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Benefits of applying X-ray computed tomography in bentonite based material research focussed on geological disposal of radioactive waste.

Reijonen HM, Kuva J, Heikkilä P.

Environ Sci Pollut Res Int. 2020 Mar 2. doi: 10.1007/s11356-020-08151-2. [Epub ahead of print]


Increased islet antigen-specific regulatory and effector CD4+ T cells in healthy individuals with the type 1 diabetes-protective haplotype.

Wen X, Yang J, James E, Chow IT, Reijonen H, Kwok WW.

Sci Immunol. 2020 Feb 14;5(44). pii: eaax8767. doi: 10.1126/sciimmunol.aax8767.


Production of Antigen-Specific Human CD4+ T Cell Lines and Clones.

Matthis J, King V, Reijonen H.

Methods Mol Biol. 2019;1988:387-402. doi: 10.1007/978-1-4939-9450-2_27.


Epitope Stealing as a Mechanism of Dominant Protection by HLA-DQ6 in Type 1 Diabetes.

van Lummel M, Buis DTP, Ringeling C, de Ru AH, Pool J, Papadopoulos GK, van Veelen PA, Reijonen H, Drijfhout JW, Roep BO.

Diabetes. 2019 Apr;68(4):787-795. doi: 10.2337/db18-0501. Epub 2019 Jan 9.


Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4+ T Cells in Peripheral Blood of Subjects with Type 1 Diabetes.

Cerosaletti K, Barahmand-Pour-Whitman F, Yang J, DeBerg HA, Dufort MJ, Murray SA, Israelsson E, Speake C, Gersuk VH, Eddy JA, Reijonen H, Greenbaum CJ, Kwok WW, Wambre E, Prlic M, Gottardo R, Nepom GT, Linsley PS.

J Immunol. 2017 Jul 1;199(1):323-335. doi: 10.4049/jimmunol.1700172. Epub 2017 May 31.


PI3Kγ Deficient NOD-Mice Are Protected from Diabetes by Restoring the Balance of Regulatory to Effector-T-Cells.

Azzi J, Thueson L, Moore R, Abdoli R, Reijonen H, Abdi R.

PLoS One. 2017 Jan 12;12(1):e0169695. doi: 10.1371/journal.pone.0169695. eCollection 2017.


Lessons From Pancreas Transplantation in Type 1 Diabetes: Recurrence of Islet Autoimmunity.

Burke GW 3rd, Vendrame F, Virdi SK, Ciancio G, Chen L, Ruiz P, Messinger S, Reijonen HK, Pugliese A.

Curr Diab Rep. 2015 Dec;15(12):121. doi: 10.1007/s11892-015-0691-5. Review.


Risk Factors for Type 1 Diabetes Recurrence in Immunosuppressed Recipients of Simultaneous Pancreas-Kidney Transplants.

Vendrame F, Hopfner YY, Diamantopoulos S, Virdi SK, Allende G, Snowhite IV, Reijonen HK, Chen L, Ruiz P, Ciancio G, Hutton JC, Messinger S, Burke GW 3rd, Pugliese A.

Am J Transplant. 2016 Jan;16(1):235-45. doi: 10.1111/ajt.13426. Epub 2015 Aug 28.


New insight on human type 1 diabetes biology: nPOD and nPOD-transplantation.

Pugliese A, Vendrame F, Reijonen H, Atkinson MA, Campbell-Thompson M, Burke GW.

Curr Diab Rep. 2014 Oct;14(10):530. doi: 10.1007/s11892-014-0530-0. Review.


Production of primary human CD4⁺ T cell lines and clones.

Matthis J, Reijonen H.

Methods Mol Biol. 2013;960:545-555. doi: 10.1007/978-1-62703-218-6_40.


Self-reactive human CD4 T cell clones form unusual immunological synapses.

Schubert DA, Gordo S, Sabatino JJ Jr, Vardhana S, Gagnon E, Sethi DK, Seth NP, Choudhuri K, Reijonen H, Nepom GT, Evavold BD, Dustin ML, Wucherpfennig KW.

J Exp Med. 2012 Feb 13;209(2):335-52. doi: 10.1084/jem.20111485. Epub 2012 Feb 6.


Autoantigen-specific memory CD4+ T cells are prevalent early in progression to Type 1 diabetes.

Oling V, Reijonen H, Simell O, Knip M, Ilonen J.

Cell Immunol. 2012;273(2):133-9. doi: 10.1016/j.cellimm.2011.12.008. Epub 2012 Jan 2.


Ultra-sensitive detection of rare T cell clones.

Robins H, Desmarais C, Matthis J, Livingston R, Andriesen J, Reijonen H, Carlson C, Nepom G, Yee C, Cerosaletti K.

J Immunol Methods. 2012 Jan 31;375(1-2):14-9. doi: 10.1016/j.jim.2011.09.001. Epub 2011 Sep 10.


Recurrence of autoimmunity in pancreas transplant patients: research update.

Pugliese A, Reijonen HK, Nepom J, Burke GW 3rd.

Diabetes Manag (Lond). 2011 Mar;1(2):229-238.


Development of diabetes mellitus in living pancreas donors and recipients.

Gruessner RW, Pugliese A, Reijonen HK, Gruessner S, Jie T, Desai C, Sutherland DE, Burke GW 3rd.

Expert Rev Clin Immunol. 2011 Jul;7(4):543-51. doi: 10.1586/eci.11.19. Review.


Recurrence of autoimmunity following pancreas transplantation.

Burke GW 3rd, Vendrame F, Pileggi A, Ciancio G, Reijonen H, Pugliese A.

Curr Diab Rep. 2011 Oct;11(5):413-9. doi: 10.1007/s11892-011-0206-y. Review.


Differences in self-peptide binding between T1D-related susceptible and protective DR4 subtypes.

Ge X, James EA, Reijonen H, Kwok WW.

J Autoimmun. 2011 Mar;36(2):155-60. doi: 10.1016/j.jaut.2010.12.004. Epub 2011 Jan 22.


Characterization of CD4+ T cells specific for glutamic acid decarboxylase (GAD65) and proinsulin in a patient with stiff-person syndrome but without type 1 diabetes.

Hänninen A, Soilu-Hänninen M, Hampe CS, Deptula A, Geubtner K, Ilonen J, Knip M, Reijonen H.

Diabetes Metab Res Rev. 2010 May;26(4):271-9. doi: 10.1002/dmrr.1083.


A low antigen dose selectively promotes expansion of high-avidity autoreactive T cells with distinct phenotypic characteristics: a study of human autoreactive CD4+T cells specific for GAD65.

Oling V, Geubtner K, Ilonen J, Reijonen H.

Autoimmunity. 2010 Dec;43(8):573-82. doi: 10.3109/08916930903540424. Epub 2010 Apr 7.


Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse.

Bollyky PL, Evanko SP, Wu RP, Potter-Perigo S, Long SA, Kinsella B, Reijonen H, Guebtner K, Teng B, Chan CK, Braun KR, Gebe JA, Nepom GT, Wight TN.

Cell Mol Immunol. 2010 May;7(3):211-20. doi: 10.1038/cmi.2010.9. Epub 2010 Mar 15.


Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells.

Vendrame F, Pileggi A, Laughlin E, Allende G, Martin-Pagola A, Molano RD, Diamantopoulos S, Standifer N, Geubtner K, Falk BA, Ichii H, Takahashi H, Snowhite I, Chen Z, Mendez A, Chen L, Sageshima J, Ruiz P, Ciancio G, Ricordi C, Reijonen H, Nepom GT, Burke GW 3rd, Pugliese A.

Diabetes. 2010 Apr;59(4):947-57. doi: 10.2337/db09-0498. Epub 2010 Jan 19.


Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy.

Orban T, Farkas K, Jalahej H, Kis J, Treszl A, Falk B, Reijonen H, Wolfsdorf J, Ricker A, Matthews JB, Tchao N, Sayre P, Bianchine P.

J Autoimmun. 2010 Jun;34(4):408-15. doi: 10.1016/j.jaut.2009.10.005.


Validity and reproducibility of measurement of islet autoreactivity by T-cell assays in subjects with early type 1 diabetes.

Herold KC, Brooks-Worrell B, Palmer J, Dosch HM, Peakman M, Gottlieb P, Reijonen H, Arif S, Spain LM, Thompson C, Lachin JM; Type 1 Diabetes TrialNet Research Group.

Diabetes. 2009 Nov;58(11):2588-95. doi: 10.2337/db09-0249. Epub 2009 Aug 12.


Insulin protein and proliferation in ductal cells in the transplanted pancreas of patients with type 1 diabetes and recurrence of autoimmunity.

Martin-Pagola A, Sisino G, Allende G, Dominguez-Bendala J, Gianani R, Reijonen H, Nepom GT, Ricordi C, Ruiz P, Sageshima J, Ciancio G, Burke GW, Pugliese A.

Diabetologia. 2008 Oct;51(10):1803-13. doi: 10.1007/s00125-008-1105-x. Epub 2008 Aug 12.


Islet-specific glucose-6-phosphatase catalytic subunit-related protein-reactive CD4+ T cells in human subjects.

Yang J, Danke NA, Berger D, Reichstetter S, Reijonen H, Greenbaum C, Pihoker C, James EA, Kwok WW.

J Immunol. 2006 Mar 1;176(5):2781-9.


GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects.

Oling V, Marttila J, Ilonen J, Kwok WW, Nepom G, Knip M, Simell O, Reijonen H.

J Autoimmun. 2005 Nov;25(3):235-43. Epub 2005 Nov 2. Erratum in: J Autoimmun. 2006 Aug;27(1):69.


Functional avidity directs T-cell fate in autoreactive CD4+ T cells.

Mallone R, Kochik SA, Reijonen H, Carson B, Ziegler SF, Kwok WW, Nepom GT.

Blood. 2005 Oct 15;106(8):2798-805. Epub 2005 Jul 19.


Inhibition of altered peptide ligand-mediated antagonism of human GAD65-responsive CD4+ T cells by non-antagonizable T cells.

Gebe JA, Masewicz SA, Kochik SA, Reijonen H, Nepom GT.

Eur J Immunol. 2004 Dec;34(12):3337-45.


GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes.

Reijonen H, Mallone R, Heninger AK, Laughlin EM, Kochik SA, Falk B, Kwok WW, Greenbaum C, Nepom GT.

Diabetes. 2004 Aug;53(8):1987-94.


Differential recognition and activation thresholds in human autoreactive GAD-specific T-cells.

Mallone R, Kochik SA, Laughlin EM, Gersuk VH, Reijonen H, Kwok WW, Nepom GT.

Diabetes. 2004 Apr;53(4):971-7.


Detection of CD4+ autoreactive T cells in T1D using HLA class II tetramers.

Reijonen H, Kwok WW, Nepom GT.

Ann N Y Acad Sci. 2003 Nov;1005:82-7.


Genetic modification of risk assessment based on staging of preclinical type 1 diabetes in siblings of affected children.

Mrena S, Savola K, Kulmala P, Reijonen H, Ilonen J, Akerblom HK, Knip M; Childhood Diabetes in Finland Study Group.

J Clin Endocrinol Metab. 2003 Jun;88(6):2682-9.


Low-avidity recognition by CD4+ T cells directed to self-antigens.

Gebe JA, Falk BA, Rock KA, Kochik SA, Heninger AK, Reijonen H, Kwok WW, Nepom GT.

Eur J Immunol. 2003 May;33(5):1409-17.


Use of HLA class II tetramers in tracking antigen-specific T cells and mapping T-cell epitopes.

Reijonen H, Kwok WW.

Methods. 2003 Mar;29(3):282-8. Review.


Polycystic liver disease is genetically heterogeneous: clinical and linkage studies in eight Finnish families.

Tahvanainen P, Tahvanainen E, Reijonen H, Halme L, Kääriäinen H, Höckerstedt K.

J Hepatol. 2003 Jan;38(1):39-43.


Defining antigen-specific responses with human MHC class II tetramers.

Buckner JH, Holzer U, Novak EJ, Reijonen H, Kwok WW, Nepom GT.

J Allergy Clin Immunol. 2002 Aug;110(2):199-208. Review.


Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects.

Reijonen H, Novak EJ, Kochik S, Heninger A, Liu AW, Kwok WW, Nepom GT.

Diabetes. 2002 May;51(5):1375-82.


HLA class II tetramers: tools for direct analysis of antigen-specific CD4+ T cells.

Nepom GT, Buckner JH, Novak EJ, Reichstetter S, Reijonen H, Gebe J, Wang R, Swanson E, Kwok WW.

Arthritis Rheum. 2002 Jan;46(1):5-12. Review.


HLA class II associated risk and protection against multiple sclerosis-a Finnish family study.

Laaksonen M, Pastinen T, Sjöroos M, Kuokkanen S, Ruutiainen J, Sumelahti ML, Reijonen H, Salonen R, Wikström J, Panelius M, Partanen J, Tienari PJ, Ilonen J.

J Neuroimmunol. 2002 Jan;122(1-2):140-5.


Radioimmunoassay for glutamic acid decarboxylase-65.

Hao W, Daniels T, Pipeleers DG, Smismans A, Reijonen H, Nepom GT, Lernmark A.

Diabetes Technol Ther. 1999 Spring;1(1):13-20.


GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65.

Reijonen H, Daniels TL, Lernmark A, Nepom GT.

Diabetes. 2000 Oct;49(10):1621-6.


Geographical differences within Finland in the frequency of HLA-DQ genotypes associated with type 1 diabetes susceptibility. The Childhood Diabetes in Finland Study Group.

Ilonen J, Reijonen H, Green A, Reunanen A, Knip M, Simell O, Akerblom HK.

Eur J Immunogenet. 2000 Aug;27(4):225-30.


Cow's milk consumption, HLA-DQB1 genotype, and type 1 diabetes: a nested case-control study of siblings of children with diabetes. Childhood diabetes in Finland study group.

Virtanen SM, Läärä E, Hyppönen E, Reijonen H, Räsänen L, Aro A, Knip M, Ilonen J, Akerblom HK.

Diabetes. 2000 Jun;49(6):912-7. Erratum in: Diabetes 2000 Sep;49(9):1617.


Disease-associated autoantibodies as surrogate markers of type 1 diabetes in young children at increased genetic risk. Childhood Diabetes in Finland Study Group.

Kimpimäki T, Kulmala P, Savola K, Vähäsalo P, Reijonen H, Ilonen J, Akerblom HK, Knip M.

J Clin Endocrinol Metab. 2000 Mar;85(3):1126-32.


Genetic markers, humoral autoimmunity, and prediction of type 1 diabetes in siblings of affected children. Childhood Diabetes in Finland Study Group.

Kulmala P, Savola K, Reijonen H, Veijola R, Vähäsalo P, Karjalainen J, Tuomilehto-Wolf E, Ilonen J, Tuomilehto J, Akerblom HK, Knip M.

Diabetes. 2000 Jan;49(1):48-58.


Clinical, autoimmune, and genetic characteristics of very young children with type 1 diabetes. Childhood Diabetes in Finland (DiMe) Study Group.

Komulainen J, Kulmala P, Savola K, Lounamaa R, Ilonen J, Reijonen H, Knip M, Akerblom HK.

Diabetes Care. 1999 Dec;22(12):1950-5.


Peptide binding affinity and pH variation establish functional thresholds for activation of HLA-DQ-restricted T cell recognition.

Kwok WW, Reijonen H, Falk BA, Koelle DM, Nepom GT.

Hum Immunol. 1999 Jul;60(7):619-26.


Disease-associated autoantibodies and HLA-DQB1 genotypes in children with newly diagnosed insulin-dependent diabetes mellitus (IDDM). The Childhood Diabetes in Finland Study Group.

Sabbah E, Savola K, Kulmala P, Reijonen H, Veijola R, Vähäsalo P, Karjalainen J, Ilonen J, Akerblom HK, Knip M.

Clin Exp Immunol. 1999 Apr;116(1):78-83.


Distribution of insulin-dependent diabetes mellitus (IDDM)-related HLA alleles correlates with the difference in IDDM incidence in four populations of the Eastern Baltic region.

Nejentsev S, Koskinen S, Sjöroos M, Reijonen H, Schwartz EI, Kovalchuk L, Sochnev A, Adojaan B, Podar T, Knip M, Simell O, Koskenvuo M, Akerblom HK, Ilonen J.

Tissue Antigens. 1998 Nov;52(5):473-7.


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