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Items: 1 to 50 of 125

1.

Current Topics in Medicinal Chemistry: The Six Most Cited Publications 2016-2019.

Reitz AB.

Curr Top Med Chem. 2019;19(17):1487. doi: 10.2174/156802661917190828110645.

PMID:
31592749
2.

Small Molecule Inhibitors of the BfrB-Bfd Interaction Decrease Pseudomonas aeruginosa Fitness and Potentiate Fluoroquinolone Activity.

Punchi Hewage AND, Yao H, Nammalwar B, Gnanasekaran KK, Lovell S, Bunce RA, Eshelman K, Phaniraj SM, Lee MM, Peterson BR, Battaile KP, Reitz AB, Rivera M.

J Am Chem Soc. 2019 May 22;141(20):8171-8184. doi: 10.1021/jacs.9b00394. Epub 2019 May 9.

3.

Effects of dopaminergic and serotonergic compounds in rats trained to discriminate a high and a low training dose of the synthetic cathinone mephedrone.

Saber I, Milewski A, Reitz AB, Rawls SM, Walker EA.

Psychopharmacology (Berl). 2019 Mar;236(3):1015-1029. doi: 10.1007/s00213-019-05241-z. Epub 2019 Apr 13.

PMID:
30980094
4.

Preface.

Reitz AB.

Curr Top Med Chem. 2019;19(1):1. doi: 10.2174/156802661901190326145545.

PMID:
30942145
5.

Non-NAD-like PARP-1 inhibitors in prostate cancer treatment.

Karpova Y, Wu C, Divan A, McDonnell ME, Hewlett E, Makhov P, Gordon J, Ye M, Reitz AB, Childers WE, Skorski T, Kolenko V, Tulin AV.

Biochem Pharmacol. 2019 Sep;167:149-162. doi: 10.1016/j.bcp.2019.03.021. Epub 2019 Mar 15.

PMID:
30880062
6.

Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth.

Messick TE, Smith GR, Soldan SS, McDonnell ME, Deakyne JS, Malecka KA, Tolvinski L, van den Heuvel APJ, Gu BW, Cassel JA, Tran DH, Wassermann BR, Zhang Y, Velvadapu V, Zartler ER, Busson P, Reitz AB, Lieberman PM.

Sci Transl Med. 2019 Mar 6;11(482). pii: eaau5612. doi: 10.1126/scitranslmed.aau5612.

PMID:
30842315
7.

Synthetic cathinone MDPV enhances reward function through purinergic P2X7 receptor-dependent pathway and increases P2X7 gene expression in nucleus accumbens.

Gentile TA, Simmons SJ, Tallarida CS, Su S, Rom S, Watson MN, Reitz AB, Potula R, Rawls SM.

Drug Alcohol Depend. 2019 Apr 1;197:22-27. doi: 10.1016/j.drugalcdep.2018.12.022. Epub 2019 Jan 31.

PMID:
30754021
8.

Advancement of the 5-Amino-1-(Carbamoylmethyl)-1H-1,2,3-Triazole-4-Carboxamide Scaffold to Disarm the Bacterial SOS Response.

Selwood T, Larsen BJ, Mo CY, Culyba MJ, Hostetler ZM, Kohli RM, Reitz AB, Baugh SDP.

Front Microbiol. 2018 Dec 18;9:2961. doi: 10.3389/fmicb.2018.02961. eCollection 2018.

9.

Mutation and structure guided discovery of an antiviral small molecule that mimics an essential C-Terminal tripeptide of the vaccinia D4 processivity factor.

Nuth M, Guan H, Xiao Y, Kulp JL 3rd, Parker MH, Strobel ED, Isaacs SN, Scott RW, Reitz AB, Ricciardi RP.

Antiviral Res. 2019 Feb;162:178-185. doi: 10.1016/j.antiviral.2018.12.011. Epub 2018 Dec 20.

PMID:
30578797
10.

Inhibitors of the protein disulfide isomerase family for the treatment of multiple myeloma.

Robinson RM, Reyes L, Duncan RM, Bian H, Reitz AB, Manevich Y, McClure JJ, Champion MM, Chou CJ, Sharik ME, Chesi M, Bergsagel PL, Dolloff NG.

Leukemia. 2019 Apr;33(4):1011-1022. doi: 10.1038/s41375-018-0263-1. Epub 2018 Oct 12.

PMID:
30315229
11.

Dipeptide Prodrugs of the Glutamate Modulator Riluzole.

Pelletier JC, Chen S, Bian H, Shah R, Smith GR, Wrobel JE, Reitz AB.

ACS Med Chem Lett. 2018 Jun 15;9(7):752-756. doi: 10.1021/acsmedchemlett.8b00189. eCollection 2018 Jul 12.

12.

Cypin: A novel target for traumatic brain injury.

Swiatkowski P, Sewell E, Sweet ES, Dickson S, Swanson RA, McEwan SA, Cuccolo N, McDonnell ME, Patel MV, Varghese N, Morrison B, Reitz AB, Meaney DF, Firestein BL.

Neurobiol Dis. 2018 Nov;119:13-25. doi: 10.1016/j.nbd.2018.07.019. Epub 2018 Jul 19.

13.

A Method for C2 Acylation of 1,3-Indandiones.

Larsen BJ, Rosano RJ, Ford-Hutchinson TA, Reitz AB, Wrobel JE.

Tetrahedron. 2018 May 31;74(22):2762-2768. doi: 10.1016/j.tet.2018.04.041. Epub 2018 Apr 17.

14.

Preface.

Sheikh AI, Reitz AB.

Curr Top Med Chem. 2018;18(1):1. doi: 10.2174/156802661801180322101825. No abstract available.

PMID:
29598812
15.

Dopamine D1-Like Receptor Agonist and D2-Like Receptor Antagonist (-)-Stepholidine Reduces Reinstatement of Drug-Seeking Behavior for 3,4-Methylenedioxypyrovalerone (MDPV) in Rats.

Hicks C, Huang P, Ramos L, Nayak SU, Caro Y, Reitz AB, Smith GR, Lee DY, Rawls SM, Liu-Chen LY.

ACS Chem Neurosci. 2018 Jun 20;9(6):1327-1337. doi: 10.1021/acschemneuro.7b00510. Epub 2018 Apr 6.

16.

Chemokines and 'bath salts': CXCR4 receptor antagonist reduces rewarding and locomotor-stimulant effects of the designer cathinone MDPV in rats.

Oliver CF, Simmons SJ, Nayak SU, Smith GR, Reitz AB, Rawls SM.

Drug Alcohol Depend. 2018 May 1;186:75-79. doi: 10.1016/j.drugalcdep.2018.01.013. Epub 2018 Mar 10.

17.

PLDT (planarian light/dark test): an invertebrate assay to quantify defensive responding and study anxiety-like effects.

Zewde AM, Yu F, Nayak S, Tallarida C, Reitz AB, Kirby LG, Rawls SM.

J Neurosci Methods. 2018 Jan 1;293:284-288. doi: 10.1016/j.jneumeth.2017.10.010. Epub 2017 Oct 16.

18.

Stereoselective Differences between the Reinforcing and Motivational Effects of Cathinone-Derived 4-Methylmethcathinone (Mephedrone) In Self-Administering Rats.

Philogene-Khalid HL, Simmons SJ, Nayak S, Martorana RM, Su SH, Caro Y, Ranieri B, DiFurio K, Mo L, Gentile TA, Murad A, Reitz AB, Muschamp JW, Rawls SM.

ACS Chem Neurosci. 2017 Dec 20;8(12):2648-2654. doi: 10.1021/acschemneuro.7b00212. Epub 2017 Sep 22.

19.

Synthetic cathinones and stereochemistry: S enantiomer of mephedrone reduces anxiety- and depressant-like effects in cocaine- or MDPV-abstinent rats.

Philogene-Khalid HL, Hicks C, Reitz AB, Liu-Chen LY, Rawls SM.

Drug Alcohol Depend. 2017 Sep 1;178:119-125. doi: 10.1016/j.drugalcdep.2017.04.024. Epub 2017 Jun 13.

20.

Glutamate carboxypeptidase II (GCPII) inhibitor 2-PMPA reduces rewarding effects of the synthetic cathinone MDPV in rats: a role for N-acetylaspartylglutamate (NAAG).

Hicks C, Gregg RA, Nayak SU, Cannella LA, Schena GJ, Tallarida CS, Reitz AB, Smith GR, Rawls SM.

Psychopharmacology (Berl). 2017 Jun;234(11):1671-1681. doi: 10.1007/s00213-017-4568-y. Epub 2017 Mar 1.

21.

Preface.

Reitz AB.

Curr Top Med Chem. 2017;17(1):1. No abstract available.

PMID:
28029085
22.

Quinoxaline-based inhibitors of Ebola and Marburg VP40 egress.

Loughran HM, Han Z, Wrobel JE, Decker SE, Ruthel G, Freedman BD, Harty RN, Reitz AB.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3429-35. doi: 10.1016/j.bmcl.2016.06.053. Epub 2016 Jun 23.

23.

Synthetic cathinone MDPV downregulates glutamate transporter subtype I (GLT-1) and produces rewarding and locomotor-activating effects that are reduced by a GLT-1 activator.

Gregg RA, Hicks C, Nayak SU, Tallarida CS, Nucero P, Smith GR, Reitz AB, Rawls SM.

Neuropharmacology. 2016 Sep;108:111-9. doi: 10.1016/j.neuropharm.2016.04.014. Epub 2016 Apr 13.

24.

Synthesis and evaluation of orally active small molecule HIV-1 Nef antagonists.

Emert-Sedlak LA, Loughran HM, Shi H, Kulp JL 3rd, Shu ST, Zhao J, Day BW, Wrobel JE, Reitz AB, Smithgall TE.

Bioorg Med Chem Lett. 2016 Mar 1;26(5):1480-1484. doi: 10.1016/j.bmcl.2016.01.043. Epub 2016 Jan 21.

25.

Calcium Regulation of Hemorrhagic Fever Virus Budding: Mechanistic Implications for Host-Oriented Therapeutic Intervention.

Han Z, Madara JJ, Herbert A, Prugar LI, Ruthel G, Lu J, Liu Y, Liu W, Liu X, Wrobel JE, Reitz AB, Dye JM, Harty RN, Freedman BD.

PLoS Pathog. 2015 Oct 29;11(10):e1005220. doi: 10.1371/journal.ppat.1005220. eCollection 2015 Oct.

26.

Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation.

Coyne AN, Yamada SB, Siddegowda BB, Estes PS, Zaepfel BL, Johannesmeyer JS, Lockwood DB, Pham LT, Hart MP, Cassel JA, Freibaum B, Boehringer AV, Taylor JP, Reitz AB, Gitler AD, Zarnescu DC.

Hum Mol Genet. 2015 Dec 15;24(24):6886-98. doi: 10.1093/hmg/ddv389. Epub 2015 Sep 18.

27.

Many, diverse topics have been covered in recent years in CTMC. Preface.

Reitz AB.

Curr Top Med Chem. 2015;14(24):2751-7. No abstract available.

PMID:
25713821
28.

Synthesis, stereochemical analysis, and derivatization of myricanol provide new probes that promote autophagic tau clearance.

Martin MD, Calcul L, Smith C, Jinwal UK, Fontaine SN, Darling A, Seeley K, Wojtas L, Narayan M, Gestwicki JE, Smith GR, Reitz AB, Baker BJ, Dickey CA.

ACS Chem Biol. 2015 Apr 17;10(4):1099-109. doi: 10.1021/cb501013w. Epub 2015 Jan 30.

29.

A selective small molecule NOP (ORL-1 receptor) partial agonist for the treatment of anxiety.

Ross TM, Battista K, Bignan GC, Brenneman DE, Connolly PJ, Liu J, Middleton SA, Orsini M, Reitz AB, Rosenthal DI, Scott MK, Vaidya AH.

Bioorg Med Chem Lett. 2015 Feb 1;25(3):602-6. doi: 10.1016/j.bmcl.2014.12.015. Epub 2014 Dec 17.

PMID:
25556095
30.

Acinetobacter baumannii OxPhos inhibitors as selective anti-infective agents.

Rubin H, Selwood T, Yano T, Weaver DG, Loughran HM, Costanzo MJ, Scott RW, Wrobel JE, Freeman KB, Reitz AB.

Bioorg Med Chem Lett. 2015 Jan 15;25(2):378-83. doi: 10.1016/j.bmcl.2014.11.020. Epub 2014 Nov 22.

PMID:
25496770
31.

Stereochemistry and neuropharmacology of a 'bath salt' cathinone: S-enantiomer of mephedrone reduces cocaine-induced reward and withdrawal in invertebrates.

Vouga A, Gregg RA, Haidery M, Ramnath A, Al-Hassani HK, Tallarida CS, Grizzanti D, Raffa RB, Smith GR, Reitz AB, Rawls SM.

Neuropharmacology. 2015 Apr;91:109-16. doi: 10.1016/j.neuropharm.2014.11.010. Epub 2014 Dec 9.

32.

8-Hydroxyquinoline and hydroxamic acid inhibitors of botulinum neurotoxin BoNT/A.

Dickerson TJ, Smith GR, Pelletier JC, Reitz AB.

Curr Top Med Chem. 2014;14(18):2094-102. Review.

PMID:
25335884
33.

Inhibition of botulinum neurotoxin BoNT/A.

Dickerson TJ, Smith GR, Reitz AB.

Curr Top Med Chem. 2014;14(18):2043. No abstract available.

PMID:
25335883
34.

Stereochemistry of mephedrone neuropharmacology: enantiomer-specific behavioural and neurochemical effects in rats.

Gregg RA, Baumann MH, Partilla JS, Bonano JS, Vouga A, Tallarida CS, Velvadapu V, Smith GR, Peet MM, Reitz AB, Negus SS, Rawls SM.

Br J Pharmacol. 2015 Feb;172(3):883-94. doi: 10.1111/bph.12951. Epub 2014 Dec 15.

35.

Intramolecular Rearrangement of α-Amino Acid Amide Derivatives of 2-Aminobenzothiazoles.

Pelletier JC, Velvadapu V, McDonnell ME, Wrobel JE, Reitz AB.

Tetrahedron Lett. 2014 Jul 23;55(30):4193-4195.

36.

Small-molecule probes targeting the viral PPxY-host Nedd4 interface block egress of a broad range of RNA viruses.

Han Z, Lu J, Liu Y, Davis B, Lee MS, Olson MA, Ruthel G, Freedman BD, Schnell MJ, Wrobel JE, Reitz AB, Harty RN.

J Virol. 2014 Jul;88(13):7294-306. doi: 10.1128/JVI.00591-14. Epub 2014 Apr 16.

37.

Anilino-monoindolylmaleimides as potent and selective JAK3 inhibitors.

McDonnell ME, Bian H, Wrobel J, Smith GR, Liang S, Ma H, Reitz AB.

Bioorg Med Chem Lett. 2014 Feb 15;24(4):1116-21. doi: 10.1016/j.bmcl.2014.01.001. Epub 2014 Jan 9.

PMID:
24461299
38.

Identification of clinically viable quinolinol inhibitors of botulinum neurotoxin A light chain.

Caglič D, Krutein MC, Bompiani KM, Barlow DJ, Benoni G, Pelletier JC, Reitz AB, Lairson LL, Houseknecht KL, Smith GR, Dickerson TJ.

J Med Chem. 2014 Feb 13;57(3):669-76. doi: 10.1021/jm4012164. Epub 2014 Jan 15.

39.

Small-molecule anticonvulsant agents with potent in vitro neuroprotection and favorable drug-like properties.

Smith GR, Brenneman DE, Zhang Y, Du Y, Reitz AB.

J Mol Neurosci. 2014 Mar;52(3):446-58. doi: 10.1007/s12031-013-0180-8. Epub 2013 Nov 26.

40.

Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112).

McComsey DF, Smith-Swintosky VL, Parker MH, Brenneman DE, Malatynska E, White HS, Klein BD, Wilcox KS, Milewski ME, Herb M, Finley MF, Liu Y, Lubin ML, Qin N, Reitz AB, Maryanoff BE.

J Med Chem. 2013 Nov 27;56(22):9019-30. doi: 10.1021/jm400894u. Epub 2013 Nov 11.

41.

Mephedrone interactions with cocaine: prior exposure to the 'bath salt' constituent enhances cocaine-induced locomotor activation in rats.

Gregg RA, Tallarida CS, Reitz AB, Rawls SM.

Behav Pharmacol. 2013 Dec;24(8):684-8. doi: 10.1097/FBP.0000000000000006.

42.
43.

Riluzole prodrugs for melanoma and ALS: design, synthesis, and in vitro metabolic profiling.

McDonnell ME, Vera MD, Blass BE, Pelletier JC, King RC, Fernandez-Metzler C, Smith GR, Wrobel J, Chen S, Wall BA, Reitz AB.

Bioorg Med Chem. 2012 Sep 15;20(18):5642-8. doi: 10.1016/j.bmc.2012.07.004. Epub 2012 Jul 21.

44.

Facile Synthesis of Mutagen X (MX): 3-Chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one.

Velvadapu V, McDonnell ME, Jaffe EK, Reitz AB.

Tetrahedron Lett. 2012 Jun 20;53(25):3144-3146.

45.

Characterization of a series of 4-aminoquinolines that stimulate caspase-7 mediated cleavage of TDP-43 and inhibit its function.

Cassel JA, McDonnell ME, Velvadapu V, Andrianov V, Reitz AB.

Biochimie. 2012 Sep;94(9):1974-81. doi: 10.1016/j.biochi.2012.05.020. Epub 2012 May 29.

46.

Mephedrone ('bath salt') elicits conditioned place preference and dopamine-sensitive motor activation.

Lisek R, Xu W, Yuvasheva E, Chiu YT, Reitz AB, Liu-Chen LY, Rawls SM.

Drug Alcohol Depend. 2012 Nov 1;126(1-2):257-62. doi: 10.1016/j.drugalcdep.2012.04.021. Epub 2012 May 29.

47.

Novel inhibitors of heat shock protein Hsp70-mediated luciferase refolding that bind to DnaJ.

Cassel JA, Ilyin S, McDonnell ME, Reitz AB.

Bioorg Med Chem. 2012 Jun 1;20(11):3609-14. doi: 10.1016/j.bmc.2012.03.067. Epub 2012 Apr 11.

PMID:
22546203
48.

Reexamining hydroxamate inhibitors of botulinum neurotoxin serotype A: extending towards the β-exosite.

Smith GR, Caglič D, Capek P, Zhang Y, Godbole S, Reitz AB, Dickerson TJ.

Bioorg Med Chem Lett. 2012 Jun 1;22(11):3754-7. doi: 10.1016/j.bmcl.2012.04.019. Epub 2012 Apr 11.

49.

Small molecule anticonvulsant agents with potent in vitro neuroprotection.

Brenneman DE, Smith GR, Zhang Y, Du Y, Kondaveeti SK, Zdilla MJ, Reitz AB.

J Mol Neurosci. 2012 Jun;47(2):368-79. doi: 10.1007/s12031-012-9765-x. Epub 2012 Apr 26.

50.

Preface.

Reitz AB.

Curr Top Med Chem. 2012;12(1):1. No abstract available.

PMID:
22393562

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