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Items: 1 to 50 of 83

1.

Colon cancer cells cultured under hyperosmotic conditions as in vitro model to investigate dehydration effects on cancer drug susceptibility.

Haileka V, George S, Steinbrecht S, Jung F, Reinehr R, Küpper JH.

Clin Hemorheol Microcirc. 2019;73(1):169-176. doi: 10.3233/CH-199210.

PMID:
31561339
2.

Siphon-Like Gall Bladder Hydrops in Chronic Cholelithiasis.

Reinehr R, Matthies A.

Dtsch Arztebl Int. 2019 Mar 29;116(13):221. doi: 10.3238/arztebl.2019.0221b. No abstract available.

3.

[Granulated Proctosigmoiditis by Antibiotic-associated Infection with Pseudomonas Aeruginosa].

Kapp P, Meier W, Reinehr R.

Dtsch Med Wochenschr. 2018 Jan;143(2):111-114. doi: 10.1055/s-0043-122032. Epub 2018 Jan 22. German.

PMID:
29359291
4.

The calcium-activated potassium channel KCa3.1 is an important modulator of hepatic injury.

Sevelsted Møller L, Fialla AD, Schierwagen R, Biagini M, Liedtke C, Laleman W, Klein S, Reul W, Koch Hansen L, Rabjerg M, Singh V, Surra J, Osada J, Reinehr R, de Muckadell OB, Köhler R, Trebicka J.

Sci Rep. 2016 Jun 29;6:28770. doi: 10.1038/srep28770.

5.
6.

Tauroursodeoxycholate Protects Rat Hepatocytes from Bile Acid-Induced Apoptosis via β1-Integrin- and Protein Kinase A-Dependent Mechanisms.

Sommerfeld A, Reinehr R, Häussinger D.

Cell Physiol Biochem. 2015;36(3):866-83. doi: 10.1159/000430262. Epub 2015 May 27.

7.

Free fatty acids shift insulin-induced hepatocyte proliferation towards CD95-dependent apoptosis.

Sommerfeld A, Reinehr R, Häussinger D.

J Biol Chem. 2015 Feb 13;290(7):4398-409. doi: 10.1074/jbc.M114.617035. Epub 2014 Dec 29.

8.

The Src family kinases: distinct functions of c-Src, Yes, and Fyn in the liver.

Reinehr R, Sommerfeld A, Häussinger D.

Biomol Concepts. 2013 Apr;4(2):129-42. doi: 10.1515/bmc-2012-0047. Review.

PMID:
25436571
9.

Investigating cell-ECM contact changes in response to hypoosmotic stimulation of hepatocytes in vivo with DW-RICM.

Mundinger TA, Sommerfeld A, Reinehr R, Spatz JP, Häussinger D, Boehm H.

PLoS One. 2012;7(10):e48100. doi: 10.1371/journal.pone.0048100. Epub 2012 Oct 26.

10.

HbG200-mediated preinduction of heme oxygenase-1 improves bile flow and ameliorates pericentral downregulation of Bsep and Mrp2 following experimental liver ischemia and reperfusion.

Donner MG, Topp SA, Cebula P, Krienen A, Gehrmann T, Sommerfeld A, Reinehr R, Macher A, Herebian D, Mayatepek E, Pannen BH, Knoefel WT, Häussinger D.

Biol Chem. 2013 Jan;394(1):97-112. doi: 10.1515/hsz-2012-0153.

PMID:
23096566
11.

α5 β1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes.

Gohlke H, Schmitz B, Sommerfeld A, Reinehr R, Häussinger D.

Hepatology. 2013 Mar;57(3):1117-29. doi: 10.1002/hep.25992. Epub 2012 Sep 17.

PMID:
22865233
12.

CD95 death receptor and epidermal growth factor receptor (EGFR) in liver cell apoptosis and regeneration.

Reinehr R, Häussinger D.

Arch Biochem Biophys. 2012 Feb 1;518(1):2-7. doi: 10.1016/j.abb.2011.12.004. Epub 2011 Dec 13. Review.

PMID:
22182753
13.

Osmotic regulation of bile acid transport, apoptosis and proliferation in rat liver.

Häussinger D, Reinehr R.

Cell Physiol Biochem. 2011;28(6):1089-98. doi: 10.1159/000335845. Epub 2011 Dec 16. Review.

14.

The Src family kinase Fyn mediates hyperosmolarity-induced Mrp2 and Bsep retrieval from canalicular membrane.

Cantore M, Reinehr R, Sommerfeld A, Becker M, Häussinger D.

J Biol Chem. 2011 Dec 30;286(52):45014-29. doi: 10.1074/jbc.M111.292896. Epub 2011 Nov 4.

15.

Cholestatic liver diseases from child to adult: the diversity of MDR3 disease.

Kubitz R, Bode J, Erhardt A, Graf D, Kircheis G, Müller-Stöver I, Reinehr R, Reuter S, Richter J, Sagir A, Schmitt M, Donner M.

Z Gastroenterol. 2011 Jun;49(6):728-36. doi: 10.1055/s-0031-1273427. Epub 2011 Jun 1.

PMID:
21638239
16.

Ceruloplasmin expression in rat liver cells is attenuated by insulin: role of FoxO transcription factors.

Leyendecker M, Korsten P, Reinehr R, Speckmann B, Schmoll D, Scherbaum WA, Bornstein SR, Barthel A, Klotz LO.

Horm Metab Res. 2011 Apr;43(4):268-74. doi: 10.1055/s-0031-1271692. Epub 2011 Feb 17.

PMID:
21332026
17.

Sorafenib activates CD95 and promotes autophagy and cell death via Src family kinases in gastrointestinal tumor cells.

Park MA, Reinehr R, Häussinger D, Voelkel-Johnson C, Ogretmen B, Yacoub A, Grant S, Dent P.

Mol Cancer Ther. 2010 Aug;9(8):2220-31. doi: 10.1158/1535-7163.MCT-10-0274. Epub 2010 Aug 3.

18.

Activation of integrins by urea in perfused rat liver.

Reinehr R, Gohlke H, Sommerfeld A, Vom Dahl S, Häussinger D.

J Biol Chem. 2010 Sep 17;285(38):29348-56. doi: 10.1074/jbc.M110.155135. Epub 2010 Jul 19.

19.

Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway.

Park MA, Mitchell C, Zhang G, Yacoub A, Allegood J, Häussinger D, Reinehr R, Larner A, Spiegel S, Fisher PB, Voelkel-Johnson C, Ogretmen B, Grant S, Dent P.

Cancer Res. 2010 Aug 1;70(15):6313-24. doi: 10.1158/0008-5472.CAN-10-0999. Epub 2010 Jul 14.

20.

Insulin induces swelling-dependent activation of the epidermal growth factor receptor in rat liver.

Reinehr R, Sommerfeld A, Häussinger D.

J Biol Chem. 2010 Aug 20;285(34):25904-12. doi: 10.1074/jbc.M110.125781. Epub 2010 Jun 22.

21.

17-allylamino-17-demethoxygeldanamycin and MEK1/2 inhibitors kill GI tumor cells via Ca2+-dependent suppression of GRP78/BiP and induction of ceramide and reactive oxygen species.

Walker T, Mitchell C, Park MA, Yacoub A, Rahmani M, Häussinger D, Reinehr R, Voelkel-Johnson C, Fisher PB, Grant S, Dent P.

Mol Cancer Ther. 2010 May;9(5):1378-95. doi: 10.1158/1535-7163.MCT-09-1131. Epub 2010 May 4.

22.

Epidermal growth factor receptor signaling in liver cell proliferation and apoptosis.

Reinehr R, Häussinger D.

Biol Chem. 2009 Oct;390(10):1033-7. doi: 10.1515/BC.2009.106. Review.

PMID:
19558330
23.

Bile acid-induced epidermal growth factor receptor activation in quiescent rat hepatic stellate cells can trigger both proliferation and apoptosis.

Sommerfeld A, Reinehr R, Häussinger D.

J Biol Chem. 2009 Aug 14;284(33):22173-83. doi: 10.1074/jbc.M109.005355. Epub 2009 Jun 24.

24.

BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing.

Martin AP, Park MA, Mitchell C, Walker T, Rahmani M, Thorburn A, Häussinger D, Reinehr R, Grant S, Dent P.

Mol Pharmacol. 2009 Aug;76(2):327-41. doi: 10.1124/mol.109.056309. Epub 2009 May 29.

25.

Silibinin protects OTA-mediated TNF-alpha release from perfused rat livers and isolated rat Kupffer cells.

Al-Anati L, Essid E, Reinehr R, Petzinger E.

Mol Nutr Food Res. 2009 Apr;53(4):460-6. doi: 10.1002/mnfr.200800110.

PMID:
19156713
26.

Selenoprotein P expression is controlled through interaction of the coactivator PGC-1alpha with FoxO1a and hepatocyte nuclear factor 4alpha transcription factors.

Speckmann B, Walter PL, Alili L, Reinehr R, Sies H, Klotz LO, Steinbrenner H.

Hepatology. 2008 Dec;48(6):1998-2006. doi: 10.1002/hep.22526.

PMID:
18972406
27.

CD95 ligation and intracellular membrane flow.

Reinehr R, Häussinger D.

Biochem J. 2008 Aug 1;413(3):e11-2. doi: 10.1042/BJ20081094.

PMID:
18613813
28.

CD95 ligand is a proliferative and antiapoptotic signal in quiescent hepatic stellate cells.

Reinehr R, Sommerfeld A, Häussinger D.

Gastroenterology. 2008 May;134(5):1494-506. doi: 10.1053/j.gastro.2008.02.021. Epub 2008 Feb 14.

PMID:
18471522
29.

Amplification of CD95 activation by caspase 8-induced endosomal acidification in rat hepatocytes.

Reinehr R, Sommerfeld A, Keitel V, Grether-Beck S, Haüssinger D.

J Biol Chem. 2008 Jan 25;283(4):2211-22. Epub 2007 Nov 28.

30.

Osmosensing and signaling in the regulation of mammalian cell function.

Schliess F, Reinehr R, Häussinger D.

FEBS J. 2007 Nov;274(22):5799-803. Epub 2007 Oct 17. Review.

31.

Hyperosmotic activation of the CD95 system.

Reinehr R, Häussinger D.

Methods Enzymol. 2007;428:145-60. Review.

PMID:
17875416
32.

Taurine deficiency and apoptosis: findings from the taurine transporter knockout mouse.

Warskulat U, Borsch E, Reinehr R, Heller-Stilb B, Roth C, Witt M, Häussinger D.

Arch Biochem Biophys. 2007 Jun 15;462(2):202-9. Epub 2007 Apr 9.

PMID:
17459327
33.

Hypoosmotic swelling and ammonia increase oxidative stress by NADPH oxidase in cultured astrocytes and vital brain slices.

Reinehr R, Görg B, Becker S, Qvartskhava N, Bidmon HJ, Selbach O, Haas HL, Schliess F, Häussinger D.

Glia. 2007 May;55(7):758-71.

PMID:
17352382
34.

The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells.

Keitel V, Reinehr R, Gatsios P, Rupprecht C, Görg B, Selbach O, Häussinger D, Kubitz R.

Hepatology. 2007 Mar;45(3):695-704.

PMID:
17326144
35.

Hydrophobic bile salts induce hepatocyte shrinkage via NADPH oxidase activation.

Becker S, Reinehr R, Graf D, vom Dahl S, Häussinger D.

Cell Physiol Biochem. 2007;19(1-4):89-98.

36.

Hydrophobic bile salts trigger ceramide formation through endosomal acidification.

Becker S, Reinehr R, Grether-Beck S, Eberle A, Häussinger D.

Biol Chem. 2007 Feb;388(2):185-96.

PMID:
17261082
37.

CD95 activation in the liver: ion fluxes and oxidative signaling.

Reinehr R, Häussinger D.

Arch Biochem Biophys. 2007 Jun 15;462(2):124-31. Epub 2007 Jan 8. Review.

PMID:
17258167
38.

CD95 tyrosine phosphorylation is required for CD95 oligomerization.

Eberle A, Reinehr R, Becker S, Keitel V, Häussinger D.

Apoptosis. 2007 Apr;12(4):719-29. Epub 2006 Dec 29.

PMID:
17195092
39.

Endosomal acidification and activation of NADPH oxidase isoforms are upstream events in hyperosmolarity-induced hepatocyte apoptosis.

Reinehr R, Becker S, Braun J, Eberle A, Grether-Beck S, Haüssinger D.

J Biol Chem. 2006 Aug 11;281(32):23150-66. Epub 2006 Jun 13.

40.

The hepatocyte integrin system and cell volume sensing.

Häussinger D, Reinehr R, Schliess F.

Acta Physiol (Oxf). 2006 May-Jun;187(1-2):249-55. Review.

PMID:
16734762
41.

Hyperosmotic activation of the CD95 death receptor system.

Reinehr R, Häussinger D.

Acta Physiol (Oxf). 2006 May-Jun;187(1-2):199-203. Review.

PMID:
16734756
42.

Chronic liver disease is triggered by taurine transporter knockout in the mouse.

Warskulat U, Borsch E, Reinehr R, Heller-Stilb B, Mönnighoff I, Buchczyk D, Donner M, Flögel U, Kappert G, Soboll S, Beer S, Pfeffer K, Marschall HU, Gabrielsen M, Amiry-Moghaddam M, Ottersen OP, Dienes HP, Häussinger D.

FASEB J. 2006 Mar;20(3):574-6. Epub 2006 Jan 18.

PMID:
16421246
43.

Protein tyrosine nitration in hyperammonemia and hepatic encephalopathy.

Häussinger D, Görg B, Reinehr R, Schliess F.

Metab Brain Dis. 2005 Dec;20(4):285-94. Review.

PMID:
16382339
44.

Bile salt-induced apoptosis involves NADPH oxidase isoform activation.

Reinehr R, Becker S, Keitel V, Eberle A, Grether-Beck S, Häussinger D.

Gastroenterology. 2005 Dec;129(6):2009-31.

PMID:
16344068
45.

In vitro induction of tumor necrosis factor-α by ochratoxin A (OTA) from rat liver: role of Kupffer cells.

Al-Anati L, Reinehr R, Van Rooijen N, Petzinger E.

Mycotoxin Res. 2005 Sep;21(3):172-5. doi: 10.1007/BF02959257.

PMID:
23605335
46.

Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis.

Reinehr R, Becker S, Eberle A, Grether-Beck S, Häussinger D.

J Biol Chem. 2005 Jul 22;280(29):27179-94. Epub 2005 May 25.

47.

Intercellular communication via gap junctions in activated rat hepatic stellate cells.

Fischer R, Reinehr R, Lu TP, Schönicke A, Warskulat U, Dienes HP, Häussinger D.

Gastroenterology. 2005 Feb;128(2):433-48.

PMID:
15685554
48.

Fluorescence resonance energy transfer analysis of proapoptotic CD95-EGF receptor interactions in Huh7 cells.

Eberle A, Reinehr R, Becker S, Häussinger D.

Hepatology. 2005 Feb;41(2):315-26.

PMID:
15660394
49.

Involvement of the Src family kinase yes in bile salt-induced apoptosis.

Reinehr R, Becker S, Wettstein M, Häussinger D.

Gastroenterology. 2004 Nov;127(5):1540-57.

PMID:
15521021
50.

Molecular aspects of medicine: from experimental to clinical hepatology.

Häussinger D, Kubitz R, Reinehr R, Bode JG, Schliess F.

Mol Aspects Med. 2004 Jun;25(3):221-360. Review. No abstract available.

PMID:
15172153

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