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Items: 37

1.

Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.

Wagner FF, Weïwer M, Steinbacher S, Schomburg A, Reinemer P, Gale JP, Campbell AJ, Fisher SL, Zhao WN, Reis SA, Hennig KM, Thomas M, Müller P, Jefson MR, Fass DM, Haggarty SJ, Zhang YL, Holson EB.

Bioorg Med Chem. 2016 Sep 15;24(18):4008-4015. doi: 10.1016/j.bmc.2016.06.040. Epub 2016 Jun 22.

PMID:
27377864
2.

Unexpected active-site flexibility in the structure of human neutrophil elastase in complex with a new dihydropyrimidone inhibitor.

Hansen G, Gielen-Haertwig H, Reinemer P, Schomburg D, Harrenga A, Niefind K.

J Mol Biol. 2011 Jun 24;409(5):681-91. doi: 10.1016/j.jmb.2011.04.047. Epub 2011 Apr 27.

PMID:
21549129
3.

Macrocyclic statine-based inhibitors of BACE-1.

Barazza A, Götz M, Cadamuro SA, Goettig P, Willem M, Steuber H, Kohler T, Jestel A, Reinemer P, Renner C, Bode W, Moroder L.

Chembiochem. 2007 Nov 23;8(17):2078-91.

PMID:
17963207
4.

Development of a simple and robust assay to screen for inhibitors of sphingosine kinases.

Togame H, Dodo R, Inaoka T, Reinemer P.

Assay Drug Dev Technol. 2007 Apr;5(2):215-23.

PMID:
17477830
5.

Cinnabaramides A-G: analogues of lactacystin and salinosporamide from a terrestrial streptomycete.

Stadler M, Bitzer J, Mayer-Bartschmid A, Müller H, Benet-Buchholz J, Gantner F, Tichy HV, Reinemer P, Bacon KB.

J Nat Prod. 2007 Feb;70(2):246-52. Epub 2007 Jan 24.

PMID:
17249727
6.
7.

Crystal structure of full length topoisomerase I from Thermotoga maritima.

Hansen G, Harrenga A, Wieland B, Schomburg D, Reinemer P.

J Mol Biol. 2006 May 19;358(5):1328-40. Epub 2006 Mar 23.

PMID:
16600296
8.

Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): an oral, direct factor Xa inhibitor.

Roehrig S, Straub A, Pohlmann J, Lampe T, Pernerstorfer J, Schlemmer KH, Reinemer P, Perzborn E.

J Med Chem. 2005 Sep 22;48(19):5900-8.

PMID:
16161994
9.

A versatile high-throughput screen for inhibitors of lipid kinase activity: development of an immobilized phospholipid plate assay for phosphoinositide 3-kinase gamma.

Fuchikami K, Togame H, Sagara A, Satoh T, Gantner F, Bacon KB, Reinemer P.

J Biomol Screen. 2002 Oct;7(5):441-50.

PMID:
14599360
10.

Development of a simple homogeneous assay to screen for inhibitors of N-acetylglucosamine-6-sulfotransferases.

Togame H, Shimazaki M, Yamato A, Watanabe S, Saito K, Reinemer P.

Anal Biochem. 2003 Apr 1;315(1):67-76.

PMID:
12672413
11.

The Interleukin-4-Receptor: From Recognition Mechanism to Pharmacological Target Structure.

Reinemer P, Sebald W, Duschl A.

Angew Chem Int Ed Engl. 2000 Aug 18;39(16):2834-2846.

PMID:
11027984
12.
13.
14.

Cloning, sequencing, crystallization and X-ray structure of glutathione S-transferase-III from Zea mays var. mutin: a leading enzyme in detoxification of maize herbicides.

Neuefeind T, Huber R, Reinemer P, Knäblein J, Prade L, Mann K, Bieseler B.

J Mol Biol. 1997 Dec 12;274(4):577-87.

PMID:
9417936
15.

Plant glutathione S-transferases and herbicide detoxification.

Neuefeind T, Reinemer P, Bieseler B.

Biol Chem. 1997 Mar-Apr;378(3-4):199-205. Review.

PMID:
9165071
16.

Three-dimensional structure of glutathione S-transferase from Arabidopsis thaliana at 2.2 A resolution: structural characterization of herbicide-conjugating plant glutathione S-transferases and a novel active site architecture.

Reinemer P, Prade L, Hof P, Neuefeind T, Huber R, Zettl R, Palme K, Schell J, Koelln I, Bartunik HD, Bieseler B.

J Mol Biol. 1996 Jan 19;255(2):289-309.

PMID:
8551521
17.

The metzincin-superfamily of zinc-peptidases.

Bode W, Grams F, Reinemer P, Gomis-Rüth FX, Baumann U, McKay DB, Stöcker W.

Adv Exp Med Biol. 1996;389:1-11. Review. No abstract available.

PMID:
8860988
18.

Crystal structure of the catalytic subunit of human protein phosphatase 1 and its complex with tungstate.

Egloff MP, Cohen PT, Reinemer P, Barford D.

J Mol Biol. 1995 Dec 15;254(5):942-59.

PMID:
7500362
19.

Mutations that stabilize folding intermediates of phage P22 tailspike protein: folding in vivo and in vitro, stability, and structural context.

Beissinger M, Lee SC, Steinbacher S, Reinemer P, Huber R, Yu MH, Seckler R.

J Mol Biol. 1995 May 26;249(1):185-94.

PMID:
7776371
20.
21.

X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design.

Grams F, Reinemer P, Powers JC, Kleine T, Pieper M, Tschesche H, Huber R, Bode W.

Eur J Biochem. 1995 Mar 15;228(3):830-41.

22.

X-ray structure methods for glutathione binding.

Reinemer P, Dirr HW, Huber R.

Methods Enzymol. 1995;251:243-54. No abstract available.

PMID:
7651203
23.

Refined crystal structure of porcine class Pi glutathione S-transferase (pGST P1-1) at 2.1 A resolution.

Dirr H, Reinemer P, Huber R.

J Mol Biol. 1994 Oct 14;243(1):72-92.

PMID:
7932743
24.

Inhibition of matrix metalloproteinases in rheumatoid arthritis and the crystallographic binding mode of a peptide inhibitor.

Tschesche H, Bläser J, Kleine T, Schnierer S, Reinemer P, Bode W, Maasjoshusmann U, Fricke C.

Ann N Y Acad Sci. 1994 Sep 6;732:400-2. No abstract available.

PMID:
7978819
25.

Crystal structure of P22 tailspike protein: interdigitated subunits in a thermostable trimer.

Steinbacher S, Seckler R, Miller S, Steipe B, Huber R, Reinemer P.

Science. 1994 Jul 15;265(5170):383-6.

PMID:
8023158
28.

Structural implications for the role of the N terminus in the 'superactivation' of collagenases. A crystallographic study.

Reinemer P, Grams F, Huber R, Kleine T, Schnierer S, Piper M, Tschesche H, Bode W.

FEBS Lett. 1994 Jan 31;338(2):227-33.

29.

Electrostatic evidence for the activation of the glutathione thiol by Tyr7 in pi-class glutathione transferases.

Karshikoff A, Reinemer P, Huber R, Ladenstein R.

Eur J Biochem. 1993 Aug 1;215(3):663-70.

30.
31.

Unusual reactivity of Tyr-7 of GSH transferase P1-1.

Meyer DJ, Xia C, Coles B, Chen H, Reinemer P, Huber R, Ketterer B.

Biochem J. 1993 Jul 15;293 ( Pt 2):351-6.

32.

Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes.

Sinning I, Kleywegt GJ, Cowan SW, Reinemer P, Dirr HW, Huber R, Gilliland GL, Armstrong RN, Ji X, Board PG, et al.

J Mol Biol. 1993 Jul 5;232(1):192-212.

PMID:
8331657
33.

Three-dimensional structure of class pi glutathione S-transferase from human placenta in complex with S-hexylglutathione at 2.8 A resolution.

Reinemer P, Dirr HW, Ladenstein R, Huber R, Lo Bello M, Federici G, Parker MW.

J Mol Biol. 1992 Sep 5;227(1):214-26.

PMID:
1522586
34.

Mutational substitution of residues implicated by crystal structure in binding the substrate glutathione to human glutathione S-transferase pi.

Manoharan TH, Gulick AM, Reinemer P, Dirr HW, Huber R, Fahl WE.

J Mol Biol. 1992 Jul 20;226(2):319-22.

PMID:
1640452
35.

Equilibrium unfolding of class pi glutathione S-transferase.

Dirr HW, Reinemer P.

Biochem Biophys Res Commun. 1991 Oct 15;180(1):294-300.

PMID:
1930226
36.

The three-dimensional structure of class pi glutathione S-transferase in complex with glutathione sulfonate at 2.3 A resolution.

Reinemer P, Dirr HW, Ladenstein R, Schäffer J, Gallay O, Huber R.

EMBO J. 1991 Aug;10(8):1997-2005.

37.

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