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Direct reprogramming of fibroblasts into antigen-presenting dendritic cells.

Rosa FF, Pires CF, Kurochkin I, Ferreira AG, Gomes AM, Palma LG, Shaiv K, Solanas L, Azenha C, Papatsenko D, Schulz O, Reis e Sousa C, Pereira CF.

Sci Immunol. 2018 Dec 7;3(30). pii: eaau4292. doi: 10.1126/sciimmunol.aau4292.


Correction: Syk Signaling in Dendritic Cells Orchestrates Innate Resistance to Systemic Fungal Infection.

Whitney PG, Bär E, Osorio F, Rogers NC, Schraml BU, Deddouche S, LeibundGut-Landmann S, Reis E Sousa C.

PLoS Pathog. 2018 Nov 21;14(11):e1007366. doi: 10.1371/journal.ppat.1007366. eCollection 2018 Nov.


The Role of Type 1 Conventional Dendritic Cells in Cancer Immunity.

Böttcher JP, Reis E Sousa C.

Trends Cancer. 2018 Nov;4(11):784-792. doi: 10.1016/j.trecan.2018.09.001. Epub 2018 Sep 29. Review.


α-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in Drosophila melanogaster.

Gordon O, Henry CM, Srinivasan N, Ahrens S, Franz A, Deddouche S, Chakravarty P, Phillips D, George R, Kjaer S, Frith D, Snijders AP, Valente RS, Simoes da Silva CJ, Teixeira L, Thompson B, Dionne MS, Wood W, Reis E Sousa C.

Elife. 2018 Sep 27;7. pii: e38636. doi: 10.7554/eLife.38636.


Myosin II Synergizes with F-Actin to Promote DNGR-1-Dependent Cross-Presentation of Dead Cell-Associated Antigens.

Schulz O, Hanč P, Böttcher JP, Hoogeboom R, Diebold SS, Tolar P, Reis E Sousa C.

Cell Rep. 2018 Jul 10;24(2):419-428. doi: 10.1016/j.celrep.2018.06.038.


Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.

Koliopoulos MG, Lethier M, van der Veen AG, Haubrich K, Hennig J, Kowalinski E, Stevens RV, Martin SR, Reis e Sousa C, Cusack S, Rittinger K.

Nat Commun. 2018 May 8;9(1):1820. doi: 10.1038/s41467-018-04214-8.


Clec9a-Mediated Ablation of Conventional Dendritic Cells Suggests a Lymphoid Path to Generating Dendritic Cells In Vivo.

Salvermoser J, van Blijswijk J, Papaioannou NE, Rambichler S, Pasztoi M, Pakalniškytė D, Rogers NC, Keppler SJ, Straub T, Reis e Sousa C, Schraml BU.

Front Immunol. 2018 Apr 16;9:699. doi: 10.3389/fimmu.2018.00699. eCollection 2018.


NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control.

Böttcher JP, Bonavita E, Chakravarty P, Blees H, Cabeza-Cabrerizo M, Sammicheli S, Rogers NC, Sahai E, Zelenay S, Reis e Sousa C.

Cell. 2018 Feb 22;172(5):1022-1037.e14. doi: 10.1016/j.cell.2018.01.004. Epub 2018 Feb 8.


The RIG-I-like receptor LGP2 inhibits Dicer-dependent processing of long double-stranded RNA and blocks RNA interference in mammalian cells.

van der Veen AG, Maillard PV, Schmidt JM, Lee SA, Deddouche-Grass S, Borg A, Kjær S, Snijders AP, Reis e Sousa C.

EMBO J. 2018 Feb 15;37(4). pii: e97479. doi: 10.15252/embj.201797479. Epub 2018 Jan 19.


Dendritic Cell Lineage Potential in Human Early Hematopoietic Progenitors.

Helft J, Anjos-Afonso F, van der Veen AG, Chakravarty P, Bonnet D, Reis e Sousa C.

Cell Rep. 2017 Jul 18;20(3):529-537. doi: 10.1016/j.celrep.2017.06.075.


Sensing infection and tissue damage.

Reis e Sousa C.

EMBO Mol Med. 2017 Mar;9(3):285-288. doi: 10.15252/emmm.201607227. No abstract available.


Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster.

Srinivasan N, Gordon O, Ahrens S, Franz A, Deddouche S, Chakravarty P, Phillips D, Yunus AA, Rosen MK, Valente RS, Teixeira L, Thompson B, Dionne MS, Wood W, Reis e Sousa C.

Elife. 2016 Nov 22;5. pii: e19662. doi: 10.7554/eLife.19662.


Inactivation of the type I interferon pathway reveals long double-stranded RNA-mediated RNA interference in mammalian cells.

Maillard PV, Van der Veen AG, Deddouche-Grass S, Rogers NC, Merits A, Reis e Sousa C.

EMBO J. 2016 Dec 1;35(23):2505-2518. Epub 2016 Nov 4.


A pH- and ionic strength-dependent conformational change in the neck region regulates DNGR-1 function in dendritic cells.

Hanč P, Schulz O, Fischbach H, Martin SR, Kjær S, Reis e Sousa C.

EMBO J. 2016 Nov 15;35(22):2484-2497. Epub 2016 Oct 17.


Reducing prostaglandin E2 production to raise cancer immunogenicity.

Zelenay S, Reis e Sousa C.

Oncoimmunology. 2016 Jan 4;5(5):e1123370. doi: 10.1080/2162402X.2015.1123370. eCollection 2016 May.


Dendritic cells in remodeling of lymph nodes during immune responses.

Acton SE, Reis e Sousa C.

Immunol Rev. 2016 May;271(1):221-9. doi: 10.1111/imr.12414. Review.


Alive but Confused: Heterogeneity of CD11c(+) MHC Class II(+) Cells in GM-CSF Mouse Bone Marrow Cultures.

Helft J, Böttcher JP, Chakravarty P, Zelenay S, Huotari J, Schraml BU, Goubau D, Reis e Sousa C.

Immunity. 2016 Jan 19;44(1):3-4. doi: 10.1016/j.immuni.2015.12.014. No abstract available.


Drosha cuts the tethers of myelopoiesis.

van der Veen AG, Maillard PV, Reis e Sousa C.

Nat Immunol. 2015 Nov;16(11):1110-2. doi: 10.1038/ni.3297. No abstract available.


Oncogenic Transformation of Dendritic Cells and Their Precursors Leads to Rapid Cancer Development in Mice.

Böttcher JP, Zelenay S, Rogers NC, Helft J, Schraml BU, Reis e Sousa C.

J Immunol. 2015 Nov 15;195(10):5066-76. doi: 10.4049/jimmunol.1500889. Epub 2015 Oct 12.


Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses.

Goubau D, van der Veen AG, Chakravarty P, Lin R, Rogers N, Rehwinkel J, Deddouche S, Rosewell I, Hiscott J, Reis e Sousa C.

Eur J Immunol. 2015 Dec;45(12):3386-403. doi: 10.1002/eji.201545794. Epub 2015 Oct 12.


RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8⁺ T cells.

Yatim N, Jusforgues-Saklani H, Orozco S, Schulz O, Barreira da Silva R, Reis e Sousa C, Green DR, Oberst A, Albert ML.

Science. 2015 Oct 16;350(6258):328-34. doi: 10.1126/science.aad0395. Epub 2015 Sep 24.


Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.

Zelenay S, van der Veen AG, Böttcher JP, Snelgrove KJ, Rogers N, Acton SE, Chakravarty P, Girotti MR, Marais R, Quezada SA, Sahai E, Reis e Sousa C.

Cell. 2015 Sep 10;162(6):1257-70. doi: 10.1016/j.cell.2015.08.015. Epub 2015 Sep 3.


GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c(+)MHCII(+) Macrophages and Dendritic Cells.

Helft J, Böttcher J, Chakravarty P, Zelenay S, Huotari J, Schraml BU, Goubau D, Reis e Sousa C.

Immunity. 2015 Jun 16;42(6):1197-211. doi: 10.1016/j.immuni.2015.05.018.


Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance.

Swamy M, Abeler-Dörner L, Chettle J, Mahlakõiv T, Goubau D, Chakravarty P, Ramsay G, Reis e Sousa C, Staeheli P, Blacklaws BA, Heeney JL, Hayday AC.

Nat Commun. 2015 May 19;6:7090. doi: 10.1038/ncomms8090.


Structure of the Complex of F-Actin and DNGR-1, a C-Type Lectin Receptor Involved in Dendritic Cell Cross-Presentation of Dead Cell-Associated Antigens.

Hanč P, Fujii T, Iborra S, Yamada Y, Huotari J, Schulz O, Ahrens S, Kjær S, Way M, Sancho D, Namba K, Reis e Sousa C.

Immunity. 2015 May 19;42(5):839-849. doi: 10.1016/j.immuni.2015.04.009. Epub 2015 May 12.


The Processed Amino-Terminal Fragment of Human TLR7 Acts as a Chaperone To Direct Human TLR7 into Endosomes.

Hipp MM, Shepherd D, Booth S, Waithe D, Reis e Sousa C, Cerundolo V.

J Immunol. 2015 Jun 1;194(11):5417-25. doi: 10.4049/jimmunol.1402703. Epub 2015 Apr 27.


Host response. Inflammation-induced disruption of SCS macrophages impairs B cell responses to secondary infection.

Gaya M, Castello A, Montaner B, Rogers N, Reis e Sousa C, Bruckbauer A, Batista FD.

Science. 2015 Feb 6;347(6222):667-72. doi: 10.1126/science.aaa1300.


Defining dendritic cells.

Schraml BU, Reis e Sousa C.

Curr Opin Immunol. 2015 Feb;32:13-20. doi: 10.1016/j.coi.2014.11.001. Epub 2014 Dec 3. Review.


Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non-human primates.

Li J, Ahmet F, Sullivan LC, Brooks AG, Kent SJ, De Rose R, Salazar AM, Reis e Sousa C, Shortman K, Lahoud MH, Heath WR, Caminschi I.

Eur J Immunol. 2015 Mar;45(3):854-64. doi: 10.1002/eji.201445127. Epub 2015 Jan 14.


Altered lymph node composition in diphtheria toxin receptor-based mouse models to ablate dendritic cells.

van Blijswijk J, Schraml BU, Rogers NC, Whitney PG, Zelenay S, Acton SE, Reis e Sousa C.

J Immunol. 2015 Jan 1;194(1):307-15. doi: 10.4049/jimmunol.1401999. Epub 2014 Nov 19.


Dendritic cells control fibroblastic reticular network tension and lymph node expansion.

Acton SE, Farrugia AJ, Astarita JL, Mourão-Sá D, Jenkins RP, Nye E, Hooper S, van Blijswijk J, Rogers NC, Snelgrove KJ, Rosewell I, Moita LF, Stamp G, Turley SJ, Sahai E, Reis e Sousa C.

Nature. 2014 Oct 23;514(7523):498-502. doi: 10.1038/nature13814.


Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates.

Goubau D, Schlee M, Deddouche S, Pruijssers AJ, Zillinger T, Goldeck M, Schuberth C, Van der Veen AG, Fujimura T, Rehwinkel J, Iskarpatyoti JA, Barchet W, Ludwig J, Dermody TS, Hartmann G, Reis e Sousa C.

Nature. 2014 Oct 16;514(7522):372-375. doi: 10.1038/nature13590. Epub 2014 Aug 10.


Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection.

Whitney PG, Bär E, Osorio F, Rogers NC, Schraml BU, Deddouche S, LeibundGut-Landmann S, Reis e Sousa C.

PLoS Pathog. 2014 Jul 17;10(7):e1004276. doi: 10.1371/journal.ppat.1004276. eCollection 2014 Jul. Erratum in: PLoS Pathog. 2018 Nov 21;14(11):e1007366.


Antigen processing.

Reis e Sousa C, Unanue ER.

Curr Opin Immunol. 2014 Feb;26:138-9. doi: 10.1016/j.coi.2013.12.003. Epub 2013 Dec 22. No abstract available.


Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells.

Deddouche S, Goubau D, Rehwinkel J, Chakravarty P, Begum S, Maillard PV, Borg A, Matthews N, Feng Q, van Kuppeveld FJ, Reis e Sousa C.

Elife. 2014 Feb 18;3:e01535. doi: 10.7554/eLife.01535.


IL-17 regulates systemic fungal immunity by controlling the functional competence of NK cells.

Bär E, Whitney PG, Moor K, Reis e Sousa C, LeibundGut-Landmann S.

Immunity. 2014 Jan 16;40(1):117-27. doi: 10.1016/j.immuni.2013.12.002. Epub 2014 Jan 9.


Processing of human toll-like receptor 7 by furin-like proprotein convertases is required for its accumulation and activity in endosomes.

Hipp MM, Shepherd D, Gileadi U, Aichinger MC, Kessler BM, Edelmann MJ, Essalmani R, Seidah NG, Reis e Sousa C, Cerundolo V.

Immunity. 2013 Oct 17;39(4):711-21. doi: 10.1016/j.immuni.2013.09.004.


Genetic tracing via DNGR-1 expression history defines dendritic cells as a hematopoietic lineage.

Schraml BU, van Blijswijk J, Zelenay S, Whitney PG, Filby A, Acton SE, Rogers NC, Moncaut N, Carvajal JJ, Reis e Sousa C.

Cell. 2013 Aug 15;154(4):843-58. doi: 10.1016/j.cell.2013.07.014.


SAMHD1-dependent retroviral control and escape in mice.

Rehwinkel J, Maelfait J, Bridgeman A, Rigby R, Hayward B, Liberatore RA, Bieniasz PD, Towers GJ, Moita LF, Crow YJ, Bonthron DT, Reis e Sousa C.

EMBO J. 2013 Sep 11;32(18):2454-62. doi: 10.1038/emboj.2013.163. Epub 2013 Jul 19.


Targeting the viral Achilles' heel: recognition of 5'-triphosphate RNA in innate anti-viral defence.

Rehwinkel J, Reis e Sousa C.

Curr Opin Microbiol. 2013 Aug;16(4):485-92. doi: 10.1016/j.mib.2013.04.009. Epub 2013 May 23. Review.


Cytosolic sensing of viruses.

Goubau D, Deddouche S, Reis e Sousa C.

Immunity. 2013 May 23;38(5):855-69. doi: 10.1016/j.immuni.2013.05.007. Review.


Adaptive immunity after cell death.

Zelenay S, Reis e Sousa C.

Trends Immunol. 2013 Jul;34(7):329-35. doi: 10.1016/ Epub 2013 Apr 20. Review.


Sensing of cell death by myeloid C-type lectin receptors.

Sancho D, Reis e Sousa C.

Curr Opin Immunol. 2013 Feb;25(1):46-52. doi: 10.1016/j.coi.2012.12.007. Epub 2013 Jan 16. Review.


Advantages and limitations of mouse models to deplete dendritic cells.

van Blijswijk J, Schraml BU, Reis e Sousa C.

Eur J Immunol. 2013 Jan;43(1):22-6. doi: 10.1002/eji.201243022.


CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis.

Tamoutounour S, Henri S, Lelouard H, de Bovis B, de Haar C, van der Woude CJ, Woltman AM, Reyal Y, Bonnet D, Sichien D, Bain CC, Mowat AM, Reis e Sousa C, Poulin LF, Malissen B, Guilliams M.

Eur J Immunol. 2012 Dec;42(12):3150-66. doi: 10.1002/eji.201242847. Epub 2012 Oct 17.


The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice.

Zelenay S, Keller AM, Whitney PG, Schraml BU, Deddouche S, Rogers NC, Schulz O, Sancho D, Reis e Sousa C.

J Clin Invest. 2012 May;122(5):1615-27. doi: 10.1172/JCI60644. Epub 2012 Apr 16.


The DC receptor DNGR-1 mediates cross-priming of CTLs during vaccinia virus infection in mice.

Iborra S, Izquierdo HM, Martínez-López M, Blanco-Menéndez N, Reis e Sousa C, Sancho D.

J Clin Invest. 2012 May;122(5):1628-43. doi: 10.1172/JCI60660. Epub 2012 Apr 16.


F-actin is an evolutionarily conserved damage-associated molecular pattern recognized by DNGR-1, a receptor for dead cells.

Ahrens S, Zelenay S, Sancho D, Hanč P, Kjær S, Feest C, Fletcher G, Durkin C, Postigo A, Skehel M, Batista F, Thompson B, Way M, Reis e Sousa C, Schulz O.

Immunity. 2012 Apr 20;36(4):635-45. doi: 10.1016/j.immuni.2012.03.008. Epub 2012 Apr 5.


DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues.

Poulin LF, Reyal Y, Uronen-Hansson H, Schraml BU, Sancho D, Murphy KM, Håkansson UK, Moita LF, Agace WW, Bonnet D, Reis e Sousa C.

Blood. 2012 Jun 21;119(25):6052-62. doi: 10.1182/blood-2012-01-406967. Epub 2012 Mar 22.


Signaling by myeloid C-type lectin receptors in immunity and homeostasis.

Sancho D, Reis e Sousa C.

Annu Rev Immunol. 2012;30:491-529. doi: 10.1146/annurev-immunol-031210-101352. Epub 2012 Jan 6. Review.

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