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Items: 1 to 50 of 121

1.

Glucocorticoid Therapy of Multiple Sclerosis Patients Induces Anti-inflammatory Polarization and Increased Chemotaxis of Monocytes.

Fischer HJ, Finck TLK, Pellkofer HL, Reichardt HM, Lühder F.

Front Immunol. 2019 May 29;10:1200. doi: 10.3389/fimmu.2019.01200. eCollection 2019.

2.

Vitamin D increases glucocorticoid efficacy via inhibition of mTORC1 in experimental models of multiple sclerosis.

Hoepner R, Bagnoud M, Pistor M, Salmen A, Briner M, Synn H, Schrewe L, Guse K, Ahmadi F, Demir S, Laverick L, Gresle M, Worley P, Reichardt HM, Butzkueven H, Gold R, Metz I, Lühder F, Chan A.

Acta Neuropathol. 2019 Sep;138(3):443-456. doi: 10.1007/s00401-019-02018-8. Epub 2019 Apr 27.

3.

Glucocorticoid Receptor-Deficient Foxp3+ Regulatory T Cells Fail to Control Experimental Inflammatory Bowel Disease.

Rocamora-Reverte L, Tuzlak S, von Raffay L, Tisch M, Fiegl H, Drach M, Reichardt HM, Villunger A, Tischner D, Wiegers GJ.

Front Immunol. 2019 Mar 18;10:472. doi: 10.3389/fimmu.2019.00472. eCollection 2019.

4.

Publisher Correction: β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration.

Lodygin D, Hermann M, Schweingruber N, Flügel-Koch C, Watanabe T, Schlosser C, Merlini A, Körner H, Chang HF, Fischer HJ, Reichardt HM, Zagrebelsky M, Mollenhauer B, Kügler S, Fitzner D, Frahm J, Stadelmann C, Haberl M, Odoardi F, Flügel A.

Nature. 2019 Mar;567(7749):E15. doi: 10.1038/s41586-019-1047-0.

PMID:
30867589
5.

β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration.

Lodygin D, Hermann M, Schweingruber N, Flügel-Koch C, Watanabe T, Schlosser C, Merlini A, Körner H, Chang HF, Fischer HJ, Reichardt HM, Zagrebelsky M, Mollenhauer B, Kügler S, Fitzner D, Frahm J, Stadelmann C, Haberl M, Odoardi F, Flügel A.

Nature. 2019 Feb;566(7745):503-508. doi: 10.1038/s41586-019-0964-2. Epub 2019 Feb 20. Erratum in: Nature. 2019 Mar;567(7749):E15.

PMID:
30787438
6.

Progesterone modulates the T-cell response via glucocorticoid receptor-dependent pathways.

Hierweger AM, Engler JB, Friese MA, Reichardt HM, Lydon J, DeMayo F, Mittrücker HW, Arck PC.

Am J Reprod Immunol. 2019 Feb;81(2):e13084. doi: 10.1111/aji.13084. Epub 2019 Jan 28.

PMID:
30604567
7.

An alternative for extracorporeal photopheresis: 8-methoxypsoralen and UVA-treated leucocytes from allogeneic donors improve graft-versus-host disease in mice.

Budde H, Papert S, Reichardt HM, Jarry H, Riggert J, Legler TJ.

Vox Sang. 2018 Nov;113(8):803-810. doi: 10.1111/vox.12723. Epub 2018 Oct 23.

PMID:
30353554
8.

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice.

Ballegeer M, Van Looveren K, Timmermans S, Eggermont M, Vandevyver S, Thery F, Dendoncker K, Souffriau J, Vandewalle J, Van Wyngene L, De Rycke R, Takahashi N, Vandenabeele P, Tuckermann J, Reichardt HM, Impens F, Beyaert R, De Bosscher K, Vandenbroucke RE, Libert C.

J Clin Invest. 2018 Aug 1;128(8):3265-3279. doi: 10.1172/JCI96636. Epub 2018 Jun 25.

9.

The glucocorticoid receptor in recipient cells keeps cytokine secretion in acute graft-versus-host disease at bay.

Baake T, Jörß K, Suennemann J, Roßmann L, Bohnenberger H, Tuckermann JP, Reichardt HM, Fischer HJ, Reichardt SD.

Oncotarget. 2018 Mar 2;9(21):15437-15450. doi: 10.18632/oncotarget.24602. eCollection 2018 Mar 20.

10.

Impaired resolution of DSS-induced colitis in mice lacking the glucocorticoid receptor in myeloid cells.

Meers GK, Bohnenberger H, Reichardt HM, Lühder F, Reichardt SD.

PLoS One. 2018 Jan 11;13(1):e0190846. doi: 10.1371/journal.pone.0190846. eCollection 2018.

11.

Deletion of the Mineralocorticoid Receptor in Myeloid Cells Attenuates Central Nervous System Autoimmunity.

Montes-Cobos E, Schweingruber N, Li X, Fischer HJ, Reichardt HM, Lühder F.

Front Immunol. 2017 Oct 13;8:1319. doi: 10.3389/fimmu.2017.01319. eCollection 2017.

12.

Novel Drug Delivery Systems Tailored for Improved Administration of Glucocorticoids.

Lühder F, Reichardt HM.

Int J Mol Sci. 2017 Aug 24;18(9). pii: E1836. doi: 10.3390/ijms18091836. Review.

13.

T-cell autonomous death induced by regeneration of inert glucocorticoid metabolites.

Rocamora-Reverte L, Reichardt HM, Villunger A, Wiegers G.

Cell Death Dis. 2017 Jul 20;8(7):e2948. doi: 10.1038/cddis.2017.344.

14.

Airway Epithelial Cells Are Crucial Targets of Glucocorticoids in a Mouse Model of Allergic Asthma.

Klaßen C, Karabinskaya A, Dejager L, Vettorazzi S, Van Moorleghem J, Lühder F, Meijsing SH, Tuckermann JP, Bohnenberger H, Libert C, Reichardt HM.

J Immunol. 2017 Jul 1;199(1):48-61. doi: 10.4049/jimmunol.1601691. Epub 2017 May 17.

15.

Prediction of graft-versus-host disease: a biomarker panel based on lymphocytes and cytokines.

Budde H, Papert S, Maas JH, Reichardt HM, Wulf G, Hasenkamp J, Riggert J, Legler TJ.

Ann Hematol. 2017 Jul;96(7):1127-1133. doi: 10.1007/s00277-017-2999-5. Epub 2017 Apr 26.

PMID:
28447161
16.

The Insulin Receptor Plays a Critical Role in T Cell Function and Adaptive Immunity.

Fischer HJ, Sie C, Schumann E, Witte AK, Dressel R, van den Brandt J, Reichardt HM.

J Immunol. 2017 Mar 1;198(5):1910-1920. doi: 10.4049/jimmunol.1601011. Epub 2017 Jan 23.

17.

Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy.

Engler JB, Kursawe N, Solano ME, Patas K, Wehrmann S, Heckmann N, Lühder F, Reichardt HM, Arck PC, Gold SM, Friese MA.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E181-E190. doi: 10.1073/pnas.1617115114. Epub 2017 Jan 3.

18.

Targeted delivery of glucocorticoids to macrophages in a mouse model of multiple sclerosis using inorganic-organic hybrid nanoparticles.

Montes-Cobos E, Ring S, Fischer HJ, Heck J, Strauß J, Schwaninger M, Reichardt SD, Feldmann C, Lühder F, Reichardt HM.

J Control Release. 2017 Jan 10;245:157-169. doi: 10.1016/j.jconrel.2016.12.003. Epub 2016 Dec 3.

PMID:
27919626
19.

T cell abundance in blood predicts acute organ toxicity in chemoradiotherapy for head and neck cancer.

Beschel LM, Leu M, Reichardt SD, Rave-Fränk M, Schirmer MA, Stadelmann C, Canis M, Wolff HA, Reichardt HM.

Oncotarget. 2016 Oct 4;7(40):65902-65915. doi: 10.18632/oncotarget.11677.

20.

Distinct roles of T-cell lymphopenia and the microbial flora for gastrointestinal and CNS autoimmunity.

Fischer HJ, Witte AK, Walter L, Gröne HJ, van den Brandt J, Reichardt HM.

FASEB J. 2016 May;30(5):1724-32. doi: 10.1096/fj.15-277384. Epub 2016 Jan 6.

PMID:
26740263
21.

Modulation of CNS autoimmune responses by CD8(+) T cells coincides with their oligoclonal expansion.

Fischer HJ, van den Brandt J, Lingner T, Odoardi F, Flügel A, Weishaupt A, Reichardt HM.

J Neuroimmunol. 2016 Jan 15;290:26-32. doi: 10.1016/j.jneuroim.2015.10.020. Epub 2015 Oct 29.

PMID:
26711565
22.

Inducible Knock-Down of the Mineralocorticoid Receptor in Mice Disturbs Regulation of the Renin-Angiotensin-Aldosterone System and Attenuates Heart Failure Induced by Pressure Overload.

Montes-Cobos E, Li X, Fischer HJ, Sasse A, Kügler S, Didié M, Toischer K, Fassnacht M, Dressel R, Reichardt HM.

PLoS One. 2015 Nov 25;10(11):e0143954. doi: 10.1371/journal.pone.0143954. eCollection 2015.

23.

Prognostic value of CXCL12 and CXCR4 in inoperable head and neck squamous cell carcinoma.

Rave-Fränk M, Tehrany N, Kitz J, Leu M, Weber HE, Burfeind P, Schliephake H, Canis M, Beissbarth T, Reichardt HM, Wolff HA.

Strahlenther Onkol. 2016 Jan;192(1):47-54. doi: 10.1007/s00066-015-0892-5. Epub 2015 Sep 15.

PMID:
26374452
24.

Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1.

Vettorazzi S, Bode C, Dejager L, Frappart L, Shelest E, Klaßen C, Tasdogan A, Reichardt HM, Libert C, Schneider M, Weih F, Henriette Uhlenhaut N, David JP, Gräler M, Kleiman A, Tuckermann JP.

Nat Commun. 2015 Jul 17;6:7796. doi: 10.1038/ncomms8796.

25.

Corrigendum: Wild-type microglia do not reverse pathology in mouse models of Rett syndrome.

Wang J, Wegener JE, Huang TW, Sripathy S, De Jesus-Cortes H, Xu P, Tran S, Knobbe W, Leko V, Britt J, Starwalt R, McDaniel L, Ward CS, Parra D, Newcomb B, Lao U, Nourigat C, Flowers DA, Cullen S, Jorstad NL, Yang Y, Glaskova L, Vigneau S, Kozlitina J, Yetman MJ, Jankowsky JL, Reichardt SD, Reichardt HM, Gärtner J, Bartolomei MS, Fang M, Loeb K, Keene CD, Bernstein I, Goodell M, Brat DJ, Huppke P, Neul JL, Bedalov A, Pieper AA.

Nature. 2015 Sep 24;525(7570):552. doi: 10.1038/nature14671. Epub 2015 Jul 15. No abstract available.

26.

Multifunctional phosphate-based inorganic-organic hybrid nanoparticles.

Heck JG, Napp J, Simonato S, Möllmer J, Lange M, Reichardt HM, Staudt R, Alves F, Feldmann C.

J Am Chem Soc. 2015 Jun 17;137(23):7329-36. doi: 10.1021/jacs.5b01172. Epub 2015 Jun 8.

PMID:
26018463
27.

Wild-type microglia do not reverse pathology in mouse models of Rett syndrome.

Wang J, Wegener JE, Huang TW, Sripathy S, De Jesus-Cortes H, Xu P, Tran S, Knobbe W, Leko V, Britt J, Starwalt R, McDaniel L, Ward CS, Parra D, Newcomb B, Lao U, Nourigat C, Flowers DA, Cullen S, Jorstad NL, Yang Y, Glaskova L, Vingeau S, Kozlitina J, Yetman MJ, Jankowsky JL, Reichardt SD, Reichardt HM, Gärtner J, Bartolomei MS, Fang M, Loeb K, Keene CD, Bernstein I, Goodell M, Brat DJ, Huppke P, Neul JL, Bedalov A, Pieper AA.

Nature. 2015 May 21;521(7552):E1-4. doi: 10.1038/nature14444. No abstract available. Erratum in: Nature. 2015 Sep 24;525(7570):552. Vigneau, Sebastian [Corrected to Vingeau, Sébastien].

28.

Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism.

Menzfeld C, John M, van Rossum D, Regen T, Scheffel J, Janova H, Götz A, Ribes S, Nau R, Borisch A, Boutin P, Neumann K, Bremes V, Wienands J, Reichardt HM, Lühder F, Tischner D, Waetzig V, Herdegen T, Teismann P, Greig I, Müller M, Pukrop T, Mildner A, Kettenmann H, Brück W, Prinz M, Rotshenker S, Weber MS, Hanisch UK.

Glia. 2015 Jun;63(6):1083-99. doi: 10.1002/glia.22803. Epub 2015 Mar 2.

PMID:
25731696
29.

Thymocyte-derived BDNF influences T-cell maturation at the DN3/DN4 transition stage.

Linker RA, Lee DH, Flach AC, Litke T, van den Brandt J, Reichardt HM, Lingner T, Bommhardt U, Sendtner M, Gold R, Flügel A, Lühder F.

Eur J Immunol. 2015 May;45(5):1326-38. doi: 10.1002/eji.201444985. Epub 2015 Feb 19.

30.

High-grade acute organ toxicity and p16(INK4A) expression as positive prognostic factors in primary radio(chemo)therapy for patients with head and neck squamous cell carcinoma.

Tehrany N, Kitz J, Rave-Fränk M, Lorenzen S, Li L, Küffer S, Hess CF, Burfeind P, Reichardt HM, Canis M, Beissbarth T, Wolff HA.

Strahlenther Onkol. 2015 Jul;191(7):566-72. doi: 10.1007/s00066-014-0801-3. Epub 2015 Jan 10.

PMID:
25575976
31.

Glucocorticoids attenuate acute graft-versus-host disease by suppressing the cytotoxic capacity of CD8(+) T cells.

Theiss-Suennemann J, Jörß K, Messmann JJ, Reichardt SD, Montes-Cobos E, Lühder F, Tuckermann JP, AWolff H, Dressel R, Gröne HJ, Strauß G, Reichardt HM.

J Pathol. 2015 Mar;235(4):646-55. doi: 10.1002/path.4475. Epub 2015 Jan 7.

PMID:
25358639
32.

Modified extracorporeal photopheresis with cells from a healthy donor for acute graft-versus-host disease in a mouse model.

Budde H, Kolb S, Salinas Tejedor L, Wulf G, Reichardt HM, Riggert J, Legler TJ.

PLoS One. 2014 Aug 22;9(8):e105896. doi: 10.1371/journal.pone.0105896. eCollection 2014.

33.

Generation of Transgenic Rats Using Lentiviral Vectors.

Reichardt HM, Fischer HJ.

Methods Mol Biol. 2016;1304:25-37. doi: 10.1007/7651_2014_107.

PMID:
25063498
34.

Glucocorticoids induce gastroparesis in mice through depletion of l-arginine.

Reichardt SD, Weinhage T, Rotte A, Föller M, Oppermann M, Lühder F, Tuckermann JP, Lang F, van den Brandt J, Reichardt HM.

Endocrinology. 2014 Oct;155(10):3899-908. doi: 10.1210/en.2014-1246. Epub 2014 Jul 24.

PMID:
25057793
35.

Erythropoietin responsive cardiomyogenic cells contribute to heart repair post myocardial infarction.

Zafiriou MP, Noack C, Unsöld B, Didie M, Pavlova E, Fischer HJ, Reichardt HM, Bergmann MW, El-Armouche A, Zimmermann WH, Zelarayan LC.

Stem Cells. 2014 Sep;32(9):2480-91. doi: 10.1002/stem.1741.

36.

Depletion of cutaneous macrophages and dendritic cells promotes growth of basal cell carcinoma in mice.

König S, Nitzki F, Uhmann A, Dittmann K, Theiss-Suennemann J, Herrmann M, Reichardt HM, Schwendener R, Pukrop T, Schulz-Schaeffer W, Hahn H.

PLoS One. 2014 Apr 1;9(4):e93555. doi: 10.1371/journal.pone.0093555. eCollection 2014.

37.

Chemokine-mediated redirection of T cells constitutes a critical mechanism of glucocorticoid therapy in autoimmune CNS responses.

Schweingruber N, Fischer HJ, Fischer L, van den Brandt J, Karabinskaya A, Labi V, Villunger A, Kretzschmar B, Huppke P, Simons M, Tuckermann JP, Flügel A, Lühder F, Reichardt HM.

Acta Neuropathol. 2014 May;127(5):713-29. doi: 10.1007/s00401-014-1248-4. Epub 2014 Feb 1.

38.

Glucocorticoid-induced apoptosis in animal models of multiple sclerosis.

Herold MJ, Reichardt HM.

Crit Rev Immunol. 2013;33(3):183-202. Review.

PMID:
23756243
39.

CD8⁺ T cell help is required for efficient induction of EAE in Lewis rats.

Camara M, Beyersdorf N, Fischer HJ, Herold MJ, Ip CW, van den Brandt J, Toyka KV, Taurog JD, Hünig T, Herrmann T, Reichardt HM, Weishaupt A, Kerkau T.

J Neuroimmunol. 2013 Jul 15;260(1-2):17-27. doi: 10.1016/j.jneuroim.2013.04.014. Epub 2013 May 7.

PMID:
23664330
40.

A combination of fluorescent NFAT and H2B sensors uncovers dynamics of T cell activation in real time during CNS autoimmunity.

Lodygin D, Odoardi F, Schläger C, Körner H, Kitz A, Nosov M, van den Brandt J, Reichardt HM, Haberl M, Flügel A.

Nat Med. 2013 Jun;19(6):784-90. doi: 10.1038/nm.3182. Epub 2013 Apr 28.

PMID:
23624600
41.

The potential role of T cell migration and chemotaxis as targets of glucocorticoids in multiple sclerosis and experimental autoimmune encephalomyelitis.

Fischer HJ, Schweingruber N, Lühder F, Reichardt HM.

Mol Cell Endocrinol. 2013 Nov 5;380(1-2):99-107. doi: 10.1016/j.mce.2013.04.001. Epub 2013 Apr 8. Review.

PMID:
23578583
42.

The hedgehog receptor patched1 in T cells is dispensable for adaptive immunity in mice.

Michel KD, Uhmann A, Dressel R, van den Brandt J, Hahn H, Reichardt HM.

PLoS One. 2013;8(4):e61034. doi: 10.1371/journal.pone.0061034. Epub 2013 Apr 8.

43.

Glucocorticoids induce effector T cell depolarization via ERM proteins, thereby impeding migration and APC conjugation.

Müller N, Fischer HJ, Tischner D, van den Brandt J, Reichardt HM.

J Immunol. 2013 Apr 15;190(8):4360-70. doi: 10.4049/jimmunol.1201520. Epub 2013 Mar 8.

44.

Preventive treatment with methylprednisolone paradoxically exacerbates experimental autoimmune encephalomyelitis.

Wüst S, van den Brandt J, Reichardt HM, Lühder F.

Int J Endocrinol. 2012;2012:417017. doi: 10.1155/2012/417017. Epub 2012 Nov 29.

45.

Healthy bone marrow cells reduce progression of kidney failure better than CKD bone marrow cells in rats with established chronic kidney disease.

van Koppen A, Joles JA, Bongartz LG, van den Brandt J, Reichardt HM, Goldschmeding R, Nguyen TQ, Verhaar MC.

Cell Transplant. 2012;21(10):2299-312. doi: 10.3727/096368912X636795.

PMID:
23231961
46.

Permanent CNI treatment for prevention of renal allograft rejection in sensitized hosts can be replaced by regulatory T cells.

Siepert A, Ahrlich S, Vogt K, Appelt C, Stanko K, Kühl A, van den Brandt J, Reichardt HM, Nizze H, Lehmann M, Tiedge M, Volk HD, Sawitzki B, Reinke P.

Am J Transplant. 2012 Sep;12(9):2384-94. doi: 10.1111/j.1600-6143.2012.04143.x. Epub 2012 Jun 15.

47.

The ambivalent role of apoptosis in experimental autoimmune encephalomyelitis and multiple sclerosis.

Reichardt HM, Lühder F.

Curr Pharm Des. 2012;18(29):4453-64. Review.

PMID:
22612741
48.

Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice.

Ottina E, Grespi F, Tischner D, Soratroi C, Geley S, Ploner A, Reichardt HM, Villunger A, Herold MJ.

Blood. 2012 Jun 21;119(25):6032-42. doi: 10.1182/blood-2011-12-399089. Epub 2012 May 11.

49.

A cell-autonomous role for the glucocorticoid receptor in skeletal muscle atrophy induced by systemic glucocorticoid exposure.

Watson ML, Baehr LM, Reichardt HM, Tuckermann JP, Bodine SC, Furlow JD.

Am J Physiol Endocrinol Metab. 2012 May 1;302(10):E1210-20. doi: 10.1152/ajpendo.00512.2011. Epub 2012 Feb 21.

50.

Glucocorticoids enhance intestinal glucose uptake via the dimerized glucocorticoid receptor in enterocytes.

Reichardt SD, Föller M, Rexhepaj R, Pathare G, Minnich K, Tuckermann JP, Lang F, Reichardt HM.

Endocrinology. 2012 Apr;153(4):1783-94. doi: 10.1210/en.2011-1747. Epub 2012 Jan 31.

PMID:
22294744

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