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Items: 26


Challenges and strategies for developing efficacious and long-lasting malaria vaccines.

Beeson JG, Kurtovic L, Dobaño C, Opi DH, Chan JA, Feng G, Good MF, Reiling L, Boyle MJ.

Sci Transl Med. 2019 Jan 9;11(474). pii: eaau1458. doi: 10.1126/scitranslmed.aau1458. Review.


Antibody Targets on the Surface of Plasmodium falciparum-Infected Erythrocytes That Are Associated With Immunity to Severe Malaria in Young Children.

Chan JA, Boyle MJ, Moore KA, Reiling L, Lin Z, Hasang W, Avril M, Manning L, Mueller I, Laman M, Davis T, Smith JD, Rogerson SJ, Simpson JA, Fowkes FJI, Beeson JG.

J Infect Dis. 2018 Oct 26. doi: 10.1093/infdis/jiy580. [Epub ahead of print]


Dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria during pregnancy and risk of malaria in early childhood: A randomized controlled trial.

Jagannathan P, Kakuru A, Okiring J, Muhindo MK, Natureeba P, Nakalembe M, Opira B, Olwoch P, Nankya F, Ssewanyana I, Tetteh K, Drakeley C, Beeson J, Reiling L, Clark TD, Rodriguez-Barraquer I, Greenhouse B, Wallender E, Aweeka F, Prahl M, Charlebois ED, Feeney ME, Havlir DV, Kamya MR, Dorsey G.

PLoS Med. 2018 Jul 17;15(7):e1002606. doi: 10.1371/journal.pmed.1002606. eCollection 2018 Jul.


Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children.

Kurtovic L, Behet MC, Feng G, Reiling L, Chelimo K, Dent AE, Mueller I, Kazura JW, Sauerwein RW, Fowkes FJI, Beeson JG.

BMC Med. 2018 Apr 30;16(1):61. doi: 10.1186/s12916-018-1054-2.


Human Immunization With a Polymorphic Malaria Vaccine Candidate Induced Antibodies to Conserved Epitopes That Promote Functional Antibodies to Multiple Parasite Strains.

Feng G, Boyle MJ, Cross N, Chan JA, Reiling L, Osier F, Stanisic DI, Mueller I, Anders RF, McCarthy JS, Richards JS, Beeson JG.

J Infect Dis. 2018 Jun 5;218(1):35-43. doi: 10.1093/infdis/jiy170.


Identifying Immune Correlates of Protection Against Plasmodium falciparum Through a Novel Approach to Account for Heterogeneity in Malaria Exposure.

Valmaseda A, Macete E, Nhabomba A, Guinovart C, Aide P, Bardají A, Bassat Q, Nhampossa T, Maculuve S, Casellas A, Quintó L, Sanz S, Jiménez A, Feng G, Langer C, Reiling L, Reddy KS, Pandey A, Chitnis CE, Chauhan VS, Aguilar R, Aponte JJ, Dobaño C, Beeson JG, Gaur D, Menéndez C, Alonso PL, Mayor A.

Clin Infect Dis. 2018 Feb 1;66(4):586-593. doi: 10.1093/cid/cix837.


Acquisition, maintenance and adaptation of invasion inhibitory antibodies against Plasmodium falciparum invasion ligands involved in immune evasion.

Tijani MK, Babalola OA, Odaibo AB, Anumudu CI, Asinobi AO, Morenikeji OA, Asuzu MC, Langer C, Reiling L, Beeson JG, Wahlgren M, Nwuba RI, Persson KEM.

PLoS One. 2017 Aug 7;12(8):e0182187. doi: 10.1371/journal.pone.0182187. eCollection 2017.


Evaluating Complement-Mediated Humoral Immunity to P. falciparum Blood Stages.

Boyle MJ, Reiling L, Beeson JG.

EBioMedicine. 2016 Dec;14:9-10. doi: 10.1016/j.ebiom.2016.11.022. Epub 2016 Nov 19. No abstract available.


Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance.

McCallum FJ, Persson KE, Fowkes FJ, Reiling L, Mugyenyi CK, Richards JS, Simpson JA, Williams TN, Gilson PR, Hodder AN, Sanders PR, Anders RF, Narum DL, Chitnis C, Crabb BS, Marsh K, Beeson JG.

J Leukoc Biol. 2017 Apr;101(4):913-925. doi: 10.1189/jlb.5MA0716-294R. Epub 2016 Nov 11.


The association between naturally acquired IgG subclass specific antibodies to the PfRH5 invasion complex and protection from Plasmodium falciparum malaria.

Weaver R, Reiling L, Feng G, Drew DR, Mueller I, Siba PM, Tsuboi T, Richards JS, Fowkes FJ, Beeson JG.

Sci Rep. 2016 Sep 8;6:33094. doi: 10.1038/srep33094.


Recent insights into humoral immunity targeting Plasmodium falciparum and Plasmodium vivax malaria.

Boyle MJ, Reiling L, Osier FH, Fowkes FJ.

Int J Parasitol. 2017 Feb;47(2-3):99-104. doi: 10.1016/j.ijpara.2016.06.002. Epub 2016 Jul 20. Review.


Human antibodies fix complement to inhibit Plasmodium falciparum invasion of erythrocytes and are associated with protection against malaria.

Boyle MJ, Reiling L, Feng G, Langer C, Osier FH, Aspeling-Jones H, Cheng YS, Stubbs J, Tetteh KK, Conway DJ, McCarthy JS, Muller I, Marsh K, Anders RF, Beeson JG.

Immunity. 2015 Mar 17;42(3):580-90. doi: 10.1016/j.immuni.2015.02.012.


Research priorities for the development and implementation of serological tools for malaria surveillance.

Elliott SR, Fowkes FJ, Richards JS, Reiling L, Drew DR, Beeson JG.

F1000Prime Rep. 2014 Nov 4;6:100. doi: 10.12703/P6-100. eCollection 2014. Review.


Subclass responses and their half-lives for antibodies against EBA175 and PfRh2 in naturally acquired immunity against Plasmodium falciparum malaria.

Ahmed Ismail H, Tijani MK, Langer C, Reiling L, White MT, Beeson JG, Wahlgren M, Nwuba R, Persson KE.

Malar J. 2014 Nov 5;13:425. doi: 10.1186/1475-2875-13-425.


Opsonic phagocytosis of Plasmodium falciparum merozoites: mechanism in human immunity and a correlate of protection against malaria.

Osier FH, Feng G, Boyle MJ, Langer C, Zhou J, Richards JS, McCallum FJ, Reiling L, Jaworowski A, Anders RF, Marsh K, Beeson JG.

BMC Med. 2014 Jul 1;12:108. doi: 10.1186/1741-7015-12-108.


Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker development.

Richards JS, Arumugam TU, Reiling L, Healer J, Hodder AN, Fowkes FJ, Cross N, Langer C, Takeo S, Uboldi AD, Thompson JK, Gilson PR, Coppel RL, Siba PM, King CL, Torii M, Chitnis CE, Narum DL, Mueller I, Crabb BS, Cowman AF, Tsuboi T, Beeson JG.

J Immunol. 2013 Jul 15;191(2):795-809. doi: 10.4049/jimmunol.1300778. Epub 2013 Jun 17.


Erythrocyte-binding antigens of Plasmodium falciparum are targets of human inhibitory antibodies and function to evade naturally acquired immunity.

Persson KE, Fowkes FJ, McCallum FJ, Gicheru N, Reiling L, Richards JS, Wilson DW, Lopaticki S, Cowman AF, Marsh K, Beeson JG.

J Immunol. 2013 Jul 15;191(2):785-94. doi: 10.4049/jimmunol.1300444. Epub 2013 Jun 17.


Acquired antibodies to merozoite antigens in children from Uganda with uncomplicated or severe Plasmodium falciparum malaria.

Ahmed Ismail H, Ribacke U, Reiling L, Normark J, Egwang T, Kironde F, Beeson JG, Wahlgren M, Persson KE.

Clin Vaccine Immunol. 2013 Aug;20(8):1170-80. doi: 10.1128/CVI.00156-13. Epub 2013 Jun 5.


The Plasmodium falciparum erythrocyte invasion ligand Pfrh4 as a target of functional and protective human antibodies against malaria.

Reiling L, Richards JS, Fowkes FJ, Wilson DW, Chokejindachai W, Barry AE, Tham WH, Stubbs J, Langer C, Donelson J, Michon P, Tavul L, Crabb BS, Siba PM, Cowman AF, Mueller I, Beeson JG.

PLoS One. 2012;7(9):e45253. doi: 10.1371/journal.pone.0045253. Epub 2012 Sep 20.


Antigenic characterization of an intrinsically unstructured protein, Plasmodium falciparum merozoite surface protein 2.

Adda CG, MacRaild CA, Reiling L, Wycherley K, Boyle MJ, Kienzle V, Masendycz P, Foley M, Beeson JG, Norton RS, Anders RF.

Infect Immun. 2012 Dec;80(12):4177-85. doi: 10.1128/IAI.00665-12. Epub 2012 Sep 10.


Targets of antibodies against Plasmodium falciparum-infected erythrocytes in malaria immunity.

Chan JA, Howell KB, Reiling L, Ataide R, Mackintosh CL, Fowkes FJ, Petter M, Chesson JM, Langer C, Warimwe GM, Duffy MF, Rogerson SJ, Bull PC, Cowman AF, Marsh K, Beeson JG.

J Clin Invest. 2012 Sep;122(9):3227-38. doi: 10.1172/JCI62182. Epub 2012 Aug 1.


Evidence that the erythrocyte invasion ligand PfRh2 is a target of protective immunity against Plasmodium falciparum malaria.

Reiling L, Richards JS, Fowkes FJ, Barry AE, Triglia T, Chokejindachai W, Michon P, Tavul L, Siba PM, Cowman AF, Mueller I, Beeson JG.

J Immunol. 2010 Nov 15;185(10):6157-67. doi: 10.4049/jimmunol.1001555. Epub 2010 Oct 20.


Overexpression of a single Leishmania major gene enhances parasite infectivity in vivo and in vitro.

Reiling L, Chrobak M, Schmetz C, Clos J.

Mol Microbiol. 2010 Jun 1;76(5):1175-90. doi: 10.1111/j.1365-2958.2010.07130.x. Epub 2010 Mar 25.


Antibodies to reticulocyte binding protein-like homologue 4 inhibit invasion of Plasmodium falciparum into human erythrocytes.

Tham WH, Wilson DW, Reiling L, Chen L, Beeson JG, Cowman AF.

Infect Immun. 2009 Jun;77(6):2427-35. doi: 10.1128/IAI.00048-09. Epub 2009 Mar 23.


Variation in use of erythrocyte invasion pathways by Plasmodium falciparum mediates evasion of human inhibitory antibodies.

Persson KE, McCallum FJ, Reiling L, Lister NA, Stubbs J, Cowman AF, Marsh K, Beeson JG.

J Clin Invest. 2008 Jan;118(1):342-51.


Spontaneous recovery of pathogenicity by Leishmania major hsp100-/- alters the immune response in mice.

Reiling L, Jacobs T, Kroemer M, Gaworski I, Graefe S, Clos J.

Infect Immun. 2006 Nov;74(11):6027-36.

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