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Items: 1 to 50 of 109

1.

A novel retroviral vector system to analyze expression from mRNA with retained introns using fluorescent proteins and flow cytometry.

Jackson PEH, Huang J, Sharma M, Rasmussen SK, Hammarskjold ML, Rekosh D.

Sci Rep. 2019 Apr 23;9(1):6467. doi: 10.1038/s41598-019-42914-3.

2.

Evolution of the HIV-1 Rev Response Element during Natural Infection Reveals Nucleotide Changes That Correlate with Altered Structure and Increased Activity over Time.

Sherpa C, Jackson PEH, Gray LR, Anastos K, Le Grice SFJ, Hammarskjold ML, Rekosh D.

J Virol. 2019 May 15;93(11). pii: e02102-18. doi: 10.1128/JVI.02102-18. Print 2019 Jun 1.

3.

Characterization of APOBEC3 variation in a population of HIV-1 infected individuals in northern South Africa.

Matume ND, Tebit DM, Gray LR, Turner SD, Rekosh D, Bessong PO, Hammarskjöld ML.

BMC Med Genet. 2019 Jan 19;20(1):21. doi: 10.1186/s12881-018-0740-4.

4.

Next generation sequencing reveals a high frequency of CXCR4 utilizing viruses in HIV-1 chronically infected drug experienced individuals in South Africa.

Matume ND, Tebit DM, Gray LR, Hammarskjold ML, Rekosh D, Bessong PO.

J Clin Virol. 2018 Jun;103:81-87. doi: 10.1016/j.jcv.2018.02.008. Epub 2018 Feb 15.

PMID:
29661652
5.

Intron retention in viruses and cellular genes: Detention, border controls and passports.

Rekosh D, Hammarskjold ML.

Wiley Interdiscip Rev RNA. 2018 May;9(3):e1470. doi: 10.1002/wrna.1470. Epub 2018 Mar 6. Review.

6.

High level of HIV-1 drug resistance mutations in patients with unsuppressed viral loads in rural northern South Africa.

Etta EM, Mavhandu L, Manhaeve C, McGonigle K, Jackson P, Rekosh D, Hammarskjold ML, Bessong PO, Tebit DM.

AIDS Res Ther. 2017 Jul 27;14(1):36. doi: 10.1186/s12981-017-0161-z.

7.

SR proteins: To shuttle or not to shuttle, that is the question.

Hammarskjold ML, Rekosh D.

J Cell Biol. 2017 Jul 3;216(7):1875-1877. doi: 10.1083/jcb.201705009. Epub 2017 Jun 9.

8.

An NXF1 mRNA with a retained intron is expressed in hippocampal and neocortical neurons and is translated into a protein that functions as an Nxf1 cofactor.

Li Y, Bor YC, Fitzgerald MP, Lee KS, Rekosh D, Hammarskjold ML.

Mol Biol Cell. 2016 Dec 1;27(24):3903-3912. Epub 2016 Oct 5.

9.

Effect of intercalator and Lewis acid-base branched peptide complex formation: boosting affinity towards HIV-1 RRE RNA.

Wynn JE, Zhang W, Tebit DM, Gray LR, Hammarskjold ML, Rekosh D, Santos WL.

Medchemcomm. 2016 Jul 1;7(7):1436-1440. Epub 2016 Jun 6.

10.

Rev-RRE Functional Activity Differs Substantially Among Primary HIV-1 Isolates.

Jackson PE, Tebit DM, Rekosh D, Hammarskjold ML.

AIDS Res Hum Retroviruses. 2016 Sep;32(9):923-34. doi: 10.1089/AID.2016.0047. Epub 2016 Jun 3.

11.

Characterization and in vitro activity of a branched peptide boronic acid that interacts with HIV-1 RRE RNA.

Wynn JE, Zhang W, Tebit DM, Gray LR, Hammarskjold ML, Rekosh D, Santos WL.

Bioorg Med Chem. 2016 Sep 1;24(17):3947-3952. doi: 10.1016/j.bmc.2016.04.009. Epub 2016 Apr 5.

12.

The HIV-1 Rev response element (RRE) adopts alternative conformations that promote different rates of virus replication.

Sherpa C, Rausch JW, Le Grice SF, Hammarskjold ML, Rekosh D.

Nucleic Acids Res. 2015 May 19;43(9):4676-86. doi: 10.1093/nar/gkv313. Epub 2015 Apr 8.

13.

Evolutionary conservation of a molecular machinery for export and expression of mRNAs with retained introns.

Wang B, Rekosh D, Hammarskjold ML.

RNA. 2015 Mar;21(3):426-37. doi: 10.1261/rna.048520.114. Epub 2015 Jan 20.

14.

Limited nucleotide changes in the Rev response element (RRE) during HIV-1 infection alter overall Rev-RRE activity and Rev multimerization.

Sloan EA, Kearney MF, Gray LR, Anastos K, Daar ES, Margolick J, Maldarelli F, Hammarskjold ML, Rekosh D.

J Virol. 2013 Oct;87(20):11173-86. doi: 10.1128/JVI.01392-13. Epub 2013 Aug 7.

15.

Xenotropic MLV envelope proteins induce tumor cells to secrete factors that promote the formation of immature blood vessels.

Murgai M, Thomas J, Cherepanova O, Delviks-Frankenberry K, Deeble P, Pathak VK, Rekosh D, Owens G.

Retrovirology. 2013 Mar 27;10:34. doi: 10.1186/1742-4690-10-34.

16.

Molecular epidemiology of HIV in two highly endemic areas of northeastern South Africa.

Iweriebor BC, Mavhandu LG, Masebe T, Rekosh D, Hammarskjold ML, Mphahlele JM, Bessong PO.

Arch Virol. 2012 Mar;157(3):455-65. doi: 10.1007/s00705-011-1180-z. Epub 2011 Dec 22.

17.

A long-awaited structure is rev-ealed.

Hammarskjold MH, Rekosh D.

Viruses. 2011 May;3(5):484-92. doi: 10.3390/v3050484.

18.

The Tpr protein regulates export of mRNAs with retained introns that traffic through the Nxf1 pathway.

Coyle JH, Bor YC, Rekosh D, Hammarskjold ML.

RNA. 2011 Jul;17(7):1344-56. doi: 10.1261/rna.2616111. Epub 2011 May 25.

19.

Single-nucleotide changes in the HIV Rev-response element mediate resistance to compounds that inhibit Rev function.

Shuck-Lee D, Chang H, Sloan EA, Hammarskjold ML, Rekosh D.

J Virol. 2011 Apr;85(8):3940-9. doi: 10.1128/JVI.02683-10. Epub 2011 Feb 2.

20.

Probing the HIV-1 genomic RNA trafficking pathway and dimerization by genetic recombination and single virion analyses.

Moore MD, Nikolaitchik OA, Chen J, Hammarskjöld ML, Rekosh D, Hu WS.

PLoS Pathog. 2009 Oct;5(10):e1000627. doi: 10.1371/journal.ppat.1000627. Epub 2009 Oct 16.

21.
22.

Resistance to RevM10 inhibition reflects a conformational switch in the HIV-1 Rev response element.

Legiewicz M, Badorrek CS, Turner KB, Fabris D, Hamm TE, Rekosh D, Hammarskjöld ML, Le Grice SF.

Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14365-70. doi: 10.1073/pnas.0804461105. Epub 2008 Sep 5.

23.

Heterocyclic compounds that inhibit Rev-RRE function and human immunodeficiency virus type 1 replication.

Shuck-Lee D, Chen FF, Willard R, Raman S, Ptak R, Hammarskjold ML, Rekosh D.

Antimicrob Agents Chemother. 2008 Sep;52(9):3169-79. doi: 10.1128/AAC.00274-08. Epub 2008 Jul 14.

24.

Nef does not contribute to replication differences between R5 pre-AIDS and AIDS HIV-1 clones from patient ACH142.

Olivieri KC, Scoggins RM, Broderick B, Powell ML, Alexander MA, Hammarskjöld ML, Rekosh D, Camerini D.

Retrovirology. 2008 May 29;5:42. doi: 10.1186/1742-4690-5-42.

25.

Genotype testing and antiretroviral resistance profiles from HIV-1 patients experiencing therapeutic failure in northeast Brazil.

Medeiros MS, Arruda EA, Guerrant RL, Brown C, Hammarskjold ML, Rekosh D, Lima AA.

Braz J Infect Dis. 2007 Aug;11(4):390-4. Erratum in: Braz J Infect Dis. 2007 Oct;11(5):528-9.

PMID:
17873990
26.

The shuttling SR protein 9G8 plays a role in translation of unspliced mRNA containing a constitutive transport element.

Swartz JE, Bor YC, Misawa Y, Rekosh D, Hammarskjold ML.

J Biol Chem. 2007 Jul 6;282(27):19844-53. Epub 2007 May 18.

27.

Resistance mutational analysis of HIV type 1 subtype C among rural South African drug-naive patients prior to large-scale availability of antiretrovirals.

Bessong PO, Mphahlele J, Choge IA, Obi LC, Morris L, Hammarskjold ML, Rekosh DM.

AIDS Res Hum Retroviruses. 2006 Dec;22(12):1306-12.

PMID:
17209775
28.

The envelope gene is a cytopathic determinant of CCR5 tropic HIV-1.

Olivieri K, Scoggins RM, Bor YC, Matthews A, Mark D, Taylor JR Jr, Chernauskas D, Hammarskjöld ML, Rekosh D, Camerini D.

Virology. 2007 Feb 5;358(1):23-38. Epub 2006 Sep 26.

29.

An intron with a constitutive transport element is retained in a Tap messenger RNA.

Li Y, Bor YC, Misawa Y, Xue Y, Rekosh D, Hammarskjöld ML.

Nature. 2006 Sep 14;443(7108):234-7.

PMID:
16971948
30.

The Wilms' tumor 1 (WT1) gene (+KTS isoform) functions with a CTE to enhance translation from an unspliced RNA with a retained intron.

Bor YC, Swartz J, Morrison A, Rekosh D, Ladomery M, Hammarskjöld ML.

Genes Dev. 2006 Jun 15;20(12):1597-608. Epub 2006 May 31.

31.

Mutations in tap uncouple RNA export activity from translocation through the nuclear pore complex.

Lévesque L, Bor YC, Matzat LH, Jin L, Berberoglu S, Rekosh D, Hammarskjöld ML, Paschal BM.

Mol Biol Cell. 2006 Feb;17(2):931-43. Epub 2005 Nov 28.

33.

Tap and NXT promote translation of unspliced mRNA.

Jin L, Guzik BW, Bor YC, Rekosh D, Hammarskjöld ML.

Genes Dev. 2003 Dec 15;17(24):3075-86.

34.

Chondrocyte transplantation into articular cartilage defects with use of calcium alginate: the fate of the cells.

Mierisch CM, Wilson HA, Turner MA, Milbrandt TA, Berthoux L, Hammarskjöld ML, Rekosh D, Balian G, Diduch DR.

J Bone Joint Surg Am. 2003 Sep;85(9):1757-67.

PMID:
12954835
35.

Tracing transduced cells in osteochondral defects.

Milbrandt T, Berthoux L, Christenson V, Baumbusch C, Rekosh D, Balian G, Diduch D.

J Pediatr Orthop. 2003 Jul-Aug;23(4):430-6.

PMID:
12826937
36.

Sam68 enhances the cytoplasmic utilization of intron-containing RNA and is functionally regulated by the nuclear kinase Sik/BRK.

Coyle JH, Guzik BW, Bor YC, Jin L, Eisner-Smerage L, Taylor SJ, Rekosh D, Hammarskjöld ML.

Mol Cell Biol. 2003 Jan;23(1):92-103.

37.

RNA export mediated by tap involves NXT1-dependent interactions with the nuclear pore complex.

Lévesque L, Guzik B, Guan T, Coyle J, Black BE, Rekosh D, Hammarskjöld ML, Paschal BM.

J Biol Chem. 2001 Nov 30;276(48):44953-62. Epub 2001 Sep 28.

38.
39.

NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells.

Guzik BW, Levesque L, Prasad S, Bor YC, Black BE, Paschal BM, Rekosh D, Hammarskjöld ML.

Mol Cell Biol. 2001 Apr;21(7):2545-54.

40.

RNA trafficking signals in human immunodeficiency virus type 1.

Mouland AJ, Xu H, Cui H, Krueger W, Munro TP, Prasol M, Mercier J, Rekosh D, Smith R, Barbarese E, Cohen EA, Carson JH.

Mol Cell Biol. 2001 Mar;21(6):2133-43.

41.

Design and use of an inducibly activated human immunodeficiency virus type 1 Nef to study immune modulation.

Walk SF, Alexander M, Maier B, Hammarskjold ML, Rekosh DM, Ravichandran KS.

J Virol. 2001 Jan;75(2):834-43.

42.

Intravirion targeting of a functional anti-human immunodeficiency virus ribozyme directed to pol.

Giordano V, Jin DY, Rekosh D, Jeang KT.

Virology. 2000 Feb 15;267(2):174-84.

45.

The constitutive transport element (CTE) of Mason-Pfizer monkey virus (MPMV) accesses a cellular mRNA export pathway.

Pasquinelli AE, Ernst RK, Lund E, Grimm C, Zapp ML, Rekosh D, Hammarskjöld ML, Dahlberg JE.

EMBO J. 1997 Dec 15;16(24):7500-10.

46.

The effect of viral regulatory protein expression on gene delivery by human immunodeficiency virus type 1 vectors produced in stable packaging cell lines.

Srinivasakumar N, Chazal N, Helga-Maria C, Prasad S, Hammarskjöld ML, Rekosh D.

J Virol. 1997 Aug;71(8):5841-8.

47.

A class of nonribosomal nucleolar components is located in chromosome periphery and in nucleolus-derived foci during anaphase and telophase.

Dundr M, Meier UT, Lewis N, Rekosh D, Hammarskjöld ML, Olson MO.

Chromosoma. 1997 Jun;105(7-8):407-17.

PMID:
9211968
48.
49.

A structured retroviral RNA element that mediates nucleocytoplasmic export of intron-containing RNA.

Ernst RK, Bray M, Rekosh D, Hammarskjöld ML.

Mol Cell Biol. 1997 Jan;17(1):135-44.

50.

Location of the HIV-1 Rev protein during mitosis: inactivation of the nuclear export signal alters the pathway for postmitotic reentry into nucleoli.

Dundr M, Leno GH, Lewis N, Rekosh D, Hammarskjöid ML, Olson MO.

J Cell Sci. 1996 Sep;109 ( Pt 9):2239-51.

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