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Fiber alignment drives changes in architectural and mechanical features in collagen matrices.

Taufalele PV, VanderBurgh JA, Muñoz A, Zanotelli MR, Reinhart-King CA.

PLoS One. 2019 May 15;14(5):e0216537. doi: 10.1371/journal.pone.0216537. eCollection 2019.


Clinical doses of radiation reduce collagen matrix stiffness.

Miller JP, Borde BH, Bordeleau F, Zanotelli MR, LaValley DJ, Parker DJ, Bonassar LJ, Pannullo SC, Reinhart-King CA.

APL Bioeng. 2018 Apr 3;2(3):031901. doi: 10.1063/1.5018327. eCollection 2018 Sep.


Matrix stiffness regulates microvesicle-induced fibroblast activation.

Schwager SC, Bordeleau F, Zhang J, Antonyak MA, Cerione RA, Reinhart-King CA.

Am J Physiol Cell Physiol. 2019 Jul 1;317(1):C82-C92. doi: 10.1152/ajpcell.00418.2018. Epub 2019 Apr 24.


Energetic regulation of coordinated leader-follower dynamics during collective invasion of breast cancer cells.

Zhang J, Goliwas KF, Wang W, Taufalele PV, Bordeleau F, Reinhart-King CA.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7867-7872. doi: 10.1073/pnas.1809964116. Epub 2019 Mar 28.


Substrate stiffness heterogeneities disrupt endothelial barrier integrity in a micropillar model of heterogeneous vascular stiffening.

VanderBurgh JA, Hotchkiss H, Potharazu A, Taufalele PV, Reinhart-King CA.

Integr Biol (Camb). 2018 Dec 19;10(12):734-746. doi: 10.1039/c8ib00124c.


Traction Force Microscopy for Noninvasive Imaging of Cell Forces.

Mulligan JA, Bordeleau F, Reinhart-King CA, Adie SG.

Adv Exp Med Biol. 2018;1092:319-349. doi: 10.1007/978-3-319-95294-9_15.


Mechanical Forces in Tumor Angiogenesis.

Zanotelli MR, Reinhart-King CA.

Adv Exp Med Biol. 2018;1092:91-112. doi: 10.1007/978-3-319-95294-9_6.


Matrix stiffness regulates vascular integrity through focal adhesion kinase activity.

Wang W, Lollis EM, Bordeleau F, Reinhart-King CA.

FASEB J. 2019 Jan;33(1):1199-1208. doi: 10.1096/fj.201800841R. Epub 2018 Aug 13.


Quantitative assessment of cell contractility using polarized light microscopy.

Wang W, Miller JP, Pannullo SC, Reinhart-King CA, Bordeleau F.

J Biophotonics. 2018 Nov;11(11):e201800008. doi: 10.1002/jbio.201800008. Epub 2018 Jul 11.


Endothelial cells on an aged subendothelial matrix display heterogeneous strain profiles in silico.

Kohn JC, Abdalrahman T, Sack KL, Reinhart-King CA, Franz T.

Biomech Model Mechanobiol. 2018 Oct;17(5):1405-1414. doi: 10.1007/s10237-018-1034-7. Epub 2018 May 25.


Determining mechanical features of modulated epithelial monolayers using subnuclear particle tracking.

Armiger TJ, Lampi MC, Reinhart-King CA, Dahl KN.

J Cell Sci. 2018 Jun 21;131(12). pii: jcs216010. doi: 10.1242/jcs.216010.


Beneficial Effects of Exercise on Subendothelial Matrix Stiffness are Short-Lived.

Kohn JC, Bordeleau F, Miller J, Watkins HC, Modi S, Ma J, Azar J, Putnam D, Reinhart-King CA.

J Biomech Eng. 2018 Jul 1;140(7). doi: 10.1115/1.4039579.


Eigenstrain as a mechanical set-point of cells.

Lin S, Lampi MC, Reinhart-King CA, Tsui G, Wang J, Nelson CA, Gu L.

Biomech Model Mechanobiol. 2018 Aug;17(4):951-959. doi: 10.1007/s10237-018-1004-0. Epub 2018 Feb 5.


Cell Migration in Microfabricated 3D Collagen Microtracks is Mediated through the Prometastatic Protein Girdin.

Rahman-Zaman A, Shan S, Reinhart-King CA.

Cell Mol Bioeng. 2018 Feb;11(1):1-10. doi: 10.1007/s12195-017-0511-x. Epub 2017 Oct 17.


The Role of Age-Related Intimal Remodeling and Stiffening in Atherosclerosis.

VanderBurgh JA, Reinhart-King CA.

Adv Pharmacol. 2018;81:365-391. doi: 10.1016/bs.apha.2017.08.008. Epub 2017 Oct 27.


Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials.

Lampi MC, Reinhart-King CA.

Sci Transl Med. 2018 Jan 3;10(422). pii: eaao0475. doi: 10.1126/scitranslmed.aao0475. Review.


High-Fat, High-Sugar Diet-Induced Subendothelial Matrix Stiffening is Mitigated by Exercise.

Kohn JC, Azar J, Seta F, Reinhart-King CA.

Cardiovasc Eng Technol. 2018 Mar;9(1):84-93. doi: 10.1007/s13239-017-0335-9. Epub 2017 Nov 20.


Regulation of ATP utilization during metastatic cell migration by collagen architecture.

Zanotelli MR, Goldblatt ZE, Miller JP, Bordeleau F, Li J, VanderBurgh JA, Lampi MC, King MR, Reinhart-King CA.

Mol Biol Cell. 2018 Jan 1;29(1):1-9. doi: 10.1091/mbc.E17-01-0041. Epub 2017 Nov 8.


Measurement of dynamic cell-induced 3D displacement fields in vitro for traction force optical coherence microscopy.

Mulligan JA, Bordeleau F, Reinhart-King CA, Adie SG.

Biomed Opt Express. 2017 Jan 27;8(2):1152-1171. doi: 10.1364/BOE.8.001152. eCollection 2017 Feb 1.


Three-dimensional collagen matrix induces a mechanosensitive invasive epithelial phenotype.

Carey SP, Martin KE, Reinhart-King CA.

Sci Rep. 2017 Feb 10;7:42088. doi: 10.1038/srep42088.


Matrix Stiffness Enhances VEGFR-2 Internalization, Signaling, and Proliferation in Endothelial Cells.

LaValley DJ, Zanotelli MR, Bordeleau F, Wang W, Schwager SC, Reinhart-King CA.

Converg Sci Phys Oncol. 2017;3. pii: 044001. doi: 10.1088/2057-1739/aa9263. Epub 2017 Nov 29.


Matrix stiffening promotes a tumor vasculature phenotype.

Bordeleau F, Mason BN, Lollis EM, Mazzola M, Zanotelli MR, Somasegar S, Califano JP, Montague C, LaValley DJ, Huynh J, Mencia-Trinchant N, Negrón Abril YL, Hassane DC, Bonassar LJ, Butcher JT, Weiss RS, Reinhart-King CA.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):492-497. doi: 10.1073/pnas.1613855114. Epub 2016 Dec 29.


The Mechanics of Single Cell and Collective Migration of Tumor Cells.

Lintz M, Muñoz A, Reinhart-King CA.

J Biomech Eng. 2017 Feb 1;139(2). doi: 10.1115/1.4035121. Review.


Tuning cell migration: contractility as an integrator of intracellular signals from multiple cues.

Bordeleau F, Reinhart-King CA.

F1000Res. 2016 Jul 26;5. pii: F1000 Faculty Rev-1819. doi: 10.12688/f1000research.7884.1. eCollection 2016. Review.


Local extracellular matrix alignment directs cellular protrusion dynamics and migration through Rac1 and FAK.

Carey SP, Goldblatt ZE, Martin KE, Romero B, Williams RM, Reinhart-King CA.

Integr Biol (Camb). 2016 Aug 8;8(8):821-35. doi: 10.1039/c6ib00030d. Epub 2016 Jul 7.


Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation.

Desrochers LM, Bordeleau F, Reinhart-King CA, Cerione RA, Antonyak MA.

Nat Commun. 2016 Jun 15;7:11958. doi: 10.1038/ncomms11958.


Improving fascin inhibitors to block tumor cell migration and metastasis.

Han S, Huang J, Liu B, Xing B, Bordeleau F, Reinhart-King CA, Li W, Zhang JJ, Huang XY.

Mol Oncol. 2016 Aug;10(7):966-80. doi: 10.1016/j.molonc.2016.03.006. Epub 2016 Apr 1.


Mechanical heterogeneities in the subendothelial matrix develop with age and decrease with exercise.

Kohn JC, Chen A, Cheng S, Kowal DR, King MR, Reinhart-King CA.

J Biomech. 2016 Jun 14;49(9):1447-1453. doi: 10.1016/j.jbiomech.2016.03.016. Epub 2016 Mar 16.


Vinculin Regulates Directionality and Cell Polarity in 2D, 3D Matrix and 3D Microtrack Migration.

Rahman A, Carey SP, Kraning-Rush CM, Goldblatt ZE, Bordeleau F, Lampi MC, Lin DY, García AJ, Reinhart-King CA.

Mol Biol Cell. 2016 Mar 9. pii: mbc.E15-06-0432. [Epub ahead of print]


Simvastatin Ameliorates Matrix Stiffness-Mediated Endothelial Monolayer Disruption.

Lampi MC, Faber CJ, Huynh J, Bordeleau F, Zanotelli MR, Reinhart-King CA.

PLoS One. 2016 Jan 13;11(1):e0147033. doi: 10.1371/journal.pone.0147033. eCollection 2016.


Manipulation of in vitro collagen matrix architecture for scaffolds of improved physiological relevance.

Hapach LA, VanderBurgh JA, Miller JP, Reinhart-King CA.

Phys Biol. 2015 Dec 21;12(6):061002. doi: 10.1088/1478-3975/12/6/061002. Review.


Self-Assembled Cationic Biodegradable Nanoparticles from pH-Responsive Amino-Acid-Based Poly(Ester Urea Urethane)s and Their Application As a Drug Delivery Vehicle.

He M, Potuck A, Kohn JC, Fung K, Reinhart-King CA, Chu CC.

Biomacromolecules. 2016 Feb 8;17(2):523-37. doi: 10.1021/acs.biomac.5b01449. Epub 2016 Jan 12.


Microvesicles released from tumor cells disrupt epithelial cell morphology and contractility.

Bordeleau F, Chan B, Antonyak MA, Lampi MC, Cerione RA, Reinhart-King CA.

J Biomech. 2016 May 24;49(8):1272-1279. doi: 10.1016/j.jbiomech.2015.10.003. Epub 2015 Oct 9.


The 2015 Young Innovators of Cellular and Molecular Bioengineering.

Reinhart-King CA, Schmidt CE, Peppas NA.

Cell Mol Bioeng. 2015 Sep;8(3):305-306. No abstract available.


Tissue stiffness regulates serine/arginine-rich protein-mediated splicing of the extra domain B-fibronectin isoform in tumors.

Bordeleau F, Califano JP, Negrón Abril YL, Mason BN, LaValley DJ, Shin SJ, Weiss RS, Reinhart-King CA.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8314-9. doi: 10.1073/pnas.1505421112. Epub 2015 Jun 23.


Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization.

Huang FK, Han S, Xing B, Huang J, Liu B, Bordeleau F, Reinhart-King CA, Zhang JJ, Huang XY.

Nat Commun. 2015 Jun 17;6:7465. doi: 10.1038/ncomms8465.


Age-related vascular stiffening: causes and consequences.

Kohn JC, Lampi MC, Reinhart-King CA.

Front Genet. 2015 Mar 30;6:112. doi: 10.3389/fgene.2015.00112. eCollection 2015. Review.


Probing the biophysical properties of primary breast tumor-derived fibroblasts.

Alcoser TA, Bordeleau F, Carey SP, Lampi MC, Kowal DR, Somasegar S, Varma S, Shin SJ, Reinhart-King CA.

Cell Mol Bioeng. 2015 Mar;8(1):76-85.


Biophysical induction of vascular smooth muscle cell podosomes.

Kim NY, Kohn JC, Huynh J, Carey SP, Mason BN, Vouyouka AG, Reinhart-King CA.

PLoS One. 2015 Mar 18;10(3):e0119008. doi: 10.1371/journal.pone.0119008. eCollection 2015.


Cooperative effects of matrix stiffness and fluid shear stress on endothelial cell behavior.

Kohn JC, Zhou DW, Bordeleau F, Zhou AL, Mason BN, Mitchell MJ, King MR, Reinhart-King CA.

Biophys J. 2015 Feb 3;108(3):471-8. doi: 10.1016/j.bpj.2014.12.023.


Comparative mechanisms of cancer cell migration through 3D matrix and physiological microtracks.

Carey SP, Rahman A, Kraning-Rush CM, Romero B, Somasegar S, Torre OM, Williams RM, Reinhart-King CA.

Am J Physiol Cell Physiol. 2015 Mar 15;308(6):C436-47. doi: 10.1152/ajpcell.00225.2014. Epub 2014 Dec 10.


The Young Innovators of Cellular and Molecular Bioengineering.

Reinhart-King CA, Mooney DJ, Schaffer DV.

Cell Mol Bioeng. 2014 Sep 1;7(3):291-292. No abstract available.


Mechanical cell-matrix feedback explains pairwise and collective endothelial cell behavior in vitro.

van Oers RF, Rens EG, LaValley DJ, Reinhart-King CA, Merks RM.

PLoS Comput Biol. 2014 Aug 14;10(8):e1003774. doi: 10.1371/journal.pcbi.1003774. eCollection 2014 Aug.


A microfluidic device to select for cells based on chemotactic phenotype.

Bajpai S, Mitchell MJ, King MR, Reinhart-King CA.

Technology (Singap World Sci). 2014 Jun;2(2):101-105.


Substrate Stiffness Regulates PDGF-Induced Circular Dorsal Ruffle Formation Through MLCK.

Huynh J, Bordeleau F, Kraning-Rush CM, Reinhart-King CA.

Cell Mol Bioeng. 2013 Jun;6(2). doi: 10.1007/s12195-013-0278-7.


Topographical guidance of 3D tumor cell migration at an interface of collagen densities.

Bordeleau F, Tang LN, Reinhart-King CA.

Phys Biol. 2013 Dec;10(6):065004. doi: 10.1088/1478-3975/10/6/065004. Epub 2013 Dec 4.


Physical biology in cancer. 5. The rocky road of metastasis: the role of cytoskeletal mechanics in cell migratory response to 3D matrix topography.

Bordeleau F, Alcoser TA, Reinhart-King CA.

Am J Physiol Cell Physiol. 2014 Jan 15;306(2):C110-20. doi: 10.1152/ajpcell.00283.2013. Epub 2013 Nov 6. Review.


Arterial stiffening precedes systolic hypertension in diet-induced obesity.

Weisbrod RM, Shiang T, Al Sayah L, Fry JL, Bajpai S, Reinhart-King CA, Lob HE, Santhanam L, Mitchell G, Cohen RA, Seta F.

Hypertension. 2013 Dec;62(6):1105-10. doi: 10.1161/HYPERTENSIONAHA.113.01744. Epub 2013 Sep 23.


Controlling the mechanical properties of three-dimensional matrices via non-enzymatic collagen glycation.

Mason BN, Reinhart-King CA.

Organogenesis. 2013 Apr-Jun;9(2):70-5. doi: 10.4161/org.24942. Epub 2013 Apr 1.


A physical sciences network characterization of non-tumorigenic and metastatic cells.

Physical Sciences - Oncology Centers Network, Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH.

Sci Rep. 2013;3:1449. doi: 10.1038/srep01449.

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