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Items: 1 to 50 of 130

1.

Aurora A selective inhibitor LY3295668 leads to dominant mitotic arrest, apoptosis in cancer cells and shows potent preclinical antitumor efficacy.

Du J, Yan L, Torres R, Gong X, Bian H, Marugán C, Boehnke K, Baquero C, Hui YH, Chapman SC, Yang Y, Zeng Y, Bogner SM, Foreman RT, Capen A, Donoho GP, Van Horn RD, Barnard DS, Dempsey JA, Beckmann RP, Marshall MS, Chio LC, Qian Y, Webster YW, Aggarwal A, Chu S, Bhattachar S, Stancato LF, Dowless MS, Iversen PW, Manro JR, Walgren JL, Halstead BW, Dieter MZ, Martinez R, Bhagwat SV, Kreklau EL, Lallena MJ, Ye XS, Patel BKR, Reinhard C, Plowman GD, Barda DA, Henry JR, Buchanan SG, Campbell RM.

Mol Cancer Ther. 2019 Sep 17. pii: molcanther.0529.2018. doi: 10.1158/1535-7163.MCT-18-0529. [Epub ahead of print]

PMID:
31530649
2.

A paleosol record of the evolution of Cr redox cycling and evidence for an increase in atmospheric oxygen during the Neoproterozoic.

Colwyn DA, Sheldon ND, Maynard JB, Gaines R, Hofmann A, Wang X, Gueguen B, Asael D, Reinhard CT, Planavsky NJ.

Geobiology. 2019 Aug 22. doi: 10.1111/gbi.12360. [Epub ahead of print]

PMID:
31436043
3.

Anoxygenic photosynthesis and the delayed oxygenation of Earth's atmosphere.

Ozaki K, Thompson KJ, Simister RL, Crowe SA, Reinhard CT.

Nat Commun. 2019 Jul 9;10(1):3026. doi: 10.1038/s41467-019-10872-z.

4.

Longitudinal changes in cocaine intake and cognition are linked to cortical thickness adaptations in cocaine users.

Hirsiger S, Hänggi J, Germann J, Vonmoos M, Preller KH, Engeli EJE, Kirschner M, Reinhard C, Hulka LM, Baumgartner MR, Chakravarty MM, Seifritz E, Herdener M, Quednow BB.

Neuroimage Clin. 2019;21:101652. doi: 10.1016/j.nicl.2019.101652. Epub 2019 Jan 4.

5.

IBDoc Canadian User Performance Evaluation.

Moore AC, Huang VW, Bourdages R, Fedorak RN, Reinhard C, Leung Y, Bressler B, Rosenfeld G.

Inflamm Bowel Dis. 2019 May 4;25(6):1107-1114. doi: 10.1093/ibd/izy357.

PMID:
30535387
6.

Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene.

Gong X, Du J, Parsons SH, Merzoug FF, Webster Y, Iversen PW, Chio LC, Van Horn RD, Lin X, Blosser W, Han B, Jin S, Yao S, Bian H, Ficklin C, Fan L, Kapoor A, Antonysamy S, Mc Nulty AM, Froning K, Manglicmot D, Pustilnik A, Weichert K, Wasserman SR, Dowless M, Marugán C, Baquero C, Lallena MJ, Eastman SW, Hui YH, Dieter MZ, Doman T, Chu S, Qian HR, Ye XS, Barda DA, Plowman GD, Reinhard C, Campbell RM, Henry JR, Buchanan SG.

Cancer Discov. 2019 Feb;9(2):248-263. doi: 10.1158/2159-8290.CD-18-0469. Epub 2018 Oct 29.

PMID:
30373917
7.

A sluggish mid-Proterozoic biosphere and its effect on Earth's redox balance.

Ozaki K, Reinhard CT, Tajika E.

Geobiology. 2019 Jan;17(1):3-11. doi: 10.1111/gbi.12317. Epub 2018 Oct 3.

8.

Nitrous oxide from chemodenitrification: A possible missing link in the Proterozoic greenhouse and the evolution of aerobic respiration.

Stanton CL, Reinhard CT, Kasting JF, Ostrom NE, Haslun JA, Lyons TW, Glass JB.

Geobiology. 2018 Nov;16(6):597-609. doi: 10.1111/gbi.12311. Epub 2018 Aug 22.

PMID:
30133143
9.

Influence of eukaryotic translation initiation factor 6 on non-small cell lung cancer development and progression.

Gantenbein N, Bernhart E, Anders I, Golob-Schwarzl N, Krassnig S, Wodlej C, Brcic L, Lindenmann J, Fink-Neuboeck N, Gollowitsch F, Stacher-Priehse E, Asslaber M, Gogg-Kamerer M, Rolff J, Hoffmann J, Silvestri A, Regenbrecht C, Reinhard C, Pehserl AM, Pichler M, Sokolova O, Naumann M, Mitterer V, Pertschy B, Bergler H, Popper H, Sattler W, Haybaeck J.

Eur J Cancer. 2018 Sep;101:165-180. doi: 10.1016/j.ejca.2018.07.001. Epub 2018 Aug 1.

10.

Constraints on Paleoproterozoic atmospheric oxygen levels.

Bellefroid EJ, Hood AVS, Hoffman PF, Thomas MD, Reinhard CT, Planavsky NJ.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):8104-8109. doi: 10.1073/pnas.1806216115. Epub 2018 Jul 23.

11.

Exoplanet Biosignatures: Future Directions.

Walker SI, Bains W, Cronin L, DasSarma S, Danielache S, Domagal-Goldman S, Kacar B, Kiang NY, Lenardic A, Reinhard CT, Moore W, Schwieterman EW, Shkolnik EL, Smith HB.

Astrobiology. 2018 Jun;18(6):779-824. doi: 10.1089/ast.2017.1738. Review.

12.

Tracking the rise of eukaryotes to ecological dominance with zinc isotopes.

Isson TT, Love GD, Dupont CL, Reinhard CT, Zumberge AJ, Asael D, Gueguen B, McCrow J, Gill BC, Owens J, Rainbird RH, Rooney AD, Zhao MY, Stueeken EE, Konhauser KO, John SG, Lyons TW, Planavsky NJ.

Geobiology. 2018 Jul;16(4):341-352. doi: 10.1111/gbi.12289. Epub 2018 Jun 5.

PMID:
29869832
13.

Exoplanet Biosignatures: Understanding Oxygen as a Biosignature in the Context of Its Environment.

Meadows VS, Reinhard CT, Arney GN, Parenteau MN, Schwieterman EW, Domagal-Goldman SD, Lincowski AP, Stapelfeldt KR, Rauer H, DasSarma S, Hegde S, Narita N, Deitrick R, Lustig-Yaeger J, Lyons TW, Siegler N, Grenfell JL.

Astrobiology. 2018 Jun;18(6):630-662. doi: 10.1089/ast.2017.1727. Epub 2018 May 10. Review.

14.

Exoplanet Biosignatures: A Review of Remotely Detectable Signs of Life.

Schwieterman EW, Kiang NY, Parenteau MN, Harman CE, DasSarma S, Fisher TM, Arney GN, Hartnett HE, Reinhard CT, Olson SL, Meadows VS, Cockell CS, Walker SI, Grenfell JL, Hegde S, Rugheimer S, Hu R, Lyons TW.

Astrobiology. 2018 Jun;18(6):663-708. doi: 10.1089/ast.2017.1729. Epub 2018 May 4. Review.

15.

Separation of low and high grade colon and rectum carcinoma by eukaryotic translation initiation factors 1, 5 and 6.

Golob-Schwarzl N, Schweiger C, Koller C, Krassnig S, Gogg-Kamerer M, Gantenbein N, Toeglhofer AM, Wodlej C, Bergler H, Pertschy B, Uranitsch S, Holter M, El-Heliebi A, Fuchs J, Punschart A, Stiegler P, Keil M, Hoffmann J, Henderson D, Lehrach H, Reinhard C, Regenbrecht C, Schicho R, Fickert P, Lax S, Haybaeck J.

Oncotarget. 2017 Sep 5;8(60):101224-101243. doi: 10.18632/oncotarget.20642. eCollection 2017 Nov 24.

16.

Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib.

Gong X, Litchfield LM, Webster Y, Chio LC, Wong SS, Stewart TR, Dowless M, Dempsey J, Zeng Y, Torres R, Boehnke K, Mur C, Marugán C, Baquero C, Yu C, Bray SM, Wulur IH, Bi C, Chu S, Qian HR, Iversen PW, Merzoug FF, Ye XS, Reinhard C, De Dios A, Du J, Caldwell CW, Lallena MJ, Beckmann RP, Buchanan SG.

Cancer Cell. 2017 Dec 11;32(6):761-776.e6. doi: 10.1016/j.ccell.2017.11.006.

17.

Redox-independent chromium isotope fractionation induced by ligand-promoted dissolution.

Saad EM, Wang X, Planavsky NJ, Reinhard CT, Tang Y.

Nat Commun. 2017 Nov 17;8(1):1590. doi: 10.1038/s41467-017-01694-y.

18.

The effect of long-term bisphosphonate therapy on trabecular bone strength and microcrack density.

Jin A, Cobb J, Hansen U, Bhattacharya R, Reinhard C, Vo N, Atwood R, Li J, Karunaratne A, Wiles C, Abel R.

Bone Joint Res. 2017 Oct;6(10):602-609. doi: 10.1302/2046-3758.610.BJR-2016-0321.R1.

19.

Usability of a home-based test for the measurement of fecal calprotectin in asymptomatic IBD patients.

Bello C, Roseth A, Guardiola J, Reenaers C, Ruiz-Cerulla A, Van Kemseke C, Arajol C, Reinhard C, Seidel L, Louis E.

Dig Liver Dis. 2017 Sep;49(9):991-996. doi: 10.1016/j.dld.2017.05.009. Epub 2017 May 19.

20.

False Negatives for Remote Life Detection on Ocean-Bearing Planets: Lessons from the Early Earth.

Reinhard CT, Olson SL, Schwieterman EW, Lyons TW.

Astrobiology. 2017 Apr;17(4):287-297. doi: 10.1089/ast.2016.1598.

21.

A novel molten-salt electrochemical cell for investigating the reduction of uranium dioxide to uranium metal by lithium using in situ synchrotron radiation.

Brown LD, Abdulaziz R, Jervis R, Bharath V, Mason TJ, Atwood RC, Reinhard C, Connor LD, Inman D, Brett DJ, Shearing PR.

J Synchrotron Radiat. 2017 Mar 1;24(Pt 2):439-444. doi: 10.1107/S1600577517000625. Epub 2017 Feb 16.

22.

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.

Schütte M, Risch T, Abdavi-Azar N, Boehnke K, Schumacher D, Keil M, Yildiriman R, Jandrasits C, Borodina T, Amstislavskiy V, Worth CL, Schweiger C, Liebs S, Lange M, Warnatz HJ, Butcher LM, Barrett JE, Sultan M, Wierling C, Golob-Schwarzl N, Lax S, Uranitsch S, Becker M, Welte Y, Regan JL, Silvestrov M, Kehler I, Fusi A, Kessler T, Herwig R, Landegren U, Wienke D, Nilsson M, Velasco JA, Garin-Chesa P, Reinhard C, Beck S, Schäfer R, Regenbrecht CR, Henderson D, Lange B, Haybaeck J, Keilholz U, Hoffmann J, Lehrach H, Yaspo ML.

Nat Commun. 2017 Feb 10;8:14262. doi: 10.1038/ncomms14262.

23.

Evolution of the global phosphorus cycle.

Reinhard CT, Planavsky NJ, Gill BC, Ozaki K, Robbins LJ, Lyons TW, Fischer WW, Wang C, Cole DB, Konhauser KO.

Nature. 2017 Jan 19;541(7637):386-389. doi: 10.1038/nature20772. Epub 2016 Dec 21.

PMID:
28002400
24.

Simultaneous Differential Scanning Calorimetry-Synchrotron X-ray Powder Diffraction: A Powerful Technique for Physical Form Characterization in Pharmaceutical Materials.

Clout A, Buanz AB, Prior TJ, Reinhard C, Wu Y, O'Hare D, Williams GR, Gaisford S.

Anal Chem. 2016 Oct 18;88(20):10111-10117. Epub 2016 Sep 30.

PMID:
27642771
25.

Cyanobacterial Diazotrophy and Earth's Delayed Oxygenation.

Olson SL, Reinhard CT, Lyons TW.

Front Microbiol. 2016 Sep 23;7:1526. eCollection 2016.

26.

Limited role for methane in the mid-Proterozoic greenhouse.

Olson SL, Reinhard CT, Lyons TW.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11447-11452. Epub 2016 Sep 26.

27.

Lonza Error Prevention System (EPS) - Changing Human Performance in Pharmaceutical Operations.

Bodmann K, Reinhard C, Mödler M, Tinson K, Johnson M.

Chimia (Aarau). 2016;70(9):610-5. doi: 10.2533/chimia.2016.610.

PMID:
27646541
28.

Earth's oxygen cycle and the evolution of animal life.

Reinhard CT, Planavsky NJ, Olson SL, Lyons TW, Erwin DH.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):8933-8. doi: 10.1073/pnas.1521544113. Epub 2016 Jul 25.

29.

Recombination Rate Heterogeneity within Arabidopsis Disease Resistance Genes.

Choi K, Reinhard C, Serra H, Ziolkowski PA, Underwood CJ, Zhao X, Hardcastle TJ, Yelina NE, Griffin C, Jackson M, Mézard C, McVean G, Copenhaver GP, Henderson IR.

PLoS Genet. 2016 Jul 14;12(7):e1006179. doi: 10.1371/journal.pgen.1006179. eCollection 2016 Jul.

30.

Assay Establishment and Validation of a High-Throughput Screening Platform for Three-Dimensional Patient-Derived Colon Cancer Organoid Cultures.

Boehnke K, Iversen PW, Schumacher D, Lallena MJ, Haro R, Amat J, Haybaeck J, Liebs S, Lange M, Schäfer R, Regenbrecht CR, Reinhard C, Velasco JA.

J Biomol Screen. 2016 Oct;21(9):931-41. doi: 10.1177/1087057116650965. Epub 2016 May 27.

31.

Genomic alterations and molecular subtypes of gastric cancers in Asians.

Ye XS, Yu C, Aggarwal A, Reinhard C.

Chin J Cancer. 2016 May 9;35:42. doi: 10.1186/s40880-016-0106-2. Review.

32.

No evidence for high atmospheric oxygen levels 1,400 million years ago.

Planavsky NJ, Cole DB, Reinhard CT, Diamond C, Love GD, Luo G, Zhang S, Konhauser KO, Lyons TW.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2550-1. doi: 10.1073/pnas.1601925113. Epub 2016 Apr 20. No abstract available.

33.

Analysis of B Cell Repertoire Dynamics Following Hepatitis B Vaccination in Humans, and Enrichment of Vaccine-specific Antibody Sequences.

Galson JD, Trück J, Fowler A, Clutterbuck EA, Münz M, Cerundolo V, Reinhard C, van der Most R, Pollard AJ, Lunter G, Kelly DF.

EBioMedicine. 2015 Nov 24;2(12):2070-9. doi: 10.1016/j.ebiom.2015.11.034. eCollection 2015 Dec.

34.

Transient episodes of mild environmental oxygenation and oxidative continental weathering during the late Archean.

Kendall B, Creaser RA, Reinhard CT, Lyons TW, Anbar AD.

Sci Adv. 2015 Nov 20;1(10):e1500777. doi: 10.1126/sciadv.1500777. eCollection 2015 Nov.

35.

Phase-Contrast Micro-Computed Tomography Measurements of the Intraocular Pressure-Induced Deformation of the Porcine Lamina Cribrosa.

Coudrillier B, Geraldes DM, Vo NT, Atwood R, Reinhard C, Campbell IC, Raji Y, Albon J, Abel RL, Ethier CR.

IEEE Trans Med Imaging. 2016 Apr;35(4):988-99. doi: 10.1109/TMI.2015.2504440. Epub 2015 Nov 30.

36.

I12: the Joint Engineering, Environment and Processing (JEEP) beamline at Diamond Light Source.

Drakopoulos M, Connolley T, Reinhard C, Atwood R, Magdysyuk O, Vo N, Hart M, Connor L, Humphreys B, Howell G, Davies S, Hill T, Wilkin G, Pedersen U, Foster A, De Maio N, Basham M, Yuan F, Wanelik K.

J Synchrotron Radiat. 2015 May;22(3):828-38. doi: 10.1107/S1600577515003513. Epub 2015 Apr 8.

37.

Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes.

Cristescu R, Lee J, Nebozhyn M, Kim KM, Ting JC, Wong SS, Liu J, Yue YG, Wang J, Yu K, Ye XS, Do IG, Liu S, Gong L, Fu J, Jin JG, Choi MG, Sohn TS, Lee JH, Bae JM, Kim ST, Park SH, Sohn I, Jung SH, Tan P, Chen R, Hardwick J, Kang WK, Ayers M, Hongyue D, Reinhard C, Loboda A, Kim S, Aggarwal A.

Nat Med. 2015 May;21(5):449-56. doi: 10.1038/nm.3850. Epub 2015 Apr 20.

PMID:
25894828
38.

Mutational landscape of gastric adenocarcinoma in Chinese: implications for prognosis and therapy.

Chen K, Yang D, Li X, Sun B, Song F, Cao W, Brat DJ, Gao Z, Li H, Liang H, Zhao Y, Zheng H, Li M, Buckner J, Patterson SD, Ye X, Reinhard C, Bhathena A, Joshi D, Mischel PS, Croce CM, Wang YM, Raghavakaimal S, Li H, Lu X, Pan Y, Chang H, Ba S, Luo L, Cavenee WK, Zhang W, Hao X.

Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1107-12. doi: 10.1073/pnas.1422640112. Epub 2015 Jan 12.

39.

Flow cytometry protocols for surface and intracellular antigen analyses of neural cell types.

Menon V, Thomas R, Ghale AR, Reinhard C, Pruszak J.

J Vis Exp. 2014 Dec 18;(94). doi: 10.3791/52241.

40.

Genomic landscape and genetic heterogeneity in gastric adenocarcinoma revealed by whole-genome sequencing.

Wong SS, Kim KM, Ting JC, Yu K, Fu J, Liu S, Cristescu R, Nebozhyn M, Gong L, Yue YG, Wang J, Ronghua C, Loboda A, Hardwick J, Liu X, Dai H, Jin JG, Ye XS, Kang SY, Do IG, Park JO, Sohn TS, Reinhard C, Lee J, Kim S, Aggarwal A.

Nat Commun. 2014 Nov 19;5:5477. doi: 10.1038/ncomms6477.

PMID:
25407104
41.

Earth history. Low mid-Proterozoic atmospheric oxygen levels and the delayed rise of animals.

Planavsky NJ, Reinhard CT, Wang X, Thomson D, McGoldrick P, Rainbird RH, Johnson T, Fischer WW, Lyons TW.

Science. 2014 Oct 31;346(6209):635-8. doi: 10.1126/science.1258410.

42.

Reliable method for calculating the center of rotation in parallel-beam tomography.

Vo NT, Drakopoulos M, Atwood RC, Reinhard C.

Opt Express. 2014 Aug 11;22(16):19078-86. doi: 10.1364/OE.22.019078.

PMID:
25320994
43.

A multimerized form of recombinant human CD40 ligand supports long-term activation and proliferation of B cells.

Garcia-Marquez MA, Shimabukuro-Vornhagen A, Theurich S, Kochanek M, Weber T, Wennhold K, Dauben A, Dzionek A, Reinhard C, von Bergwelt-Baildon M.

Cytotherapy. 2014 Nov;16(11):1537-1544. doi: 10.1016/j.jcyt.2014.05.011.

PMID:
25287602
44.

Whole-genome sequencing of asian lung cancers: second-hand smoke unlikely to be responsible for higher incidence of lung cancer among Asian never-smokers.

Krishnan VG, Ebert PJ, Ting JC, Lim E, Wong SS, Teo AS, Yue YG, Chua HH, Ma X, Loh GS, Lin Y, Tan JH, Yu K, Zhang S, Reinhard C, Tan DS, Peters BA, Lincoln SE, Ballinger DG, Laramie JM, Nilsen GB, Barber TD, Tan P, Hillmer AM, Ng PC.

Cancer Res. 2014 Nov 1;74(21):6071-81. doi: 10.1158/0008-5472.CAN-13-3195. Epub 2014 Sep 4.

45.

A novel high-temperature furnace for combined in situ synchrotron X-ray diffraction and infrared thermal imaging to investigate the effects of thermal gradients upon the structure of ceramic materials.

Robinson JB, Brown LD, Jervis R, Taiwo OO, Millichamp J, Mason TJ, Neville TP, Eastwood DS, Reinhard C, Lee PD, Brett DJ, Shearing PR.

J Synchrotron Radiat. 2014 Sep;21(Pt 5):1134-9. doi: 10.1107/S1600577514014209. Epub 2014 Aug 15.

46.

Evolution: a fixed-nitrogen fix in the early ocean?

Lyons TW, Reinhard CT, Planavsky NJ.

Curr Biol. 2014 Mar 31;24(7):R276-8. doi: 10.1016/j.cub.2014.02.034.

47.

The rise of oxygen in Earth's early ocean and atmosphere.

Lyons TW, Reinhard CT, Planavsky NJ.

Nature. 2014 Feb 20;506(7488):307-15. doi: 10.1038/nature13068. Review.

PMID:
24553238
48.

Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration.

Reinhard C, Bottinelli D, Kim B, Luban J.

Retrovirology. 2014 Feb 1;11:12. doi: 10.1186/1742-4690-11-12.

49.

Ammonia-rich high-temperature superconducting intercalates of iron selenide revealed through time-resolved in situ X-ray and neutron diffraction.

Sedlmaier SJ, Cassidy SJ, Morris RG, Drakopoulos M, Reinhard C, Moorhouse SJ, O'Hare D, Manuel P, Khalyavin D, Clarke SJ.

J Am Chem Soc. 2014 Jan 15;136(2):630-3. doi: 10.1021/ja411624q. Epub 2014 Jan 2.

PMID:
24354523
50.

Culturally Tailored Depression/Suicide Prevention in Latino Youth: Community Perspectives.

Ford-Paz RE, Reinhard C, Kuebbeler A, Contreras R, Sánchez B.

J Behav Health Serv Res. 2015 Oct;42(4):519-33. doi: 10.1007/s11414-013-9368-5.

PMID:
24132548

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