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Items: 37

1.

Discovery of a Photoinduced Dark Catalytic Cycle using in situ LED-NMR Spectroscopy.

Lehnherr D, Ji Y, Neel AJ, Cohen RD, Brunskill APJ, Yang J, Reibarkh M.

J Am Chem Soc. 2018 Sep 24. doi: 10.1021/jacs.8b08596. [Epub ahead of print]

PMID:
30244565
2.

Facile Quantum Yield Determination via NMR Actinometry.

Ji Y, DiRocco DA, Hong CM, Wismer MK, Reibarkh M.

Org Lett. 2018 Apr 20;20(8):2156-2159. doi: 10.1021/acs.orglett.8b00391. Epub 2018 Mar 28.

PMID:
29589943
3.

Oxyfunctionalization of the Remote C-H Bonds of Aliphatic Amines by Decatungstate Photocatalysis.

Schultz DM, Lévesque F, DiRocco DA, Reibarkh M, Ji Y, Joyce LA, Dropinski JF, Sheng H, Sherry BD, Davies IW.

Angew Chem Int Ed Engl. 2017 Nov 27;56(48):15274-15278. doi: 10.1002/anie.201707537. Epub 2017 Oct 26.

PMID:
29044797
4.

The protecting-group free selective 3'-functionalization of nucleosides.

McCabe Dunn JM, Reibarkh M, Sherer EC, Orr RK, Ruck RT, Simmons B, Bellomo A.

Chem Sci. 2017 Apr 1;8(4):2804-2810. doi: 10.1039/c6sc05081f. Epub 2017 Jan 18.

5.

A multifunctional catalyst that stereoselectively assembles prodrugs.

DiRocco DA, Ji Y, Sherer EC, Klapars A, Reibarkh M, Dropinski J, Mathew R, Maligres P, Hyde AM, Limanto J, Brunskill A, Ruck RT, Campeau LC, Davies IW.

Science. 2017 Apr 28;356(6336):426-430. doi: 10.1126/science.aam7936.

PMID:
28450641
6.

Discovery of N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia.

Debenham JS, Madsen-Duggan C, Clements MJ, Walsh TF, Kuethe JT, Reibarkh M, Salowe SP, Sonatore LM, Hajdu R, Milligan JA, Visco DM, Zhou D, Lingham RB, Stickens D, DeMartino JA, Tong X, Wolff M, Pang J, Miller RR, Sherer EC, Hale JJ.

J Med Chem. 2016 Dec 22;59(24):11039-11049. doi: 10.1021/acs.jmedchem.6b01242. Epub 2016 Nov 30.

PMID:
28002958
7.

Band-Selective 2D HSQMBC: A Universal Technique for Detection and Measurement of 35,37Cl Isotope Effects for 13C Nuclei.

Saurí J, Reibarkh M, Zhang T, Cohen RD, Wang X, Molinski TF, Martin GE, Williamson RT.

Org Lett. 2016 Oct 7;18(19):4786-4789. Epub 2016 Sep 28.

PMID:
27681329
8.

Visualizing small differences using subtractive chromatographic analysis.

Zawatzky K, Reibarkh M, Canfield N, Wang TC, Li S, Du L, Welch CJ.

J Chromatogr A. 2016 Oct 14;1468:245-249. doi: 10.1016/j.chroma.2016.09.025. Epub 2016 Sep 13.

PMID:
27663729
9.

Using Electron Paramagnetic Resonance Spectroscopy To Facilitate Problem Solving in Pharmaceutical Research and Development.

Mangion I, Liu Y, Reibarkh M, Williamson RT, Welch CJ.

J Org Chem. 2016 Aug 19;81(16):6937-44. doi: 10.1021/acs.joc.6b00937. Epub 2016 Jun 22.

PMID:
27322370
10.

Use of hydrostatic pressure for modulation of protein chemical modification and enzymatic selectivity.

Makarov AA, Helmy R, Joyce L, Reibarkh M, Maust M, Ren S, Mergelsberg I, Welch CJ.

Org Biomol Chem. 2016 May 11;14(19):4448-55. doi: 10.1039/c6ob00550k.

PMID:
27088756
11.

Discovery of Novel Indoline Cholesterol Ester Transfer Protein Inhibitors (CETP) through a Structure-Guided Approach.

Wilson JE, Kurukulasuriya R, Reibarkh M, Reiter M, Zwicker A, Zhao K, Zhang F, Anand R, Colandrea VJ, Cumiskey AM, Crespo A, Duffy RA, Murphy BA, Mitra K, Johns DG, Duffy JL, Vachal P.

ACS Med Chem Lett. 2016 Jan 4;7(3):261-5. doi: 10.1021/acsmedchemlett.5b00404. eCollection 2016 Mar 10.

12.

SAR exploration at the C-3 position of tetrahydro-β-carboline sstr3 antagonists.

He S, Dobbelaar PH, Guo L, Ye Z, Liu J, Jian T, Truong Q, Shah SK, Du W, Qi H, Bakshi RK, Hong Q, Dellureficio JD, Sherer E, Pasternak A, Feng Z, Reibarkh M, Lin M, Samuel K, Reddy VB, Mitelman S, Tong SX, Chicchi GG, Tsao KL, Trusca D, Wu M, Shao Q, Trujillo ME, Fernandez G, Nelson D, Bunting P, Kerr J, Fitzgerald P, Morissette P, Volksdorf S, Eiermann GJ, Li C, Zhang BB, Howard AD, Zhou YP, Nargund RP, Hagmann WK.

Bioorg Med Chem Lett. 2016 Mar 15;26(6):1529-1535. doi: 10.1016/j.bmcl.2016.02.022. Epub 2016 Feb 10.

PMID:
26898814
13.

Structure elucidation of uniformly 13C labeled small molecule natural products.

Reibarkh M, Wyche TP, Saurí J, Bugni TS, Martin GE, Williamson RT.

Magn Reson Chem. 2015 Dec;53(12):i. doi: 10.1002/mrc.4384.

14.

Structure elucidation of uniformly (13)C labeled small molecule natural products.

Reibarkh M, Wyche TP, Saurí J, Bugni TS, Martin GE, Thomas Williamson R.

Magn Reson Chem. 2015 Dec;53(12):996-1002. doi: 10.1002/mrc.4333.

PMID:
26768304
15.

Promotion of a Ti-Mediated Mannich Reaction by a Proton Source.

Limanto J, Yoshikawa N, Reamer RA, Tan L, Brunskill A, Reibarkh M.

J Org Chem. 2016 Jan 15;81(2):723-8. doi: 10.1021/acs.joc.5b02452. Epub 2015 Dec 21.

PMID:
26656787
16.

Asymmetric synthesis of cyclic indole aminals via 1,3-stereoinduction.

Li H, Chen CY, Nguyen H, Cohen R, Maligres PE, Yasuda N, Mangion I, Zavialov I, Reibarkh M, Chung JY.

J Org Chem. 2014 Sep 19;79(18):8533-40. doi: 10.1021/jo501581e. Epub 2014 Sep 3.

PMID:
25162915
17.

Investigation of Cardiovascular Effects of Tetrahydro-β-carboline sstr3 antagonists.

He S, Lai Z, Ye Z, Dobbelaar PH, Shah SK, Truong Q, Du W, Guo L, Liu J, Jian T, Qi H, Bakshi RK, Hong Q, Dellureficio J, Reibarkh M, Samuel K, Reddy VB, Mitelman S, Tong SX, Chicchi GG, Tsao KL, Trusca D, Wu M, Shao Q, Trujillo ME, Fernandez G, Nelson D, Bunting P, Kerr J, Fitzgerald P, Morissette P, Volksdorf S, Eiermann GJ, Li C, Zhang B, Howard AD, Zhou YP, Nargund RP, Hagmann WK.

ACS Med Chem Lett. 2014 Apr 21;5(7):748-53. doi: 10.1021/ml500028c. eCollection 2014 Jul 10.

18.

Broadband inversion of 1J(CC) responses in 1,n-ADEQUATE spectra.

Reibarkh M, Williamson RT, Martin GE, Bermel W.

J Magn Reson. 2013 Nov;236:126-33. doi: 10.1016/j.jmr.2013.07.016. Epub 2013 Aug 9.

PMID:
24035003
19.

Coniothyrione: anatomy of a structure revision.

Martin GE, Buevich AV, Reibarkh M, Singh SB, Ondeyka JG, Williamson RT.

Magn Reson Chem. 2013 Jul;51(7):383-90. doi: 10.1002/mrc.3952. Epub 2013 May 15.

PMID:
23674343
20.

1J(CC)-edited HSQC-1,n-ADEQUATE: a new paradigm for simultaneous direct and long-range carbon-carbon correlation.

Martin GE, Blinov KA, Reibarkh M, Williamson RT.

Magn Reson Chem. 2012 Nov;50(11):722-8. doi: 10.1002/mrc.3870. Epub 2012 Sep 19.

PMID:
22996413
21.

The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2β.

Luna RE, Arthanari H, Hiraishi H, Nanda J, Martin-Marcos P, Markus MA, Akabayov B, Milbradt AG, Luna LE, Seo HC, Hyberts SG, Fahmy A, Reibarkh M, Miles D, Hagner PR, O'Day EM, Yi T, Marintchev A, Hinnebusch AG, Lorsch JR, Asano K, Wagner G.

Cell Rep. 2012 Jun 28;1(6):689-702. doi: 10.1016/j.celrep.2012.04.007. Epub 2012 May 24.

22.

The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes.

He S, Ye Z, Truong Q, Shah S, Du W, Guo L, Dobbelaar PH, Lai Z, Liu J, Jian T, Qi H, Bakshi RK, Hong Q, Dellureficio J, Pasternak A, Feng Z, deJesus R, Yang L, Reibarkh M, Bradley SA, Holmes MA, Ball RG, Ruck RT, Huffman MA, Wong F, Samuel K, Reddy VB, Mitelman S, Tong SX, Chicchi GG, Tsao KL, Trusca D, Wu M, Shao Q, Trujillo ME, Eiermann GJ, Li C, Zhang BB, Howard AD, Zhou YP, Nargund RP, Hagmann WK.

ACS Med Chem Lett. 2012 May 7;3(6):484-9. doi: 10.1021/ml300063m. eCollection 2012 Jun 14.

23.

A new class of prolylcarboxypeptidase inhibitors, part 2: the aminocyclopentanes.

Graham TH, Liu W, Verras A, Reibarkh M, Bleasby K, Bhatt UR, Chen Q, Garcia-Calvo M, Geissler WM, Gorski JN, He H, Lassman ME, Lisnock J, Li X, Shen Z, Tong X, Tung EC, Wiltsie J, Xie D, Xu S, Xiao J, Hale JJ, Pinto S, Shen DM.

Bioorg Med Chem Lett. 2012 Apr 15;22(8):2818-22. doi: 10.1016/j.bmcl.2012.02.077. Epub 2012 Mar 1.

PMID:
22444685
24.

Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.

Miao B, Skidan I, Yang J, Lugovskoy A, Reibarkh M, Long K, Brazell T, Durugkar KA, Maki J, Ramana CV, Schaffhausen B, Wagner G, Torchilin V, Yuan J, Degterev A.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20126-31. doi: 10.1073/pnas.1004522107. Epub 2010 Nov 1.

25.

Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity.

He S, Ye Z, Dobbelaar PH, Bakshi RK, Hong Q, Dellureficio JP, Sebhat IK, Guo L, Liu J, Jian T, Lai Y, Franklin CL, Reibarkh M, Holmes MA, Weinberg DH, MacNeil T, Tang R, Tamvakopoulos C, Peng Q, Miller RR, Stearns RA, Chen HY, Chen AS, Strack AM, Fong TM, Wyvratt MJ Jr, Nargund RP.

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6524-32. doi: 10.1016/j.bmcl.2010.09.049. Epub 2010 Sep 19.

PMID:
20933410
26.

Substituted fused bicyclic pyrrolizinones as potent, orally bioavailable hNK1 antagonists.

Morriello GJ, Mills SG, Johnson T, Reibarkh M, Chicchi G, DeMartino J, Kurtz M, Davies P, Tsao KL, Zheng S, Tong X, Carlson E, Townson K, Tattersall FD, Wheeldon A, Boyce S, Collinson N, Rupniak N, Moore S, DeVita RJ.

Bioorg Med Chem Lett. 2010 Mar 15;20(6):2007-12. doi: 10.1016/j.bmcl.2010.01.065. Epub 2010 Jan 20.

PMID:
20153964
27.

Selective pharmacological targeting of a DEAD box RNA helicase.

Lindqvist L, Oberer M, Reibarkh M, Cencic R, Bordeleau ME, Vogt E, Marintchev A, Tanaka J, Fagotto F, Altmann M, Wagner G, Pelletier J.

PLoS One. 2008 Feb 13;3(2):e1583. doi: 10.1371/journal.pone.0001583.

28.

Eukaryotic initiation factor (eIF) 1 carries two distinct eIF5-binding faces important for multifactor assembly and AUG selection.

Reibarkh M, Yamamoto Y, Singh CR, del Rio F, Fahmy A, Lee B, Luna RE, Ii M, Wagner G, Asano K.

J Biol Chem. 2008 Jan 11;283(2):1094-103. Epub 2007 Nov 1.

29.

Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G.

Moerke NJ, Aktas H, Chen H, Cantel S, Reibarkh MY, Fahmy A, Gross JD, Degterev A, Yuan J, Chorev M, Halperin JA, Wagner G.

Cell. 2007 Jan 26;128(2):257-67.

30.

Identification of individual protein-ligand NOEs in the limit of intermediate exchange.

Reibarkh M, Malia TJ, Hopkins BT, Wagner G.

J Biomol NMR. 2006 Sep;36(1):1-11. Epub 2006 Sep 9.

PMID:
16964534
31.

NMR distinction of single- and multiple-mode binding of small-molecule protein ligands.

Reibarkh M, Malia TJ, Wagner G.

J Am Chem Soc. 2006 Feb 22;128(7):2160-1.

32.

[I87E mutation prevents barstar dimerization].

Korchuganov DS, Shul'ga AA, Ermoliuk IaS, Mit'kevich VA, Reĭbarkh MIa, Nol'de SB, Makarov AA, Arsen'ev AS, Kirpichnikov MP.

Bioorg Khim. 2004 Nov-Dec;30(6):638-43. Russian.

PMID:
15586816
33.

Interatomic potentials and solvation parameters from protein engineering data for buried residues.

Lomize AL, Reibarkh MY, Pogozheva ID.

Protein Sci. 2002 Aug;11(8):1984-2000.

34.

NMR study of monomer-dimer equilibrium of barstar in solution.

Korchuganov DS, Nolde SB, Reibarkh MY, Orekhov VY, Schulga AA, Ermolyuk YS, Kirpichnikov MP, Arseniev AS.

J Am Chem Soc. 2001 Mar 7;123(9):2068-9. No abstract available.

PMID:
11456835
35.

Three-dimensional structure of binase in solution.

Reibarkh MYa, Nolde DE, Vasilieva LI, Bocharov EV, Shulga AA, Kirpichnikov MP, Arseniev AS.

FEBS Lett. 1998 Jul 17;431(2):250-4.

36.

[Secondary structure of binase in solution by 1H NMR].

Reĭbarkh MYa, Nol'de DE, Bocharov EV, Vasil'eva LI, Shul'ga AA, Kirpichnikov MP, Arsen'ev AS.

Bioorg Khim. 1997 Oct;23(10):783-94. Russian.

PMID:
9490613
37.

Three-dimensional structure of toxin OSK1 from Orthochirus scrobiculosus scorpion venom.

Jaravine VA, Nolde DE, Reibarkh MJ, Korolkova YV, Kozlov SA, Pluzhnikov KA, Grishin EV, Arseniev AS.

Biochemistry. 1997 Feb 11;36(6):1223-32.

PMID:
9063870

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