lupus nephritis by enhancing enzymatic chromatin degradation and preventing chromatin binding in glomerular membranes.

Hedberg A, Fismen S, Fenton KA, Fenton C, Osterud B, Mortensen ES, Rekvig OP.

Arthritis Rheum. 2011 Apr;63(4):1065-75. doi: 10.1002/art.30211.


Renal Dnase1 enzyme activity and protein expression is selectively shut down in murine and human membranoproliferative lupus nephritis.

Zykova SN, Tveita AA, Rekvig OP.

PLoS One. 2010 Aug 10;5(8). pii: e12096. doi: 10.1371/journal.pone.0012096.


Nuclease deficiencies promote end-stage lupus nephritis but not nephritogenic autoimmunity in (NZB × NZW) F1 mice.

Fismen S, Mortensen ES, Rekvig OP.

Immunol Cell Biol. 2011 Jan;89(1):90-9. doi: 10.1038/icb.2010.75. Epub 2010 Jun 15. Review.


Deposition of chromatin-IgG complexes in skin of nephritic MRL-lpr/lpr mice is associated with increased local matrix metalloprotease activities.

Hedberg A, Fismen S, Fenton KA, Mortensen ES, Rekvig OP.

Exp Dermatol. 2010 Aug;19(8):e265-74. doi: 10.1111/j.1600-0625.2010.01064.x.


Anti-dsDNA antibodies promote initiation, and acquired loss of renal Dnase1 promotes progression of lupus nephritis in autoimmune (NZBxNZW)F1 mice.

Fenton K, Fismen S, Hedberg A, Seredkina N, Fenton C, Mortensen ES, Rekvig OP.

PLoS One. 2009 Dec 29;4(12):e8474. doi: 10.1371/journal.pone.0008474.


European League Against Rheumatism recommendations for monitoring patients with systemic lupus erythematosus in clinical practice and in observational studies.

Mosca M, Tani C, Aringer M, Bombardieri S, Boumpas D, Brey R, Cervera R, Doria A, Jayne D, Khamashta MA, Kuhn A, Gordon C, Petri M, Rekvig OP, Schneider M, Sherer Y, Shoenfeld Y, Smolen JS, Talarico R, Tincani A, van Vollenhoven RF, Ward MM, Werth VP, Carmona L.

Ann Rheum Dis. 2010 Jul;69(7):1269-74. doi: 10.1136/ard.2009.117200. Epub 2009 Nov 5.


Pure anti-dsDNA mAbs need chromatin structures to promote glomerular mesangial deposits in BALB/c mice.

Fenton KA, Tømmerås B, Marion TN, Rekvig OP.

Autoimmunity. 2010 Mar;43(2):179-88. doi: 10.3109/08916930903305633.


Progression of murine lupus nephritis is linked to acquired renal Dnase1 deficiency and not to up-regulated apoptosis.

Seredkina N, Zykova SN, Rekvig OP.

Am J Pathol. 2009 Jul;175(1):97-106. doi: 10.2353/ajpath.2009.080943. Epub 2009 Jun 15.


Circulating chromatin-anti-chromatin antibody complexes bind with high affinity to dermo-epidermal structures in murine and human lupus nephritis.

Fismen S, Hedberg A, Fenton KA, Jacobsen S, Krarup E, Kamper AL, Rekvig OP, Mortensen ES.

Lupus. 2009 Jun;18(7):597-607. doi: 10.1177/0961203308100512.


Nephritogenic potential of anti-DNA antibodies against necrotic nucleosomes.

Mortensen ES, Rekvig OP.

J Am Soc Nephrol. 2009 Apr;20(4):696-704. doi: 10.1681/ASN.2008010112. Review.


Development of lupus nephritis is associated with qualitative changes in the glomerular collagen IV matrix composition.

Tveita AA, Ninomiya Y, Sado Y, Rekvig OP, Zykova SN.

Lupus. 2009 Apr;18(4):355-60. doi: 10.1177/0961203308100842.


Glomerular matrix metalloproteinases and their regulators in the pathogenesis of lupus nephritis.

Tveita A, Rekvig OP, Zykova SN.

Arthritis Res Ther. 2008;10(6):229. doi: 10.1186/ar2532. Epub 2008 Dec 1. Review.


Exposure of chromatin and not high affinity for dsDNA determines the nephritogenic impact of anti-dsDNA antibodies in (NZBxNZW)F1 mice.

Mjelle JE, Kalaaji M, Rekvig OP.

Autoimmunity. 2009 Feb;42(2):104-11. doi: 10.1080/08916930802375729.


Increased glomerular matrix metalloproteinase activity in murine lupus nephritis.

Tveita AA, Rekvig OP, Zykova SN.

Kidney Int. 2008 Nov;74(9):1150-8. doi: 10.1038/ki.2008.308. Epub 2008 Jul 2.


Glomerular targets of nephritogenic autoantibodies in systemic lupus erythematosus.

van Bavel CC, Fenton KA, Rekvig OP, van der Vlag J, Berden JH.

Arthritis Rheum. 2008 Jul;58(7):1892-9. doi: 10.1002/art.23626. Review. No abstract available.


Renal expression of polyomavirus large T antigen is associated with nephritis in human systemic lupus erythematosus.

Fenton KA, Mjelle JE, Jakobsen S, Olsen R, Rekvig OP.

Mol Immunol. 2008 Jun;45(11):3117-24. doi: 10.1016/j.molimm.2008.03.001.


Reduced fragmentation of apoptotic chromatin is associated with nephritis in lupus-prone (NZB x NZW)F(1) mice.

Zykova SN, Seredkina N, Benjaminsen J, Rekvig OP.

Arthritis Rheum. 2008 Mar;58(3):813-25. doi: 10.1002/art.23276.


Lupus nephritis: the central role of nucleosomes revealed.

Mortensen ES, Fenton KA, Rekvig OP.

Am J Pathol. 2008 Feb;172(2):275-83. doi: 10.2353/ajpath.2008.070563. Epub 2008 Jan 10. Review.


A central role of nucleosomes in lupus nephritis.

Fenton KA, Rekvig OP.

Ann N Y Acad Sci. 2007 Jun;1108:104-13. Review.


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