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Topological analysis of the gp41 MPER on lipid bilayers relevant to the metastable HIV-1 envelope prefusion state.

Wang Y, Kaur P, Sun ZJ, Elbahnasawy MA, Hayati Z, Qiao ZS, Bui NN, Chile C, Nasr ML, Wagner G, Wang JH, Song L, Reinherz EL, Kim M.

Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22556-22566. doi: 10.1073/pnas.1912427116. Epub 2019 Oct 17.


The structure of a T-cell mechanosensor.

Reinherz EL.

Nature. 2019 Sep;573(7775):502-504. doi: 10.1038/d41586-019-02646-w. No abstract available.


NMR: an essential structural tool for integrative studies of T cell development, pMHC ligand recognition and TCR mechanobiology.

Mallis RJ, Brazin KN, Duke-Cohan JS, Hwang W, Wang JH, Wagner G, Arthanari H, Lang MJ, Reinherz EL.

J Biomol NMR. 2019 Jul;73(6-7):319-332. doi: 10.1007/s10858-019-00234-8. Epub 2019 Feb 27.


Pillars Article: Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes. Science. 1993. 259: 822-825.

Shinkai Y, Koyasu S, Nakayama KI, Murphy KM, Loh DY, Reinherz EL, Alt FW.

J Immunol. 2019 Mar 1;202(5):1317-1320. No abstract available.


The T Cell Antigen Receptor α Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations.

Brazin KN, Mallis RJ, Boeszoermenyi A, Feng Y, Yoshizawa A, Reche PA, Kaur P, Bi K, Hussey RE, Duke-Cohan JS, Song L, Wagner G, Arthanari H, Lang MJ, Reinherz EL.

Immunity. 2018 Nov 20;49(5):829-841.e6. doi: 10.1016/j.immuni.2018.09.007. Epub 2018 Oct 30.


Co-delivery of a CD4 T cell helper epitope via covalent liposome attachment with a surface-arrayed B cell target antigen fosters higher affinity antibody responses.

Elbahnasawy MA, Donius LR, Reinherz EL, Kim M.

Vaccine. 2018 Oct 1;36(41):6191-6201. doi: 10.1016/j.vaccine.2018.08.014. Epub 2018 Sep 7.


αβ T Cell Receptor Mechanosensing Forces out Serial Engagement.

Feng Y, Reinherz EL, Lang MJ.

Trends Immunol. 2018 Aug;39(8):596-609. doi: 10.1016/ Epub 2018 Jul 4. Review.


Regulation of thymocyte trafficking by Tagap, a GAP domain protein linked to human autoimmunity.

Duke-Cohan JS, Ishikawa Y, Yoshizawa A, Choi YI, Lee CN, Acuto O, Kissler S, Reinherz EL.

Sci Signal. 2018 Jun 12;11(534). pii: eaan8799. doi: 10.1126/scisignal.aan8799.


Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody.

Kwon YD, Chuang GY, Zhang B, Bailer RT, Doria-Rose NA, Gindin TS, Lin B, Louder MK, McKee K, O'Dell S, Pegu A, Schmidt SD, Asokan M, Chen X, Choe M, Georgiev IS, Jin V, Pancera M, Rawi R, Wang K, Chaudhuri R, Kueltzo LA, Manceva SD, Todd JP, Scorpio DG, Kim M, Reinherz EL, Wagh K, Korber BM, Connors M, Shapiro L, Mascola JR, Kwong PD.

Cell Rep. 2018 Feb 13;22(7):1798-1809. doi: 10.1016/j.celrep.2018.01.023.


NMR-directed design of pre-TCRβ and pMHC molecules implies a distinct geometry for pre-TCR relative to αβTCR recognition of pMHC.

Mallis RJ, Arthanari H, Lang MJ, Reinherz EL, Wagner G.

J Biol Chem. 2018 Jan 19;293(3):754-766. doi: 10.1074/jbc.M117.813493. Epub 2017 Nov 3.


TCR-pMHC encounter differentially regulates transcriptomes of tissue-resident CD8 T cells.

Yoshizawa A, Bi K, Keskin DB, Zhang G, Reinhold B, Reinherz EL.

Eur J Immunol. 2018 Jan;48(1):128-150. doi: 10.1002/eji.201747174. Epub 2017 Sep 29.


Mechanosensing drives acuity of αβ T-cell recognition.

Feng Y, Brazin KN, Kobayashi E, Mallis RJ, Reinherz EL, Lang MJ.

Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8204-E8213. doi: 10.1073/pnas.1703559114. Epub 2017 Aug 15.


TANTIGEN: a comprehensive database of tumor T cell antigens.

Olsen LR, Tongchusak S, Lin H, Reinherz EL, Brusic V, Zhang GL.

Cancer Immunol Immunother. 2017 Jun;66(6):731-735. doi: 10.1007/s00262-017-1978-y. Epub 2017 Mar 9.


Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination.

Abbott RK, Thayer M, Labuda J, Silva M, Philbrook P, Cain DW, Kojima H, Hatfield S, Sethumadhavan S, Ohta A, Reinherz EL, Kelsoe G, Sitkovsky M.

J Immunol. 2016 Nov 15;197(10):4014-4020. Epub 2016 Oct 19.


Pre-T Cell Receptors (Pre-TCRs) Leverage Vβ Complementarity Determining Regions (CDRs) and Hydrophobic Patch in Mechanosensing Thymic Self-ligands.

Das DK, Mallis RJ, Duke-Cohan JS, Hussey RE, Tetteh PW, Hilton M, Wagner G, Lang MJ, Reinherz EL.

J Biol Chem. 2016 Dec 2;291(49):25292-25305. Epub 2016 Oct 5.


Generation of Long-Lived Bone Marrow Plasma Cells Secreting Antibodies Specific for the HIV-1 gp41 Membrane-Proximal External Region in the Absence of Polyreactivity.

Donius LR, Cheng Y, Choi J, Sun ZY, Hanson M, Zhang M, Gierahn TM, Marquez S, Uduman M, Kleinstein SH, Irvine D, Love JC, Reinherz EL, Kim M.

J Virol. 2016 Sep 12;90(19):8875-90. doi: 10.1128/JVI.01089-16. Print 2016 Oct 1.


A computational method for identification of vaccine targets from protein regions of conserved human leukocyte antigen binding.

Olsen LR, Simon C, Kudahl UJ, Bagger FO, Winther O, Reinherz EL, Zhang GL, Brusic V.

BMC Med Genomics. 2015;8 Suppl 4:S1. doi: 10.1186/1755-8794-8-S4-S1. Epub 2015 Dec 9.


FluKB: A Knowledge-Based System for Influenza Vaccine Target Discovery and Analysis of the Immunological Properties of Influenza Viruses.

Simon C, Kudahl UJ, Sun J, Olsen LR, Zhang GL, Reinherz EL, Brusic V.

J Immunol Res. 2015;2015:380975. doi: 10.1155/2015/380975. Epub 2015 Oct 4.


Structural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC Discrimination.

Brazin KN, Mallis RJ, Das DK, Feng Y, Hwang W, Wang JH, Wagner G, Lang MJ, Reinherz EL.

Front Immunol. 2015 Sep 3;6:441. doi: 10.3389/fimmu.2015.00441. eCollection 2015. Review.


Backbone resonance assignment of N15, N30 and D10 T cell receptor β subunits.

Mallis RJ, Reinherz EL, Wagner G, Arthanari H.

Biomol NMR Assign. 2016 Apr;10(1):35-9. doi: 10.1007/s12104-015-9632-0. Epub 2015 Aug 15.


Pre-TCR ligand binding impacts thymocyte development before αβTCR expression.

Mallis RJ, Bai K, Arthanari H, Hussey RE, Handley M, Li Z, Chingozha L, Duke-Cohan JS, Lu H, Wang JH, Zhu C, Wagner G, Reinherz EL.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8373-8. doi: 10.1073/pnas.1504971112. Epub 2015 Jun 8.


Reply to van de Sandt and Rimmelzwaan: Matching epitope display with functional avidity.

Keskin DB, Reinhold BR, Zhang GL, Ivanov AR, Karger BL, Reinherz EL.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):E2418. doi: 10.1073/pnas.1503931112. Epub 2015 Apr 6. No abstract available. Erratum in: Proc Natl Acad Sci U S A. 2015 May 26;112(21):E2845.


αβ TCR-mediated recognition: relevance to tumor-antigen discovery and cancer immunotherapy.

Reinherz EL.

Cancer Immunol Res. 2015 Apr;3(4):305-12. doi: 10.1158/2326-6066.CIR-15-0042. Review.


Codification of bidentate pMHC interaction with TCR and its co-receptor.

Reinherz EL, Wang JH.

Trends Immunol. 2015 May;36(5):300-6. doi: 10.1016/ Epub 2015 Mar 26. Review.


Physical detection of influenza A epitopes identifies a stealth subset on human lung epithelium evading natural CD8 immunity.

Keskin DB, Reinhold BB, Zhang GL, Ivanov AR, Karger BL, Reinherz EL.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2151-6. doi: 10.1073/pnas.1423482112. Epub 2015 Feb 2.


Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime.

Das DK, Feng Y, Mallis RJ, Li X, Keskin DB, Hussey RE, Brady SK, Wang JH, Wagner G, Reinherz EL, Lang MJ.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1517-22. doi: 10.1073/pnas.1424829112. Epub 2015 Jan 20.


Liposomal vaccines incorporating molecular adjuvants and intrastructural T-cell help promote the immunogenicity of HIV membrane-proximal external region peptides.

Hanson MC, Abraham W, Crespo MP, Chen SH, Liu H, Szeto GL, Kim M, Reinherz EL, Irvine DJ.

Vaccine. 2015 Feb 11;33(7):861-8. doi: 10.1016/j.vaccine.2014.12.045. Epub 2015 Jan 2.


Human leukocyte antigen typing using a knowledge base coupled with a high-throughput oligonucleotide probe array analysis.

Zhang GL, Keskin DB, Lin HN, Lin HH, DeLuca DS, Leppanen S, Milford EL, Reinherz EL, Brusic V.

Front Immunol. 2014 Nov 27;5:597. doi: 10.3389/fimmu.2014.00597. eCollection 2014.


Revisiting the Discovery of the αβ TCR Complex and Its Co-Receptors.

Reinherz EL.

Front Immunol. 2014 Nov 21;5:583. doi: 10.3389/fimmu.2014.00583. eCollection 2014. Review. No abstract available.


Forward Vaccinology: CTL Targeting Based upon Physical Detection of HLA-Bound Peptides.

Reinherz EL, Keskin DB, Reinhold B.

Front Immunol. 2014 Sep 4;5:418. doi: 10.3389/fimmu.2014.00418. eCollection 2014. Review.


Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments.

Brazin KN, Mallis RJ, Li C, Keskin DB, Arthanari H, Gao Y, Wu SL, Karger BL, Wagner G, Reinherz EL.

J Biol Chem. 2014 Jul 4;289(27):18880-92. doi: 10.1074/jbc.M114.574996. Epub 2014 May 21. Erratum in: J Biol Chem. 2015 Jan 2;290(1):239.


Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells.

Yi T, Zhai B, Yu Y, Kiyotsugu Y, Raschle T, Etzkorn M, Seo HC, Nagiec M, Luna RE, Reinherz EL, Blenis J, Gygi SP, Wagner G.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):E2182-90. doi: 10.1073/pnas.1404943111. Epub 2014 Apr 29. Erratum in: Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11223.


HPVdb: a data mining system for knowledge discovery in human papillomavirus with applications in T cell immunology and vaccinology.

Zhang GL, Riemer AB, Keskin DB, Chitkushev L, Reinherz EL, Brusic V.

Database (Oxford). 2014 Apr 4;2014:bau031. doi: 10.1093/database/bau031. Print 2014.


Large-scale analysis of B-cell epitopes on influenza virus hemagglutinin - implications for cross-reactivity of neutralizing antibodies.

Sun J, Kudahl UJ, Simon C, Cao Z, Reinherz EL, Brusic V.

Front Immunol. 2014 Feb 7;5:38. doi: 10.3389/fimmu.2014.00038. eCollection 2014.


Dynamic control of β1 integrin adhesion by the plexinD1-sema3E axis.

Choi YI, Duke-Cohan JS, Chen W, Liu B, Rossy J, Tabarin T, Ju L, Gui J, Gaus K, Zhu C, Reinherz EL.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):379-84. doi: 10.1073/pnas.1314209111. Epub 2013 Dec 16.


Plxnd1 expression in thymocytes regulates their intrathymic migration while that in thymic endothelium impacts medullary topology.

Choi YI, Duke-Cohan JS, Tan J, Gui J, Singh MK, Epstein JA, Reinherz EL.

Front Immunol. 2013 Nov 19;4:392. doi: 10.3389/fimmu.2013.00392. eCollection 2013.


Disruption of helix-capping residues 671 and 674 reveals a role in HIV-1 entry for a specialized hinge segment of the membrane proximal external region of gp41.

Sun ZY, Cheng Y, Kim M, Song L, Choi J, Kudahl UJ, Brusic V, Chowdhury B, Yu L, Seaman MS, Bellot G, Shih WM, Wagner G, Reinherz EL.

J Mol Biol. 2014 Mar 6;426(5):1095-108. doi: 10.1016/j.jmb.2013.09.030. Epub 2013 Sep 26.


Immunogenicity of membrane-bound HIV-1 gp41 membrane-proximal external region (MPER) segments is dominated by residue accessibility and modulated by stereochemistry.

Kim M, Song L, Moon J, Sun ZY, Bershteyn A, Hanson M, Cain D, Goka S, Kelsoe G, Wagner G, Irvine D, Reinherz EL.

J Biol Chem. 2013 Nov 1;288(44):31888-901. doi: 10.1074/jbc.M113.494609. Epub 2013 Sep 18.


Identification of human leucocyte antigen (HLA)-A*0201-restricted cytotoxic T lymphocyte epitopes derived from HLA-DOβ as a novel target for multiple myeloma.

Kang YJ, Zeng W, Song W, Reinhold B, Choi J, Brusic V, Yamashita T, Munshi A, Li C, Minvielle S, Anderson KC, Munshi N, Reinherz EL, Sasada T.

Br J Haematol. 2013 Nov;163(3):343-51. doi: 10.1111/bjh.12544. Epub 2013 Aug 30.


BlockLogo: visualization of peptide and sequence motif conservation.

Olsen LR, Kudahl UJ, Simon C, Sun J, Schönbach C, Reinherz EL, Zhang GL, Brusic V.

J Immunol Methods. 2013 Dec 31;400-401:37-44. doi: 10.1016/j.jim.2013.08.014. Epub 2013 Aug 31.


Anti-HIV IgA isotypes: differential virion capture and inhibition of transcytosis are linked to prevention of mucosal R5 SHIV transmission.

Watkins JD, Sholukh AM, Mukhtar MM, Siddappa NB, Lakhashe SK, Kim M, Reinherz EL, Gupta S, Forthal DN, Sattentau QJ, Villinger F, Corti D, Ruprecht RM; CAVD Project Group.

AIDS. 2013 Jun 1;27(9):F13-20. doi: 10.1097/QAD.0b013e328360eac6.


Pillars article: Monoclonal antibodies defining distinctive human T cell surface antigens. Science. 1979. 206: 347-349.

Kung PC, Goldstein G, Reinherz EL, Schlossman SF.

J Immunol. 2013 Jun 1;190(11):5351-3. No abstract available.


Pillars article: Separation of functional subsets of human T cells by a monoclonal antibody. Proc. Natl. Acad. Sci. 1979. 76: 4061-4065.

Reinherz EL, Kung PC, Goldstein G, Schlossman SF.

J Immunol. 2013 Jun 1;190(11):5346-50. No abstract available.


Revisiting the putative TCR Cα dimerization model through structural analysis.

Wang JH, Reinherz EL.

Front Immunol. 2013 Jan 30;4:16. doi: 10.3389/fimmu.2013.00016. eCollection 2013.


The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function.

Wang JH, Reinherz EL.

Immunol Rev. 2012 Nov;250(1):102-19. doi: 10.1111/j.1600-065X.2012.01161.x. Review.


Stochastic optical active rheology.

Lee H, Shin Y, Kim ST, Reinherz EL, Lang MJ.

Appl Phys Lett. 2012 Jul 16;101(3):31902. Epub 2012 Jul 17.


Ultra-high resolution HLA genotyping and allele discovery by highly multiplexed cDNA amplicon pyrosequencing.

Lank SM, Golbach BA, Creager HM, Wiseman RW, Keskin DB, Reinherz EL, Brusic V, O'Connor DH.

BMC Genomics. 2012 Aug 6;13:378. doi: 10.1186/1471-2164-13-378.


Pharmacology: A false sense of non-self.

Reinherz EL.

Nature. 2012 Jun 27;486(7404):479-81. doi: 10.1038/486479a. No abstract available.

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