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Items: 1 to 50 of 92


The Circulating Protease Persephone Is an Immune Sensor for Microbial Proteolytic Activities Upstream of the Drosophila Toll Pathway.

Issa N, Guillaumot N, Lauret E, Matt N, Schaeffer-Reiss C, Van Dorsselaer A, Reichhart JM, Veillard F.

Mol Cell. 2018 Feb 15;69(4):539-550.e6. doi: 10.1016/j.molcel.2018.01.029.


The SUMO-targeted ubiquitin ligase, Dgrn, is essential for Drosophila innate immunity.

Koltun B, Shackelford E, Bonnay F, Matt N, Reichhart JM, Orian A.

Int J Dev Biol. 2017;61(3-4-5):319-327. doi: 10.1387/ijdb.160250ao.


Advances in Myeloid-Like Cell Origins and Functions in the Model Organism Drosophila melanogaster.

El Chamy L, Matt N, Reichhart JM.

Microbiol Spectr. 2017 Jan;5(1). doi: 10.1128/microbiolspec.MCHD-0038-2016. Review.


The LBP/BPI multigenic family in invertebrates: Evolutionary history and evidences of specialization in mollusks.

Baron OL, Deleury E, Reichhart JM, Coustau C.

Dev Comp Immunol. 2016 Apr;57:20-30. doi: 10.1016/j.dci.2015.11.006. Epub 2015 Dec 1.


Drosophila melanogaster clip-domain serine proteases: Structure, function and regulation.

Veillard F, Troxler L, Reichhart JM.

Biochimie. 2016 Mar;122:255-69. doi: 10.1016/j.biochi.2015.10.007. Epub 2015 Oct 8. Review.


The multilayered innate immune defense of the gut.

El Chamy L, Matt N, Ntwasa M, Reichhart JM.

Biomed J. 2015 Jul-Aug;38(4):276-84. doi: 10.4103/2319-4170.158621. Review.


Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling.

Bonnay F, Nguyen XH, Cohen-Berros E, Troxler L, Batsche E, Camonis J, Takeuchi O, Reichhart JM, Matt N.

EMBO J. 2014 Oct 16;33(20):2349-62. doi: 10.15252/embj.201488456. Epub 2014 Sep 1.


Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complex.

Tartey S, Matsushita K, Vandenbon A, Ori D, Imamura T, Mino T, Standley DM, Hoffmann JA, Reichhart JM, Akira S, Takeuchi O.

EMBO J. 2014 Oct 16;33(20):2332-48. doi: 10.15252/embj.201488447. Epub 2014 Aug 8.


Parental transfer of the antimicrobial protein LBP/BPI protects Biomphalaria glabrata eggs against oomycete infections.

Baron OL, van West P, Industri B, Ponchet M, Dubreuil G, Gourbal B, Reichhart JM, Coustau C.

PLoS Pathog. 2013;9(12):e1003792. doi: 10.1371/journal.ppat.1003792. Epub 2013 Dec 19.


The Shigella OspC3 effector inhibits caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection.

Kobayashi T, Ogawa M, Sanada T, Mimuro H, Kim M, Ashida H, Akakura R, Yoshida M, Kawalec M, Reichhart JM, Mizushima T, Sasakawa C.

Cell Host Microbe. 2013 May 15;13(5):570-583. doi: 10.1016/j.chom.2013.04.012.


big bang gene modulates gut immune tolerance in Drosophila.

Bonnay F, Cohen-Berros E, Hoffmann M, Kim SY, Boulianne GL, Hoffmann JA, Matt N, Reichhart JM.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2957-62. doi: 10.1073/pnas.1221910110. Epub 2013 Feb 1.


Lawrence's book review unfair to Hoffmann.

Ezekowitz A, Dimarcq JL, Kafatos F, Levashina E, Ferrandon D, Hetru C, Imler JL, Reichhart JM.

Curr Biol. 2012 Jun 19;22(12):R482. doi: 10.1016/j.cub.2012.05.015. No abstract available.


Specific versus non-specific immune responses in an invertebrate species evidenced by a comparative de novo sequencing study.

Deleury E, Dubreuil G, Elangovan N, Wajnberg E, Reichhart JM, Gourbal B, Duval D, Baron OL, Gouzy J, Coustau C.

PLoS One. 2012;7(3):e32512. doi: 10.1371/journal.pone.0032512. Epub 2012 Mar 12.


Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway.

Boyer L, Magoc L, Dejardin S, Cappillino M, Paquette N, Hinault C, Charriere GM, Ip WK, Fracchia S, Hennessy E, Erturk-Hasdemir D, Reichhart JM, Silverman N, Lacy-Hulbert A, Stuart LM.

Immunity. 2011 Oct 28;35(4):536-49. doi: 10.1016/j.immuni.2011.08.015. Epub 2011 Oct 20.


The Drosophila serpins: multiple functions in immunity and morphogenesis.

Reichhart JM, Gubb D, Leclerc V.

Methods Enzymol. 2011;499:205-25. doi: 10.1016/B978-0-12-386471-0.00011-0.


A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens.

Ogawa M, Yoshikawa Y, Kobayashi T, Mimuro H, Fukumatsu M, Kiga K, Piao Z, Ashida H, Yoshida M, Kakuta S, Koyama T, Goto Y, Nagatake T, Nagai S, Kiyono H, Kawalec M, Reichhart JM, Sasakawa C.

Cell Host Microbe. 2011 May 19;9(5):376-89. doi: 10.1016/j.chom.2011.04.010.


Structure-function analysis of grass clip serine protease involved in Drosophila Toll pathway activation.

Kellenberger C, Leone P, Coquet L, Jouenne T, Reichhart JM, Roussel A.

J Biol Chem. 2011 Apr 8;286(14):12300-7. doi: 10.1074/jbc.M110.182741. Epub 2011 Feb 10.


Involvement of the cytokine MIF in the snail host immune response to the parasite Schistosoma mansoni.

Baeza Garcia A, Pierce RJ, Gourbal B, Werkmeister E, Colinet D, Reichhart JM, Dissous C, Coustau C.

PLoS Pathog. 2010 Sep 23;6(9):e1001115. doi: 10.1371/journal.ppat.1001115.


Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems.

Silverman GA, Whisstock JC, Bottomley SP, Huntington JA, Kaiserman D, Luke CJ, Pak SC, Reichhart JM, Bird PI.

J Biol Chem. 2010 Aug 6;285(32):24299-305. doi: 10.1074/jbc.R110.112771. Epub 2010 May 24. Review. Erratum in: J Biol Chem. 2010 Dec 3;285(49):38740.


Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions.

Whisstock JC, Silverman GA, Bird PI, Bottomley SP, Kaiserman D, Luke CJ, Pak SC, Reichhart JM, Huntington JA.

J Biol Chem. 2010 Aug 6;285(32):24307-12. doi: 10.1074/jbc.R110.141408. Epub 2010 May 24. Review.


Caspase-mediated cleavage, IAP binding, and ubiquitination: linking three mechanisms crucial for Drosophila NF-kappaB signaling.

Paquette N, Broemer M, Aggarwal K, Chen L, Husson M, Ertürk-Hasdemir D, Reichhart JM, Meier P, Silverman N.

Mol Cell. 2010 Jan 29;37(2):172-82. doi: 10.1016/j.molcel.2009.12.036.


Toll-dependent antimicrobial responses in Drosophila larval fat body require Spätzle secreted by haemocytes.

Shia AK, Glittenberg M, Thompson G, Weber AN, Reichhart JM, Ligoxygakis P.

J Cell Sci. 2009 Dec 15;122(Pt 24):4505-15. doi: 10.1242/jcs.049155. Epub 2009 Nov 24.


Sensing of 'danger signals' and pathogen-associated molecular patterns defines binary signaling pathways 'upstream' of Toll.

El Chamy L, Leclerc V, Caldelari I, Reichhart JM.

Nat Immunol. 2008 Oct;9(10):1165-70. doi: 10.1038/ni.1643. Epub 2008 Aug 24.


Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice.

Goto A, Matsushita K, Gesellchen V, El Chamy L, Kuttenkeuler D, Takeuchi O, Hoffmann JA, Akira S, Boutros M, Reichhart JM.

Nat Immunol. 2008 Jan;9(1):97-104. Epub 2007 Dec 9. Erratum in: Nat Immunol. 2008 Feb;9(2):216.


Dual detection of fungal infections in Drosophila via recognition of glucans and sensing of virulence factors.

Gottar M, Gobert V, Matskevich AA, Reichhart JM, Wang C, Butt TM, Belvin M, Hoffmann JA, Ferrandon D.

Cell. 2006 Dec 29;127(7):1425-37.


Immune challenge induces N-terminal cleavage of the Drosophila serpin Necrotic.

Pelte N, Robertson AS, Zou Z, Belorgey D, Dafforn TR, Jiang H, Lomas D, Reichhart JM, Gubb D.

Insect Biochem Mol Biol. 2006 Jan;36(1):37-46. Epub 2005 Nov 8.


Prophenoloxidase activation is not required for survival to microbial infections in Drosophila.

Leclerc V, Pelte N, El Chamy L, Martinelli C, Ligoxygakis P, Hoffmann JA, Reichhart JM.

EMBO Rep. 2006 Feb;7(2):231-5.


Tip of another iceberg: Drosophila serpins.

Reichhart JM.

Trends Cell Biol. 2005 Dec;15(12):659-65. Epub 2005 Nov 2. Review.


Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila.

Kocks C, Cho JH, Nehme N, Ulvila J, Pearson AM, Meister M, Strom C, Conto SL, Hetru C, Stuart LM, Stehle T, Hoffmann JA, Reichhart JM, Ferrandon D, Rämet M, Ezekowitz RA.

Cell. 2005 Oct 21;123(2):335-46.


Evolution and integration of innate immune systems from fruit flies to man: lessons and questions.

Martinelli C, Reichhart JM.

J Endotoxin Res. 2005;11(4):243-8. Review.


Sensing and signaling during infection in Drosophila.

Royet J, Reichhart JM, Hoffmann JA.

Curr Opin Immunol. 2005 Feb;17(1):11-7. Review.


Toll-dependent and Toll-independent immune responses in Drosophila.

Imler JL, Ferrandon D, Royet J, Reichhart JM, Hetru C, Hoffmann JA.

J Endotoxin Res. 2004;10(4):241-6. Review.


The immune response of Drosophila melanogaster.

Leclerc V, Reichhart JM.

Immunol Rev. 2004 Apr;198:59-71. Review.


Cg-Rel, the first Rel/NF-kappaB homolog characterized in a mollusk, the Pacific oyster Crassostrea gigas.

Montagnani C, Kappler C, Reichhart JM, Escoubas JM.

FEBS Lett. 2004 Mar 12;561(1-3):75-82.


A serpin regulates dorsal-ventral axis formation in the Drosophila embryo.

Ligoxygakis P, Roth S, Reichhart JM.

Curr Biol. 2003 Dec 2;13(23):2097-102.


TLR5 takes aim at bacterial propeller.

Reichhart JM.

Nat Immunol. 2003 Dec;4(12):1159-60. No abstract available.


Detection of peptidoglycans by NOD proteins.

Royet J, Reichhart JM.

Trends Cell Biol. 2003 Dec;13(12):610-4. Review.


Silencing of Toll pathway components by direct injection of double-stranded RNA into Drosophila adult flies.

Goto A, Blandin S, Royet J, Reichhart JM, Levashina EA.

Nucleic Acids Res. 2003 Nov 15;31(22):6619-23.


Drosophila necrotic mutations mirror disease-associated variants of human serpins.

Green C, Brown G, Dafforn TR, Reichhart JM, Morley T, Lomas DA, Gubb D.

Development. 2003 Apr;130(7):1473-8.


A serpin mutant links Toll activation to melanization in the host defence of Drosophila.

Ligoxygakis P, Pelte N, Ji C, Leclerc V, Duvic B, Belvin M, Jiang H, Hoffmann JA, Reichhart JM.

EMBO J. 2002 Dec 2;21(23):6330-7.


The Drosophila immune defense against gram-negative infection requires the death protein dFADD.

Naitza S, Rossé C, Kappler C, Georgel P, Belvin M, Gubb D, Camonis J, Hoffmann JA, Reichhart JM.

Immunity. 2002 Nov;17(5):575-81.


Immunity-related genes and gene families in Anopheles gambiae.

Christophides GK, Zdobnov E, Barillas-Mury C, Birney E, Blandin S, Blass C, Brey PT, Collins FH, Danielli A, Dimopoulos G, Hetru C, Hoa NT, Hoffmann JA, Kanzok SM, Letunic I, Levashina EA, Loukeris TG, Lycett G, Meister S, Michel K, Moita LF, Müller HM, Osta MA, Paskewitz SM, Reichhart JM, Rzhetsky A, Troxler L, Vernick KD, Vlachou D, Volz J, von Mering C, Xu J, Zheng L, Bork P, Kafatos FC.

Science. 2002 Oct 4;298(5591):159-65.


Splice-activated UAS hairpin vector gives complete RNAi knockout of single or double target transcripts in Drosophila melanogaster.

Reichhart JM, Ligoxygakis P, Naitza S, Woerfel G, Imler JL, Gubb D.

Genesis. 2002 Sep-Oct;34(1-2):160-4. No abstract available.


Activation of Drosophila Toll during fungal infection by a blood serine protease.

Ligoxygakis P, Pelte N, Hoffmann JA, Reichhart JM.

Science. 2002 Jul 5;297(5578):114-6.


Drosophila innate immunity: an evolutionary perspective.

Hoffmann JA, Reichhart JM.

Nat Immunol. 2002 Feb;3(2):121-6. Review.


Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein.

Michel T, Reichhart JM, Hoffmann JA, Royet J.

Nature. 2001 Dec 13;414(6865):756-9.


A genome-wide analysis of immune responses in Drosophila.

Irving P, Troxler L, Heuer TS, Belvin M, Kopczynski C, Reichhart JM, Hoffmann JA, Hetru C.

Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15119-24. Epub 2001 Dec 11.

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