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De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans.

Deuse T, Hu X, Agbor-Enoh S, Koch M, Spitzer MH, Gravina A, Alawi M, Marishta A, Peters B, Kosaloglu-Yalcin Z, Yang Y, Rajalingam R, Wang D, Nashan B, Kiefmann R, Reichenspurner H, Valantine H, Weissman IL, Schrepfer S.

Nat Biotechnol. 2019 Aug 19. doi: 10.1038/s41587-019-0227-7. [Epub ahead of print]


The Bridge Occlusion Balloon for Venous Angioplasty in Superior Vena Cava Occlusion.

Pecha S, Burger H, Castro L, Gosau N, Atlihan G, Willems S, Reichenspurner H, Hakmi S.

Braz J Cardiovasc Surg. 2019 Jun 1;34(3):368-371. doi: 10.21470/1678-9741-2018-0289.


Persistence of Reduced Left Ventricular Function after Aortic Valve Surgery for Aortic Valve Regurgitation: Bicuspid versus Tricuspid.

Petersen J, Neumann N, Naito S, Sequeira Gross T, Massel R, Reichenspurner H, Girdauskas E.

Thorac Cardiovasc Surg. 2019 Jul 12. doi: 10.1055/s-0039-1692664. [Epub ahead of print]


Human iPS cell-derived engineered heart tissue does not affect ventricular arrhythmias in a guinea pig cryo-injury model.

Pecha S, Yorgan K, Röhl M, Geertz B, Hansen A, Weinberger F, Sehner S, Ehmke H, Reichenspurner H, Eschenhagen T, Schwoerer AP.

Sci Rep. 2019 Jul 8;9(1):9831. doi: 10.1038/s41598-019-46409-z.


Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies.

Irmscher S, Brix SR, Zipfel SLH, Halder LD, Mutlutürk S, Wulf S, Girdauskas E, Reichenspurner H, Stahl RAK, Jungnickel B, Wiech T, Zipfel PF, Skerka C.

Nat Commun. 2019 Jul 4;10(1):2961. doi: 10.1038/s41467-019-10766-0.


Standardized subannular repair improves outcomes in type IIIB Functional Mitral Regurgitation.

Harmel E, Pausch J, Gross T, Petersen J, Sinning C, Kubitz J, Reichenspurner H, Girdauskas E.

Ann Thorac Surg. 2019 Jun 26. pii: S0003-4975(19)30890-2. doi: 10.1016/j.athoracsur.2019.04.120. [Epub ahead of print]


Increased admission central venous-arterial CO2 difference predicts ICU-mortality in adult cardiac surgery patients.

Zante B, Reichenspurner H, Kubik M, Schefold JC, Kluge S.

Heart Lung. 2019 Sep - Oct;48(5):421-427. doi: 10.1016/j.hrtlng.2019.05.015. Epub 2019 Jun 12.


Corrigendum to 'Simplified frozen elephant trunk technique for combined open and endovascular treatment of extensive aortic diseases' [Eur J Cardiothoracic Surg 2019; doi:10.1093/ejcts/ezz082].

Detter C, Demal TJ, Bax L, Tsilimparis N, Kölbel T, von Kodolitsch Y, Vettorazzi E, Reichenspurner H, Brickwedel J.

Eur J Cardiothorac Surg. 2019 Jun 1. pii: ezz181. doi: 10.1093/ejcts/ezz181. [Epub ahead of print] No abstract available.


Endovascular Repair of Ascending Aortic Pathologies With Tubular Endografts: A Single-Center Experience.

Tsilimparis N, Drewitz S, Detter C, Spanos K, von Kodolitsch Y, Rohlffs F, Reichenspurner H, Debus ES, Kölbel T.

J Endovasc Ther. 2019 Aug;26(4):439-445. doi: 10.1177/1526602819852083. Epub 2019 May 29.


Minimally invasive mitral valve repair for functional mitral regurgitation.

Girdauskas E, Pausch J, Harmel E, Gross T, Detter C, Sinning C, Kubitz J, Reichenspurner H.

Eur J Cardiothorac Surg. 2019 Jun 1;55(Supplement_1):i17-i25. doi: 10.1093/ejcts/ezy344.


The treatment of heart failure: an ideal challenge for the heart team.

Reichenspurner H.

Eur J Cardiothorac Surg. 2019 Jun 1;55(Supplement_1):i1-i2. doi: 10.1093/ejcts/ezy419. No abstract available.


Impella 5.0 therapy as a bridge-to-decision option for patients on extracorporeal life support with unclear neurological outcomes†.

Bernhardt AM, Zipfel S, Reiter B, Hakmi S, Castro L, Söffker G, Kluge S, Lubos E, Rybczinski M, Grahn H, Schrage B, Becher PM, Barten MJ, Westermann D, Blankenberg S, Reichenspurner H.

Eur J Cardiothorac Surg. 2019 Apr 30. pii: ezz118. doi: 10.1093/ejcts/ezz118. [Epub ahead of print]


Autologous Tissue Technique to Repair Unilateral Isolated Absence of a Pulmonary Artery.

von Stumm M, Biermann D, Reichenspurner H, Gottschalk U, Müller G, Kozlik-Feldmann R, Riso A, Sachweh JS.

World J Pediatr Congenit Heart Surg. 2019 Apr 24:2150135119825588. doi: 10.1177/2150135119825588. [Epub ahead of print]


Sex differences in preformed panel-reactive antibody levels and outcomes in patients undergoing heart transplantation.

Magnussen C, Ruebsamen N, Ojeda FM, Rybczynski M, Kobashigawa J, Reichenspurner H, Bernhardt AM, Schnabel RB.

Clin Transplant. 2019 Jun;33(6):e13572. doi: 10.1111/ctr.13572. Epub 2019 May 12.


Standardized subannular repair for type IIIb functional mitral regurgitation in a minimally invasive mitral valve surgery setting.

Pausch J, Harmel E, Sinning C, Reichenspurner H, Girdauskas E.

Eur J Cardiothorac Surg. 2019 Apr 21. pii: ezz114. doi: 10.1093/ejcts/ezz114. [Epub ahead of print]


Can We Predict Failure of Mitral Valve Repair?

Gasser S, von Stumm M, Sinning C, Schaefer U, Reichenspurner H, Girdauskas E.

J Clin Med. 2019 Apr 17;8(4). pii: E526. doi: 10.3390/jcm8040526.


The heterotopic heart transplantation in mice as a small animal model to study mechanical unloading - Establishment of the procedure, perioperative management and postoperative scoring.

Westhofen S, Jelinek M, Dreher L, Biermann D, Martin J, Vitzhum H, Reichenspurner H, Ehmke H, Schwoerer AP.

PLoS One. 2019 Apr 12;14(4):e0214513. doi: 10.1371/journal.pone.0214513. eCollection 2019.


Simplified frozen elephant trunk technique for combined open and endovascular treatment of extensive aortic diseases.

Detter C, Demal TJ, Bax L, Tsilimparis N, Koelbel T, von Kodolitsch Y, Vettorazzi E, Reichenspurner H, Brickwedel J.

Eur J Cardiothorac Surg. 2019 Apr 8. pii: ezz082. doi: 10.1093/ejcts/ezz082. [Epub ahead of print]


Analysis of fibrosis in control or pressure overloaded rat hearts after mechanical unloading by heterotopic heart transplantation.

Schaefer A, Schneeberger Y, Schulz S, Krasemann S, Werner T, Piasecki A, Höppner G, Müller C, Morhenn K, Lorenz K, Wieczorek D, Schwoerer AP, Eschenhagen T, Ehmke H, Reichenspurner H, Stenzig J, Cuello F.

Sci Rep. 2019 Apr 5;9(1):5710. doi: 10.1038/s41598-019-42263-1.


1-Year Outcomes of the CENTERA-EU Trial Assessing a Novel Self-Expanding Transcatheter Heart Valve.

Tchétché D, Windecker S, Kasel AM, Schaefer U, Worthley S, Linke A, Abdel-Wahab M, Le Breton H, Søndergaard L, Spence MS, Petronio S, Baumgartner H, Hovorka T, Blanke P, Reichenspurner H.

JACC Cardiovasc Interv. 2019 Apr 8;12(7):673-680. doi: 10.1016/j.jcin.2019.01.231.


Implantation of hiPSC-derived Cardiac-muscle Patches after Myocardial Injury in a Guinea Pig Model.

Castro L, Geertz B, Reinsch M, Aksehirlioglu B, Hansen A, Eschenhagen T, Reichenspurner H, Weinberger F, Pecha S.

J Vis Exp. 2019 Mar 18;(145). doi: 10.3791/58810.


A familial congenital heart disease with a possible multigenic origin involving a mutation in BMPR1A.

Demal TJ, Heise M, Reiz B, Dogra D, Brænne I, Reichenspurner H, Männer J, Aherrahrou Z, Schunkert H, Erdmann J, Abdelilah-Seyfried S.

Sci Rep. 2019 Feb 27;9(1):2959. doi: 10.1038/s41598-019-39648-7.


Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients.

Deuse T, Hu X, Gravina A, Wang D, Tediashvili G, De C, Thayer WO, Wahl A, Garcia JV, Reichenspurner H, Davis MM, Lanier LL, Schrepfer S.

Nat Biotechnol. 2019 Mar;37(3):252-258. doi: 10.1038/s41587-019-0016-3. Epub 2019 Feb 18.


Aortic valve repair in adult congenital heart disease.

Girdauskas E, Petersen J, Sachweh J, Kozlik-Feldmann R, Sinning C, Rickers C, von Kodolitsch Y, Reichenspurner H.

Cardiovasc Diagn Ther. 2018 Dec;8(6):789-798. doi: 10.21037/cdt.2018.11.01. Review.


The DEDICATE Trial: An independent all-comers trial of transcatheter aortic valve implantation vs. surgical aortic valve replacement in patients at low to intermediate operative risk is recruiting patients.

Seiffert M, Walther T, Hamm C, Falk V, Frey N, Thiele H, Hagl C, Landmesser U, Borger M, Massberg S, Reichenspurner H, Baumgartner H, Blankenberg S, Cremer J.

Eur Heart J. 2019 Jan 21;40(4):331-333. doi: 10.1093/eurheartj/ehy851. No abstract available.


Neuron-specific-enolase as a predictor of the neurologic outcome after cardiopulmonary resuscitation in patients on ECMO.

Schrage B, Rübsamen N, Becher PM, Roedl K, Söffker G, Schwarzl M, Dreher A, Schewel J, Ghanem A, Grahn H, Lubos E, Bernhardt A, Kluge S, Reichenspurner H, Blankenberg S, Spangenberg T, Westermann D.

Resuscitation. 2019 Mar;136:14-20. doi: 10.1016/j.resuscitation.2019.01.011. Epub 2019 Jan 14.


Venoarterial Extracorporeal Membrane Oxygenation for Cardiopulmonary Support.

Becher PM, Schrage B, Sinning CR, Schmack B, Fluschnik N, Schwarzl M, Waldeyer C, Lindner D, Seiffert M, Neumann JT, Bernhardt AM, Zeymer U, Thiele H, Reichenspurner H, Blankenberg S, Twerenbold R, Westermann D.

Circulation. 2018 Nov 13;138(20):2298-2300. doi: 10.1161/CIRCULATIONAHA.118.036691. No abstract available.


Transaxillary transcatheter aortic valve implantation utilizing a novel vascular closure device with resorbable collagen material: a feasibility study.

Schaefer A, Schirmer J, Schofer N, Schneeberger Y, Deuschl F, Blankenberg S, Reichenspurner H, Conradi L, Schäfer U.

Clin Res Cardiol. 2019 Jul;108(7):779-786. doi: 10.1007/s00392-018-1407-z. Epub 2018 Dec 17.


Unloading of the Left Ventricle During Venoarterial Extracorporeal Membrane Oxygenation Therapy in Cardiogenic Shock.

Schrage B, Burkhoff D, Rübsamen N, Becher PM, Schwarzl M, Bernhardt A, Grahn H, Lubos E, Söffker G, Clemmensen P, Reichenspurner H, Blankenberg S, Westermann D.

JACC Heart Fail. 2018 Dec;6(12):1035-1043. doi: 10.1016/j.jchf.2018.09.009.


Hemadsorption during cardiopulmonary bypass reduces interleukin 8 and tumor necrosis factor α serum levels in cardiac surgery: a randomized controlled trial.

Garau I, März A, Sehner S, Reuter DA, Reichenspurner H, Zöllner C, Kubitz JC.

Minerva Anestesiol. 2019 Jul;85(7):715-723. doi: 10.23736/S0375-9393.18.12898-7. Epub 2018 Nov 22.


Head-to-head comparison of two continuous glucose monitoring systems on a cardio-surgical ICU.

Punke MA, Decker C, Petzoldt M, Reuter DA, Wodack KH, Reichenspurner H, Kubik M, Kluge S.

J Clin Monit Comput. 2019 Oct;33(5):895-901. doi: 10.1007/s10877-018-0221-5. Epub 2018 Nov 12.


Prosthesis-patient mismatch after transcatheter aortic valve implantation: prevalence and prognostic impact with respect to baseline left ventricular function.

Schofer N, Deuschl F, Rübsamen N, Skibowski J, Seiffert M, Voigtländer L, Schaefer A, Schneeberger Y, Schirmer J, Reichenspurner H, Blankenberg S, Conradi L, Schäfer U.

EuroIntervention. 2019 Mar 20;14(16):1648-1655. doi: 10.4244/EIJ-D-18-00827.


Atrial-like Engineered Heart Tissue: An In Vitro Model of the Human Atrium.

Lemme M, Ulmer BM, Lemoine MD, Zech ATL, Flenner F, Ravens U, Reichenspurner H, Rol-Garcia M, Smith G, Hansen A, Christ T, Eschenhagen T.

Stem Cell Reports. 2018 Dec 11;11(6):1378-1390. doi: 10.1016/j.stemcr.2018.10.008. Epub 2018 Nov 8.


A newly developed transaortic axial flow ventricular assist device: Early clinical experience.

Bernhardt AM, Hakmi S, Sinning C, Lubos E, Reichenspurner H.

J Heart Lung Transplant. 2019 Apr;38(4):466-467. doi: 10.1016/j.healun.2018.09.022. Epub 2018 Oct 2. No abstract available.


Transcatheter aortic valve implantation utilizing a non-occlusive balloon for predilatation.

Schneeberger Y, Schaefer A, Schofer N, Silaschi M, Deuschl F, Blankenberg S, Reichenspurner H, Treede H, Schäfer U, Charitos EI, Conradi L.

Int J Cardiol. 2019 Jan 15;275:65-69. doi: 10.1016/j.ijcard.2018.10.059. Epub 2018 Oct 18.


Normalization of force to muscle cross-sectional area: A helpful attempt to reduce data scattering in contractility studies?

Pecha S, Koivumäki J, Geelhoed B, Kempe R, Berk E, Engel A, Reichenspurner H, Eschenhagen T, Ravens U, Kaumann A, Christ T.

Acta Physiol (Oxf). 2018 Dec;224(4):e13202. doi: 10.1111/apha.13202. No abstract available.


Base excess is superior to lactate-levels in prediction of ICU mortality after cardiac surgery.

Zante B, Reichenspurner H, Kubik M, Kluge S, Schefold JC, Pfortmueller CA.

PLoS One. 2018 Oct 5;13(10):e0205309. doi: 10.1371/journal.pone.0205309. eCollection 2018.


Insights from eight years of adoption experience of transcatheter mitral valve repair in Germany: observed utilisation patterns and impact on overall mitral valve procedure volumes.

Schaefer A, Lubos E, Pietzsch JB, Pietzsch M, Weber S, Blankenberg S, Reichenspurner H, Schäfer U, Conradi L.

EuroIntervention. 2018 Oct 12;14(9):e981-e987. doi: 10.4244/EIJ-D-18-00403.


Normalization of Transvalvular Flow Patterns After Bicuspid Aortic Valve Repair: Insights From Four-Dimensional Flow Cardiovascular Magnetic Resonance Imaging.

Bannas P, Lenz A, Petersen J, Sinn M, Adam G, Reichenspurner H, Girdauskas E.

Ann Thorac Surg. 2018 Dec;106(6):e319-e320. doi: 10.1016/j.athoracsur.2018.06.040. Epub 2018 Aug 1. No abstract available.


MiR-145 expression and rare NOTCH1 variants in bicuspid aortic valve-associated aortopathy.

Girdauskas E, Petersen J, Neumann N, Ungelenk M, Kurth I, Reichenspurner H, Zeller T.

PLoS One. 2018 Jul 30;13(7):e0200205. doi: 10.1371/journal.pone.0200205. eCollection 2018.


Novel Approaches for BAV Aortopathy Prediction-Is There a Need for Cohort Studies and Biomarkers?

Girdauskas E, Petersen J, Neumann N, Naito S, Gross T, Jagodzinski A, Reichenspurner H, Zeller T.

Biomolecules. 2018 Jul 19;8(3). pii: E58. doi: 10.3390/biom8030058. Review.


Left coronary artery anomaly in a patient with severe aortic regurgitation and subvalvular membrane.

Petersen J, Lenz A, Bannas P, Reichenspurner H, Girdauskas E.

J Card Surg. 2018 Sep;33(9):548-549. doi: 10.1111/jocs.13768. Epub 2018 Jul 11. No abstract available.


Does statin therapy impact the proximal aortopathy in aortic valve disease?

Sequeira Gross T, Naito S, Neumann N, Petersen J, Kuntze T, Reichenspurner H, von Kodolitsch Y, Girdauskas E.

QJM. 2018 Sep 1;111(9):623-628. doi: 10.1093/qjmed/hcy129.


Heart re-transplantation in Eurotransplant.

Smits JM, De Pauw M, Schulz U, Van Cleemput J, Raake P, Knezevic I, Caliskan K, Sutlic Z, Knosalla C, Schoenrath F, Szabolcs Z, Gottlieb J, Hagl C, Doesch A, Baric D, Rudez I, Strelniece A, De Vries E, Green D, Samuel U, Milicic D, Hartyanszky I, Berchtold-Herz M, Schulze PC, Mohr F, Meiser B, Haverich A, Reichenspurner H, Gummert J, Laufer G, Zuckermann A.

Transpl Int. 2018 Nov;31(11):1223-1232. doi: 10.1111/tri.13289. Epub 2018 Jul 16.


Analysis of Minimally Invasive Left Thoracotomy HVAD Implantation - A Single-Center Experience.

Reichart D, Brand CF, Bernhardt AM, Schmidt S, Schaefer A, Blankenberg S, Reichenspurner H, Wagner FM, Deuse T, Barten MJ.

Thorac Cardiovasc Surg. 2019 Apr;67(3):170-175. doi: 10.1055/s-0038-1649493. Epub 2018 May 27.


Pharmacological inhibition of DNA methylation attenuates pressure overload-induced cardiac hypertrophy in rats.

Stenzig J, Schneeberger Y, Löser A, Peters BS, Schaefer A, Zhao RR, Ng SL, Höppner G, Geertz B, Hirt MN, Tan W, Wong E, Reichenspurner H, Foo RS, Eschenhagen T.

J Mol Cell Cardiol. 2018 Jul;120:53-63. doi: 10.1016/j.yjmcc.2018.05.012. Epub 2018 May 21.


Computed tomography-based oversizing and incidence of paravalvular aortic regurgitation and permanent pacemaker implantation with a new-generation self-expanding transcatheter heart valve.

Kim U, Blanke P, Windecker S, Kasel AM, Schäfer U, Walters D, Linke A, Le Breton H, Schymik G, Spence MS, Søndergaard L, Abdel-Wahab M, Worthley S, Tchétché D, Reichenspurner H, Ohana M, Sellers SL, Leipsic JA.

EuroIntervention. 2018 Aug 3;14(5):e511-e518. doi: 10.4244/EIJ-D-17-01040.


Outcomes with a latest generation self-expandable, intra-annular, re-sheathable transcatheter heart valve system: analysis of patients with impaired left ventricular function and determinants for pacemaker implantation.

Schaefer A, Neumann N, Linder M, Schofer N, Schneeberger Y, Deuschl F, Schoen G, Blankenberg S, Reichenspurner H, Conradi L, Schäfer U.

Clin Res Cardiol. 2018 Oct;107(10):914-923. doi: 10.1007/s00392-018-1263-x. Epub 2018 Apr 28.


Differences in laser lead extraction of infected vs. non-infected leads.

Pecha S, Castro L, Vogler J, Linder M, Gosau N, Willems S, Reichenspurner H, Hakmi S.

Heart Vessels. 2018 Oct;33(10):1245-1250. doi: 10.1007/s00380-018-1162-0. Epub 2018 Apr 5.


Navigation of lead extraction-is it possible? Impact of preprocedural electrocardiogram-triggered computed tomography on navigation of lead extraction.

Vogler J, Pecha S, Azarrafiy R, Castro L, Deuschl F, Spink C, Linder M, von Hehn U, Willems S, Reichenspurner H, Gosau N, Hakmi S.

Eur J Cardiothorac Surg. 2018 Oct 1;54(4):745-751. doi: 10.1093/ejcts/ezy106.


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