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Items: 1 to 50 of 207

1.

Truncated (N)-Methanocarba Nucleosides as Partial Agonists at Mouse and Human A3 Adenosine Receptors: Affinity Enhancement by N6-(2-Phenylethyl) Substitution.

Tosh DK, Salmaso V, Rao H, Bitant A, Fisher CL, Lieberman DI, Vorbrüggen H, Reitman ML, Gavrilova O, Gao ZG, Auchampach JA, Jacobson KA.

J Med Chem. 2020 Apr 9. doi: 10.1021/acs.jmedchem.0c00235. [Epub ahead of print]

PMID:
32271569
2.

BRS3 in both MC4R- and SIM1-expressing neurons regulates energy homeostasis in mice.

Xiao C, Liu N, Province H, Piñol RA, Gavrilova O, Reitman ML.

Mol Metab. 2020 Feb 29;36:100969. doi: 10.1016/j.molmet.2020.02.012. [Epub ahead of print]

3.

Reply to Letter to the Editor: "No insulating effect of obesity, neither in mice nor in humans".

Brychta RJ, Cypess AM, Reitman ML, Chen KY.

Am J Physiol Endocrinol Metab. 2019 Nov 1;317(5):E954-E956. doi: 10.1152/ajpendo.00363.2019. No abstract available.

PMID:
31697208
4.

Reply to DS Ludwig et al.

Hall KD, Guo J, Chen KY, Leibel RL, Reitman ML, Rosenbaum M, Smith SR, Ravussin E.

Am J Clin Nutr. 2019 Nov 1;110(5):1255-1256. doi: 10.1093/ajcn/nqz157. No abstract available.

PMID:
31667517
5.

Accurate quantification of astrocyte and neurotransmitter fluorescence dynamics for single-cell and population-level physiology.

Wang Y, DelRosso NV, Vaidyanathan TV, Cahill MK, Reitman ME, Pittolo S, Mi X, Yu G, Poskanzer KE.

Nat Neurosci. 2019 Nov;22(11):1936-1944. doi: 10.1038/s41593-019-0492-2. Epub 2019 Sep 30.

6.

Cool(ing) brain stem GABA neurons.

Piñol RA, Reitman ML.

Cell Res. 2019 Oct;29(10):785-786. doi: 10.1038/s41422-019-0223-y. No abstract available.

PMID:
31471559
7.

Quantification of the Capacity for Cold-Induced Thermogenesis in Young Men With and Without Obesity.

Brychta RJ, Huang S, Wang J, Leitner BP, Hattenbach JD, Bell SL, Fletcher LA, Perron Wood R, Idelson CR, Duckworth CJ, McGehee S, Courville AB, Bernstein SB, Reitman ML, Cypess AM, Chen KY.

J Clin Endocrinol Metab. 2019 Oct 1;104(10):4865-4878. doi: 10.1210/jc.2019-00728.

8.

Glucose and Lipid Homeostasis and Inflammation in Humans Following an Isocaloric Ketogenic Diet.

Rosenbaum M, Hall KD, Guo J, Ravussin E, Mayer LS, Reitman ML, Smith SR, Walsh BT, Leibel RL.

Obesity (Silver Spring). 2019 Jun;27(6):971-981. doi: 10.1002/oby.22468. Epub 2019 May 8.

9.

Methodologic considerations for measuring energy expenditure differences between diets varying in carbohydrate using the doubly labeled water method.

Hall KD, Guo J, Chen KY, Leibel RL, Reitman ML, Rosenbaum M, Smith SR, Ravussin E.

Am J Clin Nutr. 2019 May 1;109(5):1328-1334. doi: 10.1093/ajcn/nqy390.

PMID:
31028699
10.

Physiology and effects of nucleosides in mice lacking all four adenosine receptors.

Xiao C, Liu N, Jacobson KA, Gavrilova O, Reitman ML.

PLoS Biol. 2019 Mar 1;17(3):e3000161. doi: 10.1371/journal.pbio.3000161. eCollection 2019 Mar.

11.

Design and in Vivo Characterization of A1 Adenosine Receptor Agonists in the Native Ribose and Conformationally Constrained (N)-Methanocarba Series.

Tosh DK, Rao H, Bitant A, Salmaso V, Mannes P, Lieberman DI, Vaughan KL, Mattison JA, Rothwell AC, Auchampach JA, Ciancetta A, Liu N, Cui Z, Gao ZG, Reitman ML, Gavrilova O, Jacobson KA.

J Med Chem. 2019 Feb 14;62(3):1502-1522. doi: 10.1021/acs.jmedchem.8b01662. Epub 2019 Jan 3.

12.

Brs3 neurons in the mouse dorsomedial hypothalamus regulate body temperature, energy expenditure, and heart rate, but not food intake.

Piñol RA, Zahler SH, Li C, Saha A, Tan BK, Škop V, Gavrilova O, Xiao C, Krashes MJ, Reitman ML.

Nat Neurosci. 2018 Nov;21(11):1530-1540. doi: 10.1038/s41593-018-0249-3. Epub 2018 Oct 22.

13.

Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors.

Jain S, Panyutin A, Liu N, Xiao C, Piñol RA, Pundir P, Girardet C, Butler AA, Dong X, Gavrilova O, Reitman ML.

Am J Physiol Endocrinol Metab. 2018 Sep 1;315(3):E357-E366. doi: 10.1152/ajpendo.00024.2018. Epub 2018 May 29.

14.

Of mice and men - environmental temperature, body temperature, and treatment of obesity.

Reitman ML.

FEBS Lett. 2018 Jun;592(12):2098-2107. doi: 10.1002/1873-3468.13070. Epub 2018 May 10. Review.

15.

Activation of adenosine A2A or A2B receptors causes hypothermia in mice.

Carlin JL, Jain S, Duroux R, Suresh RR, Xiao C, Auchampach JA, Jacobson KA, Gavrilova O, Reitman ML.

Neuropharmacology. 2018 Sep 1;139:268-278. doi: 10.1016/j.neuropharm.2018.02.035. Epub 2018 Mar 13.

16.

Corrigendum to "Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism" [Mol Metabol 6 (2017) 1540-1550].

Xiao C, Piñol RA, Carlin JL, Li C, Deng C, Gavrilova O, Reitman ML.

Mol Metab. 2018 Mar;9:220. doi: 10.1016/j.molmet.2017.12.009. Epub 2017 Dec 27. No abstract available.

17.

Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism.

Xiao C, Piñol RA, Carlin JL, Li C, Deng C, Gavrilova O, Reitman ML.

Mol Metab. 2017 Nov;6(11):1540-1550. doi: 10.1016/j.molmet.2017.08.013. Epub 2017 Sep 15. Erratum in: Mol Metab. 2017 Dec 27;:.

18.

Peripheral cannabinoid-1 receptor blockade restores hypothalamic leptin signaling.

Tam J, Szanda G, Drori A, Liu Z, Cinar R, Kashiwaya Y, Reitman ML, Kunos G.

Mol Metab. 2017 Oct;6(10):1113-1125. doi: 10.1016/j.molmet.2017.06.010. Epub 2017 Jun 24.

19.

How Does Fat Transition from White to Beige?

Reitman ML.

Cell Metab. 2017 Jul 5;26(1):14-16. doi: 10.1016/j.cmet.2017.06.011.

20.

Hypothermia in mouse is caused by adenosine A1 and A3 receptor agonists and AMP via three distinct mechanisms.

Carlin JL, Jain S, Gizewski E, Wan TC, Tosh DK, Xiao C, Auchampach JA, Jacobson KA, Gavrilova O, Reitman ML.

Neuropharmacology. 2017 Mar 1;114:101-113. doi: 10.1016/j.neuropharm.2016.11.026. Epub 2016 Nov 30.

21.

Reply to DS Ludwig and CB Ebbeling.

Hall KD, Chen KY, Guo J, Leibel RL, Mayer LE, Reitman ML, Rosenbaum M, Smith SR, Walsh BT, Ravussin E.

Am J Clin Nutr. 2016 Nov;104(5):1488-1490. No abstract available.

22.

Hormone-Replacement Therapy for Melanocyte-Stimulating Hormone Deficiency.

Reitman ML.

N Engl J Med. 2016 Jul 21;375(3):278-9. doi: 10.1056/NEJMe1606919. No abstract available.

PMID:
27468065
23.

Energy expenditure and body composition changes after an isocaloric ketogenic diet in overweight and obese men.

Hall KD, Chen KY, Guo J, Lam YY, Leibel RL, Mayer LE, Reitman ML, Rosenbaum M, Smith SR, Walsh BT, Ravussin E.

Am J Clin Nutr. 2016 Aug;104(2):324-33. doi: 10.3945/ajcn.116.133561. Epub 2016 Jul 6.

24.

Coadministration of Rifampin Significantly Reduces Odanacatib Concentrations in Healthy Subjects.

Stoch SA, Ballard J, Gibson C, Kesisoglou F, Witter R, Kassahun K, Zajic S, Mehta A, Brandquist C, Dempsey C, Stypinski D, Reitman ML.

J Clin Pharmacol. 2017 Jan;57(1):110-117. doi: 10.1002/jcph.780. Epub 2016 Aug 1.

PMID:
27321774
25.

Bombesin-Like Receptor 3: Physiology of a Functional Orphan.

Xiao C, Reitman ML.

Trends Endocrinol Metab. 2016 Sep;27(9):603-605. doi: 10.1016/j.tem.2016.03.003. Epub 2016 Apr 4. Review.

26.

Bombesin-like receptor 3 regulates blood pressure and heart rate via a central sympathetic mechanism.

Lateef DM, Xiao C, Brychta RJ, Diedrich A, Schnermann J, Reitman ML.

Am J Physiol Heart Circ Physiol. 2016 Apr 1;310(7):H891-8. doi: 10.1152/ajpheart.00963.2015. Epub 2016 Jan 22.

27.

Peripheral Adenosine A3 Receptor Activation Causes Regulated Hypothermia in Mice That Is Dependent on Central Histamine H1 Receptors.

Carlin JL, Tosh DK, Xiao C, Piñol RA, Chen Z, Salvemini D, Gavrilova O, Jacobson KA, Reitman ML.

J Pharmacol Exp Ther. 2016 Feb;356(2):474-82. doi: 10.1124/jpet.115.229872. Epub 2015 Nov 25.

28.

Search for an Endogenous Bombesin-Like Receptor 3 (BRS-3) Ligand Using Parabiotic Mice.

Lateef DM, Xiao C, Reitman ML.

PLoS One. 2015 Nov 12;10(11):e0142637. doi: 10.1371/journal.pone.0142637. eCollection 2015.

29.

Anti-obesity and metabolic efficacy of the β3-adrenergic agonist, CL316243, in mice at thermoneutrality compared to 22°C.

Xiao C, Goldgof M, Gavrilova O, Reitman ML.

Obesity (Silver Spring). 2015 Jul;23(7):1450-9. doi: 10.1002/oby.21124. Epub 2015 Jun 5.

30.

Integration of body temperature into the analysis of energy expenditure in the mouse.

Abreu-Vieira G, Xiao C, Gavrilova O, Reitman ML.

Mol Metab. 2015 Mar 10;4(6):461-70. doi: 10.1016/j.molmet.2015.03.001. eCollection 2015 Jun.

31.

RM-493, a melanocortin-4 receptor (MC4R) agonist, increases resting energy expenditure in obese individuals.

Chen KY, Muniyappa R, Abel BS, Mullins KP, Staker P, Brychta RJ, Zhao X, Ring M, Psota TL, Cone RD, Panaro BL, Gottesdiener KM, Van der Ploeg LH, Reitman ML, Skarulis MC.

J Clin Endocrinol Metab. 2015 Apr;100(4):1639-45. doi: 10.1210/jc.2014-4024. Epub 2015 Feb 12.

32.

A semi-mechanistic model for the effects of a novel glucagon receptor antagonist on glucagon and the interaction between glucose, glucagon, and insulin applied to adaptive phase II design.

Peng JZ, Denney WS, Musser BJ, Liu R, Tsai K, Fang L, Reitman ML, Troyer MD, Engel SS, Xu L, Stoch A, Stone JA, Kowalski KG.

AAPS J. 2014 Nov;16(6):1259-70. doi: 10.1208/s12248-014-9648-x. Epub 2014 Aug 27.

33.

Biphasic effect of melanocortin agonists on metabolic rate and body temperature.

Lute B, Jou W, Lateef DM, Goldgof M, Xiao C, Piñol RA, Kravitz AV, Miller NR, Huang YG, Girardet C, Butler AA, Gavrilova O, Reitman ML.

Cell Metab. 2014 Aug 5;20(2):333-45. doi: 10.1016/j.cmet.2014.05.021. Epub 2014 Jun 26.

34.

The chemical uncoupler 2,4-dinitrophenol (DNP) protects against diet-induced obesity and improves energy homeostasis in mice at thermoneutrality.

Goldgof M, Xiao C, Chanturiya T, Jou W, Gavrilova O, Reitman ML.

J Biol Chem. 2014 Jul 11;289(28):19341-50. doi: 10.1074/jbc.M114.568204. Epub 2014 May 28.

35.

Polypropylene mesh: evidence for lack of carcinogenicity.

Moalli P, Brown B, Reitman MT, Nager CW.

Int Urogynecol J. 2014 May;25(5):573-6. doi: 10.1007/s00192-014-2343-8. Epub 2014 Mar 11.

36.

Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice.

Ravussin Y, Xiao C, Gavrilova O, Reitman ML.

PLoS One. 2014 Jan 17;9(1):e85876. doi: 10.1371/journal.pone.0085876. eCollection 2014.

37.

Regulation of body temperature and brown adipose tissue thermogenesis by bombesin receptor subtype-3.

Lateef DM, Abreu-Vieira G, Xiao C, Reitman ML.

Am J Physiol Endocrinol Metab. 2014 Mar;306(6):E681-7. doi: 10.1152/ajpendo.00615.2013. Epub 2014 Jan 22.

38.

FGF21 mimetic shows therapeutic promise.

Reitman ML.

Cell Metab. 2013 Sep 3;18(3):307-9. doi: 10.1016/j.cmet.2013.08.014.

39.

Comparative pharmacology of bombesin receptor subtype-3, nonpeptide agonist MK-5046, a universal peptide agonist, and peptide antagonist Bantag-1 for human bombesin receptors.

Moreno P, Mantey SA, Nuche-Berenguer B, Reitman ML, González N, Coy DH, Jensen RT.

J Pharmacol Exp Ther. 2013 Oct;347(1):100-16. doi: 10.1124/jpet.113.206896. Epub 2013 Jul 26.

40.

Weight loss after gastric bypass is associated with a variant at 15q26.1.

Hatoum IJ, Greenawalt DM, Cotsapas C, Daly MJ, Reitman ML, Kaplan LM.

Am J Hum Genet. 2013 May 2;92(5):827-34. doi: 10.1016/j.ajhg.2013.04.009.

41.

Response to Letter Regarding Article, “Prediction of Progression of Coronary Artery Disease and Clinical Outcomes Using Vascular Profiling of Endothelial Shear Stress and Arterial Plaque Characteristics: The PREDICTION Study”.

Makita Y, Nakamura S, Kawasaki T, Takahashi A, Katsuki T, Nakamura S, Namiki A, Hirohata A, Matsumura T, Yamazaki S, Yokoi H, Tanaka S, Otsuji S, Yoshimachi F, Honye J, Harwood D, Reitman M, Coskun AU, Papafaklis MI, Feldman CL.

Circulation. 2013 Mar 12;127(10):e489-90. No abstract available.

PMID:
23599923
42.

Leptin in the liver: a toxic or beneficial mix?

Reitman ML.

Cell Metab. 2012 Jul 3;16(1):1-2. doi: 10.1016/j.cmet.2012.06.009.

43.

Prediction of progression of coronary artery disease and clinical outcomes using vascular profiling of endothelial shear stress and arterial plaque characteristics: the PREDICTION Study.

Stone PH, Saito S, Takahashi S, Makita Y, Nakamura S, Kawasaki T, Takahashi A, Katsuki T, Nakamura S, Namiki A, Hirohata A, Matsumura T, Yamazaki S, Yokoi H, Tanaka S, Otsuji S, Yoshimachi F, Honye J, Harwood D, Reitman M, Coskun AU, Papafaklis MI, Feldman CL; PREDICTION Investigators.

Circulation. 2012 Jul 10;126(2):172-81. doi: 10.1161/CIRCULATIONAHA.112.096438. Epub 2012 Jun 21.

PMID:
22723305
44.

The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization.

Chobanian HR, Guo Y, Liu P, Lanza TJ Jr, Chioda M, Chang L, Kelly TM, Kan Y, Palyha O, Guan XM, Marsh DJ, Metzger JM, Raustad K, Wang SP, Strack AM, Gorski JN, Miller R, Pang J, Lyons K, Dragovic J, Ning JG, Schafer WA, Welch CJ, Gong X, Gao YD, Hornak V, Reitman ML, Nargund RP, Lin LS.

Bioorg Med Chem. 2012 May 1;20(9):2845-9. doi: 10.1016/j.bmc.2012.03.029. Epub 2012 Mar 24.

PMID:
22494842
45.

4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators.

Jimenez HN, Liu KG, Hong SP, Reitman MS, Uberti MA, Bacolod MD, Cajina M, Nattini M, Sabio M, Doller D.

Bioorg Med Chem Lett. 2012 May 1;22(9):3235-9. doi: 10.1016/j.bmcl.2012.03.032. Epub 2012 Mar 15.

PMID:
22465637
46.

Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity.

Chobanian HR, Guo Y, Liu P, Chioda M, Lanza TJ Jr, Chang L, Kelly TM, Kan Y, Palyha O, Guan XM, Marsh DJ, Metzger JM, Gorski JN, Raustad K, Wang SP, Strack AM, Miller R, Pang J, Madeira M, Lyons K, Dragovic J, Reitman ML, Nargund RP, Lin LS.

ACS Med Chem Lett. 2012 Jan 21;3(3):252-6. doi: 10.1021/ml200304j. eCollection 2012 Mar 8.

47.

A guide to analysis of mouse energy metabolism.

Tschöp MH, Speakman JR, Arch JR, Auwerx J, Brüning JC, Chan L, Eckel RH, Farese RV Jr, Galgani JE, Hambly C, Herman MA, Horvath TL, Kahn BB, Kozma SC, Maratos-Flier E, Müller TD, Münzberg H, Pfluger PT, Plum L, Reitman ML, Rahmouni K, Shulman GI, Thomas G, Kahn CR, Ravussin E.

Nat Methods. 2011 Dec 28;9(1):57-63. doi: 10.1038/nmeth.1806.

48.

Pharmacokinetics and pharmacodynamics of MK-5046, a bombesin receptor subtype-3 (BRS-3) agonist, in healthy patients.

Reitman ML, Dishy V, Moreau A, Denney WS, Liu C, Kraft WK, Mejia AV, Matson MA, Stoch SA, Wagner JA, Lai E.

J Clin Pharmacol. 2012 Sep;52(9):1306-16. doi: 10.1177/0091270011419854. Epub 2011 Dec 12.

49.

Discovery of benzodiazepine sulfonamide-based bombesin receptor subtype 3 agonists and their unusual chirality.

Liu P, Lanza TJ Jr, Chioda M, Jones C, Chobanian HR, Guo Y, Chang L, Kelly TM, Kan Y, Palyha O, Guan XM, Marsh DJ, Metzger JM, Ramsay K, Wang SP, Strack AM, Miller R, Pang J, Lyons K, Dragovic J, Ning JG, Schafer WA, Welch CJ, Gong X, Gao YD, Hornak V, Ball RG, Tsou N, Reitman ML, Wyvratt MJ, Nargund RP, Lin LS.

ACS Med Chem Lett. 2011 Oct 3;2(12):933-7. doi: 10.1021/ml200207w. eCollection 2011 Dec 8.

50.

Bombesin receptor subtype-3 (BRS-3) regulates glucose-stimulated insulin secretion in pancreatic islets across multiple species.

Feng Y, Guan XM, Li J, Metzger JM, Zhu Y, Juhl K, Zhang BB, Thornberry NA, Reitman ML, Zhou YP.

Endocrinology. 2011 Nov;152(11):4106-15. doi: 10.1210/en.2011-1440. Epub 2011 Aug 30.

PMID:
21878513

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