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Items: 37

1.

High-Diversity Mouse Populations for Complex Traits.

Saul MC, Philip VM, Reinholdt LG; Center for Systems Neurogenetics of Addiction, Chesler EJ.

Trends Genet. 2019 Jul;35(7):501-514. doi: 10.1016/j.tig.2019.04.003. Epub 2019 May 24. Review.

2.

The Genome of C57BL/6J "Eve", the Mother of the Laboratory Mouse Genome Reference Strain.

Sarsani VK, Raghupathy N, Fiddes IT, Armstrong J, Thibaud-Nissen F, Zinder O, Bolisetty M, Howe K, Hinerfeld D, Ruan X, Rowe L, Barter M, Ananda G, Paten B, Weinstock GM, Churchill GA, Wiles MV, Schneider VA, Srivastava A, Reinholdt LG.

G3 (Bethesda). 2019 Jun 5;9(6):1795-1805. doi: 10.1534/g3.119.400071.

3.

Mitotic chromosome alignment ensures mitotic fidelity by promoting interchromosomal compaction during anaphase.

Fonseca CL, Malaby HLH, Sepaniac LA, Martin W, Byers C, Czechanski A, Messinger D, Tang M, Ohi R, Reinholdt LG, Stumpff J.

J Cell Biol. 2019 Apr 1;218(4):1148-1163. doi: 10.1083/jcb.201807228. Epub 2019 Feb 7.

PMID:
30733233
4.

Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis.

Goodwin LO, Splinter E, Davis TL, Urban R, He H, Braun RE, Chesler EJ, Kumar V, van Min M, Ndukum J, Philip VM, Reinholdt LG, Svenson K, White JK, Sasner M, Lutz C, Murray SA.

Genome Res. 2019 Mar;29(3):494-505. doi: 10.1101/gr.233866.117. Epub 2019 Jan 18.

5.

Biallelic mutations in FDXR cause neurodegeneration associated with inflammation.

Slone J, Peng Y, Chamberlin A, Harris B, Kaylor J, McDonald MT, Lemmon M, El-Dairi MA, Tchapyjnikov D, Gonzalez-Krellwitz LA, Sellars EA, McConkie-Rosell A, Reinholdt LG, Huang T.

J Hum Genet. 2018 Dec;63(12):1211-1222. doi: 10.1038/s10038-018-0515-y. Epub 2018 Sep 25.

6.

Injectable polypeptide hydrogels via methionine modification for neural stem cell delivery.

Wollenberg AL, O'Shea TM, Kim JH, Czechanski A, Reinholdt LG, Sofroniew MV, Deming TJ.

Biomaterials. 2018 Sep;178:527-545. doi: 10.1016/j.biomaterials.2018.03.057. Epub 2018 Apr 5.

PMID:
29657091
7.

Biallelic mutations in the ferredoxin reductase gene cause novel mitochondriopathy with optic atrophy.

Peng Y, Shinde DN, Valencia CA, Mo JS, Rosenfeld J, Truitt Cho M, Chamberlin A, Li Z, Liu J, Gui B, Brockhage R, Basinger A, Alvarez-Leon B, Heydemann P, Magoulas PL, Lewis AM, Scaglia F, Gril S, Chong SC, Bower M, Monaghan KG, Willaert R, Plona MR, Dineen R, Milan F, Hoganson G, Powis Z, Helbig KL, Keller-Ramey J, Harris B, Anderson LC, Green T, Sukoff Rizzo SJ, Kaylor J, Chen J, Guan MX, Sellars E, Sparagana SP, Gibson JB, Reinholdt LG, Tang S, Huang T.

Hum Mol Genet. 2017 Dec 15;26(24):4937-4950. doi: 10.1093/hmg/ddx377. Erratum in: Hum Mol Genet. 2018 Jun 15;27(12):2224.

8.

CRISPRtools: a flexible computational platform for performing CRISPR/Cas9 experiments in the mouse.

Peterson KA, Beane GL, Goodwin LO, Kutny PM, Reinholdt LG, Murray SA.

Mamm Genome. 2017 Aug;28(7-8):283-290. doi: 10.1007/s00335-017-9681-z. Epub 2017 Mar 9.

9.

Spontaneous 8bp Deletion in Nbeal2 Recapitulates the Gray Platelet Syndrome in Mice.

Tomberg K, Khoriaty R, Westrick RJ, Fairfield HE, Reinholdt LG, Brodsky GL, Davizon-Castillo P, Ginsburg D, Di Paola J.

PLoS One. 2016 Mar 7;11(3):e0150852. doi: 10.1371/journal.pone.0150852. eCollection 2016.

10.

Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology.

Palmer K, Fairfield H, Borgeia S, Curtain M, Hassan MG, Dionne L, Yong Karst S, Coombs H, Bronson RT, Reinholdt LG, Bergstrom DE, Donahue LR, Cox TC, Murray SA.

Dev Biol. 2016 Jul 15;415(2):216-227. doi: 10.1016/j.ydbio.2015.07.023. Epub 2015 Jul 31.

11.

DBA/2J genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease.

Jackson HM, Onos KD, Pepper KW, Graham LC, Akeson EC, Byers C, Reinholdt LG, Frankel WN, Howell GR.

PLoS One. 2015 May 1;10(5):e0125897. doi: 10.1371/journal.pone.0125897. eCollection 2015.

12.

Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders.

Fairfield H, Srivastava A, Ananda G, Liu R, Kircher M, Lakshminarayana A, Harris BS, Karst SY, Dionne LA, Kane CC, Curtain M, Berry ML, Ward-Bailey PF, Greenstein I, Byers C, Czechanski A, Sharp J, Palmer K, Gudis P, Martin W, Tadenev A, Bogdanik L, Pratt CH, Chang B, Schroeder DG, Cox GA, Cliften P, Milbrandt J, Murray S, Burgess R, Bergstrom DE, Donahue LR, Hamamy H, Masri A, Santoni FA, Makrythanasis P, Antonarakis SE, Shendure J, Reinholdt LG.

Genome Res. 2015 Jul;25(7):948-57. doi: 10.1101/gr.186882.114. Epub 2015 Apr 27.

13.

Nuclear localization of PRDM9 and its role in meiotic chromatin modifications and homologous synapsis.

Sun F, Fujiwara Y, Reinholdt LG, Hu J, Saxl RL, Baker CL, Petkov PM, Paigen K, Handel MA.

Chromosoma. 2015 Sep;124(3):397-415. doi: 10.1007/s00412-015-0511-3. Epub 2015 Apr 18.

14.

Kif18a is specifically required for mitotic progression during germ line development.

Czechanski A, Kim H, Byers C, Greenstein I, Stumpff J, Reinholdt LG.

Dev Biol. 2015 Jun 15;402(2):253-262. doi: 10.1016/j.ydbio.2015.03.011. Epub 2015 Mar 28.

15.

Dsp rul: a spontaneous mouse mutation in desmoplakin as a model of Carvajal-Huerta syndrome.

Herbert Pratt C, Potter CS, Fairfield H, Reinholdt LG, Bergstrom DE, Harris BS, Greenstein I, Dadras SS, Liang BT, Schofield PN, Sundberg JP.

Exp Mol Pathol. 2015 Apr;98(2):164-72. doi: 10.1016/j.yexmp.2015.01.015. Epub 2015 Feb 7.

16.

Discovery of transgene insertion sites by high throughput sequencing of mate pair libraries.

Srivastava A, Philip VM, Greenstein I, Rowe LB, Barter M, Lutz C, Reinholdt LG.

BMC Genomics. 2014 May 14;15:367. doi: 10.1186/1471-2164-15-367.

17.

Derivation and characterization of mouse embryonic stem cells from permissive and nonpermissive strains.

Czechanski A, Byers C, Greenstein I, Schrode N, Donahue LR, Hadjantonakis AK, Reinholdt LG.

Nat Protoc. 2014 Mar;9(3):559-74. doi: 10.1038/nprot.2014.030. Epub 2014 Feb 6.

18.

Generating embryonic stem cells from the inbred mouse strain DBA/2J, a model of glaucoma and other complex diseases.

Reinholdt LG, Howell GR, Czechanski AM, Macalinao DG, Macnicoll KH, Lin CS, Donahue LR, John SW.

PLoS One. 2012;7(11):e50081. doi: 10.1371/journal.pone.0050081. Epub 2012 Nov 27.

19.

High throughput sequencing approaches to mutation discovery in the mouse.

Simon MM, Mallon AM, Howell GR, Reinholdt LG.

Mamm Genome. 2012 Oct;23(9-10):499-513. doi: 10.1007/s00335-012-9424-0. Epub 2012 Sep 19. Review.

20.

Sequencing and characterization of the FVB/NJ mouse genome.

Wong K, Bumpstead S, Van Der Weyden L, Reinholdt LG, Wilming LG, Adams DJ, Keane TM.

Genome Biol. 2012 Aug 23;13(8):R72. doi: 10.1186/gb-2012-13-8-r72.

21.

Discovery Genetics - The History and Future of Spontaneous Mutation Research.

Davisson MT, Bergstrom DE, Reinholdt LG, Donahue LR.

Curr Protoc Mouse Biol. 2012 Jun 1;2:103-118.

22.

The impact of entropy on the spatial organization of synaptonemal complexes within the cell nucleus.

Fritsche M, Reinholdt LG, Lessard M, Handel MA, Bewersdorf J, Heermann DW.

PLoS One. 2012;7(5):e36282. doi: 10.1371/journal.pone.0036282. Epub 2012 May 4.

23.

Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn.

Reinholdt LG, Ding Y, Gilbert GJ, Czechanski A, Solzak JP, Roper RJ, Johnson MT, Donahue LR, Lutz C, Davisson MT.

Mamm Genome. 2011 Dec;22(11-12):685-91. doi: 10.1007/s00335-011-9357-z. Epub 2011 Sep 28. Erratum in: Mamm Genome. 2011 Dec;22(11-12):692. Gilbert, Griffith T [corrected to Gilbert, Griffith J].

24.

Mouse genomic variation and its effect on phenotypes and gene regulation.

Keane TM, Goodstadt L, Danecek P, White MA, Wong K, Yalcin B, Heger A, Agam A, Slater G, Goodson M, Furlotte NA, Eskin E, Nellåker C, Whitley H, Cleak J, Janowitz D, Hernandez-Pliego P, Edwards A, Belgard TG, Oliver PL, McIntyre RE, Bhomra A, Nicod J, Gan X, Yuan W, van der Weyden L, Steward CA, Bala S, Stalker J, Mott R, Durbin R, Jackson IJ, Czechanski A, Guerra-Assunção JA, Donahue LR, Reinholdt LG, Payseur BA, Ponting CP, Birney E, Flint J, Adams DJ.

Nature. 2011 Sep 14;477(7364):289-94. doi: 10.1038/nature10413.

25.

Mutation discovery in mice by whole exome sequencing.

Fairfield H, Gilbert GJ, Barter M, Corrigan RR, Curtain M, Ding Y, D'Ascenzo M, Gerhardt DJ, He C, Huang W, Richmond T, Rowe L, Probst FJ, Bergstrom DE, Murray SA, Bult C, Richardson J, Kile BT, Gut I, Hager J, Sigurdsson S, Mauceli E, Di Palma F, Lindblad-Toh K, Cunningham ML, Cox TC, Justice MJ, Spector MS, Lowe SW, Albert T, Donahue LR, Jeddeloh J, Shendure J, Reinholdt LG.

Genome Biol. 2011 Sep 14;12(9):R86. doi: 10.1186/gb-2011-12-9-r86.

26.

Altered testicular gene expression patterns in mice lacking the polyubiquitin gene Ubb.

Sinnar SA, Small CL, Evanoff RM, Reinholdt LG, Griswold MD, Kopito RR, Ryu KY.

Mol Reprod Dev. 2011 Jun;78(6):415-25. doi: 10.1002/mrd.21318. Epub 2011 May 3.

27.

BMD regulation on mouse distal chromosome 1, candidate genes, and response to ovariectomy or dietary fat.

Beamer WG, Shultz KL, Coombs HF 3rd, DeMambro VE, Reinholdt LG, Ackert-Bicknell CL, Canalis E, Rosen CJ, Donahue LR.

J Bone Miner Res. 2011 Jan;26(1):88-99. doi: 10.1002/jbmr.200.

28.

Mutations in sterol O-acyltransferase 1 (Soat1) result in hair interior defects in AKR/J mice.

Wu B, Potter CS, Silva KA, Liang Y, Reinholdt LG, Alley LM, Rowe LB, Roopenian DC, Awgulewitsch A, Sundberg JP.

J Invest Dermatol. 2010 Nov;130(11):2666-8. doi: 10.1038/jid.2010.168. Epub 2010 Jun 24. No abstract available.

29.

Meiotic behavior of aneuploid chromatin in mouse models of Down syndrome.

Reinholdt LG, Czechanski A, Kamdar S, King BL, Sun F, Handel MA.

Chromosoma. 2009 Dec;118(6):723-36. doi: 10.1007/s00412-009-0230-8. Epub 2009 Jul 29.

30.

The mouse polyubiquitin gene Ubb is essential for meiotic progression.

Ryu KY, Sinnar SA, Reinholdt LG, Vaccari S, Hall S, Garcia MA, Zaitseva TS, Bouley DM, Boekelheide K, Handel MA, Conti M, Kopito RR.

Mol Cell Biol. 2008 Feb;28(3):1136-46. Epub 2007 Dec 10.

31.

Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over.

Ward JO, Reinholdt LG, Motley WW, Niswander LM, Deacon DC, Griffin LB, Langlais KK, Backus VL, Schimenti KJ, O'Brien MJ, Eppig JJ, Schimenti JC.

PLoS Genet. 2007 Aug;3(8):e139. Epub 2007 Jul 6.

32.

The mouse gcd2 mutation causes primordial germ cell depletion.

Reinholdt LG, Munroe RJ, Kamdar S, Schimenti JC.

Mech Dev. 2006 Jul;123(7):559-69. Epub 2006 May 25.

33.

Mei1 is epistatic to Dmc1 during mouse meiosis.

Reinholdt LG, Schimenti JC.

Chromosoma. 2005 Jul;114(2):127-34. Epub 2005 Jun 1.

PMID:
15928951
34.

Positional cloning and characterization of mouse mei8, a disrupted allelle of the meiotic cohesin Rec8.

Bannister LA, Reinholdt LG, Munroe RJ, Schimenti JC.

Genesis. 2004 Nov;40(3):184-94.

PMID:
15515002
35.

Positional cloning and characterization of Mei1, a vertebrate-specific gene required for normal meiotic chromosome synapsis in mice.

Libby BJ, Reinholdt LG, Schimenti JC.

Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15706-11. Epub 2003 Dec 10.

36.

Toward the genetics of mammalian reproduction: induction and mapping of gametogenesis mutants in mice.

Ward JO, Reinholdt LG, Hartford SA, Wilson LA, Munroe RJ, Schimenti KJ, Libby BJ, O'Brien M, Pendola JK, Eppig J, Schimenti JC.

Biol Reprod. 2003 Nov;69(5):1615-25. Epub 2003 Jul 9.

PMID:
12855593
37.

Meiotic chromosome missegregation during apyrene meiosis in the gypsy moth, Lymantria dispar, is preceded by an aberrant prophase I.

Reinholdt LG, Gutierrez GM, Krider HM.

Chromosoma. 2002 Sep;111(3):139-46. Epub 2002 Jul 31.

PMID:
12355202

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