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Items: 46


ATG2 transports lipids to promote autophagosome biogenesis.

Valverde DP, Yu S, Boggavarapu V, Kumar N, Lees JA, Walz T, Reinisch KM, Melia TJ.

J Cell Biol. 2019 Jun 3;218(6):1787-1798. doi: 10.1083/jcb.201811139. Epub 2019 Apr 5.


VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites.

Kumar N, Leonzino M, Hancock-Cerutti W, Horenkamp FA, Li P, Lees JA, Wheeler H, Reinisch KM, De Camilli P.

J Cell Biol. 2018 Oct 1;217(10):3625-3639. doi: 10.1083/jcb.201807019. Epub 2018 Aug 9.


Molecular basis for sterol transport by StART-like lipid transfer domains.

Horenkamp FA, Valverde DP, Nunnari J, Reinisch KM.

EMBO J. 2018 Mar 15;37(6). pii: e98002. doi: 10.15252/embj.201798002. Epub 2018 Feb 21.


Architecture of the human PI4KIIIα lipid kinase complex.

Lees JA, Zhang Y, Oh MS, Schauder CM, Yu X, Baskin JM, Dobbs K, Notarangelo LD, De Camilli P, Walz T, Reinisch KM.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13720-13725. doi: 10.1073/pnas.1718471115. Epub 2017 Dec 11.


Correction: Re-visiting the trans insertion model for complexin clamping.

Krishnakumar SS, Li F, Coleman J, Schauder CM, Kümmel D, Pincet F, Rothman JE, Reinisch KM.

Elife. 2017 Sep 7;6. pii: e31512. doi: 10.7554/eLife.31512. No abstract available.


Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion.

Lees JA, Messa M, Sun EW, Wheeler H, Torta F, Wenk MR, De Camilli P, Reinisch KM.

Science. 2017 Feb 17;355(6326). pii: eaah6171. doi: 10.1126/science.aah6171.


CATCHR, HOPS and CORVET tethering complexes share a similar architecture.

Chou HT, Dukovski D, Chambers MG, Reinisch KM, Walz T.

Nat Struct Mol Biol. 2016 Aug;23(8):761-3. doi: 10.1038/nsmb.3264. Epub 2016 Jul 18.


Control of plasma membrane lipid homeostasis by the extended synaptotagmins.

Saheki Y, Bian X, Schauder CM, Sawaki Y, Surma MA, Klose C, Pincet F, Reinisch KM, De Camilli P.

Nat Cell Biol. 2016 May;18(5):504-15. doi: 10.1038/ncb3339. Epub 2016 Apr 11.


SMP-domain proteins at membrane contact sites: Structure and function.

Reinisch KM, De Camilli P.

Biochim Biophys Acta. 2016 Aug;1861(8 Pt B):924-927. doi: 10.1016/j.bbalip.2015.12.003. Epub 2015 Dec 10. Review.


The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane.

Baskin JM, Wu X, Christiano R, Oh MS, Schauder CM, Gazzerro E, Messa M, Baldassari S, Assereto S, Biancheri R, Zara F, Minetti C, Raimondi A, Simons M, Walther TC, Reinisch KM, De Camilli P.

Nat Cell Biol. 2016 Jan;18(1):132-8. doi: 10.1038/ncb3271. Epub 2015 Nov 16.


The Legionella Anti-autophagy Effector RavZ Targets the Autophagosome via PI3P- and Curvature-Sensing Motifs.

Horenkamp FA, Kauffman KJ, Kohler LJ, Sherwood RK, Krueger KP, Shteyn V, Roy CR, Melia TJ, Reinisch KM.

Dev Cell. 2015 Sep 14;34(5):569-76. doi: 10.1016/j.devcel.2015.08.010. Epub 2015 Sep 3.


Re-visiting the trans insertion model for complexin clamping.

Krishnakumar SS, Li F, Coleman J, Schauder CM, Kümmel D, Pincet F, Rothman JE, Reinisch KM.

Elife. 2015 Apr 2;4. pii: e04463. doi: 10.7554/eLife.04463. Erratum in: Elife. 2017 Sep 07;6:.


Sac1-Vps74 structure reveals a mechanism to terminate phosphoinositide signaling in the Golgi apparatus.

Cai Y, Deng Y, Horenkamp F, Reinisch KM, Burd CG.

J Cell Biol. 2014 Aug 18;206(4):485-91. doi: 10.1083/jcb.201404041. Epub 2014 Aug 11.


Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer.

Schauder CM, Wu X, Saheki Y, Narayanaswamy P, Torta F, Wenk MR, De Camilli P, Reinisch KM.

Nature. 2014 Jun 26;510(7506):552-5.


A requirement for ER-derived COPII vesicles in phagophore initiation.

Wang J, Tan D, Cai Y, Reinisch KM, Walz T, Ferro-Novick S.

Autophagy. 2014 Apr;10(4):708-9. doi: 10.4161/auto.28103. Epub 2014 Feb 12.


A half-zippered SNARE complex represents a functional intermediate in membrane fusion.

Li F, Kümmel D, Coleman J, Reinisch KM, Rothman JE, Pincet F.

J Am Chem Soc. 2014 Mar 5;136(9):3456-64. doi: 10.1021/ja410690m. Epub 2014 Feb 18.


Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation.

Langemeyer L, Nunes Bastos R, Cai Y, Itzen A, Reinisch KM, Barr FA.

Elife. 2014 Feb 11;3:e01623. doi: 10.7554/eLife.01623.


Legionella pneumophila subversion of host vesicular transport by SidC effector proteins.

Horenkamp FA, Mukherjee S, Alix E, Schauder CM, Hubber AM, Roy CR, Reinisch KM.

Traffic. 2014 May;15(5):488-99. doi: 10.1111/tra.12158. Epub 2014 Mar 12.


Structural insights into assembly and regulation of the plasma membrane phosphatidylinositol 4-kinase complex.

Wu X, Chi RJ, Baskin JM, Lucast L, Burd CG, De Camilli P, Reinisch KM.

Dev Cell. 2014 Jan 13;28(1):19-29. doi: 10.1016/j.devcel.2013.11.012. Epub 2013 Dec 19.


Conformational dynamics of calcium-triggered activation of fusion by synaptotagmin.

Krishnakumar SS, Kümmel D, Jones SJ, Radoff DT, Reinisch KM, Rothman JE.

Biophys J. 2013 Dec 3;105(11):2507-16. doi: 10.1016/j.bpj.2013.10.029.


The EM structure of the TRAPPIII complex leads to the identification of a requirement for COPII vesicles on the macroautophagy pathway.

Tan D, Cai Y, Wang J, Zhang J, Menon S, Chou HT, Ferro-Novick S, Reinisch KM, Walz T.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19432-7. doi: 10.1073/pnas.1316356110. Epub 2013 Nov 11.


Structures and mechanisms of vesicle coat components and multisubunit tethering complexes.

Jackson LP, Kümmel D, Reinisch KM, Owen DJ.

Curr Opin Cell Biol. 2012 Aug;24(4):475-83. doi: 10.1016/ Epub 2012 Jun 22. Review.


Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate.

Wu X, Bradley MJ, Cai Y, Kümmel D, De La Cruz EM, Barr FA, Reinisch KM.

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18672-7. doi: 10.1073/pnas.1110415108. Epub 2011 Nov 7.


Structure of Golgi transport proteins.

Kümmel D, Reinisch KM.

Cold Spring Harb Perspect Biol. 2011 Dec 1;3(12). pii: a007609. doi: 10.1101/cshperspect.a007609. Review.


Complexin cross-links prefusion SNAREs into a zigzag array.

Kümmel D, Krishnakumar SS, Radoff DT, Li F, Giraudo CG, Pincet F, Rothman JE, Reinisch KM.

Nat Struct Mol Biol. 2011 Jul 24;18(8):927-33. doi: 10.1038/nsmb.2101.


A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion.

Krishnakumar SS, Radoff DT, Kümmel D, Giraudo CG, Li F, Khandan L, Baguley SW, Coleman J, Reinisch KM, Pincet F, Rothman JE.

Nat Struct Mol Biol. 2011 Jul 24;18(8):934-40. doi: 10.1038/nsmb.2103.


Structure and function of the polymerase core of TRAMP, a RNA surveillance complex.

Hamill S, Wolin SL, Reinisch KM.

Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15045-50. doi: 10.1073/pnas.1003505107. Epub 2010 Aug 9.


Structure of a C-terminal fragment of its Vps53 subunit suggests similarity of Golgi-associated retrograde protein (GARP) complex to a family of tethering complexes.

Vasan N, Hutagalung A, Novick P, Reinisch KM.

Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14176-81. doi: 10.1073/pnas.1009419107. Epub 2010 Jul 26.


Structure and mechanism in membrane trafficking.

Hughson FM, Reinisch KM.

Curr Opin Cell Biol. 2010 Aug;22(4):454-60. doi: 10.1016/ Epub 2010 Apr 24. Review.


Kinetic analysis of the guanine nucleotide exchange activity of TRAPP, a multimeric Ypt1p exchange factor.

Chin HF, Cai Y, Menon S, Ferro-Novick S, Reinisch KM, De La Cruz EM.

J Mol Biol. 2009 Jun 5;389(2):275-88. doi: 10.1016/j.jmb.2009.03.068. Epub 2009 Apr 8.


Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer.

Dong G, Wearsch PA, Peaper DR, Cresswell P, Reinisch KM.

Immunity. 2009 Jan 16;30(1):21-32. doi: 10.1016/j.immuni.2008.10.018.


The structural basis for activation of the Rab Ypt1p by the TRAPP membrane-tethering complexes.

Cai Y, Chin HF, Lazarova D, Menon S, Fu C, Cai H, Sclafani A, Rodgers DW, De La Cruz EM, Ferro-Novick S, Reinisch KM.

Cell. 2008 Jun 27;133(7):1202-13. doi: 10.1016/j.cell.2008.04.049.


Emerging themes in non-coding RNA quality control.

Reinisch KM, Wolin SL.

Curr Opin Struct Biol. 2007 Apr;17(2):209-14. Epub 2007 Mar 28. Review.


A catalytic coiled coil: structural insights into the activation of the Rab GTPase Sec4p by Sec2p.

Dong G, Medkova M, Novick P, Reinisch KM.

Mol Cell. 2007 Feb 9;25(3):455-62.


Structural and biochemical basis for misfolded RNA recognition by the Ro autoantigen.

Fuchs G, Stein AJ, Fu C, Reinisch KM, Wolin SL.

Nat Struct Mol Biol. 2006 Nov;13(11):1002-9. Epub 2006 Oct 15.


The Ro 60 kDa autoantigen comes into focus: interpreting epitope mapping experiments on the basis of structure.

Wolin SL, Reinisch KM.

Autoimmun Rev. 2006 Jul;5(6):367-72. Epub 2005 Nov 15. Review.


The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif.

Dong G, Hutagalung AH, Fu C, Novick P, Reinisch KM.

Nat Struct Mol Biol. 2005 Dec;12(12):1094-100. Epub 2005 Oct 26.


Structural insights into RNA quality control: the Ro autoantigen binds misfolded RNAs via its central cavity.

Stein AJ, Fuchs G, Fu C, Wolin SL, Reinisch KM.

Cell. 2005 May 20;121(4):529-539. doi: 10.1016/j.cell.2005.03.009.


Orthoreovirus and Aquareovirus core proteins: conserved enzymatic surfaces, but not protein-protein interfaces.

Kim J, Tao Y, Reinisch KM, Harrison SC, Nibert ML.

Virus Res. 2004 Apr;101(1):15-28. Review.


Structure of the La motif: a winged helix domain mediates RNA binding via a conserved aromatic patch.

Dong G, Chakshusmathi G, Wolin SL, Reinisch KM.

EMBO J. 2004 Mar 10;23(5):1000-7. Epub 2004 Feb 19.


The dsRNA Viridae and their catalytic capsids.

Reinisch KM.

Nat Struct Biol. 2002 Oct;9(10):714-6. No abstract available.


Structure of the reovirus core at 3.6 A resolution.

Reinisch KM, Nibert ML, Harrison SC.

Nature. 2000 Apr 27;404(6781):960-7.


Identification of the guanylyltransferase region and active site in reovirus mRNA capping protein lambda2.

Luongo CL, Reinisch KM, Harrison SC, Nibert ML.

J Biol Chem. 2000 Jan 28;275(4):2804-10.


Molecular structure of Bacillus subtilis aspartate transcarbamoylase at 3.0 A resolution.

Stevens RC, Reinisch KM, Lipscomb WN.

Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):6087-91.

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