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Items: 1 to 50 of 70

1.

Single-Dose Primaquine in a Preclinical Model of Glucose-6-Phosphate Dehydrogenase Deficiency: Implications for Use in Malaria Transmission-Blocking Programs.

Wickham KS, Baresel PC, Marcsisin SR, Sousa J, Vuong CT, Reichard GA, Campo B, Tekwani BL, Walker LA, Rochford R.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):5906-13. doi: 10.1128/AAC.00600-16. Print 2016 Oct.

2.

Differential kinetic profiles and metabolism of primaquine enantiomers by human hepatocytes.

Fasinu PS, Avula B, Tekwani BL, Nanayakkara NP, Wang YH, Bandara Herath HM, McChesney JD, Reichard GA, Marcsisin SR, Elsohly MA, Khan SI, Khan IA, Walker LA.

Malar J. 2016 Apr 19;15:224. doi: 10.1186/s12936-016-1270-1.

3.

Differential cytochrome P450 2D metabolism alters tafenoquine pharmacokinetics.

Vuong C, Xie LH, Potter BM, Zhang J, Zhang P, Duan D, Nolan CK, Sciotti RJ, Zottig VE, Nanayakkara NP, Tekwani BL, Walker LA, Smith PL, Paris RM, Read LT, Li Q, Pybus BS, Sousa JC, Reichard GA, Smith B, Marcsisin SR.

Antimicrob Agents Chemother. 2015 Jul;59(7):3864-9. doi: 10.1128/AAC.00343-15. Epub 2015 Apr 13.

4.

Differential CYP 2D6 metabolism alters primaquine pharmacokinetics.

Potter BM, Xie LH, Vuong C, Zhang J, Zhang P, Duan D, Luong TL, Bandara Herath HM, Dhammika Nanayakkara NP, Tekwani BL, Walker LA, Nolan CK, Sciotti RJ, Zottig VE, Smith PL, Paris RM, Read LT, Li Q, Pybus BS, Sousa JC, Reichard GA, Marcsisin SR.

Antimicrob Agents Chemother. 2015 Apr;59(4):2380-7. doi: 10.1128/AAC.00015-15. Epub 2015 Feb 2.

5.

Enantioselective metabolism of primaquine by human CYP2D6.

Fasinu PS, Tekwani BL, Nanayakkara NP, Avula B, Herath HM, Wang YH, Adelli VR, Elsohly MA, Khan SI, Khan IA, Pybus BS, Marcsisin SR, Reichard GA, McChesney JD, Walker LA.

Malar J. 2014 Dec 17;13:507. doi: 10.1186/1475-2875-13-507.

6.

Scalable preparation and differential pharmacologic and toxicologic profiles of primaquine enantiomers.

Nanayakkara NP, Tekwani BL, Herath HM, Sahu R, Gettayacamin M, Tungtaeng A, van Gessel Y, Baresel P, Wickham KS, Bartlett MS, Fronczek FR, Melendez V, Ohrt C, Reichard GA, McChesney JD, Rochford R, Walker LA.

Antimicrob Agents Chemother. 2014 Aug;58(8):4737-44. doi: 10.1128/AAC.02674-13. Epub 2014 Jun 9.

7.

Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds.

Marcsisin SR, Sousa JC, Reichard GA, Caridha D, Zeng Q, Roncal N, McNulty R, Careagabarja J, Sciotti RJ, Bennett JW, Zottig VE, Deye G, Li Q, Read L, Hickman M, Dhammika Nanayakkara NP, Walker LA, Smith B, Melendez V, Pybus BS.

Malar J. 2014 Jan 3;13:2. doi: 10.1186/1475-2875-13-2.

8.

CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever.

Marcsisin SR, Jin X, Bettger T, McCulley N, Sousa JC, Shanks GD, Tekwani BL, Sahu R, Reichard GA, Sciotti RJ, Melendez V, Pybus BS.

Malar J. 2013 Jun 21;12:214. doi: 10.1186/1475-2875-12-214.

9.

The metabolism of primaquine to its active metabolite is dependent on CYP 2D6.

Pybus BS, Marcsisin SR, Jin X, Deye G, Sousa JC, Li Q, Caridha D, Zeng Q, Reichard GA, Ockenhouse C, Bennett J, Walker LA, Ohrt C, Melendez V.

Malar J. 2013 Jun 20;12:212. doi: 10.1186/1475-2875-12-212.

10.

CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine.

Pybus BS, Sousa JC, Jin X, Ferguson JA, Christian RE, Barnhart R, Vuong C, Sciotti RJ, Reichard GA, Kozar MP, Walker LA, Ohrt C, Melendez V.

Malar J. 2012 Aug 2;11:259. doi: 10.1186/1475-2875-11-259.

11.

Discovery of a novel, potent and orally active series of gamma-lactams as selective NK1 antagonists.

Paliwal S, Reichard GA, Shah S, Wrobleski ML, Wang C, Stengone C, Tsui HC, Xiao D, Duffy RA, Lachowicz JE, Nomeir AA, Varty GB, Shih NY.

Bioorg Med Chem Lett. 2008 Jul 15;18(14):4168-71. doi: 10.1016/j.bmcl.2008.05.082. Epub 2008 May 24.

PMID:
18547807
12.

SARVision Plus.

Reichard GA.

J Chem Inf Model. 2008 Jun;48(6):1287-8. doi: 10.1021/ci800152v. Epub 2008 Jun 5. No abstract available.

PMID:
18528997
13.

An efficient approach for the rapid assessment of oral rat exposures for new chemical entities in drug discovery.

Han HK, Sadagopan N, Reichard GA, Yapa U, Zhu T, Hubbel A, Johnson K, Brodfuehrer J.

J Pharm Sci. 2006 Aug;95(8):1684-92.

PMID:
16732590
14.

Cyclobutane derivatives as potent NK1 selective antagonists.

Wrobleski ML, Reichard GA, Paliwal S, Shah S, Tsui HC, Duffy RA, Lachowicz JE, Morgan CA, Varty GB, Shih NY.

Bioorg Med Chem Lett. 2006 Jul 15;16(14):3859-63. Epub 2006 May 8.

PMID:
16682196
15.

Cyclic urea derivatives as potent NK1 selective antagonists. Part II: Effects of fluoro and benzylic methyl substitutions.

Shue HJ, Chen X, Schwerdt JH, Paliwal S, Blythin DJ, Lin L, Gu D, Wang C, Reichard GA, Wang H, Piwinski JJ, Duffy RA, Lachowicz JE, Coffin VL, Nomeir AA, Morgan CA, Varty GB, Shih NY.

Bioorg Med Chem Lett. 2006 Feb 15;16(4):1065-9. Epub 2005 Nov 14.

PMID:
16290143
16.

Cyclic urea derivatives as potent NK1 selective antagonists.

Shue HJ, Chen X, Shih NY, Blythin DJ, Paliwal S, Lin L, Gu D, Schwerdt JH, Shah S, Reichard GA, Piwinski JJ, Duffy RA, Lachowicz JE, Coffin VL, Liu F, Nomeir AA, Morgan CA, Varty GB.

Bioorg Med Chem Lett. 2005 Sep 1;15(17):3896-9.

PMID:
16019209
17.

Asymmetric synthesis of 4,4-disubstituted-2-imidazoli-dinones: potent NK1 antagonists.

Reichard GA, Stengone C, Paliwal S, Mergelsberg I, Majmundar S, Wang C, Tiberi R, McPhail AT, Piwinski JJ, Shih NY.

Org Lett. 2003 Nov 13;5(23):4249-51.

PMID:
14601972
18.

Development and potential utility of dual and triple NK receptor antagonists.

Rizzo CA, Anthes JC, Corboz MR, Chapman RW, Shih NY, Reichard GA, Ng KJ, Hey JA.

Curr Top Med Chem. 2003;3(12):1410-22. Review.

PMID:
12871172
19.

Preparation of oxime dual NK(1)/NK(2) antagonists with reduced NK(3) affinity.

Reichard GA, Grice CA, Shih NY, Spitler J, Majmundar S, Wang SD, Paliwal S, Anthes JC, Piwinski JJ.

Bioorg Med Chem Lett. 2002 Sep 2;12(17):2355-8.

PMID:
12161132
20.

Structure-activity relationships of oxime neurokinin antagonists: oxime modifications.

Reichard GA, Spitler J, Aslanian R, Mutahi Mw, Shih NY, Lin L, Ting PC, Anthes JC, Piwinski JJ.

Bioorg Med Chem Lett. 2002 Mar 11;12(5):833-6.

PMID:
11859013
21.

Synthesis and structure-activity relationships of oxime neurokinin antagonists: discovery of potent arylamides.

Shih NY, Albanese M, Anthes JC, Carruthers NI, Grice CA, Lin L, Mangiaracina P, Reichard GA, Schwerdt J, Seidl V, Wong SC, Piwinski JJ.

Bioorg Med Chem Lett. 2002 Jan 21;12(2):141-5.

PMID:
11755340
22.

Plasma concentrations of soluble tumor necrosis factor receptor I and tumor necrosis factor during cardiopulmonary bypass.

Marano CW, Garulacan LA, Laughlin KV, Igidbashian L, Trace C, Goldman SM, Sutter FP, Reichard GA Jr, Mullin JM.

Ann Thorac Surg. 2000 Oct;70(4):1313-8.

PMID:
11081891
23.

The design and synthesis of novel NK1/NK2 dual antagonists.

Reichard GA, Ball ZT, Aslanian R, Anthes JC, Shih NY, Piwinski JJ.

Bioorg Med Chem Lett. 2000 Oct 16;10(20):2329-32.

PMID:
11055349
24.

A beta-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line.

Fenteany G, Standaert RF, Reichard GA, Corey EJ, Schreiber SL.

Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3358-62.

25.

Properties of ornithine decarboxylase in human colorectal adenocarcinomas.

Hietala OA, Yum KY, Pilon J, O'Donnell K, Holroyde CP, Kline I, Reichard GA, Litwin S, Gilmour SK, O'Brien TG.

Cancer Res. 1990 Apr 1;50(7):2088-94.

26.
27.

Ethanol causes acute inhibition of carbohydrate, fat, and protein oxidation and insulin resistance.

Shelmet JJ, Reichard GA, Skutches CL, Hoeldtke RD, Owen OE, Boden G.

J Clin Invest. 1988 Apr;81(4):1137-45.

28.

General metabolic abnormalities in cancer patients: anorexia and cachexia.

Holroyde CP, Reichard GA Jr.

Surg Clin North Am. 1986 Oct;66(5):947-56. Review.

PMID:
3532380
29.

Acetone metabolism in humans during diabetic ketoacidosis.

Reichard GA Jr, Skutches CL, Hoeldtke RD, Owen OE.

Diabetes. 1986 Jun;35(6):668-74.

PMID:
3086164
30.

The disposal of an oral glucose load in healthy subjects. A quantitative study.

Ferrannini E, Bjorkman O, Reichard GA Jr, Pilo A, Olsson M, Wahren J, DeFronzo RA.

Diabetes. 1985 Jun;34(6):580-8.

PMID:
3891471
31.

Effect of phentolamine in controlling temperature and acidosis associated with cardiopulmonary bypass.

Bridges KG, Reichard GA Jr, MacVaugh H 3rd, Kues JR, Cevallos WH, Lechman MJ, Hoffman WS, Donahoo JS.

Crit Care Med. 1985 Feb;13(2):72-6.

PMID:
2981656
32.

Glucose metabolism in cachectic patients with colorectal cancer.

Holroyde CP, Skutches CL, Boden G, Reichard GA.

Cancer Res. 1984 Dec;44(12 Pt 1):5910-3.

33.

Improvement of metabolic control in diabetic patients during mebendazole administration: preliminary studies.

Caprio S, Ray TK, Boden G, Reichard GA Jr, Shuman CR, Smith RH, Mozzoli MA, Dayal VK, Hoeldtke RD, Owen OE.

Diabetologia. 1984 Jul;27(1):52-5.

PMID:
6381196
34.

Acetate and energy metabolism during hemodialysis.

Sigler MH, Skutches CL, Teehan BP, Cooper JH, Reichard GA.

Kidney Int Suppl. 1983 Dec;16:S97-101.

PMID:
6429408
35.

Nature and quantity of fuels consumed in patients with alcoholic cirrhosis.

Owen OE, Trapp VE, Reichard GA Jr, Mozzoli MA, Moctezuma J, Paul P, Skutches CL, Boden G.

J Clin Invest. 1983 Nov;72(5):1821-32.

36.

Ketosis of starvation: a revisit and new perspectives.

Owen OE, Caprio S, Reichard GA Jr, Mozzoli MA, Boden G, Owen RS.

Clin Endocrinol Metab. 1983 Jul;12(2):359-79. Review. No abstract available.

PMID:
6347450
37.

Assessment of norepinephrine secretion and production.

Hoeldtke RD, Cilmi KM, Reichard GA Jr, Boden G, Owen OE.

J Lab Clin Med. 1983 May;101(5):772-82.

PMID:
6339653
38.

Contribution of dialysate acetate to energy metabolism: metabolic implications.

Skutches CL, Sigler MH, Teehan BP, Cooper JH, Reichard GA.

Kidney Int. 1983 Jan;23(1):57-63.

39.

Acetone metabolism during diabetic ketoacidosis.

Owen OE, Trapp VE, Skutches CL, Mozzoli MA, Hoeldtke RD, Boden G, Reichard GA Jr.

Diabetes. 1982 Mar;31(3):242-8.

PMID:
6818074
40.

Severe insulin-induced hypoglycemia associated with deficiencies in the release of counterregulatory hormones.

Boden G, Reichard GA Jr, Hoeldtke RD, Rezvani I, Owen OE.

N Engl J Med. 1981 Nov 12;305(20):1200-5. No abstract available.

PMID:
7027041
41.

Carbohydrate metabolism in cancer cachexia.

Holroyde CP, Reichard GA.

Cancer Treat Rep. 1981;65 Suppl 5:55-9.

PMID:
6809325
42.

Plasma free fatty acid turnover and oxidation during fat-free and intralipid TPN.

Skutches CL, Myers RN, Paul P, Smink RD Jr, Reichard GA Jr.

JPEN J Parenter Enteral Nutr. 1980 Nov-Dec;4(6):572-4.

PMID:
6780710
43.

Substrate, hormone, and temperature responses in males and females to a common breakfast.

Owen OE, Mozzoli MA, Boden G, Patel MS, Reichard GA Jr, Trapp V, Shuman CR, Felig P.

Metabolism. 1980 Jun;29(6):511-23.

PMID:
6991856
44.

Effects of therapy on the nature and quantity of fuels oxidized during diabetic ketoacidosis.

Owen OE, Trapp VE, Reichard GA Jr, Mozzoli MA, Smith R, Boden G.

Diabetes. 1980 May;29(5):365-72. No abstract available.

PMID:
6769726
45.

Acid-base balance in continuous ambulatory peritoneal dialysis.

Schleifer CR, Teehan BP, Reichard GA, Sigler MH, Cupit M, Haff AC.

Proc Clin Dial Transplant Forum. 1980;10:100-4.

PMID:
7346838
46.

Lactate metabolism in patients with metastatic colorectal cancer.

Holroyde CP, Axelrod RS, Skutches CL, Haff AC, Paul P, Reichard GA.

Cancer Res. 1979 Dec;39(12):4900-4. No abstract available.

47.

Plasma acetate turnover and oxidation.

Skutches CL, Holroyde CP, Myers RN, Paul P, Reichard GA.

J Clin Invest. 1979 Sep;64(3):708-13.

48.

Plasma acetone metabolism in the fasting human.

Reichard GA Jr, Haff AC, Skutches CL, Paul P, Holroyde CP, Owen OE.

J Clin Invest. 1979 Apr;63(4):619-26.

49.

Energy metabolism in feasting and fasting.

Owen OE, Reichard GA Jr, Patel MS, Boden G.

Adv Exp Med Biol. 1979;111:169-88. Review.

PMID:
371355
50.

A method for estimation of acetone radioactivity and concentration in blood and urine.

Haff AC, Reichard GA Jr.

Biochem Med. 1977 Dec;18(3):308-14. No abstract available.

PMID:
597280

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