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Items: 1 to 50 of 87

1.

Sprifermin (rhFGF18) modulates extracellular matrix turnover in cartilage explants ex vivo.

Reker D, Kjelgaard-Petersen CF, Siebuhr AS, Michaelis M, Gigout A, Karsdal MA, Ladel C, Bay-Jensen AC.

J Transl Med. 2017 Dec 12;15(1):250. doi: 10.1186/s12967-017-1356-8.

2.

Sprifermin (rhFGF18) enables proliferation of chondrocytes producing a hyaline cartilage matrix.

Gigout A, Guehring H, Froemel D, Meurer A, Ladel C, Reker D, Bay-Jensen AC, Karsdal MA, Lindemann S.

Osteoarthritis Cartilage. 2017 Nov;25(11):1858-1867. doi: 10.1016/j.joca.2017.08.004. Epub 2017 Aug 18.

3.

Active learning for computational chemogenomics.

Reker D, Schneider P, Schneider G, Brown JB.

Future Med Chem. 2017 Mar;9(4):381-402. doi: 10.4155/fmc-2016-0197. Epub 2017 Mar 6.

4.

New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate.

Cui J, Hollmén M, Li L, Chen Y, Proulx ST, Reker D, Schneider G, Detmar M.

Oncotarget. 2017 Jan 3;8(1):1007-1022. doi: 10.18632/oncotarget.13537.

5.

Matrix-based Molecular Descriptors for Prospective Virtual Compound Screening.

Grisoni F, Reker D, Schneider P, Friedrich L, Consonni V, Todeschini R, Koeberle A, Werz O, Schneider G.

Mol Inform. 2017 Jan;36(1-2). doi: 10.1002/minf.201600091. Epub 2016 Sep 21.

PMID:
27650559
6.

Deorphaning the Macromolecular Targets of the Natural Anticancer Compound Doliculide.

Schneider G, Reker D, Chen T, Hauenstein K, Schneider P, Altmann KH.

Angew Chem Int Ed Engl. 2016 Sep 26;55(40):12408-11. doi: 10.1002/anie.201605707. Epub 2016 Sep 8.

PMID:
27605391
7.

Counting on natural products for drug design.

Rodrigues T, Reker D, Schneider P, Schneider G.

Nat Chem. 2016 Jun;8(6):531-41. doi: 10.1038/nchem.2479. Epub 2016 Apr 25. Review.

PMID:
27219696
8.

Osteoarthritis year in review 2015: soluble biomarkers and the BIPED criteria.

Bay-Jensen AC, Reker D, Kjelgaard-Petersen CF, Mobasheri A, Karsdal MA, Ladel C, Henrotin Y, Thudium CS.

Osteoarthritis Cartilage. 2016 Jan;24(1):9-20. doi: 10.1016/j.joca.2015.10.014. Review.

9.

Spotting and designing promiscuous ligands for drug discovery.

Schneider P, Röthlisberger M, Reker D, Schneider G.

Chem Commun (Camb). 2016 Jan 21;52(6):1135-8. doi: 10.1039/c5cc07506h.

PMID:
26602698
10.

De Novo Fragment Design for Drug Discovery and Chemical Biology.

Rodrigues T, Reker D, Welin M, Caldera M, Brunner C, Gabernet G, Schneider P, Walse B, Schneider G.

Angew Chem Int Ed Engl. 2015 Dec 7;54(50):15079-83. doi: 10.1002/anie.201508055. Epub 2015 Oct 21.

PMID:
26486226
11.

Revealing the Macromolecular Targets of Fragment-Like Natural Products.

Rodrigues T, Reker D, Kunze J, Schneider P, Schneider G.

Angew Chem Int Ed Engl. 2015 Sep 1;54(36):10516-20. doi: 10.1002/anie.201504241. Epub 2015 Jul 17.

PMID:
26202212
12.

Fragment-Based De Novo Design Reveals a Small-Molecule Inhibitor of Helicobacter Pylori HtrA.

Perna AM, Rodrigues T, Schmidt TP, Böhm M, Stutz K, Reker D, Pfeiffer B, Altmann KH, Backert S, Wessler S, Schneider G.

Angew Chem Int Ed Engl. 2015 Aug 24;54(35):10244-8. doi: 10.1002/anie.201504035. Epub 2015 Jun 9.

PMID:
26069090
13.

Chemography of natural product space.

Miyao T, Reker D, Schneider P, Funatsu K, Schneider G.

Planta Med. 2015 Apr;81(6):429-35. doi: 10.1055/s-0034-1396322. Epub 2015 Feb 26.

PMID:
25719940
14.

Active-learning strategies in computer-assisted drug discovery.

Reker D, Schneider G.

Drug Discov Today. 2015 Apr;20(4):458-65. doi: 10.1016/j.drudis.2014.12.004. Epub 2014 Dec 9. Review.

PMID:
25499665
15.

Multidimensional de novo design reveals 5-HT2B receptor-selective ligands.

Rodrigues T, Hauser N, Reker D, Reutlinger M, Wunderlin T, Hamon J, Koch G, Schneider G.

Angew Chem Int Ed Engl. 2015 Jan 26;54(5):1551-5. doi: 10.1002/anie.201410201. Epub 2014 Dec 4.

PMID:
25475886
16.

Coping with polypharmacology by computational medicinal chemistry.

Schneider G, Reker D, Rodrigues T, Schneider P.

Chimia (Aarau). 2014 Sep;68(9):648-53. doi: 10.2533/chimia.2014.648.

PMID:
25437786
17.

Revealing the macromolecular targets of complex natural products.

Reker D, Perna AM, Rodrigues T, Schneider P, Reutlinger M, Mönch B, Koeberle A, Lamers C, Gabler M, Steinmetz H, Müller R, Schubert-Zsilavecz M, Werz O, Schneider G.

Nat Chem. 2014 Dec;6(12):1072-8. doi: 10.1038/nchem.2095. Epub 2014 Nov 2.

PMID:
25411885
18.

Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents.

Reker D, Seet M, Pillong M, Koch CP, Schneider P, Witschel MC, Rottmann M, Freymond C, Brun R, Schweizer B, Illarionov B, Bacher A, Fischer M, Diederich F, Schneider G.

Angew Chem Int Ed Engl. 2014 Jul 1;53(27):7079-84. doi: 10.1002/anie.201311162. Epub 2014 Jun 4.

PMID:
24895172
19.

Identifying the macromolecular targets of de novo-designed chemical entities through self-organizing map consensus.

Reker D, Rodrigues T, Schneider P, Schneider G.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4067-72. doi: 10.1073/pnas.1320001111. Epub 2014 Mar 3.

20.

Validated detection of anti-GD2 antibody ch14.18/CHO in serum of neuroblastoma patients using anti-idiotype antibody ganglidiomab.

Siebert N, Seidel D, Eger C, Brackrock D, Reker D, Schmidt M, Lode HN.

J Immunol Methods. 2013 Dec 15;398-399:51-9. doi: 10.1016/j.jim.2013.09.008. Epub 2013 Sep 18.

PMID:
24055592
21.

Common non-epigenetic drugs as epigenetic modulators.

Lötsch J, Schneider G, Reker D, Parnham MJ, Schneider P, Geisslinger G, Doehring A.

Trends Mol Med. 2013 Dec;19(12):742-53. doi: 10.1016/j.molmed.2013.08.006. Epub 2013 Sep 18. Review.

PMID:
24054876
22.

Chemically Advanced Template Search (CATS) for Scaffold-Hopping and Prospective Target Prediction for 'Orphan' Molecules.

Reutlinger M, Koch CP, Reker D, Todoroff N, Schneider P, Rodrigues T, Schneider G.

Mol Inform. 2013 Feb;32(2):133-138. Epub 2013 Feb 7. No abstract available.

23.

MicroRNA profiling in ocular adnexal lymphoma: a role for MYC and NFKB1 mediated dysregulation of microRNA expression in aggressive disease.

Hother C, Rasmussen PK, Joshi T, Reker D, Ralfkiær U, Workman CT, Heegaard S, Ralfkiær E, Grønbæk K.

Invest Ophthalmol Vis Sci. 2013 Aug 5;54(8):5169-75. doi: 10.1167/iovs.13-12272.

PMID:
23821202
24.

Vaccination with anti-idiotype antibody ganglidiomab mediates a GD(2)-specific anti-neuroblastoma immune response.

Lode HN, Schmidt M, Seidel D, Huebener N, Brackrock D, Bleeke M, Reker D, Brandt S, Mueller HP, Helm C, Siebert N.

Cancer Immunol Immunother. 2013 Jun;62(6):999-1010. doi: 10.1007/s00262-013-1413-y. Epub 2013 Apr 17.

PMID:
23591980
25.

Bioinformatic challenges in targeted proteomics.

Reker D, Malmström L.

J Proteome Res. 2012 Sep 7;11(9):4393-402. doi: 10.1021/pr300276f. Epub 2012 Aug 23.

PMID:
22866949
26.

Adolescent peer interaction and trait surgency weaken medial prefrontal cortex responses to failure.

Segalowitz SJ, Santesso DL, Willoughby T, Reker DL, Campbell K, Chalmers H, Rose-Krasnor L.

Soc Cogn Affect Neurosci. 2012 Jan;7(1):115-24. doi: 10.1093/scan/nsq090. Epub 2011 Jan 5.

27.

Computation of mutual information from Hidden Markov Models.

Reker D, Katzenbeisser S, Hamacher K.

Comput Biol Chem. 2010 Dec;34(5-6):328-33. doi: 10.1016/j.compbiolchem.2010.08.005. Epub 2010 Sep 22.

PMID:
20951093
28.
29.

Demographic and clinical variation in Veterans Health Administration provision of assistive technology devices to veterans poststroke.

Hubbard Winkler SL, Cowper Ripley DC, Wu S, Reker DM, Vogel B, Fitzgerald SG, Mann WC, Hoenig H.

Arch Phys Med Rehabil. 2010 Mar;91(3):369-377.e1. doi: 10.1016/j.apmr.2009.10.028.

PMID:
20298826
30.

Cost, utilization, and policy of provision of assistive technology devices to veterans poststroke by Medicare and VA.

Winkler SL, Vogel B, Hoenig H, Ripley DC, Wu S, Fitzgerald SG, Mann WC, Reker DM.

Med Care. 2010 Jun;48(6):558-62. doi: 10.1097/MLR.0b013e3181bd4a11.

PMID:
20125048
31.

Factors influencing decisions to admit patients to veterans affairs specialized rehabilitation units after lower-extremity amputation.

Bates BE, Kwong PL, Kurichi JE, Bidelspach DE, Reker DM, Maislin G, Xie D, Stineman M.

Arch Phys Med Rehabil. 2009 Dec;90(12):2012-8. doi: 10.1016/j.apmr.2009.07.016.

32.

Survival analysis in amputees based on physical independence grade achievement.

Stineman MG, Kurichi JE, Kwong PL, Maislin G, Reker DM, Vogel WB, Prvu-Bettger JA, Bidelspach DE, Bates BE.

Arch Surg. 2009 Jun;144(6):543-51; discussion 552. doi: 10.1001/archsurg.2009.37.

33.

The effectiveness of inpatient rehabilitation in the acute postoperative phase of care after transtibial or transfemoral amputation: study of an integrated health care delivery system.

Stineman MG, Kwong PL, Kurichi JE, Prvu-Bettger JA, Vogel WB, Maislin G, Bates BE, Reker DM.

Arch Phys Med Rehabil. 2008 Oct;89(10):1863-72. doi: 10.1016/j.apmr.2008.03.013.

34.

Distribution and cost of wheelchairs and scooters provided by Veterans Health Administration.

Hubbard SL, Fitzgerald SG, Vogel B, Reker DM, Cooper RA, Boninger ML.

J Rehabil Res Dev. 2007;44(4):581-92.

35.

Factors associated with VHA costs of care for first 12 months after first stroke.

Hayes J, Vogel B, Reker DM.

J Rehabil Res Dev. 2008;45(9):1375-84.

36.

Does the presence of a specialized rehabilitation unit in a Veterans Affairs facility impact referral for rehabilitative care after a lower-extremity amputation?

Bates BE, Kurichi JE, Marshall CR, Reker D, Maislin G, Stineman MG.

Arch Phys Med Rehabil. 2007 Oct;88(10):1249-55.

37.

Characteristics of community nursing homes serving per diem veterans, 1999 to 2002.

Johnson CE, Weech-Maldonado R, Huanguang Jia, Reker D, Buchanan R, Laberge A.

Med Care Res Rev. 2007 Dec;64(6):673-90. Epub 2007 Sep 18.

PMID:
17878290
38.

Clinical factors associated with prescription of a prosthetic limb in elderly veterans.

Kurichi JE, Kwong PL, Reker DM, Bates BE, Marshall CR, Stineman MG.

J Am Geriatr Soc. 2007 Jun;55(6):900-6.

39.

Risk factors associated with mortality in veteran population following transtibial or transfemoral amputation.

Bates B, Stineman MG, Reker DM, Kurichi JE, Kwong PL.

J Rehabil Res Dev. 2006 Nov-Dec;43(7):917-28.

40.

Demographic characteristics of veterans who received wheelchairs and scooters from Veterans Health Administration.

Hubbard SL, Fitzgerald SG, Reker DM, Boninger ML, Cooper RA, Kazis LE.

J Rehabil Res Dev. 2006 Nov-Dec;43(7):831-44.

41.

Assessing and using comorbidity measures in elderly veterans with lower extremity amputations.

Kurichi JE, Stineman MG, Kwong PL, Bates BE, Reker DM.

Gerontology. 2007;53(5):255-9. Epub 2007 Apr 13.

42.

Multiple system utilization and mortality for veterans with stroke.

Jia H, Zheng Y, Reker DM, Cowper DC, Wu SS, Vogel WB, Young GC, Duncan PW.

Stroke. 2007 Feb;38(2):355-60. Epub 2006 Dec 28.

43.

Race/ethnicity: who is counting what?

Jia H, Zheng YE, Cowper DC, Stansbury JP, Wu SS, Vogel WB, Duncan PW, Reker DM.

J Rehabil Res Dev. 2006 Jul-Aug;43(4):475-84.

44.

Dysplasia and cancer in a large multicenter cohort of patients with Barrett's esophagus.

Sharma P, Falk GW, Weston AP, Reker D, Johnston M, Sampliner RE.

Clin Gastroenterol Hepatol. 2006 May;4(5):566-72. Epub 2006 Apr 17.

PMID:
16630761
45.

Measuring stroke impact with SIS: construct validity of SIS telephone administration.

Kwon S, Duncan P, Studenski S, Perera S, Lai SM, Reker D.

Qual Life Res. 2006 Apr;15(3):367-76.

PMID:
16547774
46.

Therapeutic exercise and depressive symptoms after stroke.

Lai SM, Studenski S, Richards L, Perera S, Reker D, Rigler S, Duncan PW.

J Am Geriatr Soc. 2006 Feb;54(2):240-7.

PMID:
16460374
47.

Frontal electroencephalogram activation asymmetry, emotional intelligence, and externalizing behaviors in 10-year-old children.

Santesso D, Reker DL, Schmidt LA, Segalowitz SJ.

Child Psychiatry Hum Dev. 2006 Spring;36(3):311-28.

PMID:
16369699
48.

Veterans Affairs/Department of Defense Clinical Practice Guideline for the Management of Adult Stroke Rehabilitation Care: executive summary.

Bates B, Choi JY, Duncan PW, Glasberg JJ, Graham GD, Katz RC, Lamberty K, Reker D, Zorowitz R; US Department of Defense; Department of Veterans Affairs.

Stroke. 2005 Sep;36(9):2049-56.

49.

Management of Adult Stroke Rehabilitation Care: a clinical practice guideline.

Duncan PW, Zorowitz R, Bates B, Choi JY, Glasberg JJ, Graham GD, Katz RC, Lamberty K, Reker D.

Stroke. 2005 Sep;36(9):e100-43. No abstract available.

50.

Use of the Conners-wells adolescent self-report scale (short form) with children.

Parker JD, Bond BJ, Reker DL, Wood LM.

J Atten Disord. 2005 May;8(4):188-94.

PMID:
16110049

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