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Single-Cell Analysis Uncovers a Vast Diversity in Intracellular Viral Defective Interfering RNA Content Affecting the Large Cell-to-Cell Heterogeneity in Influenza A Virus Replication.

Kupke SY, Ly LH, Börno ST, Ruff A, Timmermann B, Vingron M, Haas S, Reichl U.

Viruses. 2020 Jan 7;12(1). pii: E71. doi: 10.3390/v12010071.


Perfusion Control for High Cell Density Cultivation and Viral Vaccine Production.

Nikolay A, Bissinger T, Gränicher G, Wu Y, Genzel Y, Reichl U.

Methods Mol Biol. 2020;2095:141-168. doi: 10.1007/978-1-0716-0191-4_9.


Orbitally Shaken Single-Use Bioreactor for Animal Cell Cultivation: Fed-Batch and Perfusion Mode.

Bürgin T, Coronel J, Hagens G, Keebler MV, Genzel Y, Reichl U, Anderlei T.

Methods Mol Biol. 2020;2095:105-123. doi: 10.1007/978-1-0716-0191-4_7.


Continuous influenza virus production in a tubular bioreactor system provides stable titers and avoids the "von Magnus effect".

Tapia F, Wohlfarth D, Sandig V, Jordan I, Genzel Y, Reichl U.

PLoS One. 2019 Nov 5;14(11):e0224317. doi: 10.1371/journal.pone.0224317. eCollection 2019.


Production of Defective Interfering Particles of Influenza A Virus in Parallel Continuous Cultures at Two Residence Times-Insights From qPCR Measurements and Viral Dynamics Modeling.

Tapia F, Laske T, Wasik MA, Rammhold M, Genzel Y, Reichl U.

Front Bioeng Biotechnol. 2019 Oct 18;7:275. doi: 10.3389/fbioe.2019.00275. eCollection 2019.


Enzymatic Cascades for Tailored 13C6 and 15N Enriched Human Milk Oligosaccharides.

Fischöder T, Cajic S, Grote V, Heinzler R, Reichl U, Franzreb M, Rapp E, Elling L.

Molecules. 2019 Sep 25;24(19). pii: E3482. doi: 10.3390/molecules24193482.


A Robust and Universal Metaproteomics Workflow for Research Studies and Routine Diagnostics Within 24 h Using Phenol Extraction, FASP Digest, and the MetaProteomeAnalyzer.

Heyer R, Schallert K, Büdel A, Zoun R, Dorl S, Behne A, Kohrs F, Püttker S, Siewert C, Muth T, Saake G, Reichl U, Benndorf D.

Front Microbiol. 2019 Aug 16;10:1883. doi: 10.3389/fmicb.2019.01883. eCollection 2019.


Influenza A virus production in a single-use orbital shaken bioreactor with ATF or TFF perfusion systems.

Coronel J, Behrendt I, Bürgin T, Anderlei T, Sandig V, Reichl U, Genzel Y.

Vaccine. 2019 Nov 8;37(47):7011-7018. doi: 10.1016/j.vaccine.2019.06.005. Epub 2019 Jun 29.


Semi-perfusion cultures of suspension MDCK cells enable high cell concentrations and efficient influenza A virus production.

Bissinger T, Fritsch J, Mihut A, Wu Y, Liu X, Genzel Y, Tan WS, Reichl U.

Vaccine. 2019 Nov 8;37(47):7003-7010. doi: 10.1016/j.vaccine.2019.04.054. Epub 2019 Apr 29.


Metaproteome analysis reveals that syntrophy, competition, and phage-host interaction shape microbial communities in biogas plants.

Heyer R, Schallert K, Siewert C, Kohrs F, Greve J, Maus I, Klang J, Klocke M, Heiermann M, Hoffmann M, Püttker S, Calusinska M, Zoun R, Saake G, Benndorf D, Reichl U.

Microbiome. 2019 Apr 27;7(1):69. doi: 10.1186/s40168-019-0673-y.


Metaproteomics of fecal samples of Crohn's disease and Ulcerative Colitis.

Lehmann T, Schallert K, Vilchez-Vargas R, Benndorf D, Püttker S, Sydor S, Schulz C, Bechmann L, Canbay A, Heidrich B, Reichl U, Link A, Heyer R.

J Proteomics. 2019 Jun 15;201:93-103. doi: 10.1016/j.jprot.2019.04.009. Epub 2019 Apr 19.


Hydrophobic-interaction chromatography for purification of influenza A and B virus.

Weigel T, Soliman R, Wolff MW, Reichl U.

J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Jun 1;1117:103-117. doi: 10.1016/j.jchromb.2019.03.037. Epub 2019 Apr 1.


Efficient influenza A virus production in high cell density using the novel porcine suspension cell line PBG.PK2.1.

Gränicher G, Coronel J, Pralow A, Marichal-Gallardo P, Wolff M, Rapp E, Karlas A, Sandig V, Genzel Y, Reichl U.

Vaccine. 2019 Nov 8;37(47):7019-7028. doi: 10.1016/j.vaccine.2019.04.030. Epub 2019 Apr 17.


Model-based analysis of influenza A virus replication in genetically engineered cell lines elucidates the impact of host cell factors on key kinetic parameters of virus growth.

Laske T, Bachmann M, Dostert M, Karlas A, Wirth D, Frensing T, Meyer TF, Hauser H, Reichl U.

PLoS Comput Biol. 2019 Apr 11;15(4):e1006944. doi: 10.1371/journal.pcbi.1006944. eCollection 2019 Apr.


A system for production of defective interfering particles in the absence of infectious influenza A virus.

Bdeir N, Arora P, Gärtner S, Hoffmann M, Reichl U, Pöhlmann S, Winkler M.

PLoS One. 2019 Mar 1;14(3):e0212757. doi: 10.1371/journal.pone.0212757. eCollection 2019.


High titer MVA and influenza A virus production using a hybrid fed-batch/perfusion strategy with an ATF system.

Vázquez-Ramírez D, Jordan I, Sandig V, Genzel Y, Reichl U.

Appl Microbiol Biotechnol. 2019 Apr;103(7):3025-3035. doi: 10.1007/s00253-019-09694-2. Epub 2019 Feb 23.


Multiscale modeling of influenza A virus replication in cell cultures predicts infection dynamics for highly different infection conditions.

Rüdiger D, Kupke SY, Laske T, Zmora P, Reichl U.

PLoS Comput Biol. 2019 Feb 19;15(2):e1006819. doi: 10.1371/journal.pcbi.1006819. eCollection 2019 Feb.


RedCom: A strategy for reduced metabolic modeling of complex microbial communities and its application for analyzing experimental datasets from anaerobic digestion.

Koch S, Kohrs F, Lahmann P, Bissinger T, Wendschuh S, Benndorf D, Reichl U, Klamt S.

PLoS Comput Biol. 2019 Feb 1;15(2):e1006759. doi: 10.1371/journal.pcbi.1006759. eCollection 2019 Feb.


Improvement of electrospray stability in negative ion mode for nano-PGC-LC-MS glycoanalysis via post-column make-up flow.

Nguyen-Khuong T, Pralow A, Reichl U, Rapp E.

Glycoconj J. 2018 Dec;35(6):499-509. doi: 10.1007/s10719-018-9848-1. Epub 2018 Nov 23.


A Novel Type of Influenza A Virus-Derived Defective Interfering Particle with Nucleotide Substitutions in Its Genome.

Kupke SY, Riedel D, Frensing T, Zmora P, Reichl U.

J Virol. 2019 Feb 5;93(4). pii: e01786-18. doi: 10.1128/JVI.01786-18. Print 2019 Feb 15.


The Fine Art of Destruction: A Guide to In-Depth Glycoproteomic Analyses-Exploiting the Diagnostic Potential of Fragment Ions.

Hoffmann M, Pioch M, Pralow A, Hennig R, Kottler R, Reichl U, Rapp E.

Proteomics. 2018 Dec;18(24):e1800282. doi: 10.1002/pmic.201800282.


glyXtoolMS: An Open-Source Pipeline for Semiautomated Analysis of Glycopeptide Mass Spectrometry Data.

Pioch M, Hoffmann M, Pralow A, Reichl U, Rapp E.

Anal Chem. 2018 Oct 16;90(20):11908-11916. doi: 10.1021/acs.analchem.8b02087. Epub 2018 Sep 25.


High-throughput Serum N-Glycomics: Method Comparison and Application to Study Rheumatoid Arthritis and Pregnancy-associated Changes.

Reiding KR, Bondt A, Hennig R, Gardner RA, O'Flaherty R, Trbojević-Akmačić I, Shubhakar A, Hazes JMW, Reichl U, Fernandes DL, Pučić-Baković M, Rapp E, Spencer DIR, Dolhain RJEM, Rudd PM, Lauc G, Wuhrer M.

Mol Cell Proteomics. 2019 Jan;18(1):3-15. doi: 10.1074/mcp.RA117.000454. Epub 2018 Sep 21.


Process intensification of EB66® cell cultivations leads to high-yield yellow fever and Zika virus production.

Nikolay A, Léon A, Schwamborn K, Genzel Y, Reichl U.

Appl Microbiol Biotechnol. 2018 Oct;102(20):8725-8737. doi: 10.1007/s00253-018-9275-z. Epub 2018 Aug 8.


Enzymatic Cascade Synthesis Provides Novel Linear Human Milk Oligosaccharides as Reference Standards for xCGE-LIF Based High-Throughput Analysis.

Fischöder T, Cajic S, Reichl U, Rapp E, Elling L.

Biotechnol J. 2019 Mar;14(3):e1800305. doi: 10.1002/biot.201800305. Epub 2018 Aug 23.


Establishment of a five-enzyme cell-free cascade for the synthesis of uridine diphosphate N-acetylglucosamine.

Mahour R, Klapproth J, Rexer TFT, Schildbach A, Klamt S, Pietzsch M, Rapp E, Reichl U.

J Biotechnol. 2018 Oct 10;283:120-129. doi: 10.1016/j.jbiotec.2018.07.027. Epub 2018 Jul 22.


Purification of influenza virus-like particles using sulfated cellulose membrane adsorbers.

B Carvalho S, Fortuna AR, Wolff MW, Peixoto C, M Alves P, Reichl U, Jt Carrondo M.

J Chem Technol Biotechnol. 2018 Jul;93(7):1988-1996. doi: 10.1002/jctb.5474. Epub 2017 Dec 16.


High-cell-density cultivations to increase MVA virus production.

Vázquez-Ramírez D, Genzel Y, Jordan I, Sandig V, Reichl U.

Vaccine. 2018 May 24;36(22):3124-3133. doi: 10.1016/j.vaccine.2017.10.112. Epub 2018 Feb 9.


MPA Portable: A Stand-Alone Software Package for Analyzing Metaproteome Samples on the Go.

Muth T, Kohrs F, Heyer R, Benndorf D, Rapp E, Reichl U, Martens L, Renard BY.

Anal Chem. 2018 Jan 2;90(1):685-689. doi: 10.1021/acs.analchem.7b03544. Epub 2017 Dec 19.


Cell culture-based production of defective interfering particles for influenza antiviral therapy.

Wasik MA, Eichwald L, Genzel Y, Reichl U.

Appl Microbiol Biotechnol. 2018 Feb;102(3):1167-1177. doi: 10.1007/s00253-017-8660-3. Epub 2017 Dec 5.


Animal Cell Expression Systems.

Butler M, Reichl U.

Adv Biochem Eng Biotechnol. 2017 Oct 3. doi: 10.1007/10_2017_31. [Epub ahead of print] Erratum in: Adv Biochem Eng Biotechnol. 2018 Apr 29;:.


One pot synthesis of GDP-mannose by a multi-enzyme cascade for enzymatic assembly of lipid-linked oligosaccharides.

Rexer TFT, Schildbach A, Klapproth J, Schierhorn A, Mahour R, Pietzsch M, Rapp E, Reichl U.

Biotechnol Bioeng. 2018 Jan;115(1):192-205. doi: 10.1002/bit.26454. Epub 2017 Oct 23.


Improvement of the glycoproteomic toolbox with the discovery of a unique C-terminal cleavage specificity of flavastacin for N-glycosylated asparagine.

Pralow A, Hoffmann M, Nguyen-Khuong T, Rapp E, Reichl U.

Sci Rep. 2017 Sep 12;7(1):11419. doi: 10.1038/s41598-017-11668-1.


Efficient and stable production of Modified Vaccinia Ankara virus in two-stage semi-continuous and in continuous stirred tank cultivation systems.

Tapia F, Jordan I, Genzel Y, Reichl U.

PLoS One. 2017 Aug 24;12(8):e0182553. doi: 10.1371/journal.pone.0182553. eCollection 2017.


Purification of cell culture-derived influenza A virus via continuous anion exchange chromatography on monoliths.

Fischer LM, Wolff MW, Reichl U.

Vaccine. 2018 May 24;36(22):3153-3160. doi: 10.1016/j.vaccine.2017.06.086. Epub 2017 Jul 17.


Propagation of Brazilian Zika virus strains in static and suspension cultures using Vero and BHK cells.

Nikolay A, Castilho LR, Reichl U, Genzel Y.

Vaccine. 2018 May 24;36(22):3140-3145. doi: 10.1016/j.vaccine.2017.03.018. Epub 2017 Mar 23.


Proteotyping of laboratory-scale biogas plants reveals multiple steady-states in community composition.

Kohrs F, Heyer R, Bissinger T, Kottler R, Schallert K, Püttker S, Behne A, Rapp E, Benndorf D, Reichl U.

Anaerobe. 2017 Aug;46:56-68. doi: 10.1016/j.anaerobe.2017.02.005. Epub 2017 Feb 9.


Steric exclusion chromatography for purification of cell culture-derived influenza A virus using regenerated cellulose membranes and polyethylene glycol.

Marichal-Gallardo P, Pieler MM, Wolff MW, Reichl U.

J Chromatogr A. 2016 Dec 29. pii: S0021-9673(16)31742-3. doi: 10.1016/j.chroma.2016.12.076. [Epub ahead of print]


Steric exclusion chromatography for purification of cell culture-derived influenza A virus using regenerated cellulose membranes and polyethylene glycol.

Marichal-Gallardo P, Pieler MM, Wolff MW, Reichl U.

J Chromatogr A. 2017 Feb 3;1483:110-119. doi: 10.1016/j.chroma.2016.12.076. Epub 2016 Dec 29.


A cell culture-derived whole virus influenza A vaccine based on magnetic sulfated cellulose particles confers protection in mice against lethal influenza A virus infection.

Pieler MM, Frentzel S, Bruder D, Wolff MW, Reichl U.

Vaccine. 2016 Dec 7;34(50):6367-6374. doi: 10.1016/j.vaccine.2016.10.041. Epub 2016 Nov 2.


Ezrin and HNRNP expression correlate with increased virus release rate and early onset of virus-induced apoptosis of MDCK suspension cells.

Kluge S, Genzel Y, Laus K, Serve A, Pflugmacher A, Peschel B, Rapp E, Reichl U.

Biotechnol J. 2016 Oct;11(10):1332-1342. doi: 10.1002/biot.201600384.


Proteotyping of biogas plant microbiomes separates biogas plants according to process temperature and reactor type.

Heyer R, Benndorf D, Kohrs F, De Vrieze J, Boon N, Hoffmann M, Rapp E, Schlüter A, Sczyrba A, Reichl U.

Biotechnol Biofuels. 2016 Jul 26;9:155. doi: 10.1186/s13068-016-0572-4. eCollection 2016.


Early changes in the metabolic profile of activated CD8(+) T cells.

Cammann C, Rath A, Reichl U, Lingel H, Brunner-Weinzierl M, Simeoni L, Schraven B, Lindquist JA.

BMC Cell Biol. 2016 Jul 7;17(1):28. doi: 10.1186/s12860-016-0104-x.


Reprint of "Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAs.

Laske T, Heldt FS, Hoffmann H, Frensing T, Reichl U.

Virus Res. 2016 Jun 15;218:86-95. doi: 10.1016/j.virusres.2016.05.009.


Influenza virus intracellular replication dynamics, release kinetics, and particle morphology during propagation in MDCK cells.

Frensing T, Kupke SY, Bachmann M, Fritzsche S, Gallo-Ramirez LE, Reichl U.

Appl Microbiol Biotechnol. 2016 Aug;100(16):7181-92. doi: 10.1007/s00253-016-7542-4. Epub 2016 Apr 29.


Binding kinetics and multi-bond: Finding correlations by synthesizing interactions between ligand-coated bionanoparticles and receptor surfaces.

Wang W, Voigt A, Wolff MW, Reichl U, Sundmacher K.

Anal Biochem. 2016 Jul 15;505:8-17. doi: 10.1016/j.ab.2016.04.002. Epub 2016 Apr 20.


Metaproteomics Applied to Activated Sludge for Industrial Wastewater Treatment Revealed a Dominant Methylotrophic Metabolism of Hyphomicrobium zavarzinii.

Salerno C, Benndorf D, Kluge S, Palese LL, Reichl U, Pollice A.

Microb Ecol. 2016 Jul;72(1):9-13. doi: 10.1007/s00248-016-0769-x. Epub 2016 Apr 18.


Towards personalized diagnostics via longitudinal study of the human plasma N-glycome.

Hennig R, Cajic S, Borowiak M, Hoffmann M, Kottler R, Reichl U, Rapp E.

Biochim Biophys Acta. 2016 Aug;1860(8):1728-38. doi: 10.1016/j.bbagen.2016.03.035. Epub 2016 Mar 31.


Sialic acid-specific affinity chromatography for the separation of erythropoietin glycoforms using serotonin as a ligand.

Meininger M, Stepath M, Hennig R, Cajic S, Rapp E, Rotering H, Wolff MW, Reichl U.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Feb 15;1012-1013:193-203. doi: 10.1016/j.jchromb.2016.01.005. Epub 2016 Jan 11.


Predicting compositions of microbial communities from stoichiometric models with applications for the biogas process.

Koch S, Benndorf D, Fronk K, Reichl U, Klamt S.

Biotechnol Biofuels. 2016 Jan 22;9:17. doi: 10.1186/s13068-016-0429-x. eCollection 2016.

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