Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 62

1.

Pharmacokinetics of 40‚ÄČkDa PEG in rodents using high-field NMR spectroscopy.

Khandelwal P, Zhang L, Chimalakonda A, Caceres-Cortes J, Huang C, Marathe P, Reily MD.

J Pharm Biomed Anal. 2019 Jul 15;171:30-34. doi: 10.1016/j.jpba.2019.03.066. Epub 2019 Apr 1.

PMID:
30959317
2.

Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys.

Shen H, Nelson DM, Oliveira RV, Zhang Y, Mcnaney CA, Gu X, Chen W, Su C, Reily MD, Shipkova PA, Gan J, Lai Y, Marathe P, Humphreys WG.

Drug Metab Dispos. 2018 Feb;46(2):178-188. doi: 10.1124/dmd.117.077586. Epub 2017 Nov 21.

PMID:
29162614
3.

NMR in drug design.

Harner MJ, Mueller L, Robbins KJ, Reily MD.

Arch Biochem Biophys. 2017 Aug 15;628:132-147. doi: 10.1016/j.abb.2017.06.005. Epub 2017 Jun 13.

PMID:
28619618
4.

Metabolomic profiling distinction of human nonalcoholic fatty liver disease progression from a common rat model.

Han J, Dzierlenga AL, Lu Z, Billheimer DD, Torabzadeh E, Lake AD, Li H, Novak P, Shipkova P, Aranibar N, Robertson D, Reily MD, Lehman-McKeeman LD, Cherrington NJ.

Obesity (Silver Spring). 2017 Jun;25(6):1069-1076. doi: 10.1002/oby.21855. Epub 2017 Apr 28.

5.

Understanding and Controlling Sialylation in a CHO Fc-Fusion Process.

Lewis AM, Croughan WD, Aranibar N, Lee AG, Warrack B, Abu-Absi NR, Patel R, Drew B, Borys MC, Reily MD, Li ZJ.

PLoS One. 2016 Jun 16;11(6):e0157111. doi: 10.1371/journal.pone.0157111. eCollection 2016.

6.

The utility of stable isotope labeled (SIL) analogues in the bioanalysis of endogenous compounds by LC-MS applied to the study of bile acids in a metabolomics assay.

Zheng JJ, Shields EE, Snow KJ, Nelson DM, Olah TV, Reily MD, Robertson DG, Shipkova PA, Stryker SA, Xin B, Drexler DM.

Anal Biochem. 2016 Jun 15;503:71-8. doi: 10.1016/j.ab.2016.03.011. Epub 2016 Mar 28.

PMID:
27033006
7.

Metabolomics in the pharmaceutical industry.

Reily MD, Tymiak AA.

Drug Discov Today Technol. 2015 Jun;13:25-31. doi: 10.1016/j.ddtec.2015.03.001. Epub 2015 Apr 1. Review.

PMID:
26190680
8.

Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease.

Lake AD, Novak P, Shipkova P, Aranibar N, Robertson DG, Reily MD, Lehman-McKeeman LD, Vaillancourt RR, Cherrington NJ.

Amino Acids. 2015 Mar;47(3):603-15. doi: 10.1007/s00726-014-1894-9. Epub 2014 Dec 23.

9.

1H NMR-based lipidomics of rodent fur: species-specific lipid profiles and SCD1 inhibitor-related dermal toxicity.

Khandelwal P, Stryker S, Chao H, Aranibar N, Lawrence RM, Madireddi M, Zhao W, Chen L, Reily MD.

J Lipid Res. 2014 Jul;55(7):1366-74. doi: 10.1194/jlr.M049155. Epub 2014 Apr 22.

10.

NMR methods for metabolomics of mammalian cell culture bioreactors.

Aranibar N, Reily MD.

Methods Mol Biol. 2014;1104:223-36. doi: 10.1007/978-1-62703-733-4_15.

PMID:
24297419
11.

Characterization of hepatocellular carcinoma related genes and metabolites in human nonalcoholic fatty liver disease.

Clarke JD, Novak P, Lake AD, Shipkova P, Aranibar N, Robertson D, Severson PL, Reily MD, Futscher BW, Lehman-McKeeman LD, Cherrington NJ.

Dig Dis Sci. 2014 Feb;59(2):365-74. doi: 10.1007/s10620-013-2873-9. Epub 2013 Sep 19.

12.

Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease.

Lake AD, Novak P, Shipkova P, Aranibar N, Robertson D, Reily MD, Lu Z, Lehman-McKeeman LD, Cherrington NJ.

Toxicol Appl Pharmacol. 2013 Apr 15;268(2):132-40. doi: 10.1016/j.taap.2013.01.022. Epub 2013 Feb 4.

13.

Intra- and interlaboratory reproducibility of ultra performance liquid chromatography-time-of-flight mass spectrometry for urinary metabolic profiling.

Benton HP, Want E, Keun HC, Amberg A, Plumb RS, Goldfain-Blanc F, Walther B, Reily MD, Lindon JC, Holmes E, Nicholson JK, Ebbels TM.

Anal Chem. 2012 Mar 6;84(5):2424-32. doi: 10.1021/ac203200x. Epub 2012 Feb 13.

PMID:
22304021
14.

Metabolomic and transcriptomic changes induced by overnight (16 h) fasting in male and female Sprague-Dawley rats.

Robertson DG, Ruepp SU, Stryker SA, Hnatyshyn SY, Shipkova PA, Aranibar N, Mcnaney CA, Fiehn O, Reily MD.

Chem Res Toxicol. 2011 Apr 18;24(4):481-7. doi: 10.1021/tx200074f. Epub 2011 Mar 25.

PMID:
21381695
15.

NMR-based metabolomics of mammalian cell and tissue cultures.

Aranibar N, Borys M, Mackin NA, Ly V, Abu-Absi N, Abu-Absi S, Niemitz M, Schilling B, Li ZJ, Brock B, Russell RJ 2nd, Tymiak A, Reily MD.

J Biomol NMR. 2011 Apr;49(3-4):195-206. doi: 10.1007/s10858-011-9490-8. Epub 2011 Mar 4.

PMID:
21373840
16.

Metabolomics in toxicology: preclinical and clinical applications.

Robertson DG, Watkins PB, Reily MD.

Toxicol Sci. 2011 Mar;120 Suppl 1:S146-70. doi: 10.1093/toxsci/kfq358. Epub 2010 Dec 2. Review. No abstract available.

PMID:
21127352
17.

Advances in mass spectrometry applied to pharmaceutical metabolomics.

Drexler DM, Reily MD, Shipkova PA.

Anal Bioanal Chem. 2011 Mar;399(8):2645-53. doi: 10.1007/s00216-010-4370-8. Epub 2010 Nov 25. Review.

PMID:
21107980
18.

NMR spectroscopy as a tool to close the gap on metabolite characterization under MIST.

Caceres-Cortes J, Reily MD.

Bioanalysis. 2010 Jul;2(7):1263-76. doi: 10.4155/bio.10.77. Review.

PMID:
21083239
19.

Ultra performance liquid chromatography-mass spectrometry profiling of bile acid metabolites in biofluids: application to experimental toxicology studies.

Want EJ, Coen M, Masson P, Keun HC, Pearce JT, Reily MD, Robertson DG, Rohde CM, Holmes E, Lindon JC, Plumb RS, Nicholson JK.

Anal Chem. 2010 Jun 15;82(12):5282-9. doi: 10.1021/ac1007078.

PMID:
20469835
20.

Chemical shift calibration of 1H MAS NMR liver tissue spectra exemplified using a study of glycine protection of galactosamine toxicity.

Hong YS, Coen M, Rhode CM, Reily MD, Robertson DG, Holmes E, Lindon JC, Nicholson JK.

Magn Reson Chem. 2009 Dec;47 Suppl 1:S47-53. doi: 10.1002/mrc.2521.

PMID:
19856339
21.

Mechanistic aspects and novel biomarkers of responder and non-responder phenotypes in galactosamine-induced hepatitis.

Coen M, Want EJ, Clayton TA, Rhode CM, Hong YS, Keun HC, Cantor GH, Metz AL, Robertson DG, Reily MD, Holmes E, Lindon JC, Nicholson JK.

J Proteome Res. 2009 Nov;8(11):5175-87. doi: 10.1021/pr9005266.

22.

Normalization strategies for metabonomic analysis of urine samples.

Warrack BM, Hnatyshyn S, Ott KH, Reily MD, Sanders M, Zhang H, Drexler DM.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Feb 15;877(5-6):547-52. doi: 10.1016/j.jchromb.2009.01.007. Epub 2009 Jan 14.

PMID:
19185549
23.

Quantitative evaluation of sebum lipid components with nuclear magnetic resonance.

Robosky LC, Wade K, Woolson D, Baker JD, Manning ML, Gage DA, Reily MD.

J Lipid Res. 2008 Mar;49(3):686-92. Epub 2007 Dec 19.

24.

Metabonomic evaluation of metabolic dysregulation in rats induced by PF 376304, a novel inhibitor of phosphoinositide 3-kinase.

Robertson DG, Datta K, Wells D, Egnash L, Robosky L, Manning M, Rohde C, Reily MD.

Chem Res Toxicol. 2007 Dec;20(12):1871-7. Epub 2007 Nov 15.

PMID:
18001061
25.

Heteronuclear 1H-31P statistical total correlation NMR spectroscopy of intact liver for metabolic biomarker assignment: application to galactosamine-induced hepatotoxicity.

Coen M, Hong YS, Cloarec O, Rhode CM, Reily MD, Robertson DG, Holmes E, Lindon JC, Nicholson JK.

Anal Chem. 2007 Dec 1;79(23):8956-66. Epub 2007 Nov 1.

PMID:
17973499
26.

Metabonomic evaluation of Schaedler altered microflora rats.

Rohde CM, Wells DF, Robosky LC, Manning ML, Clifford CB, Reily MD, Robertson DG.

Chem Res Toxicol. 2007 Oct;20(10):1388-92. Epub 2007 Sep 28.

PMID:
17900170
27.

Proposed minimum reporting standards for chemical analysis Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI).

Sumner LW, Amberg A, Barrett D, Beale MH, Beger R, Daykin CA, Fan TW, Fiehn O, Goodacre R, Griffin JL, Hankemeier T, Hardy N, Harnly J, Higashi R, Kopka J, Lane AN, Lindon JC, Marriott P, Nicholls AW, Reily MD, Thaden JJ, Viant MR.

Metabolomics. 2007 Sep;3(3):211-221.

28.

The mechanism of galactosamine toxicity revisited; a metabonomic study.

Coen M, Hong YS, Clayton TA, Rohde CM, Pearce JT, Reily MD, Robertson DG, Holmes E, Lindon JC, Nicholson JK.

J Proteome Res. 2007 Jul;6(7):2711-9. Epub 2007 Jun 20.

PMID:
17580851
29.

Metabonomics in pharmaceutical discovery and development.

Robertson DG, Reily MD, Baker JD.

J Proteome Res. 2007 Feb;6(2):526-39. Review.

PMID:
17269709
30.

Improving NMR sensitivity by use of salt-tolerant cryogenically cooled probes.

Robosky LC, Reily MD, Avizonis D.

Anal Bioanal Chem. 2007 Jan;387(2):529-32. Epub 2006 Nov 25. No abstract available.

PMID:
17206512
31.

DFTMP, an NMR reagent for assessing the near-neutral pH of biological samples.

Reily MD, Robosky LC, Manning ML, Butler A, Baker JD, Winters RT.

J Am Chem Soc. 2006 Sep 27;128(38):12360-1.

PMID:
16984154
32.

Metabonomics in preclinical drug development.

Robertson DG, Reily MD, Baker JD.

Expert Opin Drug Metab Toxicol. 2005 Oct;1(3):363-76. Review.

PMID:
16863449
33.

Mechanisms and biomarkers of cardiovascular injury induced by phosphodiesterase inhibitor III SK&F 95654 in the spontaneously hypertensive rat.

Zhang J, Herman EH, Robertson DG, Reily MD, Knapton A, Ratajczak HV, Rifai N, Honchel R, Blanchard KT, Stoll RE, Sistare FD.

Toxicol Pathol. 2006;34(2):152-63.

PMID:
16537294
34.

Communication regarding metabonomic identification of two distinct phenotypes in Sprague-Dawley (Crl:CD(SD)) rats.

Robosky LC, Wells DF, Egnash LA, Manning ML, Reily MD, Robertson DG.

Toxicol Sci. 2006 May;91(1):309. Epub 2006 Feb 16. No abstract available.

PMID:
16484286
35.

Summary recommendations for standardization and reporting of metabolic analyses.

Lindon JC, Nicholson JK, Holmes E, Keun HC, Craig A, Pearce JT, Bruce SJ, Hardy N, Sansone SA, Antti H, Jonsson P, Daykin C, Navarange M, Beger RD, Verheij ER, Amberg A, Baunsgaard D, Cantor GH, Lehman-McKeeman L, Earll M, Wold S, Johansson E, Haselden JN, Kramer K, Thomas C, Lindberg J, Schuppe-Koistinen I, Wilson ID, Reily MD, Robertson DG, Senn H, Krotzky A, Kochhar S, Powell J, van der Ouderaa F, Plumb R, Schaefer H, Spraul M; Standard Metabolic Reporting Structures working group.

Nat Biotechnol. 2005 Jul;23(7):833-8. No abstract available.

PMID:
16003371
36.

Metabonomic identification of two distinct phenotypes in Sprague-Dawley (Crl:CD(SD)) rats.

Robosky LC, Wells DF, Egnash LA, Manning ML, Reily MD, Robertson DG.

Toxicol Sci. 2005 Sep;87(1):277-84. Epub 2005 Jun 2.

PMID:
15933226
37.

Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved.

He K, Talaat RE, Pool WF, Reily MD, Reed JE, Bridges AJ, Woolf TF.

Drug Metab Dispos. 2004 Jun;32(6):639-46.

PMID:
15155556
38.

Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project.

Lindon JC, Nicholson JK, Holmes E, Antti H, Bollard ME, Keun H, Beckonert O, Ebbels TM, Reily MD, Robertson D, Stevens GJ, Luke P, Breau AP, Cantor GH, Bible RH, Niederhauser U, Senn H, Schlotterbeck G, Sidelmann UG, Laursen SM, Tymiak A, Car BD, Lehman-McKeeman L, Colet JM, Loukaci A, Thomas C.

Toxicol Appl Pharmacol. 2003 Mar 15;187(3):137-46.

PMID:
12662897
39.

In vivo toxicity screening programs using metabonomics.

Robosky LC, Robertson DG, Baker JD, Rane S, Reily MD.

Comb Chem High Throughput Screen. 2002 Dec;5(8):651-62. Review.

PMID:
12470262
40.

Effect of dexamethasone on the metabonomics profile associated with phosphodiesterase inhibitor-induced vascular lesions in rats.

Slim RM, Robertson DG, Albassam M, Reily MD, Robosky L, Dethloff LA.

Toxicol Appl Pharmacol. 2002 Sep 1;183(2):108-9.

PMID:
12387750
41.

Metabonomic assessment of vasculitis in rats.

Robertson DG, Reily MD, Albassam M, Dethloff LA.

Cardiovasc Toxicol. 2001;1(1):7-19.

PMID:
12213993
42.

NMR of biofluids and pattern recognition: assessing the impact of NMR parameters on the principal component analysis of urine from rat and mouse.

Potts BC, Deese AJ, Stevens GJ, Reily MD, Robertson DG, Theiss J.

J Pharm Biomed Anal. 2001 Oct;26(3):463-76.

PMID:
11489392
43.

Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants.

Robertson DG, Reily MD, Sigler RE, Wells DF, Paterson DA, Braden TK.

Toxicol Sci. 2000 Oct;57(2):326-37.

PMID:
11006362
44.

Nuclear magnetic resonance spectroscopy of peptide ion channel ligands: cloning and expression as aid to evaluation of structural and dynamic properties.

Reily MD, Bokman AM, Offord J, McConnell P.

Methods Enzymol. 1999;294:92-117. No abstract available.

PMID:
9916224
45.
46.

Metabolic disposition of the cognition activator tacrine in rats, dogs, and humans. Species comparisons.

Pool WF, Reily MD, Bjorge SM, Woolf TF.

Drug Metab Dispos. 1997 May;25(5):590-7.

PMID:
9152598
47.

Biophysical characterization of zinc ejection from HIV nucleocapsid protein by anti-HIV 2,2'-dithiobis[benzamides] and benzisothiazolones.

Loo JA, Holler TP, Sanchez J, Gogliotti R, Maloney L, Reily MD.

J Med Chem. 1996 Oct 11;39(21):4313-20.

PMID:
8863808
48.

Identification of a 3-hydroxylated tacrine metabolite in rat and man: metabolic profiling implications and pharmacology.

Pool WF, Woolf TF, Reily MD, Caprathe BW, Emmerling MR, Jaen JC.

J Med Chem. 1996 Jul 19;39(15):3014-8.

PMID:
8709135
49.
50.

Supplemental Content

Loading ...
Support Center