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Items: 46


Utilizing redox-sensitive GFP fusions to detect in vivo redox changes in a genetically engineered prokaryote.

Reuter WH, Masuch T, Ke N, Lenon M, Radzinski M, Van Loi V, Ren G, Riggs P, Antelmann H, Reichmann D, Leichert LI, Berkmen M.

Redox Biol. 2019 Sep;26:101280. doi: 10.1016/j.redox.2019.101280. Epub 2019 Jul 20.


Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments.

Masson GR, Burke JE, Ahn NG, Anand GS, Borchers C, Brier S, Bou-Assaf GM, Engen JR, Englander SW, Faber J, Garlish R, Griffin PR, Gross ML, Guttman M, Hamuro Y, Heck AJR, Houde D, Iacob RE, Jørgensen TJD, Kaltashov IA, Klinman JP, Konermann L, Man P, Mayne L, Pascal BD, Reichmann D, Skehel M, Snijder J, Strutzenberg TS, Underbakke ES, Wagner C, Wales TE, Walters BT, Weis DD, Wilson DJ, Wintrode PL, Zhang Z, Zheng J, Schriemer DC, Rand KD.

Nat Methods. 2019 Jul;16(7):595-602. doi: 10.1038/s41592-019-0459-y. Epub 2019 Jun 27. Review.


Enteropathogenic Escherichia coli remodels host endosomes to promote endocytic turnover and breakdown of surface polarity.

Kassa EG, Zlotkin-Rivkin E, Friedman G, Ramachandran RP, Melamed-Book N, Weiss AM, Belenky M, Reichmann D, Breuer W, Pal RR, Rosenshine I, Lapierre LA, Goldenring JR, Aroeti B.

PLoS Pathog. 2019 Jun 26;15(6):e1007851. doi: 10.1371/journal.ppat.1007851. eCollection 2019 Jun.


First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study.

Iacobucci C, Piotrowski C, Aebersold R, Amaral BC, Andrews P, Bernfur K, Borchers C, Brodie NI, Bruce JE, Cao Y, Chaignepain S, Chavez JD, Claverol S, Cox J, Davis T, Degliesposti G, Dong MQ, Edinger N, Emanuelsson C, Gay M, Götze M, Gomes-Neto F, Gozzo FC, Gutierrez C, Haupt C, Heck AJR, Herzog F, Huang L, Hoopmann MR, Kalisman N, Klykov O, Kukačka Z, Liu F, MacCoss MJ, Mechtler K, Mesika R, Moritz RL, Nagaraj N, Nesati V, Neves-Ferreira AGC, Ninnis R, Novák P, O'Reilly FJ, Pelzing M, Petrotchenko E, Piersimoni L, Plasencia M, Pukala T, Rand KD, Rappsilber J, Reichmann D, Sailer C, Sarnowski CP, Scheltema RA, Schmidt C, Schriemer DC, Shi Y, Skehel JM, Slavin M, Sobott F, Solis-Mezarino V, Stephanowitz H, Stengel F, Stieger CE, Trabjerg E, Trnka M, Vilaseca M, Viner R, Xiang Y, Yilmaz S, Zelter A, Ziemianowicz D, Leitner A, Sinz A.

Anal Chem. 2019 Jun 4;91(11):6953-6961. doi: 10.1021/acs.analchem.9b00658. Epub 2019 May 22.


Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination.

Saez Cabodevilla J, Volbeda A, Hamelin O, Latour JM, Gigarel O, Clémancey M, Darnault C, Reichmann D, Amara P, Fontecilla-Camps JC, Ollagnier de Choudens S.

Chem Commun (Camb). 2019 Mar 26;55(26):3725-3728. doi: 10.1039/c8cc09023h.


When safeguarding goes wrong: Impact of oxidative stress on protein homeostasis in health and neurodegenerative disorders.

Mesika R, Reichmann D.

Adv Protein Chem Struct Biol. 2019;114:221-264. doi: 10.1016/bs.apcsb.2018.11.001. Epub 2018 Dec 18. Review.


Large-Scale Analysis of Redox-Sensitive Conditionally Disordered Protein Regions Reveals Their Widespread Nature and Key Roles in High-Level Eukaryotic Processes.

Erdős G, Mészáros B, Reichmann D, Dosztányi Z.

Proteomics. 2019 Mar;19(6):e1800070. doi: 10.1002/pmic.201800070. Epub 2019 Jan 28.


Proteasome lid bridges mitochondrial stress with Cdc53/Cullin1 NEDDylation status.

Bramasole L, Sinha A, Gurevich S, Radzinski M, Klein Y, Panat N, Gefen E, Rinaldi T, Jimenez-Morales D, Johnson J, Krogan NJ, Reis N, Reichmann D, Glickman MH, Pick E.

Redox Biol. 2019 Jan;20:533-543. doi: 10.1016/j.redox.2018.11.010. Epub 2018 Nov 17.


High-Reynolds Microfluidic Sorting of Large Yeast Populations.

Keinan E, Abraham AC, Cohen A, Alexandrov AI, Mintz R, Cohen M, Reichmann D, Kaganovich D, Nahmias Y.

Sci Rep. 2018 Sep 13;8(1):13739. doi: 10.1038/s41598-018-31726-6.


Variety is the spice of life: how to explore a redox-dependent heterogeneity in genomically identical cellular populations.

Radzinski M, Reichmann D.

Curr Genet. 2019 Feb;65(1):301-306. doi: 10.1007/s00294-018-0878-9. Epub 2018 Aug 18.


Temporal profiling of redox-dependent heterogeneity in single cells.

Radzinski M, Fassler R, Yogev O, Breuer W, Shai N, Gutin J, Ilyas S, Geffen Y, Tsytkin-Kirschenzweig S, Nahmias Y, Ravid T, Friedman N, Schuldiner M, Reichmann D.

Elife. 2018 Jun 5;7. pii: e37623. doi: 10.7554/eLife.37623.


Maintaining a Healthy Proteome during Oxidative Stress.

Reichmann D, Voth W, Jakob U.

Mol Cell. 2018 Jan 18;69(2):203-213. doi: 10.1016/j.molcel.2017.12.021. Review.


Kfits: a software framework for fitting and cleaning outliers in kinetic measurements.

Rimon O, Reichmann D.

Bioinformatics. 2018 Jan 1;34(1):129-130. doi: 10.1093/bioinformatics/btx577.


A Role of Metastable Regions and Their Connectivity in the Inactivation of a Redox-Regulated Chaperone and Its Inter-Chaperone Crosstalk.

Rimon O, Suss O, Goldenberg M, Fassler R, Yogev O, Amartely H, Propper G, Friedler A, Reichmann D.

Antioxid Redox Signal. 2017 Nov 20;27(15):1252-1267. doi: 10.1089/ars.2016.6900. Epub 2017 Apr 10.


Crystal Structures of Quinolinate Synthase in Complex with a Substrate Analogue, the Condensation Intermediate, and Substrate-Derived Product.

Volbeda A, Darnault C, Renoux O, Reichmann D, Amara P, Ollagnier de Choudens S, Fontecilla-Camps JC.

J Am Chem Soc. 2016 Sep 14;138(36):11802-9. doi: 10.1021/jacs.6b05884. Epub 2016 Aug 30.


Protein unfolding as a switch from self-recognition to high-affinity client binding.

Groitl B, Horowitz S, Makepeace KAT, Petrotchenko EV, Borchers CH, Reichmann D, Bardwell JCA, Jakob U.

Nat Commun. 2016 Jan 20;7:10357. doi: 10.1038/ncomms10357.


Dual activity of quinolinate synthase: triose phosphate isomerase and dehydration activities play together to form quinolinate.

Reichmann D, Couté Y, Ollagnier de Choudens S.

Biochemistry. 2015 Oct 27;54(42):6443-6. doi: 10.1021/acs.biochem.5b00991. Epub 2015 Oct 16.


Protein plasticity underlines activation and function of ATP-independent chaperones.

Suss O, Reichmann D.

Front Mol Biosci. 2015 Jul 28;2:43. doi: 10.3389/fmolb.2015.00043. eCollection 2015. Review.


Electrochemical and mARC-catalyzed enzymatic reduction of para-substituted benzamidoximes: consequences for the prodrug concept "amidoximes instead of amidines".

Bauch E, Reichmann D, Mendel RR, Bittner F, Manke AM, Kurz P, Girreser U, Havemeyer A, Clement B.

ChemMedChem. 2015 Feb;10(2):360-7. doi: 10.1002/cmdc.201402437. Epub 2014 Dec 15.


Reduction of sulfamethoxazole hydroxylamine (SMX-HA) by the mitochondrial amidoxime reducing component (mARC).

Ott G, Plitzko B, Krischkowski C, Reichmann D, Bittner F, Mendel RR, Kunze T, Clement B, Havemeyer A.

Chem Res Toxicol. 2014 Oct 20;27(10):1687-95. doi: 10.1021/tx500174u. Epub 2014 Sep 18.


About the dangers, costs and benefits of living an aerobic lifestyle.

Knoefler D, Leichert LI, Thamsen M, Cremers CM, Reichmann D, Gray MJ, Wholey WY, Jakob U.

Biochem Soc Trans. 2014 Aug;42(4):917-21. doi: 10.1042/BST20140108. Review.


The crystal structure of Fe₄S₄ quinolinate synthase unravels an enzymatic dehydration mechanism that uses tyrosine and a hydrolase-type triad.

Cherrier MV, Chan A, Darnault C, Reichmann D, Amara P, Ollagnier de Choudens S, Fontecilla-Camps JC.

J Am Chem Soc. 2014 Apr 9;136(14):5253-6. doi: 10.1021/ja501431b. Epub 2014 Mar 26.


Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.

Abu-Odeh M, Bar-Mag T, Huang H, Kim T, Salah Z, Abdeen SK, Sudol M, Reichmann D, Sidhu S, Kim PM, Aqeilan RI.

J Biol Chem. 2014 Mar 28;289(13):8865-80. doi: 10.1074/jbc.M113.506790. Epub 2014 Feb 18.


Functional characterization of protein variants encoded by nonsynonymous single nucleotide polymorphisms in MARC1 and MARC2 in healthy Caucasians.

Ott G, Reichmann D, Boerger C, Cascorbi I, Bittner F, Mendel RR, Kunze T, Clement B, Havemeyer A.

Drug Metab Dispos. 2014 Apr;42(4):718-25. doi: 10.1124/dmd.113.055202. Epub 2014 Jan 14.


The involvement of mitochondrial amidoxime reducing components 1 and 2 and mitochondrial cytochrome b5 in N-reductive metabolism in human cells.

Plitzko B, Ott G, Reichmann D, Henderson CJ, Wolf CR, Mendel R, Bittner F, Clement B, Havemeyer A.

J Biol Chem. 2013 Jul 12;288(28):20228-37. doi: 10.1074/jbc.M113.474916. Epub 2013 May 23.


The roles of conditional disorder in redox proteins.

Reichmann D, Jakob U.

Curr Opin Struct Biol. 2013 Jun;23(3):436-42. doi: 10.1016/ Epub 2013 Mar 13. Review.


Time line of redox events in aging postmitotic cells.

Brandes N, Tienson H, Lindemann A, Vitvitsky V, Reichmann D, Banerjee R, Jakob U.

Elife. 2013 Feb 5;2:e00306. doi: 10.7554/eLife.00306.


Activation of the anti-cancer agent upamostat by the mARC enzyme system.

Froriep D, Clement B, Bittner F, Mendel RR, Reichmann D, Schmalix W, Havemeyer A.

Xenobiotica. 2013 Sep;43(9):780-4. doi: 10.3109/00498254.2013.767481. Epub 2013 Feb 4.


The mitochondrial Amidoxime Reducing Component (mARC) is involved in detoxification of N-hydroxylated base analogues.

Krompholz N, Krischkowski C, Reichmann D, Garbe-Schönberg D, Mendel RR, Bittner F, Clement B, Havemeyer A.

Chem Res Toxicol. 2012 Nov 19;25(11):2443-50. doi: 10.1021/tx300298m. Epub 2012 Aug 27.


Order out of disorder: working cycle of an intrinsically unfolded chaperone.

Reichmann D, Xu Y, Cremers CM, Ilbert M, Mittelman R, Fitzgerald MC, Jakob U.

Cell. 2012 Mar 2;148(5):947-57. doi: 10.1016/j.cell.2012.01.045.


Using quantitative redox proteomics to dissect the yeast redoxome.

Brandes N, Reichmann D, Tienson H, Leichert LI, Jakob U.

J Biol Chem. 2011 Dec 2;286(48):41893-903. doi: 10.1074/jbc.M111.296236. Epub 2011 Oct 5.


Structural studies of the molybdenum center of mitochondrial amidoxime reducing component (mARC) by pulsed EPR spectroscopy and 17O-labeling.

Rajapakshe A, Astashkin AV, Klein EL, Reichmann D, Mendel RR, Bittner F, Enemark JH.

Biochemistry. 2011 Oct 18;50(41):8813-22. doi: 10.1021/bi2005762. Epub 2011 Sep 22.


A quantitative, real-time assessment of binding of peptides and proteins to gold surfaces.

Cohavi O, Reichmann D, Abramovich R, Tesler AB, Bellapadrona G, Kokh DB, Wade RC, Vaskevich A, Rubinstein I, Schreiber G.

Chemistry. 2011 Jan 24;17(4):1327-36. doi: 10.1002/chem.201001781. Epub 2010 Dec 1.


Modulation of mutant huntingtin N-terminal cleavage and its effect on aggregation and cell death.

Juenemann K, Weisse C, Reichmann D, Kaether C, Calkhoven CF, Schilling G.

Neurotox Res. 2011 Aug;20(2):120-33. doi: 10.1007/s12640-010-9227-6. Epub 2010 Nov 30.


Biochemical and spectroscopic characterization of the human mitochondrial amidoxime reducing components hmARC-1 and hmARC-2 suggests the existence of a new molybdenum enzyme family in eukaryotes.

Wahl B, Reichmann D, Niks D, Krompholz N, Havemeyer A, Clement B, Messerschmidt T, Rothkegel M, Biester H, Hille R, Mendel RR, Bittner F.

J Biol Chem. 2010 Nov 26;285(48):37847-59. doi: 10.1074/jbc.M110.169532. Epub 2010 Sep 22.


Unfolding of metastable linker region is at the core of Hsp33 activation as a redox-regulated chaperone.

Cremers CM, Reichmann D, Hausmann J, Ilbert M, Jakob U.

J Biol Chem. 2010 Apr 9;285(15):11243-51. doi: 10.1074/jbc.M109.084350. Epub 2010 Feb 5.


A global benchmark study using affinity-based biosensors.

Rich RL, Papalia GA, Flynn PJ, Furneisen J, Quinn J, Klein JS, Katsamba PS, Waddell MB, Scott M, Thompson J, Berlier J, Corry S, Baltzinger M, Zeder-Lutz G, Schoenemann A, Clabbers A, Wieckowski S, Murphy MM, Page P, Ryan TE, Duffner J, Ganguly T, Corbin J, Gautam S, Anderluh G, Bavdek A, Reichmann D, Yadav SP, Hommema E, Pol E, Drake A, Klakamp S, Chapman T, Kernaghan D, Miller K, Schuman J, Lindquist K, Herlihy K, Murphy MB, Bohnsack R, Andrien B, Brandani P, Terwey D, Millican R, Darling RJ, Wang L, Carter Q, Dotzlaf J, Lopez-Sagaseta J, Campbell I, Torreri P, Hoos S, England P, Liu Y, Abdiche Y, Malashock D, Pinkerton A, Wong M, Lafer E, Hinck C, Thompson K, Primo CD, Joyce A, Brooks J, Torta F, Bagge Hagel AB, Krarup J, Pass J, Ferreira M, Shikov S, Mikolajczyk M, Abe Y, Barbato G, Giannetti AM, Krishnamoorthy G, Beusink B, Satpaev D, Tsang T, Fang E, Partridge J, Brohawn S, Horn J, Pritsch O, Obal G, Nilapwar S, Busby B, Gutierrez-Sanchez G, Gupta RD, Canepa S, Witte K, Nikolovska-Coleska Z, Cho YH, D'Agata R, Schlick K, Calvert R, Munoz EM, Hernaiz MJ, Bravman T, Dines M, Yang MH, Puskas A, Boni E, Li J, Wear M, Grinberg A, Baardsnes J, Dolezal O, Gainey M, Anderson H, Peng J, Lewis M, Spies P, Trinh Q, Bibikov S, Raymond J, Yousef M, Chandrasekaran V, Feng Y, Emerick A, Mundodo S, Guimaraes R, McGirr K, Li YJ, Hughes H, Mantz H, Skrabana R, Witmer M, Ballard J, Martin L, Skladal P, Korza G, Laird-Offringa I, Lee CS, Khadir A, Podlaski F, Neuner P, Rothacker J, Rafique A, Dankbar N, Kainz P, Gedig E, Vuyisich M, Boozer C, Ly N, Toews M, Uren A, Kalyuzhniy O, Lewis K, Chomey E, Pak BJ, Myszka DG.

Anal Biochem. 2009 Mar 15;386(2):194-216. doi: 10.1016/j.ab.2008.11.021. Epub 2008 Nov 27.


Computational redesign of a protein-protein interface for high affinity and binding specificity using modular architecture and naturally occurring template fragments.

Potapov V, Reichmann D, Abramovich R, Filchtinski D, Zohar N, Ben Halevy D, Edelman M, Sobolev V, Schreiber G.

J Mol Biol. 2008 Dec 5;384(1):109-19. doi: 10.1016/j.jmb.2008.08.078. Epub 2008 Sep 9.


Similar chemistry, but different bond preferences in inter versus intra-protein interactions.

Cohen M, Reichmann D, Neuvirth H, Schreiber G.

Proteins. 2008 Aug;72(2):741-53. doi: 10.1002/prot.21960.


On the contribution of water-mediated interactions to protein-complex stability.

Reichmann D, Phillip Y, Carmi A, Schreiber G.

Biochemistry. 2008 Jan 22;47(3):1051-60. Epub 2007 Dec 28.


The molecular architecture of protein-protein binding sites.

Reichmann D, Rahat O, Cohen M, Neuvirth H, Schreiber G.

Curr Opin Struct Biol. 2007 Feb;17(1):67-76. Epub 2007 Jan 18. Review.


Binding hot spots in the TEM1-BLIP interface in light of its modular architecture.

Reichmann D, Cohen M, Abramovich R, Dym O, Lim D, Strynadka NC, Schreiber G.

J Mol Biol. 2007 Jan 19;365(3):663-79. Epub 2006 Oct 3.


Supreme court allows enforcement for health plans seeking reimbursement.

Reichmann D.

AHIP Cover. 2006 Jul-Aug;47(4):14, 74.


The modular architecture of protein-protein binding interfaces.

Reichmann D, Rahat O, Albeck S, Meged R, Dym O, Schreiber G.

Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):57-62. Epub 2004 Dec 23.


State medical marijuana laws: understanding the laws and their limitations.

Pacula RL, Chriqui JF, Reichmann DA, Terry-McElrath YM.

J Public Health Policy. 2002;23(4):413-39.


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