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Non invasive PET imaging of CDK4/6 activation in Breast Cancer.

Ramos N, Baquero J, Gironda Z, Zaim-Wadghiri Y, Reiner T, Boada FE, Carlucci G.

J Nucl Med. 2019 Sep 3. pii: jnumed.119.232603. doi: 10.2967/jnumed.119.232603. [Epub ahead of print]


Synovial Cytokines Significantly Correlate with Osteoarthritis-Related Knee Pain and Disability: Inflammatory Mediators of Potential Clinical Relevance.

Nees TA, Rosshirt N, Zhang JA, Reiner T, Sorbi R, Tripel E, Walker T, Schiltenwolf M, Hagmann S, Moradi B.

J Clin Med. 2019 Aug 29;8(9). pii: E1343. doi: 10.3390/jcm8091343.


Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species.

Binderup T, Duivenvoorden R, Fay F, van Leent MMT, Malkus J, Baxter S, Ishino S, Zhao Y, Sanchez-Gaytan B, Teunissen AJP, Frederico YCA, Tang J, Carlucci G, Lyashchenko S, Calcagno C, Karakatsanis N, Soultanidis G, Senders ML, Robson PM, Mani V, Ramachandran S, Lobatto ME, Hutten BA, Granada JF, Reiner T, Swirski FK, Nahrendorf M, Kjaer A, Fisher EA, Fayad ZA, Pérez-Medina C, Mulder WJM.

Sci Transl Med. 2019 Aug 21;11(506). pii: eaaw7736. doi: 10.1126/scitranslmed.aaw7736.


A 89Zr-HDL PET tracer monitors response to a CSF1R inhibitor.

Mason C, Kossatz S, Carter L, Pirovano G, Brand C, Guru N, Pérez-Medina C, Lewis JS, Mulder W, Reiner T.

J Nucl Med. 2019 Aug 16. pii: jnumed.119.230466. doi: 10.2967/jnumed.119.230466. [Epub ahead of print]


Human Bone Marrow-Derived Mesenchymal Stromal Cell-Seeded Bone Biomaterial Directs Fast and Superior Mandibular Bone Augmentation in Rats.

Deluiz D, Delcroix GJ, D'Ippolito G, Grau-Monge C, Bonnin-Marquez A, Reiner T, Tinoco EMB, Amadeu T, Pires FR, Schiller PC.

Sci Rep. 2019 Aug 14;9(1):11806. doi: 10.1038/s41598-019-48236-8.


Positron-Emission Tomographic Imaging of a Fluorine 18-Radiolabeled Poly(ADP-Ribose) Polymerase 1 Inhibitor Monitors the Therapeutic Efficacy of Talazoparib in SCLC Patient-Derived Xenografts.

Laird J, Lok BH, Carney B, Kossatz S, de Stanchina E, Reiner T, Poirier JT, Rudin CM.

J Thorac Oncol. 2019 Jun 11. pii: S1556-0864(19)30453-8. doi: 10.1016/j.jtho.2019.05.032. [Epub ahead of print]


Acid specific dark quencher QC1 pHLIP for multi-spectral optoacoustic diagnoses of breast cancer.

Roberts S, Strome A, Choi C, Andreou C, Kossatz S, Brand C, Williams T, Bradbury M, Kircher MF, Reshetnyak YK, Grimm J, Lewis JS, Reiner T.

Sci Rep. 2019 Jun 12;9(1):8550. doi: 10.1038/s41598-019-44873-1.


Novel latonduine derived proligands and their copper(ii) complexes show cytotoxicity in the nanomolar range in human colon adenocarcinoma cells and in vitro cancer selectivity.

Bacher F, Wittmann C, Nové M, Spengler G, Marć MA, Enyedy EA, Darvasiová D, Rapta P, Reiner T, Arion VB.

Dalton Trans. 2019 Jul 16;48(28):10464-10478. doi: 10.1039/c9dt01238a.


Multimodal Positron Emission Tomography Imaging to Quantify Uptake of 89Zr-Labeled Liposomes in the Atherosclerotic Vessel Wall.

Lobatto ME, Binderup T, Robson PM, Giesen LFP, Calcagno C, Witjes J, Fay F, Baxter S, Wessel CH, Eldib M, Bini J, Carlin SD, Stroes ESG, Storm G, Kjaer A, Lewis JS, Reiner T, Fayad ZA, Mulder WJM, Pérez-Medina C.

Bioconjug Chem. 2019 Jun 7. doi: 10.1021/acs.bioconjchem.9b00256. [Epub ahead of print]


Blocking Glucagon Like Peptide-1 Receptors in the Exocrine Pancreas Improves Specificity for Beta Cells in a Mouse Model of Type 1 Diabetes.

Khera E, Zhang L, Roberts S, Nessler I, Sandoval D, Reiner T, Thurber G.

J Nucl Med. 2019 May 10. pii: jnumed.118.224881. doi: 10.2967/jnumed.118.224881. [Epub ahead of print]


Author Correction: Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates.

Lameijer M, Binderup T, van Leent MMT, Senders ML, Fay F, Malkus J, Sanchez-Gaytan BL, Teunissen AJP, Karakatsanis N, Robson P, Zhou X, Ye Y, Wojtkiewicz G, Tang J, Seijkens TTP, Kroon J, Stroes ESG, Kjaer A, Ochando J, Reiner T, Pérez-Medina C, Calcagno C, Fisher EA, Zhang B, Temel RE, Swirski FK, Nahrendorf M, Fayad ZA, Lutgens E, Mulder WJM, Duivenvoorden R.

Nat Biomed Eng. 2018 Aug;2(8):623. doi: 10.1038/s41551-018-0281-3.


Specific Targeting of Somatostatin Receptor Subtype-2 for Fluorescence-Guided Surgery.

Hernandez Vargas S, Kossatz S, Voss J, Ghosh SC, Tran Cao HS, Simien J, Reiner T, Dhingra S, Fisher WE, Azhdarinia A.

Clin Cancer Res. 2019 Jul 15;25(14):4332-4342. doi: 10.1158/1078-0432.CCR-18-3312. Epub 2019 Apr 23.


Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates.

Lameijer M, Binderup T, van Leent MMT, Senders ML, Fay F, Malkus J, Sanchez-Gaytan BL, Teunissen AJP, Karakatsanis N, Robson P, Zhou X, Ye Y, Wojtkiewicz G, Tang J, Seijkens TTP, Kroon J, Stroes ESG, Kjaer A, Ochando J, Reiner T, Pérez-Medina C, Calcagno C, Fisher EA, Zhang B, Temel RE, Swirski FK, Nahrendorf M, Fayad ZA, Lutgens E, Mulder WJM, Duivenvoorden R.

Nat Biomed Eng. 2018 May;2(5):279-292. doi: 10.1038/s41551-018-0221-2. Epub 2018 Apr 16. Erratum in: Nat Biomed Eng. 2018 Aug;2(8):623.


[Inflammation and osteoarthritis-related pain].

Nees TA, Rosshirt N, Reiner T, Schiltenwolf M, Moradi B.

Schmerz. 2019 Feb;33(1):4-12. doi: 10.1007/s00482-018-0346-y. Review. German.


In vivo blood metal ion levels in patients after total shoulder arthroplasty.

Reiner T, Bader N, Panzram B, Bülhoff M, Omlor G, Kretzer JP, Raiss P, Zeifang F.

J Shoulder Elbow Surg. 2019 Mar;28(3):539-546. doi: 10.1016/j.jse.2018.08.027. Epub 2018 Dec 3.


Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance.

Braza MS, van Leent MMT, Lameijer M, Sanchez-Gaytan BL, Arts RJW, Pérez-Medina C, Conde P, Garcia MR, Gonzalez-Perez M, Brahmachary M, Fay F, Kluza E, Kossatz S, Dress RJ, Salem F, Rialdi A, Reiner T, Boros P, Strijkers GJ, Calcagno CC, Ginhoux F, Marazzi I, Lutgens E, Nicolaes GAF, Weber C, Swirski FK, Nahrendorf M, Fisher EA, Duivenvoorden R, Fayad ZA, Netea MG, Mulder WJM, Ochando J.

Immunity. 2018 Nov 20;49(5):819-828.e6. doi: 10.1016/j.immuni.2018.09.008. Epub 2018 Nov 6.


[18F]FE-OTS964: a Small Molecule Targeting TOPK for In Vivo PET Imaging in a Glioblastoma Xenograft Model.

Pirovano G, Roberts S, Brand C, Donabedian PL, Mason C, de Souza PD, Higgins GS, Reiner T.

Mol Imaging Biol. 2019 Aug;21(4):705-712. doi: 10.1007/s11307-018-1288-6.


Nanoemulsion-Based Delivery of Fluorescent PARP Inhibitors in Mouse Models of Small Cell Lung Cancer.

Gonzales J, Kossatz S, Roberts S, Pirovano G, Brand C, Pérez-Medina C, Donabedian P, de la Cruz MJ, Mulder WJM, Reiner T.

Bioconjug Chem. 2018 Nov 21;29(11):3776-3782. doi: 10.1021/acs.bioconjchem.8b00640. Epub 2018 Nov 7.


Nanobody-Facilitated Multiparametric PET/MRI Phenotyping of Atherosclerosis.

Senders ML, Hernot S, Carlucci G, van de Voort JC, Fay F, Calcagno C, Tang J, Alaarg A, Zhao Y, Ishino S, Palmisano A, Boeykens G, Meerwaldt AE, Sanchez-Gaytan BL, Baxter S, Zendman L, Lobatto ME, Karakatsanis NA, Robson PM, Broisat A, Raes G, Lewis JS, Tsimikas S, Reiner T, Fayad ZA, Devoogdt N, Mulder WJM, Pérez-Medina C.

JACC Cardiovasc Imaging. 2018 Oct 12. pii: S1936-878X(18)30753-8. doi: 10.1016/j.jcmg.2018.07.027. [Epub ahead of print]


Inhibiting Multiple Deubiquitinases to Reduce Androgen Receptor Expression in Prostate Cancer Cells.

de Las Pozas A, Reiner T, De Cesare V, Trost M, Perez-Stable C.

Sci Rep. 2018 Sep 3;8(1):13146. doi: 10.1038/s41598-018-31567-3.


Leveraging PET to image folate receptor α therapy of an antibody-drug conjugate.

Brand C, Sadique A, Houghton JL, Gangangari K, Ponte JF, Lewis JS, Pillarsetty NVK, Konner JA, Reiner T.

EJNMMI Res. 2018 Aug 28;8(1):87. doi: 10.1186/s13550-018-0437-x.


Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer.

Roberts S, Andreou C, Choi C, Donabedian P, Jayaraman M, Pratt EC, Tang J, Pérez-Medina C, Jason de la Cruz M, Mulder WJM, Grimm J, Kircher M, Reiner T.

Chem Sci. 2018 May 18;9(25):5646-5657. doi: 10.1039/c8sc01706a. eCollection 2018 Jul 7.


Discriminating radiation injury from recurrent tumor with [18F]PARPi and amino acid PET in mouse models.

Donabedian PL, Kossatz S, Engelbach JA, Jannetti SA, Carney B, Young RJ, Weber WA, Garbow JR, Reiner T.

EJNMMI Res. 2018 Jul 4;8(1):59. doi: 10.1186/s13550-018-0399-z.


Antibody with Infinite Affinity for In Vivo Tracking of Genetically Engineered Lymphocytes.

Krebs S, Ahad A, Carter LM, Eyquem J, Brand C, Bell M, Ponomarev V, Reiner T, Meares CF, Gottschalk S, Sadelain M, Larson SM, Weber WA.

J Nucl Med. 2018 Dec;59(12):1894-1900. doi: 10.2967/jnumed.118.208041. Epub 2018 Jun 14.


The influence of the twin peg design on femoral Interface temperature and maximum load to failure in cemented Oxford unicompartmental knee arthroplasty.

Reiner T, Schwarze M, Panzram B, Klotz MC, Bitsch RG, Jaeger S.

Clin Biomech (Bristol, Avon). 2018 Jun;55:23-27. doi: 10.1016/j.clinbiomech.2018.04.003. Epub 2018 Apr 5.


Direct Imaging of Drug Distribution and Target Engagement of the PARP Inhibitor Rucaparib.

Kossatz S, Carney B, Farley C, Weber WA, Drain CM, Reiner T.

J Nucl Med. 2018 Aug;59(8):1316-1320. doi: 10.2967/jnumed.117.205765. Epub 2018 Mar 23.


PARP-1-Targeted Radiotherapy in Mouse Models of Glioblastoma.

Jannetti SA, Carlucci G, Carney B, Kossatz S, Shenker L, Carter LM, Salinas B, Brand C, Sadique A, Donabedian PL, Cunanan KM, Gönen M, Ponomarev V, Zeglis BM, Souweidane MM, Lewis JS, Weber WA, Humm JL, Reiner T.

J Nucl Med. 2018 Aug;59(8):1225-1233. doi: 10.2967/jnumed.117.205054. Epub 2018 Mar 23.


Reversible Electroporation-Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With 89Zr-Labeled Reporter Nanoparticles.

Srimathveeravalli G, Abdel-Atti D, Pérez-Medina C, Takaki H, Solomon SB, Mulder WJM, Reiner T.

Mol Imaging. 2018 Jan-Dec;17:1536012117749726. doi: 10.1177/1536012117749726.


Bioorthogonal Masking of Circulating Antibody-TCO Groups Using Tetrazine-Functionalized Dextran Polymers.

Meyer JP, Tully KM, Jackson J, Dilling TR, Reiner T, Lewis JS.

Bioconjug Chem. 2018 Feb 21;29(2):538-545. doi: 10.1021/acs.bioconjchem.8b00028. Epub 2018 Feb 9.


PET/MR Imaging of Malondialdehyde-Acetaldehyde Epitopes With a Human Antibody Detects Clinically Relevant Atherothrombosis.

Senders ML, Que X, Cho YS, Yeang C, Groenen H, Fay F, Calcagno C, Meerwaldt AE, Green S, Miu P, Lobatto ME, Reiner T, Fayad ZA, Witztum JL, Mulder WJM, Pérez-Medina C, Tsimikas S.

J Am Coll Cardiol. 2018 Jan 23;71(3):321-335. doi: 10.1016/j.jacc.2017.11.036.


Cementless unicompartmental knee replacement allows early return to normal activity.

Panzram B, Bertlich I, Reiner T, Walker T, Hagmann S, Gotterbarm T.

BMC Musculoskelet Disord. 2018 Jan 17;19(1):18. doi: 10.1186/s12891-017-1883-8.


Target engagement imaging of PARP inhibitors in small-cell lung cancer.

Carney B, Kossatz S, Lok BH, Schneeberger V, Gangangari KK, Pillarsetty NVK, Weber WA, Rudin CM, Poirier JT, Reiner T.

Nat Commun. 2018 Jan 12;9(1):176. doi: 10.1038/s41467-017-02096-w.


Specific Binding of Liposomal Nanoparticles through Inverse Electron-Demand Diels-Alder Click Chemistry.

Brand C, Iacono P, Pérez-Medina C, Mulder WJM, Kircher MF, Reiner T.

ChemistryOpen. 2017 Aug 7;6(5):615-619. doi: 10.1002/open.201700105. eCollection 2017 Oct.


Integrating nanomedicine and imaging.

Pérez-Medina C, Hak S, Reiner T, Fayad ZA, Nahrendorf M, Mulder WJM.

Philos Trans A Math Phys Eng Sci. 2017 Nov 28;375(2107). pii: 20170110. doi: 10.1098/rsta.2017.0110. Review.


MRI Findings in Patients After Small-Head Metal-on-Metal Total Hip Arthroplasty with a Minimum Follow-up of 10 Years.

Reiner T, Do TD, Klotz MC, Hertzsch F, Seelmann K, Gaida MM, Weber MA, Gotterbarm T.

J Bone Joint Surg Am. 2017 Sep 20;99(18):1540-1546. doi: 10.2106/JBJS.16.01021. Erratum in: J Bone Joint Surg Am. 2017 Nov 15;99(22):e124.


Detection and Delineation of Oral Cancer With a PARP1-Targeted Optical Imaging Agent.

Kossatz S, Weber W, Reiner T.

Mol Imaging. 2017 Jan-Dec;16:1536012117723786. doi: 10.1177/1536012117723786.


cis-Tetrachlorido-bis(indazole)osmium(iv) and its osmium(iii) analogues: paving the way towards the cis-isomer of the ruthenium anticancer drugs KP1019 and/or NKP1339.

Büchel GE, Kossatz S, Sadique A, Rapta P, Zalibera M, Bucinsky L, Komorovsky S, Telser J, Eppinger J, Reiner T, Arion VB.

Dalton Trans. 2017 Sep 12;46(35):11925-11941. doi: 10.1039/c7dt02194a.


Targeted PET imaging strategy to differentiate malignant from inflamed lymph nodes in diffuse large B-cell lymphoma.

Tang J, Salloum D, Carney B, Brand C, Kossatz S, Sadique A, Lewis JS, Weber WA, Wendel HG, Reiner T.

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7441-E7449. doi: 10.1073/pnas.1705013114. Epub 2017 Aug 21.


Synthesis of a Fluorescently Labeled 68Ga-DOTA-TOC Analog for Somatostatin Receptor Targeting.

Ghosh SC, Hernandez Vargas S, Rodriguez M, Kossatz S, Voss J, Carmon KS, Reiner T, Schonbrunn A, Azhdarinia A.

ACS Med Chem Lett. 2017 Jun 6;8(7):720-725. doi: 10.1021/acsmedchemlett.7b00125. eCollection 2017 Jul 13.


A systematic comparison of clinically viable nanomedicines targeting HMG-CoA reductase in inflammatory atherosclerosis.

Alaarg A, Senders ML, Varela-Moreira A, Pérez-Medina C, Zhao Y, Tang J, Fay F, Reiner T, Fayad ZA, Hennink WE, Metselaar JM, Mulder WJM, Storm G.

J Control Release. 2017 Sep 28;262:47-57. doi: 10.1016/j.jconrel.2017.07.013. Epub 2017 Jul 9.


Measurement of drug-target engagement in live cells by two-photon fluorescence anisotropy imaging.

Vinegoni C, Fumene Feruglio P, Brand C, Lee S, Nibbs AE, Stapleton S, Shah S, Gryczynski I, Reiner T, Mazitschek R, Weissleder R.

Nat Protoc. 2017 Jul;12(7):1472-1497. doi: 10.1038/nprot.2017.043. Epub 2017 Jun 29.


Molecular Imaging of PARP.

Carney B, Kossatz S, Reiner T.

J Nucl Med. 2017 Jul;58(7):1025-1030. doi: 10.2967/jnumed.117.189936. Epub 2017 May 4. Review.


Hyaluronan Nanoparticles Selectively Target Plaque-Associated Macrophages and Improve Plaque Stability in Atherosclerosis.

Beldman TJ, Senders ML, Alaarg A, Pérez-Medina C, Tang J, Zhao Y, Fay F, Deichmöller J, Born B, Desclos E, van der Wel NN, Hoebe RA, Kohen F, Kartvelishvily E, Neeman M, Reiner T, Calcagno C, Fayad ZA, de Winther MPJ, Lutgens E, Mulder WJM, Kluza E.

ACS Nano. 2017 Jun 27;11(6):5785-5799. doi: 10.1021/acsnano.7b01385. Epub 2017 May 15.


Cementless Oxford medial unicompartimental knee replacement: an independent series with a 5-year-follow-up.

Panzram B, Bertlich I, Reiner T, Walker T, Hagmann S, Gotterbarm T.

Arch Orthop Trauma Surg. 2017 Jul;137(7):1011-1017. doi: 10.1007/s00402-017-2696-9. Epub 2017 Apr 24.


Sonophore labeled RGD: a targeted contrast agent for optoacoustic imaging.

Haedicke K, Brand C, Omar M, Ntziachristos V, Reiner T, Grimm J.

Photoacoustics. 2017 Mar 21;6:1-8. doi: 10.1016/j.pacs.2017.03.001. eCollection 2017 Jun.


A Novel Technique for Generating and Observing Chemiluminescence in a Biological Setting.

Büchel GE, Carney B, Tang J, Zeglis BM, Eppinger J, Reiner T.

J Vis Exp. 2017 Mar 9;(121). doi: 10.3791/54694.


Investigating the Cellular Specificity in Tumors of a Surface-Converting Nanoparticle by Multimodal Imaging.

Fay F, Hansen L, Hectors SJCG, Sanchez-Gaytan BL, Zhao Y, Tang J, Munitz J, Alaarg A, Braza MS, Gianella A, Aaronson SA, Reiner T, Kjems J, Langer R, Hoeben FJM, Janssen HM, Calcagno C, Strijkers GJ, Fayad ZA, Pérez-Medina C, Mulder WJM.

Bioconjug Chem. 2017 May 17;28(5):1413-1421. doi: 10.1021/acs.bioconjchem.7b00086. Epub 2017 May 5.


A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines.

Tang J, Pérez-Medina C, Zhao Y, Sadique A, Mulder WJ, Reiner T.

J Vis Exp. 2017 Mar 4;(121). doi: 10.3791/55271.


Development of a New Folate-Derived Ga-68-Based PET Imaging Agent.

Brand C, Longo VA, Groaning M, Weber WA, Reiner T.

Mol Imaging Biol. 2017 Oct;19(5):754-761. doi: 10.1007/s11307-017-1049-y.


Evaluation of [18F]-ATRi as PET tracer for in vivo imaging of ATR in mouse models of brain cancer.

Carlucci G, Carney B, Sadique A, Vansteene A, Tang J, Reiner T.

Nucl Med Biol. 2017 May;48:9-15. doi: 10.1016/j.nucmedbio.2017.01.002. Epub 2017 Jan 16.

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