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The Hunt for Degrons of the 26S Proteasome.

Ella H, Reiss Y, Ravid T.

Biomolecules. 2019 Jun 13;9(6). pii: E230. doi: 10.3390/biom9060230. Review.


Assays for dissecting the in vitro enzymatic activity of yeast Ubc7.

Mashahreh B, Reiss Y, Wiener R, Ravid T.

Methods Enzymol. 2019;619:71-95. doi: 10.1016/bs.mie.2018.12.035. Epub 2019 Feb 7.


An In Vivo Blood-brain Barrier Permeability Assay in Mice Using Fluorescently Labeled Tracers.

Devraj K, Guérit S, Macas J, Reiss Y.

J Vis Exp. 2018 Feb 26;(132). doi: 10.3791/57038.


Functional morphology of the blood-brain barrier in health and disease.

Liebner S, Dijkhuizen RM, Reiss Y, Plate KH, Agalliu D, Constantin G.

Acta Neuropathol. 2018 Mar;135(3):311-336. doi: 10.1007/s00401-018-1815-1. Epub 2018 Feb 6. Review.


Personalized translational epilepsy research - Novel approaches and future perspectives: Part I: Clinical and network analysis approaches.

Rosenow F, van Alphen N, Becker A, Chiocchetti A, Deichmann R, Deller T, Freiman T, Freitag CM, Gehrig J, Hermsen AM, Jedlicka P, Kell C, Klein KM, Knake S, Kullmann DM, Liebner S, Norwood BA, Omigie D, Plate K, Reif A, Reif PS, Reiss Y, Roeper J, Ronellenfitsch MW, Schorge S, Schratt G, Schwarzacher SW, Steinbach JP, Strzelczyk A, Triesch J, Wagner M, Walker MC, von Wegner F, Bauer S.

Epilepsy Behav. 2017 Nov;76:13-18. doi: 10.1016/j.yebeh.2017.06.041. Epub 2017 Sep 13. Review.


Personalized translational epilepsy research - Novel approaches and future perspectives: Part II: Experimental and translational approaches.

Bauer S, van Alphen N, Becker A, Chiocchetti A, Deichmann R, Deller T, Freiman T, Freitag CM, Gehrig J, Hermsen AM, Jedlicka P, Kell C, Klein KM, Knake S, Kullmann DM, Liebner S, Norwood BA, Omigie D, Plate K, Reif A, Reif PS, Reiss Y, Roeper J, Ronellenfitsch MW, Schorge S, Schratt G, Schwarzacher SW, Steinbach JP, Strzelczyk A, Triesch J, Wagner M, Walker MC, von Wegner F, Rosenow F.

Epilepsy Behav. 2017 Nov;76:7-12. doi: 10.1016/j.yebeh.2017.06.040. Epub 2017 Sep 14. Review.


Sequential Poly-ubiquitylation by Specialized Conjugating Enzymes Expands the Versatility of a Quality Control Ubiquitin Ligase.

Weber A, Cohen I, Popp O, Dittmar G, Reiss Y, Sommer T, Ravid T, Jarosch E.

Mol Cell. 2016 Sep 1;63(5):827-39. doi: 10.1016/j.molcel.2016.07.020. Epub 2016 Aug 25.


Angiopoietin-2-induced blood-brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling.

Gurnik S, Devraj K, Macas J, Yamaji M, Starke J, Scholz A, Sommer K, Di Tacchio M, Vutukuri R, Beck H, Mittelbronn M, Foerch C, Pfeilschifter W, Liebner S, Peters KG, Plate KH, Reiss Y.

Acta Neuropathol. 2016 May;131(5):753-73. doi: 10.1007/s00401-016-1551-3. Epub 2016 Mar 1.


Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma.

Scholz A, Harter PN, Cremer S, Yalcin BH, Gurnik S, Yamaji M, Di Tacchio M, Sommer K, Baumgarten P, Bähr O, Steinbach JP, Trojan J, Glas M, Herrlinger U, Krex D, Meinhardt M, Weyerbrock A, Timmer M, Goldbrunner R, Deckert M, Braun C, Schittenhelm J, Frueh JT, Ullrich E, Mittelbronn M, Plate KH, Reiss Y.

EMBO Mol Med. 2016 Jan 1;8(1):39-57. doi: 10.15252/emmm.201505505.


Degradation of Ndd1 by APC/C(Cdh1) generates a feed forward loop that times mitotic protein accumulation.

Sajman J, Zenvirth D, Nitzan M, Margalit H, Simpson-Lavy KJ, Reiss Y, Cohen I, Ravid T, Brandeis M.

Nat Commun. 2015 May 11;6:7075. doi: 10.1038/ncomms8075.


Angiopoietin-2: a multifaceted cytokine that functions in both angiogenesis and inflammation.

Scholz A, Plate KH, Reiss Y.

Ann N Y Acad Sci. 2015 Jul;1347:45-51. doi: 10.1111/nyas.12726. Epub 2015 Mar 13. Review.


Distinct activation of an E2 ubiquitin-conjugating enzyme by its cognate E3 ligases.

Cohen I, Wiener R, Reiss Y, Ravid T.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E625-32. doi: 10.1073/pnas.1415621112. Epub 2015 Feb 2.


Placing a disrupted degradation motif at the C terminus of proteasome substrates attenuates degradation without impairing ubiquitylation.

Alfassy OS, Cohen I, Reiss Y, Tirosh B, Ravid T.

J Biol Chem. 2013 May 3;288(18):12645-53. doi: 10.1074/jbc.M113.453027. Epub 2013 Mar 21.


Angiopoietin-1 mediates inhibition of hypertension-induced release of angiopoietin-2 from endothelial cells.

Korff T, Ernst E, Nobiling R, Feldner A, Reiss Y, Plate KH, Fiedler U, Augustin HG, Hecker M.

Cardiovasc Res. 2012 Jun 1;94(3):510-8. doi: 10.1093/cvr/cvs124. Epub 2012 Apr 14.


Angiopoietin-2 promotes myeloid cell infiltration in a β₂-integrin-dependent manner.

Scholz A, Lang V, Henschler R, Czabanka M, Vajkoczy P, Chavakis E, Drynski J, Harter PN, Mittelbronn M, Dumont DJ, Plate KH, Reiss Y.

Blood. 2011 Nov 3;118(18):5050-9. doi: 10.1182/blood-2011-03-343293. Epub 2011 Aug 25.


Angiopoietin 2 stimulates TIE2-expressing monocytes to suppress T cell activation and to promote regulatory T cell expansion.

Coffelt SB, Chen YY, Muthana M, Welford AF, Tal AO, Scholz A, Plate KH, Reiss Y, Murdoch C, De Palma M, Lewis CE.

J Immunol. 2011 Apr 1;186(7):4183-90. doi: 10.4049/jimmunol.1002802. Epub 2011 Mar 2.


Angiopoietin-2 regulates gene expression in TIE2-expressing monocytes and augments their inherent proangiogenic functions.

Coffelt SB, Tal AO, Scholz A, De Palma M, Patel S, Urbich C, Biswas SK, Murdoch C, Plate KH, Reiss Y, Lewis CE.

Cancer Res. 2010 Jul 1;70(13):5270-80. doi: 10.1158/0008-5472.CAN-10-0012. Epub 2010 Jun 8.


Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells.

Doebele C, Bonauer A, Fischer A, Scholz A, Reiss Y, Urbich C, Hofmann WK, Zeiher AM, Dimmeler S.

Blood. 2010 Jun 10;115(23):4944-50. doi: 10.1182/blood-2010-01-264812. Epub 2010 Mar 18.



Reiss Y.

Recent Results Cancer Res. 2010;180:3-13. doi: 10.1007/978-3-540-78281-0_2. Review.


The E3 ubiquitin-ligase Bmi1/Ring1A controls the proteasomal degradation of Top2alpha cleavage complex - a potentially new drug target.

Alchanati I, Teicher C, Cohen G, Shemesh V, Barr HM, Nakache P, Ben-Avraham D, Idelevich A, Angel I, Livnah N, Tuvia S, Reiss Y, Taglicht D, Erez O.

PLoS One. 2009 Dec 1;4(12):e8104. doi: 10.1371/journal.pone.0008104.


Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice.

Bhandarkar SS, Jaconi M, Fried LE, Bonner MY, Lefkove B, Govindarajan B, Perry BN, Parhar R, Mackelfresh J, Sohn A, Stouffs M, Knaus U, Yancopoulos G, Reiss Y, Benest AV, Augustin HG, Arbiser JL.

J Clin Invest. 2009 Aug;119(8):2359-65. doi: 10.1172/JCI33877. Epub 2009 Jul 13.


Exploring the functional interaction between POSH and ALIX and the relevance to HIV-1 release.

Votteler J, Iavnilovitch E, Fingrut O, Shemesh V, Taglicht D, Erez O, Sörgel S, Walther T, Bannert N, Schubert U, Reiss Y.

BMC Biochem. 2009 Apr 24;10:12. doi: 10.1186/1471-2091-10-12.


Switching of vascular phenotypes within a murine breast cancer model induced by angiopoietin-2.

Reiss Y, Knedla A, Tal AO, Schmidt MHH, Jugold M, Kiessling F, Burger AM, Wolburg H, Deutsch U, Plate KH.

J Pathol. 2009 Mar;217(4):571-80. doi: 10.1002/path.2484.


Involvement of endothelial ephrin-B2 in adhesion and transmigration of EphB-receptor-expressing monocytes.

Pfaff D, Héroult M, Riedel M, Reiss Y, Kirmse R, Ludwig T, Korff T, Hecker M, Augustin HG.

J Cell Sci. 2008 Nov 15;121(Pt 22):3842-50. doi: 10.1242/jcs.030627. Epub 2008 Oct 28.


Flt-1 signaling in macrophages promotes glioma growth in vivo.

Kerber M, Reiss Y, Wickersheim A, Jugold M, Kiessling F, Heil M, Tchaikovski V, Waltenberger J, Shibuya M, Plate KH, Machein MR.

Cancer Res. 2008 Sep 15;68(18):7342-51. doi: 10.1158/0008-5472.CAN-07-6241.


Angiopoietin-2 impairs revascularization after limb ischemia.

Reiss Y, Droste J, Heil M, Tribulova S, Schmidt MHH, Schaper W, Dumont DJ, Plate KH.

Circ Res. 2007 Jul 6;101(1):88-96. Epub 2007 May 31.


The ubiquitin E3 ligase POSH regulates calcium homeostasis through spatial control of Herp.

Tuvia S, Taglicht D, Erez O, Alroy I, Alchanati I, Bicoviski V, Dori-Bachash M, Ben-Avraham D, Reiss Y.

J Cell Biol. 2007 Apr 9;177(1):51-61.


Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation.

Fiedler U, Reiss Y, Scharpfenecker M, Grunow V, Koidl S, Thurston G, Gale NW, Witzenrath M, Rosseau S, Suttorp N, Sobke A, Herrmann M, Preissner KT, Vajkoczy P, Augustin HG.

Nat Med. 2006 Feb;12(2):235-9. Epub 2006 Feb 5.


The role of angiopoietins during angiogenesis in gliomas.

Reiss Y, Machein MR, Plate KH.

Brain Pathol. 2005 Oct;15(4):311-7. Review.


Cell-free assay for ubiquitin-independent proteasomal protein degradation.

Kahana C, Reiss Y.

Methods Mol Biol. 2005;301:83-96.


The Tie-2 ligand angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism.

Scharpfenecker M, Fiedler U, Reiss Y, Augustin HG.

J Cell Sci. 2005 Feb 15;118(Pt 4):771-80. Epub 2005 Feb 1.


The trans-Golgi network-associated human ubiquitin-protein ligase POSH is essential for HIV type 1 production.

Alroy I, Tuvia S, Greener T, Gordon D, Barr HM, Taglicht D, Mandil-Levin R, Ben-Avraham D, Konforty D, Nir A, Levius O, Bicoviski V, Dori M, Cohen S, Yaar L, Erez O, Propheta-Meiran O, Koskas M, Caspi-Bachar E, Alchanati I, Sela-Brown A, Moskowitz H, Tessmer U, Schubert U, Reiss Y.

Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1478-83. Epub 2005 Jan 19.


Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding.

Amit I, Yakir L, Katz M, Zwang Y, Marmor MD, Citri A, Shtiegman K, Alroy I, Tuvia S, Reiss Y, Roubini E, Cohen M, Wides R, Bacharach E, Schubert U, Yarden Y.

Genes Dev. 2004 Jul 15;18(14):1737-52.


EphB receptors and ephrinB ligands: regulators of vascular assembly and homeostasis.

Augustin HG, Reiss Y.

Cell Tissue Res. 2003 Oct;314(1):25-31. Epub 2003 Aug 2. Review.


A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1.

Nadav E, Shmueli A, Barr H, Gonen H, Ciechanover A, Reiss Y.

Biochem Biophys Res Commun. 2003 Mar 28;303(1):91-7.


An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope.

Seifert U, Marañón C, Shmueli A, Desoutter JF, Wesoloski L, Janek K, Henklein P, Diescher S, Andrieu M, de la Salle H, Weinschenk T, Schild H, Laderach D, Galy A, Haas G, Kloetzel PM, Reiss Y, Hosmalin A.

Nat Immunol. 2003 Apr;4(4):375-9. Epub 2003 Feb 24.


A role for a novel luminal endoplasmic reticulum aminopeptidase in final trimming of 26 S proteasome-generated major histocompatability complex class I antigenic peptides.

Komlosh A, Momburg F, Weinschenk T, Emmerich N, Schild H, Nadav E, Shaked I, Reiss Y.

J Biol Chem. 2001 Aug 10;276(32):30050-6. Epub 2001 May 23.


Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance.

Limmer A, Ohl J, Kurts C, Ljunggren HG, Reiss Y, Groettrup M, Momburg F, Arnold B, Knolle PA.

Nat Med. 2000 Dec;6(12):1348-54.


Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1.

Levkowitz G, Waterman H, Ettenberg SA, Katz M, Tsygankov AY, Alroy I, Lavi S, Iwai K, Reiss Y, Ciechanover A, Lipkowitz S, Yarden Y.

Mol Cell. 1999 Dec;4(6):1029-40.


26 S proteasome-mediated production of an authentic major histocompatibility class I-restricted epitope from an intact protein substrate.

Ben-Shahar S, Komlosh A, Nadav E, Shaked I, Ziv T, Admon A, DeMartino GN, Reiss Y.

J Biol Chem. 1999 Jul 30;274(31):21963-72.


Prolonged eosinophil accumulation in allergic lung interstitium of ICAM-2 deficient mice results in extended hyperresponsiveness.

Gerwin N, Gonzalo JA, Lloyd C, Coyle AJ, Reiss Y, Banu N, Wang B, Xu H, Avraham H, Engelhardt B, Springer TA, Gutierrez-Ramos JC.

Immunity. 1999 Jan;10(1):9-19.


Enhanced phosphorylation of p53 by ATM in response to DNA damage.

Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, Chessa L, Smorodinsky NI, Prives C, Reiss Y, Shiloh Y, Ziv Y.

Science. 1998 Sep 11;281(5383):1674-7.


The mouse and human genes encoding the recognition component of the N-end rule pathway.

Kwon YT, Reiss Y, Fried VA, Hershko A, Yoon JK, Gonda DK, Sangan P, Copeland NG, Jenkins NA, Varshavsky A.

Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):7898-903.


Butyrylcholinesterase-positive cells of the developing chicken retina that are non-cholinergic and GABA-positive.

Reiss Y, Layer PG, Kröger S.

Brain Res Dev Brain Res. 1997 May 20;100(1):62-72.


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