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Items: 1 to 50 of 54

1.

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.

Jones CL, Stevens BM, D'Alessandro A, Reisz JA, Culp-Hill R, Nemkov T, Pei S, Khan N, Adane B, Ye H, Krug A, Reinhold D, Smith C, DeGregori J, Pollyea DA, Jordan CT.

Cancer Cell. 2019 Feb 11;35(2):333-335. doi: 10.1016/j.ccell.2019.01.013. No abstract available.

PMID:
30753831
2.

Selective organ ischaemia/reperfusion identifies liver as the key driver of the post-injury plasma metabolome derangements.

Clendenen N, Nunns GR, Moore EE, Gonzalez E, Chapman M, Reisz JA, Peltz E, Fragoso M, Nemkov T, Wither MJ, Sauaia A, Silliman CC, Hansen K, Banerjee A, D'alessandro A, Moore HB.

Blood Transfus. 2018 Dec 13:1-13. doi: 10.2450/2018.0188-18. [Epub ahead of print]

3.

Metabolomics assessment reveals oxidative stress and altered energy production in the heart after ischemic acute kidney injury in mice.

Fox BM, Gil HW, Kirkbride-Romeo L, Bagchi RA, Wennersten SA, Haefner KR, Skrypnyk NI, Brown CN, Soranno DE, Gist KM, Griffin BR, Jovanovich A, Reisz JA, Wither MJ, D'Alessandro A, Edelstein CL, Clendenen N, McKinsey TA, Altmann C, Faubel S.

Kidney Int. 2019 Jan 29. pii: S0085-2538(18)30821-4. doi: 10.1016/j.kint.2018.10.020. [Epub ahead of print]

PMID:
30709662
4.

Red blood cell phenotype fidelity following glycerol cryopreservation optimized for research purposes.

Rogers SC, Dosier LB, McMahon TJ, Zhu H, Timm D, Zhang H, Herbert J, Atallah J, Palmer GM, Cook A, Ernst M, Prakash J, Terng M, Towfighi P, Doctor R, Said A, Joens MS, Fitzpatrick JAJ, Hanna G, Lin X, Reisz JA, Nemkov T, D'Alessandro A, Doctor A.

PLoS One. 2018 Dec 21;13(12):e0209201. doi: 10.1371/journal.pone.0209201. eCollection 2018.

5.

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.

Jones CL, Stevens BM, D'Alessandro A, Reisz JA, Culp-Hill R, Nemkov T, Pei S, Khan N, Adane B, Ye H, Krug A, Reinhold D, Smith C, DeGregori J, Pollyea DA, Jordan CT.

Cancer Cell. 2018 Nov 12;34(5):724-740.e4. doi: 10.1016/j.ccell.2018.10.005. Erratum in: Cancer Cell. 2019 Feb 11;35(2):333-335.

PMID:
30423294
6.

Heterogeneity of blood processing and storage additives in different centers impacts stored red blood cell metabolism as much as storage time: lessons from REDS-III-Omics.

D'Alessandro A, Culp-Hill R, Reisz JA, Anderson M, Fu X, Nemkov T, Gehrke S, Zheng C, Kanias T, Guo Y, Page G, Gladwin MT, Kleinman S, Lanteri M, Stone M, Busch M, Zimring JC; Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).

Transfusion. 2019 Jan;59(1):89-100. doi: 10.1111/trf.14979. Epub 2018 Oct 24.

PMID:
30353560
7.

Methylation of protein aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells.

Reisz JA, Nemkov T, Dzieciatkowska M, Culp-Hill R, Stefanoni D, Hill RC, Yoshida T, Dunham A, Kanias T, Dumont LJ, Busch M, Eisenmesser EZ, Zimring JC, Hansen KC, D'Alessandro A.

Transfusion. 2018 Dec;58(12):2978-2991. doi: 10.1111/trf.14936. Epub 2018 Oct 12.

PMID:
30312994
8.

Red blood cells as an organ? How deep omics characterization of the most abundant cell in the human body highlights other systemic metabolic functions beyond oxygen transport.

Nemkov T, Reisz JA, Xia Y, Zimring JC, D'Alessandro A.

Expert Rev Proteomics. 2018 Nov;15(11):855-864. doi: 10.1080/14789450.2018.1531710. Epub 2018 Oct 14.

PMID:
30278801
9.

H2O2 oxidation of cysteine residues in c-Jun N-terminal kinase 2 (JNK2) contributes to redox regulation in human articular chondrocytes.

Nelson KJ, Bolduc JA, Wu H, Collins JA, Burke EA, Reisz JA, Klomsiri C, Wood ST, Yammani RR, Poole LB, Furdui CM, Loeser RF.

J Biol Chem. 2018 Oct 19;293(42):16376-16389. doi: 10.1074/jbc.RA118.004613. Epub 2018 Sep 6.

PMID:
30190325
10.

Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins.

Bolduc JA, Nelson KJ, Haynes AC, Lee J, Reisz JA, Graff AH, Clodfelter JE, Parsonage D, Poole LB, Furdui CM, Lowther WT.

J Biol Chem. 2018 Jul 27;293(30):11901-11912. doi: 10.1074/jbc.RA117.001690. Epub 2018 Jun 8.

PMID:
29884768
11.

Metabolomics Analysis of Human Vitreous in Diabetic Retinopathy and Rhegmatogenous Retinal Detachment.

Haines NR, Manoharan N, Olson JL, D'Alessandro A, Reisz JA.

J Proteome Res. 2018 Jul 6;17(7):2421-2427. doi: 10.1021/acs.jproteome.8b00169. Epub 2018 Jun 19.

PMID:
29877085
12.

Metabolomics evaluation of early-storage red blood cell rejuvenation at 4°C and 37°C.

Gehrke S, Srinivasan AJ, Culp-Hill R, Reisz JA, Ansari A, Gray A, Landrigan M, Welsby I, D'Alessandro A.

Transfusion. 2018 Aug;58(8):1980-1991. doi: 10.1111/trf.14623. Epub 2018 Apr 24.

PMID:
29687892
13.

Unique Heterogeneous Topological Pattern of the Metabolic Landscape in Rabbit Fetal Lungs following Tracheal Occlusion.

Marwan AI, Shabeka U, Reisz JA, Zheng C, Serkova NJ, Dobrinskikh E.

Fetal Diagn Ther. 2018 Apr 18. doi: 10.1159/000487752. [Epub ahead of print]

PMID:
29669344
14.

Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis.

El Kasmi KC, Vue PM, Anderson AL, Devereaux MW, Ghosh S, Balasubramaniyan N, Fillon SA, Dahrenmoeller C, Allawzi A, Woods C, McKenna S, Wright CJ, Johnson L, D'Alessandro A, Reisz JA, Nozik-Grayck E, Suchy FJ, Sokol RJ.

Nat Commun. 2018 Apr 11;9(1):1393. doi: 10.1038/s41467-018-03764-1.

15.

Metabolic effect of alkaline additives and guanosine/gluconate in storage solutions for red blood cells.

D'Alessandro A, Reisz JA, Culp-Hill R, Korsten H, van Bruggen R, de Korte D.

Transfusion. 2018 Aug;58(8):1992-2002. doi: 10.1111/trf.14620. Epub 2018 Apr 6.

PMID:
29624679
16.

When nature's robots go rogue: exploring protein homeostasis dysfunction and the implications for understanding human aging disease pathologies.

Reisz JA, Barrett AS, Nemkov T, Hansen KC, D'Alessandro A.

Expert Rev Proteomics. 2018 Apr;15(4):293-309. doi: 10.1080/14789450.2018.1453362. Epub 2018 Mar 21. Review.

PMID:
29540077
17.

Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice.

Friedman JE, Dobrinskikh E, Alfonso-Garcia A, Fast A, Janssen RC, Soderborg TK, Anderson AL, Reisz JA, D'Alessandro A, Frank DN, Robertson CE, de la Houssaye BA, Johnson LK, Orlicky DJ, Wang XX, Levi M, Potma EO, El Kasmi KC, Jonscher KR.

Hepatol Commun. 2018 Jan 22;2(3):313-328. doi: 10.1002/hep4.1139. eCollection 2018 Mar.

18.

Metabolic Linkage and Correlations to Storage Capacity in Erythrocytes from Glucose 6-Phosphate Dehydrogenase-Deficient Donors.

Reisz JA, Tzounakas VL, Nemkov T, Voulgaridou AI, Papassideri IS, Kriebardis AG, D'Alessandro A, Antonelou MH.

Front Med (Lausanne). 2018 Jan 11;4:248. doi: 10.3389/fmed.2017.00248. eCollection 2017.

19.

Red blood cell metabolism in Down syndrome: hints on metabolic derangements in aging.

Culp-Hill R, Zheng C, Reisz JA, Smith K, Rachubinski A, Nemkov T, Butcher E, Granrath R, Hansen KC, Espinosa JM, D'Alessandro A.

Blood Adv. 2017 Dec 21;1(27):2776-2780. doi: 10.1182/bloodadvances.2017011957. eCollection 2017 Dec 26.

20.

Red blood cells in hemorrhagic shock: a critical role for glutaminolysis in fueling alanine transamination in rats.

Reisz JA, Slaughter AL, Culp-Hill R, Moore EE, Silliman CC, Fragoso M, Peltz ED, Hansen KC, Banerjee A, D'Alessandro A.

Blood Adv. 2017 Jul 14;1(17):1296-1305. doi: 10.1182/bloodadvances.2017007187. eCollection 2017 Jul 25.

21.

Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease.

Sun K, D'Alessandro A, Ahmed MH, Zhang Y, Song A, Ko TP, Nemkov T, Reisz JA, Wu H, Adebiyi M, Peng Z, Gong J, Liu H, Huang A, Wen YE, Wen AQ, Berka V, Bogdanov MV, Abdulmalik O, Han L, Tsai AL, Idowu M, Juneja HS, Kellems RE, Dowhan W, Hansen KC, Safo MK, Xia Y.

Sci Rep. 2017 Nov 10;7(1):15281. doi: 10.1038/s41598-017-13667-8.

22.

All animals are equal but some animals are more equal than others: Plasma lactate and succinate in hemorrhagic shock-A comparison in rodents, swine, nonhuman primates, and injured patients.

Reisz JA, Wither MJ, Moore EE, Slaughter AL, Moore HB, Ghasabyan A, Chandler J, Schaub LJ, Fragoso M, Nunns G, Silliman CC, Hansen KC, Banerjee A, Sheppard FR, D'Alessandro A.

J Trauma Acute Care Surg. 2018 Mar;84(3):537-541. doi: 10.1097/TA.0000000000001721.

PMID:
29112093
23.

Metabolism of Citrate and Other Carboxylic Acids in Erythrocytes As a Function of Oxygen Saturation and Refrigerated Storage.

Nemkov T, Sun K, Reisz JA, Yoshida T, Dunham A, Wen EY, Wen AQ, Roach RC, Hansen KC, Xia Y, D'Alessandro A.

Front Med (Lausanne). 2017 Oct 17;4:175. doi: 10.3389/fmed.2017.00175. eCollection 2017.

24.

Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage.

Nemkov T, Sun K, Reisz JA, Song A, Yoshida T, Dunham A, Wither MJ, Francis RO, Roach RC, Dzieciatkowska M, Rogers SC, Doctor A, Kriebardis A, Antonelou M, Papassideri I, Young CT, Thomas TA, Hansen KC, Spitalnik SL, Xia Y, Zimring JC, Hod EA, D'Alessandro A.

Haematologica. 2018 Feb;103(2):361-372. doi: 10.3324/haematol.2017.178608. Epub 2017 Oct 27.

25.

Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis.

Zhang H, Wang D, Li M, Plecitá-Hlavatá L, D'Alessandro A, Tauber J, Riddle S, Kumar S, Flockton A, McKeon BA, Frid MG, Reisz JA, Caruso P, El Kasmi KC, Ježek P, Morrell NW, Hu CJ, Stenmark KR.

Circulation. 2017 Dec 19;136(25):2468-2485. doi: 10.1161/CIRCULATIONAHA.117.028069. Epub 2017 Sep 26.

26.

Hydroxylamine Chemical Digestion for Insoluble Extracellular Matrix Characterization.

Barrett AS, Wither MJ, Hill RC, Dzieciatkowska M, D'Alessandro A, Reisz JA, Hansen KC.

J Proteome Res. 2017 Nov 3;16(11):4177-4184. doi: 10.1021/acs.jproteome.7b00527.

27.

Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia.

Gregory MA, Nemkov T, Reisz JA, Zaberezhnyy V, Hansen KC, D'Alessandro A, DeGregori J.

Exp Hematol. 2018 Feb;58:52-58. doi: 10.1016/j.exphem.2017.09.007. Epub 2017 Sep 22.

28.

Investigation of the effects of storage and freezing on mixes of heavy-labeled metabolite and amino acid standards.

Culp-Hill R, Reisz JA, Hansen KC, D'Alessandro A.

Rapid Commun Mass Spectrom. 2017 Dec 15;31(23):2030-2034. doi: 10.1002/rcm.7989.

29.

Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses.

Thwe PM, Pelgrom L, Cooper R, Beauchamp S, Reisz JA, D'Alessandro A, Everts B, Amiel E.

Cell Metab. 2017 Sep 5;26(3):558-567.e5. doi: 10.1016/j.cmet.2017.08.012.

30.

Measurement of metabolic fluxes using stable isotope tracers in whole animals and human patients.

Reisz JA, D'Alessandro A.

Curr Opin Clin Nutr Metab Care. 2017 Sep;20(5):366-374. doi: 10.1097/MCO.0000000000000393. Review.

31.

Blood and Plasma Proteomics: Targeted Quantitation and Posttranslational Redox Modifications.

Reisz JA, Chessler KM, Dzieciatkowska M, D'Alessandro A, Hansen KC.

Methods Mol Biol. 2017;1619:353-371. doi: 10.1007/978-1-4939-7057-5_24.

PMID:
28674896
32.

Plasma succinate is a predictor of mortality in critically injured patients.

DʼAlessandro A, Moore HB, Moore EE, Reisz JA, Wither MJ, Ghasasbyan A, Chandler J, Silliman CC, Hansen KC, Banerjee A.

J Trauma Acute Care Surg. 2017 Sep;83(3):491-495. doi: 10.1097/TA.0000000000001565.

33.

Characterization of rapid extraction protocols for high-throughput metabolomics.

Gehrke S, Reisz JA, Nemkov T, Hansen KC, D'Alessandro A.

Rapid Commun Mass Spectrom. 2017 Sep 15;31(17):1445-1452. doi: 10.1002/rcm.7916.

34.

Hemorrhagic shock and tissue injury drive distinct plasma metabolome derangements in swine.

Clendenen N, Nunns GR, Moore EE, Reisz JA, Gonzalez E, Peltz E, Silliman CC, Fragoso M, Nemkov T, Wither MJ, Hansen K, Banerjee A, Moore HB, DʼAlessandro A.

J Trauma Acute Care Surg. 2017 Oct;83(4):635-642. doi: 10.1097/TA.0000000000001504.

35.

Cell Origin Dictates Programming of Resident versus Recruited Macrophages during Acute Lung Injury.

Mould KJ, Barthel L, Mohning MP, Thomas SM, McCubbrey AL, Danhorn T, Leach SM, Fingerlin TE, O'Connor BP, Reisz JA, D'Alessandro A, Bratton DL, Jakubzick CV, Janssen WJ.

Am J Respir Cell Mol Biol. 2017 Sep;57(3):294-306. doi: 10.1165/rcmb.2017-0061OC.

36.

Mass Spectrometry-Based Bottom-Up Proteomics: Sample Preparation, LC-MS/MS Analysis, and Database Query Strategies.

Wither MJ, Hansen KC, Reisz JA.

Curr Protoc Protein Sci. 2016 Nov 1;86:16.4.1-16.4.20. doi: 10.1002/cpps.18.

PMID:
27801520
37.

Glutamine metabolism drives succinate accumulation in plasma and the lung during hemorrhagic shock.

Slaughter AL, D'Alessandro A, Moore EE, Banerjee A, Silliman CC, Hansen KC, Reisz JA, Fragoso M, Wither MJ, Bacon AW, Moore HB, Peltz ED.

J Trauma Acute Care Surg. 2016 Dec;81(6):1012-1019.

38.

Hypertonic Saline Primes Activation of the p53-p21 Signaling Axis in Human Small Airway Epithelial Cells That Prevents Inflammation Induced by Pro-inflammatory Cytokines.

Gamboni F, Anderson C, Mitra S, Reisz JA, Nemkov T, Dzieciatkowska M, Jones KL, Hansen KC, D'Alessandro A, Banerjee A.

J Proteome Res. 2016 Oct 7;15(10):3813-3826. Epub 2016 Aug 29.

39.

Oxidative modifications of glyceraldehyde 3-phosphate dehydrogenase regulate metabolic reprogramming of stored red blood cells.

Reisz JA, Wither MJ, Dzieciatkowska M, Nemkov T, Issaian A, Yoshida T, Dunham AJ, Hill RC, Hansen KC, D'Alessandro A.

Blood. 2016 Sep 22;128(12):e32-42. doi: 10.1182/blood-2016-05-714816. Epub 2016 Jul 12.

40.

Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice.

Zhang T, Pereyra AS, Wang ZM, Birbrair A, Reisz JA, Files DC, Purcell L, Feng X, Messi ML, Feng H, Chalovich J, Jin JP, Furdui C, Delbono O.

Aging Cell. 2016 Jun;15(3):488-98. doi: 10.1111/acel.12453. Epub 2016 Feb 19.

41.

Characterization of circulating APOL1 protein complexes in African Americans.

Weckerle A, Snipes JA, Cheng D, Gebre AK, Reisz JA, Murea M, Shelness GS, Hawkins GA, Furdui CM, Freedman BI, Parks JS, Ma L.

J Lipid Res. 2016 Jan;57(1):120-30. doi: 10.1194/jlr.M063453. Epub 2015 Nov 18.

42.

Cysteine-Mediated Redox Regulation of Cell Signaling in Chondrocytes Stimulated With Fibronectin Fragments.

Wood ST, Long DL, Reisz JA, Yammani RR, Burke EA, Klomsiri C, Poole LB, Furdui CM, Loeser RF.

Arthritis Rheumatol. 2016 Jan;68(1):117-26. doi: 10.1002/art.39326.

43.

A selective phosphine-based fluorescent probe for nitroxyl in living cells.

Miao Z, Reisz JA, Mitroka SM, Pan J, Xian M, King SB.

Bioorg Med Chem Lett. 2015 Jan 1;25(1):16-9. Epub 2014 Nov 21.

44.

Mass spectrometry in studies of protein thiol chemistry and signaling: opportunities and caveats.

Baez NO, Reisz JA, Furdui CM.

Free Radic Biol Med. 2015 Mar;80:191-211. doi: 10.1016/j.freeradbiomed.2014.09.016. Epub 2014 Sep 28. Review.

45.

Strained cycloalkynes as new protein sulfenic acid traps.

Poole TH, Reisz JA, Zhao W, Poole LB, Furdui CM, King SB.

J Am Chem Soc. 2014 Apr 30;136(17):6167-70. doi: 10.1021/ja500364r. Epub 2014 Apr 16.

46.

Effects of ionizing radiation on biological molecules--mechanisms of damage and emerging methods of detection.

Reisz JA, Bansal N, Qian J, Zhao W, Furdui CM.

Antioxid Redox Signal. 2014 Jul 10;21(2):260-92. doi: 10.1089/ars.2013.5489. Epub 2014 Feb 21. Review.

47.

Thiol-blocking electrophiles interfere with labeling and detection of protein sulfenic acids.

Reisz JA, Bechtold E, King SB, Poole LB, Furdui CM.

FEBS J. 2013 Dec;280(23):6150-61. doi: 10.1111/febs.12535. Epub 2013 Oct 16.

48.

Molecular basis for the resistance of human mitochondrial 2-Cys peroxiredoxin 3 to hyperoxidation.

Haynes AC, Qian J, Reisz JA, Furdui CM, Lowther WT.

J Biol Chem. 2013 Oct 11;288(41):29714-23. doi: 10.1074/jbc.M113.473470. Epub 2013 Sep 3.

49.

O2-sulfonylethyl protected isopropylamine diazen-1-ium-1,2-diolates as nitroxyl (HNO) donors: synthesis, β-elimination fragmentation, HNO release, positive inotropic properties, and blood pressure lowering studies.

Huang Z, Kaur J, Bhardwaj A, Alsaleh N, Reisz JA, DuMond JF, King SB, Seubert JM, Zhang Y, Knaus EE.

J Med Chem. 2012 Nov 26;55(22):10262-71. doi: 10.1021/jm301303p. Epub 2012 Oct 24.

PMID:
23072318
50.

Rapid and selective nitroxyl (HNO) trapping by phosphines: kinetics and new aqueous ligations for HNO detection and quantitation.

Reisz JA, Zink CN, King SB.

J Am Chem Soc. 2011 Aug 3;133(30):11675-85. doi: 10.1021/ja203652z. Epub 2011 Jul 11.

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