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Items: 48


Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer's disease model.

Reichenbach N, Delekate A, Plescher M, Schmitt F, Krauss S, Blank N, Halle A, Petzold GC.

EMBO Mol Med. 2019 Jan 7. pii: e9665. doi: 10.15252/emmm.201809665. [Epub ahead of print]


P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer's disease model.

Reichenbach N, Delekate A, Breithausen B, Keppler K, Poll S, Schulte T, Peter J, Plescher M, Hansen JN, Blank N, Keller A, Fuhrmann M, Henneberger C, Halle A, Petzold GC.

J Exp Med. 2018 Jun 4;215(6):1649-1663. doi: 10.1084/jem.20171487. Epub 2018 May 3.


Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation.

Rom S, Zuluaga-Ramirez V, Reichenbach NL, Erickson MA, Winfield M, Gajghate S, Christofidou-Solomidou M, Jordan-Sciutto KL, Persidsky Y.

J Neuroinflammation. 2018 Jan 27;15(1):25. doi: 10.1186/s12974-018-1065-0.


Characterization of human fetal brain endothelial cells reveals barrier properties suitable for in vitro modeling of the BBB with syngenic co-cultures.

Andrews AM, Lutton EM, Cannella LA, Reichenbach N, Razmpour R, Seasock MJ, Kaspin SJ, Merkel SF, Langford D, Persidsky Y, Ramirez SH.

J Cereb Blood Flow Metab. 2018 May;38(5):888-903. doi: 10.1177/0271678X17708690. Epub 2017 May 23.


PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier.

Rom S, Zuluaga-Ramirez V, Reichenbach NL, Dykstra H, Gajghate S, Pacher P, Persidsky Y.

J Neuroinflammation. 2016 Sep 27;13(1):254.


Dysfunction of brain pericytes in chronic neuroinflammation.

Persidsky Y, Hill J, Zhang M, Dykstra H, Winfield M, Reichenbach NL, Potula R, Mukherjee A, Ramirez SH, Rom S.

J Cereb Blood Flow Metab. 2016 Apr;36(4):794-807. doi: 10.1177/0271678X15606149. Epub 2015 Sep 30.


The dual action of poly(ADP-ribose) polymerase -1 (PARP-1) inhibition in HIV-1 infection: HIV-1 LTR inhibition and diminution in Rho GTPase activity.

Rom S, Reichenbach NL, Dykstra H, Persidsky Y.

Front Microbiol. 2015 Aug 25;6:878. doi: 10.3389/fmicb.2015.00878. eCollection 2015.


miR-98 and let-7g* protect the blood-brain barrier under neuroinflammatory conditions.

Rom S, Dykstra H, Zuluaga-Ramirez V, Reichenbach NL, Persidsky Y.

J Cereb Blood Flow Metab. 2015 Dec;35(12):1957-65. doi: 10.1038/jcbfm.2015.154. Epub 2015 Jul 1.


Differential effects of dopamine signalling on long-term memory formation and consolidation in rodent brain.

Reichenbach N, Herrmann U, Kähne T, Schicknick H, Pielot R, Naumann M, Dieterich DC, Gundelfinger ED, Smalla KH, Tischmeyer W.

Proteome Sci. 2015 Mar 18;13:13. doi: 10.1186/s12953-015-0069-2. eCollection 2015.


Activation of Cannabinoid Type Two Receptors (CB2) Diminish Inflammatory Responses in Macrophages and Brain Endothelium.

Persidsky Y, Fan S, Dykstra H, Reichenbach NL, Rom S, Ramirez SH.

J Neuroimmune Pharmacol. 2015 Jun;10(2):302-8. doi: 10.1007/s11481-015-9591-3. Epub 2015 Feb 11.


Heroin use promotes HCV infection and dysregulates HCV-related circulating microRNAs.

Zhou Y, Sun L, Wang X, Zhou L, Li J, Liu M, Wang F, Peng J, Gui X, Zhao H, Reichenbach N, Zhou D, Ho WZ.

J Neuroimmune Pharmacol. 2015 Mar;10(1):102-10. doi: 10.1007/s11481-014-9577-6. Epub 2015 Jan 9.


Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood-brain barrier under physiologic and neuroinflammatory conditions.

Rom S, Zuluaga-Ramirez V, Dykstra H, Reichenbach NL, Ramirez SH, Persidsky Y.

J Cereb Blood Flow Metab. 2015 Jan;35(1):28-36. doi: 10.1038/jcbfm.2014.167. Epub 2014 Sep 24.


Selective activation of cannabinoid receptor 2 in leukocytes suppresses their engagement of the brain endothelium and protects the blood-brain barrier.

Rom S, Zuluaga-Ramirez V, Dykstra H, Reichenbach NL, Pacher P, Persidsky Y.

Am J Pathol. 2013 Nov;183(5):1548-1558. doi: 10.1016/j.ajpath.2013.07.033. Epub 2013 Sep 18.


α-Synuclein: the long distance runner.

George S, Rey NL, Reichenbach N, Steiner JA, Brundin P.

Brain Pathol. 2013 May;23(3):350-7. doi: 10.1111/bpa.12046. Review.


Attenuation of HIV-1 replication in macrophages by cannabinoid receptor 2 agonists.

Ramirez SH, Reichenbach NL, Fan S, Rom S, Merkel SF, Wang X, Ho WZ, Persidsky Y.

J Leukoc Biol. 2013 May;93(5):801-10. doi: 10.1189/jlb.1012523. Epub 2013 Mar 5.


Inhibition of glycogen synthase kinase 3β promotes tight junction stability in brain endothelial cells by half-life extension of occludin and claudin-5.

Ramirez SH, Fan S, Dykstra H, Rom S, Mercer A, Reichenbach NL, Gofman L, Persidsky Y.

PLoS One. 2013;8(2):e55972. doi: 10.1371/journal.pone.0055972. Epub 2013 Feb 13.


Glycogen synthase kinase 3β inhibition prevents monocyte migration across brain endothelial cells via Rac1-GTPase suppression and down-regulation of active integrin conformation.

Rom S, Fan S, Reichenbach N, Dykstra H, Ramirez SH, Persidsky Y.

Am J Pathol. 2012 Oct;181(4):1414-25. doi: 10.1016/j.ajpath.2012.06.018. Epub 2012 Aug 3.


Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood-brain barrier dysfunction under inflammatory conditions.

Ramirez SH, Haskó J, Skuba A, Fan S, Dykstra H, McCormick R, Reichenbach N, Krizbai I, Mahadevan A, Zhang M, Tuma R, Son YJ, Persidsky Y.

J Neurosci. 2012 Mar 21;32(12):4004-16. doi: 10.1523/JNEUROSCI.4628-11.2012.


Dopamine modulates memory consolidation of discrimination learning in the auditory cortex.

Schicknick H, Reichenbach N, Smalla KH, Scheich H, Gundelfinger ED, Tischmeyer W.

Eur J Neurosci. 2012 Mar;35(5):763-74. doi: 10.1111/j.1460-9568.2012.07994.x. Epub 2012 Feb 17.


Dyad of CD40/CD40 ligand fosters neuroinflammation at the blood-brain barrier and is regulated via JNK signaling: implications for HIV-1 encephalitis.

Ramirez SH, Fan S, Dykstra H, Reichenbach N, Del Valle L, Potula R, Phipps RP, Maggirwar SB, Persidsky Y.

J Neurosci. 2010 Jul 14;30(28):9454-64. doi: 10.1523/JNEUROSCI.5796-09.2010.


Inhibition of glycogen synthase kinase 3beta (GSK3beta) decreases inflammatory responses in brain endothelial cells.

Ramirez SH, Fan S, Zhang M, Papugani A, Reichenbach N, Dykstra H, Mercer AJ, Tuma RF, Persidsky Y.

Am J Pathol. 2010 Feb;176(2):881-92. doi: 10.2353/ajpath.2010.090671. Epub 2010 Jan 7.


Methamphetamine disrupts blood-brain barrier function by induction of oxidative stress in brain endothelial cells.

Ramirez SH, Potula R, Fan S, Eidem T, Papugani A, Reichenbach N, Dykstra H, Weksler BB, Romero IA, Couraud PO, Persidsky Y.

J Cereb Blood Flow Metab. 2009 Dec;29(12):1933-45. doi: 10.1038/jcbfm.2009.112. Epub 2009 Aug 5.


Cordon-bleu is an actin nucleation factor and controls neuronal morphology.

Ahuja R, Pinyol R, Reichenbach N, Custer L, Klingensmith J, Kessels MM, Qualmann B.

Cell. 2007 Oct 19;131(2):337-50.


Inhibition of HIV type 1 replication in CD4+ and CD14+ cells purified from HIV type 1-infected individuals by the 2-5A agonist immunomodulator, 2-5A(N6B).

Dimitrova DI, Reichenbach NL, Yang X, Pfleiderer W, Charubala R, Gaughan JP, Suh B, Henderson EE, Suhadolnik RJ, Rogers TJ.

AIDS Res Hum Retroviruses. 2007 Jan;23(1):123-34.


Lentivirus-mediated transduction of PKR into CD34(+) hematopoietic stem cells inhibits HIV-1 replication in differentiated T cell progeny.

Dimitrova DI, Yang X, Reichenbach NL, Karakasidis S, Sutton RE, Henderson EE, Rogers TJ, Suhadolnik RJ.

J Interferon Cytokine Res. 2005 Jun;25(6):345-60.


Inhibition of morphine-potentiated HIV-1 replication in peripheral blood mononuclear cells with the nuclease-resistant 2-5A agonist analog, 2-5A(N6B).

Homan JW, Steele AD, Martinand-Mari C, Rogers TJ, Henderson EE, Charubala R, Pfleiderer W, Reichenbach NL, Suhadolnik RJ.

J Acquir Immune Defic Syndr. 2002 May 1;30(1):9-20.


Structural and functional features of the 37-kDa 2-5A-dependent RNase L in chronic fatigue syndrome.

Shetzline SE, Martinand-Mari C, Reichenbach NL, Buletic Z, Lebleu B, Pfleiderer W, Charubala R, De Meirleir K, De Becker P, Peterson DL, Herst CV, Englebienne P, Suhadolnik RJ.

J Interferon Cytokine Res. 2002 Apr;22(4):443-56.


Biochemical evidence for a novel low molecular weight 2-5A-dependent RNase L in chronic fatigue syndrome.

Suhadolnik RJ, Peterson DL, O'Brien K, Cheney PR, Herst CV, Reichenbach NL, Kon N, Horvath SE, Iacono KT, Adelson ME, De Meirleir K, De Becker P, Charubala R, Pfleiderer W.

J Interferon Cytokine Res. 1997 Jul;17(7):377-85.


Inhibition of growth of estrogen receptor positive and estrogen receptor negative breast cancer cells in culture by AA-etherA, a stable 2-5A derivative.

Latham KE, Cosenza S, Reichenbach NL, Mordechai E, Adelson ME, Kon N, Horvath SE, Charubala R, Mikhailov SN, Pfeiderer W, Suhadolnik RJ.

Oncogene. 1996 Feb 15;12(4):827-37.


Inhibition of HIV-1 replication and activation of RNase L by phosphorothioate/phosphodiester 2',5'-oligoadenylate derivatives.

Sobol RW, Henderson EE, Kon N, Shao J, Hitzges P, Mordechai E, Reichenbach NL, Charubala R, Schirmeister H, Pfleiderer W, et al.

J Biol Chem. 1995 Mar 17;270(11):5963-78.


Changes in the 2-5A synthetase/RNase L antiviral pathway in a controlled clinical trial with poly(I)-poly(C12U) in chronic fatigue syndrome.

Suhadolnik RJ, Reichenbach NL, Hitzges P, Adelson ME, Peterson DL, Cheney P, Salvato P, Thompson C, Loveless M, Müller WE, et al.

In Vivo. 1994 Jul-Aug;8(4):599-604.


Ampligen inhibits human herpesvirus-6 in vitro.

Ablashi DV, Berneman ZN, Williams M, Strayer DR, Kramarsky B, Suhadolnik RJ, Reichenbach N, Hiltzges P, Komaroff AL.

In Vivo. 1994 Jul-Aug;8(4):587-91.


Upregulation of the 2-5A synthetase/RNase L antiviral pathway associated with chronic fatigue syndrome.

Suhadolnik RJ, Reichenbach NL, Hitzges P, Sobol RW, Peterson DL, Henry B, Ablashi DV, Müller WE, Schröder HC, Carter WA, et al.

Clin Infect Dis. 1994 Jan;18 Suppl 1:S96-104.


HIV-1 reverse transcriptase: inhibition by 2',5'-oligoadenylates.

Sobol RW, Fisher WL, Reichenbach NL, Kumar A, Beard WA, Wilson SH, Charubala R, Pfleiderer W, Suhadolnik RJ.

Biochemistry. 1993 Nov 16;32(45):12112-8.


RNA drug therapy acting via the 2-5A synthetase/RNase L pathway.

Suhadolnik RJ, Reichenbach NL, Hitzges PM, Ablashi DV, Strayer DR, Carter WA.

Ann N Y Acad Sci. 1993 Jun 23;685:756-7. No abstract available.


Phosphorothioate and cordycepin analogues of 2',5'-oligoadenylate: inhibition of human immunodeficiency virus type 1 reverse transcriptase and infection in vitro.

Montefiori DC, Sobol RW Jr, Li SW, Reichenbach NL, Suhadolnik RJ, Charubala R, Pfleiderer W, Modliszewski A, Robinson WE Jr, Mitchell WM.

Proc Natl Acad Sci U S A. 1989 Sep;86(18):7191-4.


Decreased Epstein-Barr virus-induced transformation, and elevated 2-5A synthetase and RNase L activity in peripheral blood mononuclear cells from patients treated with recombinant interferon alfa 2b.

Fronko GE, Suhadolnik RJ, Vonderheid EC, Karikó K, Reichenbach NL, Chavin KD, Henderson EE.

Biochem Biophys Res Commun. 1988 May 31;153(1):448-53. Erratum in: Biochem Biophys Res Commun 1988 Aug 30;155(1):538.


Phosphorothioate analogues of 2',5'-oligoadenylate. Enzymatically synthesized 2',5'-phosphorothioate dimer and trimer: unequivocal structural assignment and activation of 2',5'-oligoadenylate-dependent endoribonuclease.

Karikó K, Sobol RW Jr, Suhadolnik L, Li SW, Reichenbach NL, Suhadolnik RJ, Charubala R, Pfleiderer W.

Biochemistry. 1987 Nov 3;26(22):7127-35.


Plant oligoadenylates: enzymatic synthesis, isolation, and biological activities.

Devash Y, Reichman M, Sela I, Reichenbach NL, Suhadolnik RJ.

Biochemistry. 1985 Jan 29;24(3):593-9.


Ampligen treatment of renal cell carcinoma: changes in 2-5A synthetase, 2-5A oligomer size and natural killer cell activity associated with antitumor response clinically.

Suhadolnik RJ, Reichenbach NL, Lee C, Strayer DR, Brodsky I, Carter WA.

Prog Clin Biol Res. 1985;202:449-56. No abstract available.


Accumulation of low molecular weight DNA and changes in chromatin structure in HeLa cells treated with human fibroblast interferon.

Suhadolnik RJ, Sawada Y, Gabriel J, Reichenbach NL, Henderson EE.

J Biol Chem. 1984 Apr 25;259(8):4764-9.


Effect of human fibroblast interferon on the antiviral activity of mammalian cells treated with bleomycin, vincristine, or mitomycin C.

Suhadolnik RJ, Sawada Y, Flick MB, Reichenbach NL, Mosca JD.

Cancer Res. 1983 Nov;43(11):5462-6.


Poly(ADP-ribose) polymerase activity in HeLa cells treated with various antibiotics.

Sawada Y, Reichenbach NL, Cross CC 3rd, Suhadolnik RJ.

J Antibiot (Tokyo). 1982 Jan;35(1):119-21. No abstract available.


Glutamate as the common precursor for the aglycon of the naturally occurring C-nucleoside antibiotics.

Suhadolnik RJ, Reichenbach NL.

Biochemistry. 1981 Nov 24;20(24):7042-6.


Core (2'-5')oligoadenylate and the cordycepin analog: inhibitors of Epstein--Barr virus-induced transformation of human lymphocytes in the absence of interferon.

Doetsch PW, Suhadolnik RJ, Sawada Y, Mosca JD, Flick MB, Reichenbach NL, Dang AQ, Wu JM, Charubala R, Pfleiderer W, Henderson EE.

Proc Natl Acad Sci U S A. 1981 Nov;78(11):6699-703.


Enzymic synthesis of (2'-5')ppp3'dA(p3'dA)n, the cordycepin analog of (2'-5')-oligoadenylic acid.

Suhadolnik RJ, Doetsch P, Wu JM, Sawada Y, Mosca JD, Reichenbach NL.

Methods Enzymol. 1981;79(Pt B):257-65. No abstract available.


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