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Functional heterogeneity of human tissue-resident memory T cells based on dye efflux capacities.

Kumar BV, Kratchmarov R, Miron M, Carpenter DJ, Senda T, Lerner H, Friedman A, Reiner SL, Farber DL.

JCI Insight. 2018 Nov 15;3(22). pii: 123568. doi: 10.1172/jci.insight.123568.


Transient T-bet expression functionally specifies a distinct T follicular helper subset.

Fang D, Cui K, Mao K, Hu G, Li R, Zheng M, Riteau N, Reiner SL, Sher A, Zhao K, Zhu J.

J Exp Med. 2018 Nov 5;215(11):2705-2714. doi: 10.1084/jem.20180927. Epub 2018 Sep 19.


TCF1 expression marks self-renewing human CD8+ T cells.

Kratchmarov R, Magun AM, Reiner SL.

Blood Adv. 2018 Jul 24;2(14):1685-1690. doi: 10.1182/bloodadvances.2018016279.


Clonal Bifurcation of Foxp3 Expression Visualized in Thymocytes and T Cells.

Yen B, Fortson KT, Rothman NJ, Arpaia N, Reiner SL.

Immunohorizons. 2018 Apr 1;2(4):119-128. doi: 10.4049/immunohorizons.1700064. Epub 2018 Apr 9.


Metabolic control of cell fate bifurcations in a hematopoietic progenitor population.

Kratchmarov R, Viragova S, Kim MJ, Rothman NJ, Liu K, Reizis B, Reiner SL.

Immunol Cell Biol. 2018 Sep;96(8):863-871. doi: 10.1111/imcb.12040. Epub 2018 Apr 6.


Cutting Edge: Divergent Requirement of T-Box Transcription Factors in Effector and Memory NK Cells.

Madera S, Geary CD, Lau CM, Pikovskaya O, Reiner SL, Sun JC.

J Immunol. 2018 Mar 15;200(6):1977-1981. doi: 10.4049/jimmunol.1700416. Epub 2018 Feb 9.


Securing front-line T cell defense.

Reiner SL.

Immunol Cell Biol. 2018 Mar;96(3):241-242. doi: 10.1111/imcb.12013. Epub 2018 Feb 10. No abstract available.


Asymmetric PI3K Activity in Lymphocytes Organized by a PI3K-Mediated Polarity Pathway.

Chen YH, Kratchmarov R, Lin WW, Rothman NJ, Yen B, Adams WC, Nish SA, Rathmell JC, Reiner SL.

Cell Rep. 2018 Jan 23;22(4):860-868. doi: 10.1016/j.celrep.2017.12.087. Epub 2018 Jan 28.


An Immunotherapeutic CD137 Agonist Releases Eomesodermin from ThPOK Repression in CD4 T Cells.

Mittal P, Abblett R, Ryan JM, Hagymasi AT, Agyekum-Yamoah A, Svedova J, Reiner SL, St Rose MC, Hanley MP, Vella AT, Adler AJ.

J Immunol. 2018 Feb 15;200(4):1513-1526. doi: 10.4049/jimmunol.1701039. Epub 2018 Jan 5.


Correction: IRF4 Couples Anabolic Metabolism to Th1 Cell Fate Determination.

Kratchmarov R, Nish SA, Lin WW, Adams WC, Chen YH, Yen B, Rothman NJ, Klein U, Reiner SL.

Immunohorizons. 2018 Jan 2;2(1):12-13. doi: 10.4049/immunohorizons.1700072. No abstract available.


IRF4 Couples Anabolic Metabolism to Th1 Cell Fate Determination.

Kratchmarov R, Nish SA, Lin WW, Adams WC, Chen YH, Yen B, Rothman NJ, Klein U, Reiner SL.

Immunohorizons. 2017 Sep 1;1(7):156-161. doi: 10.4049/immunohorizons.1700012. Erratum in: Immunohorizons. 2018 Jan 2;2(1):12-13.


Lymphocyte Fate and Metabolism: A Clonal Balancing Act.

Nish SA, Lin WW, Reiner SL.

Trends Cell Biol. 2017 Dec;27(12):946-954. doi: 10.1016/j.tcb.2017.07.005. Epub 2017 Aug 14. Review.


Eomesodermin and T-bet mark developmentally distinct human natural killer cells.

Collins A, Rothman N, Liu K, Reiner SL.

JCI Insight. 2017 Mar 9;2(5):e90063. doi: 10.1172/jci.insight.90063.


Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal.

Adams WC, Chen YH, Kratchmarov R, Yen B, Nish SA, Lin WW, Rothman NJ, Luchsinger LL, Klein U, Busslinger M, Rathmell JC, Snoeck HW, Reiner SL.

Cell Rep. 2016 Dec 20;17(12):3142-3152. doi: 10.1016/j.celrep.2016.11.065.


CD4+ T cell effector commitment coupled to self-renewal by asymmetric cell divisions.

Nish SA, Zens KD, Kratchmarov R, Lin WW, Adams WC, Chen YH, Yen B, Rothman NJ, Bhandoola A, Xue HH, Farber DL, Reiner SL.

J Exp Med. 2017 Jan;214(1):39-47. doi: 10.1084/jem.20161046. Epub 2016 Dec 6.


CD8+ T Lymphocyte Self-Renewal during Effector Cell Determination.

Lin WW, Nish SA, Yen B, Chen YH, Adams WC, Kratchmarov R, Rothman NJ, Bhandoola A, Xue HH, Reiner SL.

Cell Rep. 2016 Nov 8;17(7):1773-1782. doi: 10.1016/j.celrep.2016.10.032.


Cutting Edge: B Cell-Intrinsic T-bet Expression Is Required To Control Chronic Viral Infection.

Barnett BE, Staupe RP, Odorizzi PM, Palko O, Tomov VT, Mahan AE, Gunn B, Chen D, Paley MA, Alter G, Reiner SL, Lauer GM, Teijaro JR, Wherry EJ.

J Immunol. 2016 Aug 15;197(4):1017-22. doi: 10.4049/jimmunol.1500368. Epub 2016 Jul 18.


Leukemia-associated activating mutation of Flt3 expands dendritic cells and alters T cell responses.

Lau CM, Nish SA, Yogev N, Waisman A, Reiner SL, Reizis B.

J Exp Med. 2016 Mar 7;213(3):415-31. doi: 10.1084/jem.20150642. Epub 2016 Feb 22.


Cutting Edge: Eomesodermin Is Sufficient To Direct Type 1 Innate Lymphocyte Development into the Conventional NK Lineage.

Pikovskaya O, Chaix J, Rothman NJ, Collins A, Chen YH, Scipioni AM, Vivier E, Reiner SL.

J Immunol. 2016 Feb 15;196(4):1449-54. doi: 10.4049/jimmunol.1502396. Epub 2016 Jan 20.


Asymmetric PI3K Signaling Driving Developmental and Regenerative Cell Fate Bifurcation.

Lin WH, Adams WC, Nish SA, Chen YH, Yen B, Rothman NJ, Kratchmarov R, Okada T, Klein U, Reiner SL.

Cell Rep. 2015 Dec 15;13(10):2203-18. doi: 10.1016/j.celrep.2015.10.072. Epub 2015 Nov 25.


T-bet transcendent: unmasking the faces of multifarious immunity.

Reiner SL.

J Immunol. 2015 Apr 1;194(7):2959-60. doi: 10.4049/jimmunol.1500289. No abstract available.


Diverse roles for T-bet in the effector responses required for resistance to infection.

Harms Pritchard G, Hall AO, Christian DA, Wagage S, Fang Q, Muallem G, John B, Glatman Zaretsky A, Dunn WG, Perrigoue J, Reiner SL, Hunter CA.

J Immunol. 2015 Feb 1;194(3):1131-40. doi: 10.4049/jimmunol.1401617. Epub 2015 Jan 2.


Lymphocyte fate specification as a deterministic but highly plastic process.

Reiner SL, Adams WC.

Nat Rev Immunol. 2014 Oct;14(10):699-704. doi: 10.1038/nri3734. Epub 2014 Sep 5. Review.


Cutting edge: CXCR4 is critical for CD8+ memory T cell homeostatic self-renewal but not rechallenge self-renewal.

Chaix J, Nish SA, Lin WH, Rothman NJ, Ding L, Wherry EJ, Reiner SL.

J Immunol. 2014 Aug 1;193(3):1013-6. doi: 10.4049/jimmunol.1400488. Epub 2014 Jun 27.


Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin.

Curran MA, Geiger TL, Montalvo W, Kim M, Reiner SL, Al-Shamkhani A, Sun JC, Allison JP.

J Exp Med. 2013 Apr 8;210(4):743-55. doi: 10.1084/jem.20121190. Epub 2013 Apr 1.


Tbr2 expression in Cajal-Retzius cells and intermediate neuronal progenitors is required for morphogenesis of the dentate gyrus.

Hodge RD, Garcia AJ 3rd, Elsen GE, Nelson BR, Mussar KE, Reiner SL, Ramirez JM, Hevner RF.

J Neurosci. 2013 Feb 27;33(9):4165-80. doi: 10.1523/JNEUROSCI.4185-12.2013.


The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map.

Elsen GE, Hodge RD, Bedogni F, Daza RA, Nelson BR, Shiba N, Reiner SL, Hevner RF.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4081-6. doi: 10.1073/pnas.1209076110. Epub 2013 Feb 19.


Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection.

Paley MA, Kroy DC, Odorizzi PM, Johnnidis JB, Dolfi DV, Barnett BE, Bikoff EK, Robertson EJ, Lauer GM, Reiner SL, Wherry EJ.

Science. 2012 Nov 30;338(6111):1220-5. doi: 10.1126/science.1229620.


Technical Advance: Fluorescent reporter reveals insights into eomesodermin biology in cytotoxic lymphocytes.

Paley MA, Gordon SM, Bikoff EK, Robertson EJ, Wherry EJ, Reiner SL.

J Leukoc Biol. 2013 Feb;93(2):307-15. doi: 10.1189/jlb.0812400. Epub 2012 Nov 27.


The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.

Hall AO, Beiting DP, Tato C, John B, Oldenhove G, Lombana CG, Pritchard GH, Silver JS, Bouladoux N, Stumhofer JS, Harris TH, Grainger J, Wojno ED, Wagage S, Roos DS, Scott P, Turka LA, Cherry S, Reiner SL, Cua D, Belkaid Y, Elloso MM, Hunter CA.

Immunity. 2012 Sep 21;37(3):511-23. doi: 10.1016/j.immuni.2012.06.014. Epub 2012 Sep 13.


Divergent transcriptional programming of class-specific B cell memory by T-bet and RORα.

Wang NS, McHeyzer-Williams LJ, Okitsu SL, Burris TP, Reiner SL, McHeyzer-Williams MG.

Nat Immunol. 2012 May 6;13(6):604-11. doi: 10.1038/ni.2294.


Tbr2 is essential for hippocampal lineage progression from neural stem cells to intermediate progenitors and neurons.

Hodge RD, Nelson BR, Kahoud RJ, Yang R, Mussar KE, Reiner SL, Hevner RF.

J Neurosci. 2012 May 2;32(18):6275-87. doi: 10.1523/JNEUROSCI.0532-12.2012.


Cutting edge: Asymmetric memory T cell division in response to rechallenge.

Ciocca ML, Barnett BE, Burkhardt JK, Chang JT, Reiner SL.

J Immunol. 2012 May 1;188(9):4145-8. doi: 10.4049/jimmunol.1200176. Epub 2012 Mar 30.


The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation.

Gordon SM, Chaix J, Rupp LJ, Wu J, Madera S, Sun JC, Lindsten T, Reiner SL.

Immunity. 2012 Jan 27;36(1):55-67. doi: 10.1016/j.immuni.2011.11.016. Epub 2012 Jan 18.


Asymmetric B cell division in the germinal center reaction.

Barnett BE, Ciocca ML, Goenka R, Barnett LG, Wu J, Laufer TM, Burkhardt JK, Cancro MP, Reiner SL.

Science. 2012 Jan 20;335(6066):342-4. doi: 10.1126/science.1213495. Epub 2011 Dec 15.


CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation.

Qui HZ, Hagymasi AT, Bandyopadhyay S, St Rose MC, Ramanarasimhaiah R, Ménoret A, Mittler RS, Gordon SM, Reiner SL, Vella AT, Adler AJ.

J Immunol. 2011 Oct 1;187(7):3555-64. doi: 10.4049/jimmunol.1101244. Epub 2011 Aug 31.


Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection.

Kao C, Oestreich KJ, Paley MA, Crawford A, Angelosanto JM, Ali MA, Intlekofer AM, Boss JM, Reiner SL, Weinmann AS, Wherry EJ.

Nat Immunol. 2011 May 29;12(7):663-71. doi: 10.1038/ni.2046.


Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division.

Chang JT, Ciocca ML, Kinjyo I, Palanivel VR, McClurkin CE, Dejong CS, Mooney EC, Kim JS, Steinel NC, Oliaro J, Yin CC, Florea BI, Overkleeft HS, Berg LJ, Russell SM, Koretzky GA, Jordan MS, Reiner SL.

Immunity. 2011 Apr 22;34(4):492-504. doi: 10.1016/j.immuni.2011.03.017. Epub 2011 Apr 14.


Requirements for eomesodermin and promyelocytic leukemia zinc finger in the development of innate-like CD8+ T cells.

Gordon SM, Carty SA, Kim JS, Zou T, Smith-Garvin J, Alonzo ES, Haimm E, Sant'Angelo DB, Koretzky GA, Reiner SL, Jordan MS.

J Immunol. 2011 Apr 15;186(8):4573-8. doi: 10.4049/jimmunol.1100037. Epub 2011 Mar 7.


Cutting edge: Lymphoproliferation caused by Fas deficiency is dependent on the transcription factor eomesodermin.

Kinjyo I, Gordon SM, Intlekofer AM, Dowdell K, Mooney EC, Caricchio R, Grupp SA, Teachey DT, Rao VK, Lindsten T, Reiner SL.

J Immunol. 2010 Dec 15;185(12):7151-5. doi: 10.4049/jimmunol.1003193. Epub 2010 Nov 12.


Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche.

Banerjee A, Gordon SM, Intlekofer AM, Paley MA, Mooney EC, Lindsten T, Wherry EJ, Reiner SL.

J Immunol. 2010 Nov 1;185(9):4988-92. doi: 10.4049/jimmunol.1002042. Epub 2010 Oct 8.


Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms.

Oliaro J, Van Ham V, Sacirbegovic F, Pasam A, Bomzon Z, Pham K, Ludford-Menting MJ, Waterhouse NJ, Bots M, Hawkins ED, Watt SV, Cluse LA, Clarke CJ, Izon DJ, Chang JT, Thompson N, Gu M, Johnstone RW, Smyth MJ, Humbert PO, Reiner SL, Russell SM.

J Immunol. 2010 Jul 1;185(1):367-75. doi: 10.4049/jimmunol.0903627. Epub 2010 Jun 7.


Micro-RNA-155 inhibits IFN-gamma signaling in CD4+ T cells.

Banerjee A, Schambach F, DeJong CS, Hammond SM, Reiner SL.

Eur J Immunol. 2010 Jan;40(1):225-31. doi: 10.1002/eji.200939381.


T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow.

Jenne CN, Enders A, Rivera R, Watson SR, Bankovich AJ, Pereira JP, Xu Y, Roots CM, Beilke JN, Banerjee A, Reiner SL, Miller SA, Weinmann AS, Goodnow CC, Lanier LL, Cyster JG, Chun J.

J Exp Med. 2009 Oct 26;206(11):2469-81. doi: 10.1084/jem.20090525. Epub 2009 Oct 6.


The precursors of memory: models and controversies.

Ahmed R, Bevan MJ, Reiner SL, Fearon DT.

Nat Rev Immunol. 2009 Sep;9(9):662-8. doi: 10.1038/nri2619. Epub 2009 Aug 14.


A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection.

Shin H, Blackburn SD, Intlekofer AM, Kao C, Angelosanto JM, Reiner SL, Wherry EJ.

Immunity. 2009 Aug 21;31(2):309-20. doi: 10.1016/j.immuni.2009.06.019. Epub 2009 Aug 6.


KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors.

Weinreich MA, Takada K, Skon C, Reiner SL, Jameson SC, Hogquist KA.

Immunity. 2009 Jul 17;31(1):122-30. doi: 10.1016/j.immuni.2009.05.011.


Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation.

Kambayashi T, Allenspach EJ, Chang JT, Zou T, Shoag JE, Reiner SL, Caton AJ, Koretzky GA.

J Immunol. 2009 Apr 15;182(8):4686-95. doi: 10.4049/jimmunol.0803180.


CD152 (CTLA-4) regulates effector functions of CD8+ T lymphocytes by repressing Eomesodermin.

Hegel JK, Knieke K, Kolar P, Reiner SL, Brunner-Weinzierl MC.

Eur J Immunol. 2009 Mar;39(3):883-93. doi: 10.1002/eji.200838770.


Decision making during the conception and career of CD4+ T cells.

Reiner SL.

Nat Rev Immunol. 2009 Feb;9(2):81-2. doi: 10.1038/nri2490.


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