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Items: 1 to 50 of 102

1.

Safety and pharmacodynamics of anti-CD2 monoclonal antibody treatment in cynomolgus macaques - an experimental study.

Berglund E, Alonso-Guallart P, Danton M, Sellberg F, Binder C, Fröbom R, Berglund D, Llore N, Sakai H, Iuga A, Ekanayake-Alper D, Reimann KA, Sachs DH, Sykes M, Griesemer A.

Transpl Int. 2019 Sep 15. doi: 10.1111/tri.13524. [Epub ahead of print]

PMID:
31523849
2.

Blocking α4β7 integrin binding to SIV does not improve virologic control.

Iwamoto N, Mason RD, Song K, Gorman J, Welles HC, Arthos J, Cicala C, Min S, King HAD, Belli AJ, Reimann KA, Foulds KE, Kwong PD, Lifson JD, Keele BF, Roederer M.

Science. 2019 Sep 6;365(6457):1033-1036. doi: 10.1126/science.aaw7765.

PMID:
31488690
3.

Lack of therapeutic efficacy of an antibody to α4β7 in SIVmac251-infected rhesus macaques.

Abbink P, Mercado NB, Nkolola JP, Peterson RL, Tuyishime H, McMahan K, Moseley ET, Borducchi EN, Chandrashekar A, Bondzie EA, Agarwal A, Belli AJ, Reimann KA, Keele BF, Geleziunas R, Lewis MG, Barouch DH.

Science. 2019 Sep 6;365(6457):1029-1033. doi: 10.1126/science.aaw8562. Epub 2019 Sep 5.

PMID:
31488689
4.

Evaluation of an antibody to α4β7 in the control of SIVmac239-nef-stop infection.

Di Mascio M, Lifson JD, Srinivasula S, Kim I, DeGrange P, Keele BF, Belli AJ, Reimann KA, Wang Y, Proschan M, Lane HC, Fauci AS.

Science. 2019 Sep 6;365(6457):1025-1029. doi: 10.1126/science.aav6695.

PMID:
31488688
5.

Anti-CD40 antibody 2C10 binds to a conformational epitope at the CD40-CD154 interface that is conserved among primate species.

Michaels AJ, Stoppato M, Flores WJ, Reimann KA, Engelman KD.

Am J Transplant. 2019 Aug 20. doi: 10.1111/ajt.15574. [Epub ahead of print]

PMID:
31430418
6.

Total body CD4+ T cell dynamics in treated and untreated SIV infection revealed by in vivo imaging.

Di Mascio M, Srinivasula S, Kim I, Duralde G, St Claire A, DeGrange P, St Claire M, Reimann KA, Gabriel EE, Carrasquillo J, Reba RC, Paik C, Lane HC.

JCI Insight. 2018 Jul 12;3(13). pii: 97880. doi: 10.1172/jci.insight.97880.

7.

Pilot Study of Delayed ICOS/ICOS-L Blockade With αCD40 to Modulate Pathogenic Alloimmunity in a Primate Cardiac Allograft Model.

O'Neill NA, Zhang T, Braileanu G, Cheng X, Hershfeld A, Sun W, Reimann KA, Dahi S, Kubicki N, Hassanein W, Laird C, Cimeno A, Azimzadeh AM, Pierson RN.

Transplant Direct. 2018 Feb 2;4(2):e344. doi: 10.1097/TXD.0000000000000761. eCollection 2018 Feb.

8.

Integrin α4β7 Blockade Preferentially Impacts CCR6+ Lymphocyte Subsets in Blood and Mucosal Tissues of Naive Rhesus Macaques.

Calenda G, Keawvichit R, Arrode-Brusés G, Pattanapanyasat K, Frank I, Byrareddy SN, Arthos J, Cicala C, Grasperge B, Blanchard JL, Gettie A, Reimann KA, Ansari AA, Martinelli E.

J Immunol. 2018 Jan 15;200(2):810-820. doi: 10.4049/jimmunol.1701150. Epub 2017 Dec 1.

9.

Depletion of Gut-Resident CCR5+ Cells for HIV Cure Strategies.

Merriam D, Chen C, Méndez-Lagares G, Rogers KA, Michaels AJ, Yan J, Casaz P, Reimann KA, Villinger F, Hartigan-O'Connor DJ.

AIDS Res Hum Retroviruses. 2017 Nov;33(S1):S70-S80. doi: 10.1089/aid.2017.0159.

10.

Isolation of a monoclonal antibody from a phage display library binding the rhesus macaque MHC class I allomorph Mamu-A1*001.

Holman N, Weinfurter JT, Harsla TR, Wiseman RW, Belli AJ, Michaels AJ, Reimann KA, DeMars RI, Reynolds MR.

PLoS One. 2017 Jul 18;12(7):e0179039. doi: 10.1371/journal.pone.0179039. eCollection 2017.

11.

Rare Control of SIVmac239 Infection in a Vaccinated Rhesus Macaque.

Martins MA, Tully DC, Shin YC, Gonzalez-Nieto L, Weisgrau KL, Bean DJ, Gadgil R, Gutman MJ, Domingues A, Maxwell HS, Magnani DM, Ricciardi M, Pedreño-Lopez N, Bailey V, Cruz MA, Lima NS, Bonaldo MC, Altman JD, Rakasz E, Capuano S 3rd, Reimann KA, Piatak M Jr, Lifson JD, Desrosiers RC, Allen TM, Watkins DI.

AIDS Res Hum Retroviruses. 2017 Aug;33(8):843-858. doi: 10.1089/AID.2017.0046. Epub 2017 Jun 29.

12.

Biophysical and Functional Characterization of Rhesus Macaque IgG Subclasses.

Boesch AW, Osei-Owusu NY, Crowley AR, Chu TH, Chan YN, Weiner JA, Bharadwaj P, Hards R, Adamo ME, Gerber SA, Cocklin SL, Schmitz JE, Miles AR, Eckman JW, Belli AJ, Reimann KA, Ackerman ME.

Front Immunol. 2016 Dec 13;7:589. doi: 10.3389/fimmu.2016.00589. eCollection 2016.

13.

Selective Targeting of High-Affinity LFA-1 Does Not Augment Costimulation Blockade in a Nonhuman Primate Renal Transplantation Model.

Samy KP, Anderson DJ, Lo DJ, Mulvihill MS, Song M, Farris AB, Parker BS, MacDonald AL, Lu C, Springer TA, Kachlany SC, Reimann KA, How T, Leopardi FV, Franke KS, Williams KD, Collins BH, Kirk AD.

Am J Transplant. 2017 May;17(5):1193-1203. doi: 10.1111/ajt.14141. Epub 2017 Jan 27.

14.

Pre-exposure Prophylaxis With OspA-Specific Human Monoclonal Antibodies Protects Mice Against Tick Transmission of Lyme Disease Spirochetes.

Wang Y, Kern A, Boatright NK, Schiller ZA, Sadowski A, Ejemel M, Souders CA, Reimann KA, Hu L, Thomas WD Jr, Klempner MS.

J Infect Dis. 2016 Jul 15;214(2):205-11. doi: 10.1093/infdis/jiw151. Epub 2016 Apr 18.

15.

Impact of Human Mutant TGFβ1/Fc Protein on Memory and Regulatory T Cell Homeostasis Following Lymphodepletion in Nonhuman Primates.

Guo H, Lu L, Wang R, Perez-Gutierrez A, Abdulkerim HS, Zahorchak AF, Sumpter TL, Reimann KA, Thomson AW, Ezzelarab MB.

Am J Transplant. 2016 Oct;16(10):2994-3006. doi: 10.1111/ajt.13883. Epub 2016 Jul 11.

16.

Systemic administration of an HIV-1 broadly neutralizing dimeric IgA yields mucosal secretory IgA and virus neutralization.

Fouda GG, Eudailey J, Kunz EL, Amos JD, Liebl BE, Himes J, Boakye-Agyeman F, Beck K, Michaels AJ, Cohen-Wolkowiez M, Haynes BF, Reimann KA, Permar SR.

Mucosal Immunol. 2017 Jan;10(1):228-237. doi: 10.1038/mi.2016.32. Epub 2016 Apr 13.

17.

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft.

Mohiuddin MM, Singh AK, Corcoran PC, Thomas Iii ML, Clark T, Lewis BG, Hoyt RF, Eckhaus M, Pierson Iii RN, Belli AJ, Wolf E, Klymiuk N, Phelps C, Reimann KA, Ayares D, Horvath KA.

Nat Commun. 2016 Apr 5;7:11138. doi: 10.1038/ncomms11138.

18.

Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak.

Bornholdt ZA, Turner HL, Murin CD, Li W, Sok D, Souders CA, Piper AE, Goff A, Shamblin JD, Wollen SE, Sprague TR, Fusco ML, Pommert KB, Cavacini LA, Smith HL, Klempner M, Reimann KA, Krauland E, Gerngross TU, Wittrup KD, Saphire EO, Burton DR, Glass PJ, Ward AB, Walker LM.

Science. 2016 Mar 4;351(6277):1078-83. doi: 10.1126/science.aad5788. Epub 2016 Feb 18.

19.

Anti-Leukocyte Function-Associated Antigen 1 Therapy in a Nonhuman Primate Renal Transplant Model of Costimulation Blockade-Resistant Rejection.

Anderson DJ, Lo DJ, Leopardi F, Song M, Turgeon NA, Strobert EA, Jenkins JB, Wang R, Reimann KA, Larsen CP, Kirk AD.

Am J Transplant. 2016 May;16(5):1456-64. doi: 10.1111/ajt.13628. Epub 2016 Jan 14.

20.

Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection.

Byrareddy SN, Kallam B, Arthos J, Cicala C, Nawaz F, Hiatt J, Kersh EN, McNicholl JM, Hanson D, Reimann KA, Brameier M, Walter L, Rogers K, Mayne AE, Dunbar P, Villinger T, Little D, Parslow TG, Santangelo PJ, Villinger F, Fauci AS, Ansari AA.

Nat Med. 2014 Dec;20(12):1397-400. doi: 10.1038/nm.3715. Epub 2014 Nov 24.

21.

One-year heterotopic cardiac xenograft survival in a pig to baboon model.

Mohiuddin MM, Singh AK, Corcoran PC, Hoyt RF, Thomas ML 3rd, Lewis BG, Eckhaus M, Reimann KA, Klymiuk N, Wolf E, Ayares D, Horvath KA.

Am J Transplant. 2014 Feb;14(2):488-9. doi: 10.1111/ajt.12562. Epub 2013 Dec 11. No abstract available.

22.

Role of anti-CD40 antibody-mediated costimulation blockade on non-Gal antibody production and heterotopic cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon model.

Mohiuddin MM, Singh AK, Corcoran PC, Hoyt RF, Thomas ML 3rd, Lewis BG, Eckhaus M, Dabkowski NL, Belli AJ, Reimann KA, Ayares D, Horvath KA.

Xenotransplantation. 2014 Jan-Feb;21(1):35-45. doi: 10.1111/xen.12066. Epub 2013 Oct 29.

23.

A novel monoclonal antibody to CD40 prolongs islet allograft survival.

Lowe M, Badell IR, Thompson P, Martin B, Leopardi F, Strobert E, Price AA, Abdulkerim HS, Wang R, Iwakoshi NN, Adams AB, Kirk AD, Larsen CP, Reimann KA.

Am J Transplant. 2012 Aug;12(8):2079-87. doi: 10.1111/j.1600-6143.2012.04054.x. Epub 2012 May 8.

24.

CD40 blockade combines with CTLA4Ig and sirolimus to produce mixed chimerism in an MHC-defined rhesus macaque transplant model.

Page A, Srinivasan S, Singh K, Russell M, Hamby K, Deane T, Sen S, Stempora L, Leopardi F, Price AA, Strobert E, Reimann KA, Kirk AD, Larsen CP, Kean LS.

Am J Transplant. 2012 Jan;12(1):115-25. doi: 10.1111/j.1600-6143.2011.03737.x. Epub 2011 Sep 19.

25.

Nondepleting anti-CD40-based therapy prolongs allograft survival in nonhuman primates.

Badell IR, Thompson PW, Turner AP, Russell MC, Avila JG, Cano JA, Robertson JM, Leopardi FV, Strobert EA, Iwakoshi NN, Reimann KA, Ford ML, Kirk AD, Larsen CP.

Am J Transplant. 2012 Jan;12(1):126-35. doi: 10.1111/j.1600-6143.2011.03736.x. Epub 2011 Sep 15.

26.

CD8+ cellular immunity mediates rAd5 vaccine protection against Ebola virus infection of nonhuman primates.

Sullivan NJ, Hensley L, Asiedu C, Geisbert TW, Stanley D, Johnson J, Honko A, Olinger G, Bailey M, Geisbert JB, Reimann KA, Bao S, Rao S, Roederer M, Jahrling PB, Koup RA, Nabel GJ.

Nat Med. 2011 Aug 21;17(9):1128-31. doi: 10.1038/nm.2447.

PMID:
21857654
27.

Reduction of CD4+ T cells in vivo does not affect virus load in macaque elite controllers.

Mudd PA, Ericsen AJ, Price AA, Wilson NA, Reimann KA, Watkins DI.

J Virol. 2011 Jul;85(14):7454-9. doi: 10.1128/JVI.00738-11. Epub 2011 May 18.

28.

Smallpox vaccine safety is dependent on T cells and not B cells.

Gordon SN, Cecchinato V, Andresen V, Heraud JM, Hryniewicz A, Parks RW, Venzon D, Chung HK, Karpova T, McNally J, Silvera P, Reimann KA, Matsui H, Kanehara T, Shinmura Y, Yokote H, Franchini G.

J Infect Dis. 2011 Apr 15;203(8):1043-53. doi: 10.1093/infdis/jiq162.

29.

Blocking of α4β7 gut-homing integrin during acute infection leads to decreased plasma and gastrointestinal tissue viral loads in simian immunodeficiency virus-infected rhesus macaques.

Ansari AA, Reimann KA, Mayne AE, Takahashi Y, Stephenson ST, Wang R, Wang X, Li J, Price AA, Little DM, Zaidi M, Lyles R, Villinger F.

J Immunol. 2011 Jan 15;186(2):1044-59. doi: 10.4049/jimmunol.1003052. Epub 2010 Dec 13.

30.

Characterization of natural killer cells in tamarins: a technical basis for studies of innate immunity.

Yoshida T, Saito A, Iwasaki Y, Iijima S, Kurosawa T, Katakai Y, Yasutomi Y, Reimann KA, Hayakawa T, Akari H.

Front Microbiol. 2010 Dec 8;1:128. doi: 10.3389/fmicb.2010.00128. eCollection 2010.

31.

Preliminary in vivo efficacy studies of a recombinant rhesus anti-alpha(4)beta(7) monoclonal antibody.

Pereira LE, Onlamoon N, Wang X, Wang R, Li J, Reimann KA, Villinger F, Pattanapanyasat K, Mori K, Ansari AA.

Cell Immunol. 2009;259(2):165-76. doi: 10.1016/j.cellimm.2009.06.012. Epub 2009 Jun 26.

32.

Reduced protection from simian immunodeficiency virus SIVmac251 infection afforded by memory CD8+ T cells induced by vaccination during CD4+ T-cell deficiency.

Vaccari M, Mattapallil J, Song K, Tsai WP, Hryniewicz A, Venzon D, Zanetti M, Reimann KA, Roederer M, Franchini G.

J Virol. 2008 Oct;82(19):9629-38. doi: 10.1128/JVI.00893-08. Epub 2008 Jul 30.

33.

In vivo natural killer cell depletion during primary simian immunodeficiency virus infection in rhesus monkeys.

Choi EI, Reimann KA, Letvin NL.

J Virol. 2008 Jul;82(13):6758-61. doi: 10.1128/JVI.02277-07. Epub 2008 Apr 23.

34.

Use of an anti-CD16 antibody for in vivo depletion of natural killer cells in rhesus macaques.

Choi EI, Wang R, Peterson L, Letvin NL, Reimann KA.

Immunology. 2008 Jun;124(2):215-22. doi: 10.1111/j.1365-2567.2007.02757.x. Epub 2008 Jan 12.

35.

Pathogenicity of simian-human immunodeficiency virus SHIV-89.6P and SIVmac is attenuated in cynomolgus macaques and associated with early T-lymphocyte responses.

Reimann KA, Parker RA, Seaman MS, Beaudry K, Beddall M, Peterson L, Williams KC, Veazey RS, Montefiori DC, Mascola JR, Nabel GJ, Letvin NL.

J Virol. 2005 Jul;79(14):8878-85.

36.

Effect of CD8+ lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239delta3-vaccinated rhesus macaques.

Schmitz JE, Johnson RP, McClure HM, Manson KH, Wyand MS, Kuroda MJ, Lifton MA, Khunkhun RS, McEvers KJ, Gillis J, Piatak M, Lifson JD, Grosschupff G, Racz P, Tenner-Racz K, Rieber EP, Kuus-Reichel K, Gelman RS, Letvin NL, Montefiori DC, Ruprecht RM, Desrosiers RC, Reimann KA.

J Virol. 2005 Jul;79(13):8131-41.

37.

Smallpox vaccine-induced antibodies are necessary and sufficient for protection against monkeypox virus.

Edghill-Smith Y, Golding H, Manischewitz J, King LR, Scott D, Bray M, Nalca A, Hooper JW, Whitehouse CA, Schmitz JE, Reimann KA, Franchini G.

Nat Med. 2005 Jul;11(7):740-7. Epub 2005 Jun 12.

PMID:
15951823
38.

Limited contribution of humoral immunity to the clearance of measles viremia in rhesus monkeys.

Permar SR, Klumpp SA, Mansfield KG, Carville AA, Gorgone DA, Lifton MA, Schmitz JE, Reimann KA, Polack FP, Griffin DE, Letvin NL.

J Infect Dis. 2004 Sep 1;190(5):998-1005. Epub 2004 Jul 26.

PMID:
15295708
39.

Hydrolytic stability of toluene diisocyanate and polymeric methylenediphenyl diisocyanate based polyureas under environmental conditions.

Sendijarevic V, Sendijarevic A, Sendijarevic I, Bailey RE, Pemberton D, Reimann KA.

Environ Sci Technol. 2004 Feb 15;38(4):1066-72.

PMID:
14998020
40.

CD8+ cell depletion amplifies the acute retroviral syndrome.

Madden LJ, Zandonatti MA, Flynn CT, Taffe MA, Marcondes MC, Schmitz JE, Reimann KA, Henriksen SJ, Fox HS.

J Neurovirol. 2004;10 Suppl 1:58-66.

PMID:
14982741
41.

Antiretroviral activity of the anti-CD4 monoclonal antibody TNX-355 in patients infected with HIV type 1.

Kuritzkes DR, Jacobson J, Powderly WG, Godofsky E, DeJesus E, Haas F, Reimann KA, Larson JL, Yarbough PO, Curt V, Shanahan WR Jr.

J Infect Dis. 2004 Jan 15;189(2):286-91. Epub 2004 Jan 8.

PMID:
14722894
42.

Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection.

Shoukry NH, Grakoui A, Houghton M, Chien DY, Ghrayeb J, Reimann KA, Walker CM.

J Exp Med. 2003 Jun 16;197(12):1645-55.

43.

Role of CD8(+) lymphocytes in control and clearance of measles virus infection of rhesus monkeys.

Permar SR, Klumpp SA, Mansfield KG, Kim WK, Gorgone DA, Lifton MA, Williams KC, Schmitz JE, Reimann KA, Axthelm MK, Polack FP, Griffin DE, Letvin NL.

J Virol. 2003 Apr;77(7):4396-400.

44.

Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus.

Schmitz JE, Kuroda MJ, Santra S, Simon MA, Lifton MA, Lin W, Khunkhun R, Piatak M, Lifson JD, Grosschupff G, Gelman RS, Racz P, Tenner-Racz K, Mansfield KA, Letvin NL, Montefiori DC, Reimann KA.

J Virol. 2003 Feb;77(3):2165-73.

45.

CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection.

Thimme R, Wieland S, Steiger C, Ghrayeb J, Reimann KA, Purcell RH, Chisari FV.

J Virol. 2003 Jan;77(1):68-76.

46.
47.

Neutralizing antibodies as a potential secondary protective mechanism during chronic SHIV infection in CD8+ T-cell-depleted macaques.

Rasmussen RA, Hofmann-Lehmann R, Li PL, Vlasak J, Schmitz JE, Reimann KA, Kuroda MJ, Letvin NL, Montefiori DC, McClure HM, Ruprecht RM.

AIDS. 2002 Apr 12;16(6):829-38.

PMID:
11919484
48.

Development of anti-CD4 MAb hu5A8 for treatment of HIV-1 infection: preclinical assessment in non-human primates.

Boon L, Holland B, Gordon W, Liu P, Shiau F, Shanahan W, Reimann KA, Fung M.

Toxicology. 2002 Apr 2;172(3):191-203.

PMID:
11893418
50.

Role of CD8(+) lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment.

Lifson JD, Rossio JL, Piatak M Jr, Parks T, Li L, Kiser R, Coalter V, Fisher B, Flynn BM, Czajak S, Hirsch VM, Reimann KA, Schmitz JE, Ghrayeb J, Bischofberger N, Nowak MA, Desrosiers RC, Wodarz D.

J Virol. 2001 Nov;75(21):10187-99.

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