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Items: 48

1.

A Balancing Act: MDA5 in Antiviral Immunity and Autoinflammation.

Dias Junior AG, Sampaio NG, Rehwinkel J.

Trends Microbiol. 2018 Sep 7. pii: S0966-842X(18)30179-3. doi: 10.1016/j.tim.2018.08.007. [Epub ahead of print] Review.

PMID:
30201512
2.

Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling.

Hansen AL, Buchan GJ, Rühl M, Mukai K, Salvatore SR, Ogawa E, Andersen SD, Iversen MB, Thielke AL, Gunderstofte C, Motwani M, Møller CT, Jakobsen AS, Fitzgerald KA, Roos J, Lin R, Maier TJ, Goldbach-Mansky R, Miner CA, Qian W, Miner JJ, Rigby RE, Rehwinkel J, Jakobsen MR, Arai H, Taguchi T, Schopfer FJ, Olagnier D, Holm CK.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7768-E7775. doi: 10.1073/pnas.1806239115. Epub 2018 Jul 30.

3.

Mitochondrial double-stranded RNA triggers antiviral signalling in humans.

Dhir A, Dhir S, Borowski LS, Jimenez L, Teitell M, Rötig A, Crow YJ, Rice GI, Duffy D, Tamby C, Nojima T, Munnich A, Schiff M, de Almeida CR, Rehwinkel J, Dziembowski A, Szczesny RJ, Proudfoot NJ.

Nature. 2018 Aug;560(7717):238-242. doi: 10.1038/s41586-018-0363-0. Epub 2018 Jul 25.

PMID:
30046113
4.

Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling.

Hertzog J, Dias Junior AG, Rigby RE, Donald CL, Mayer A, Sezgin E, Song C, Jin B, Hublitz P, Eggeling C, Kohl A, Rehwinkel J.

Eur J Immunol. 2018 Jul;48(7):1120-1136. doi: 10.1002/eji.201847483. Epub 2018 Apr 6.

5.

Erratum to: Purification of Cyclic GMP-AMP from Viruses and Measurement of Its Activity in Cell Culture.

Mayer A, Maelfait J, Bridgeman A, Rehwinkel J.

Methods Mol Biol. 2017;1656:E1. doi: 10.1007/978-1-4939-7237-1_18. No abstract available.

6.

B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis.

Bénard A, Sakwa I, Schierloh P, Colom A, Mercier I, Tailleux L, Jouneau L, Boudinot P, Al-Saati T, Lang R, Rehwinkel J, Loxton AG, Kaufmann SHE, Anton-Leberre V, O'Garra A, Sasiain MDC, Gicquel B, Fillatreau S, Neyrolles O, Hudrisier D.

Am J Respir Crit Care Med. 2018 Mar 15;197(6):801-813. doi: 10.1164/rccm.201707-1475OC.

7.

Purification of Cyclic GMP-AMP from Viruses and Measurement of Its Activity in Cell Culture.

Mayer A, Maelfait J, Bridgeman A, Rehwinkel J.

Methods Mol Biol. 2017;1656:143-152. doi: 10.1007/978-1-4939-7237-1_8. Erratum in: Methods Mol Biol. 2017;1656:E1.

8.

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.

Glück S, Guey B, Gulen MF, Wolter K, Kang TW, Schmacke NA, Bridgeman A, Rehwinkel J, Zender L, Ablasser A.

Nat Cell Biol. 2017 Sep;19(9):1061-1070. doi: 10.1038/ncb3586. Epub 2017 Jul 31.

9.

Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis.

Maelfait J, Liverpool L, Bridgeman A, Ragan KB, Upton JW, Rehwinkel J.

EMBO J. 2017 Sep 1;36(17):2529-2543. doi: 10.15252/embj.201796476. Epub 2017 Jul 17.

10.

RECONsidering Sensing of Cyclic Dinucleotides.

Maelfait J, Rehwinkel J.

Immunity. 2017 Mar 21;46(3):337-339. doi: 10.1016/j.immuni.2017.03.005.

11.

A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1.

Erdal E, Haider S, Rehwinkel J, Harris AL, McHugh PJ.

Genes Dev. 2017 Feb 15;31(4):353-369. doi: 10.1101/gad.289769.116. Epub 2017 Mar 9.

12.

A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages.

Mlcochova P, Sutherland KA, Watters SA, Bertoli C, de Bruin RA, Rehwinkel J, Neil SJ, Lenzi GM, Kim B, Khwaja A, Gage MC, Georgiou C, Chittka A, Yona S, Noursadeghi M, Towers GJ, Gupta RK.

EMBO J. 2017 Mar 1;36(5):604-616. doi: 10.15252/embj.201696025. Epub 2017 Jan 25.

13.

Full Genome Sequence and sfRNA Interferon Antagonist Activity of Zika Virus from Recife, Brazil.

Donald CL, Brennan B, Cumberworth SL, Rezelj VV, Clark JJ, Cordeiro MT, Freitas de Oliveira França R, Pena LJ, Wilkie GS, Da Silva Filipe A, Davis C, Hughes J, Varjak M, Selinger M, Zuvanov L, Owsianka AM, Patel AH, McLauchlan J, Lindenbach BD, Fall G, Sall AA, Biek R, Rehwinkel J, Schnettler E, Kohl A.

PLoS Negl Trop Dis. 2016 Oct 5;10(10):e0005048. doi: 10.1371/journal.pntd.0005048. eCollection 2016 Oct.

14.

Is anti-viral defence the evolutionary origin of mRNA turnover? (Comment on DOI 10.1002/bies.201600100).

Rehwinkel J.

Bioessays. 2016 Sep;38(9):817. doi: 10.1002/bies.201600140. Epub 2016 Aug 1. No abstract available.

15.

Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1.

Maelfait J, Bridgeman A, Benlahrech A, Cursi C, Rehwinkel J.

Cell Rep. 2016 Aug 9;16(6):1492-1501. doi: 10.1016/j.celrep.2016.07.002. Epub 2016 Jul 28.

16.

Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses.

Goubau D, van der Veen AG, Chakravarty P, Lin R, Rogers N, Rehwinkel J, Deddouche S, Rosewell I, Hiscott J, Reis e Sousa C.

Eur J Immunol. 2015 Dec;45(12):3386-403. doi: 10.1002/eji.201545794. Epub 2015 Oct 12.

17.

Viruses transfer the antiviral second messenger cGAMP between cells.

Bridgeman A, Maelfait J, Davenne T, Partridge T, Peng Y, Mayer A, Dong T, Kaever V, Borrow P, Rehwinkel J.

Science. 2015 Sep 11;349(6253):1228-32. doi: 10.1126/science.aab3632. Epub 2015 Jul 30.

18.

RNA degradation in antiviral immunity and autoimmunity.

Rigby RE, Rehwinkel J.

Trends Immunol. 2015 Mar;36(3):179-88. doi: 10.1016/j.it.2015.02.001. Epub 2015 Feb 20. Review.

19.

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates.

Goubau D, Schlee M, Deddouche S, Pruijssers AJ, Zillinger T, Goldeck M, Schuberth C, Van der Veen AG, Fujimura T, Rehwinkel J, Iskarpatyoti JA, Barchet W, Ludwig J, Dermody TS, Hartmann G, Reis e Sousa C.

Nature. 2014 Oct 16;514(7522):372-375. doi: 10.1038/nature13590. Epub 2014 Aug 10.

20.

Mouse knockout models for HIV-1 restriction factors.

Rehwinkel J.

Cell Mol Life Sci. 2014 Oct;71(19):3749-66. doi: 10.1007/s00018-014-1646-8. Epub 2014 May 23. Review.

21.
22.

Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells.

Deddouche S, Goubau D, Rehwinkel J, Chakravarty P, Begum S, Maillard PV, Borg A, Matthews N, Feng Q, van Kuppeveld FJ, Reis e Sousa C.

Elife. 2014 Feb 18;3:e01535. doi: 10.7554/eLife.01535.

23.

SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.

Clifford R, Louis T, Robbe P, Ackroyd S, Burns A, Timbs AT, Wright Colopy G, Dreau H, Sigaux F, Judde JG, Rotger M, Telenti A, Lin YL, Pasero P, Maelfait J, Titsias M, Cohen DR, Henderson SJ, Ross MT, Bentley D, Hillmen P, Pettitt A, Rehwinkel J, Knight SJ, Taylor JC, Crow YJ, Benkirane M, Schuh A.

Blood. 2014 Feb 13;123(7):1021-31. doi: 10.1182/blood-2013-04-490847. Epub 2013 Dec 12.

24.

RNA sensing: the more RIG-I the merrier?

Rehwinkel J.

EMBO Rep. 2013 Sep;14(9):751-2. doi: 10.1038/embor.2013.120. Epub 2013 Aug 6. No abstract available.

25.

SAMHD1-dependent retroviral control and escape in mice.

Rehwinkel J, Maelfait J, Bridgeman A, Rigby R, Hayward B, Liberatore RA, Bieniasz PD, Towers GJ, Moita LF, Crow YJ, Bonthron DT, Reis e Sousa C.

EMBO J. 2013 Sep 11;32(18):2454-62. doi: 10.1038/emboj.2013.163. Epub 2013 Jul 19.

26.

Targeting the viral Achilles' heel: recognition of 5'-triphosphate RNA in innate anti-viral defence.

Rehwinkel J, Reis e Sousa C.

Curr Opin Microbiol. 2013 Aug;16(4):485-92. doi: 10.1016/j.mib.2013.04.009. Epub 2013 May 23. Review.

PMID:
23707340
27.

PYHIN proteins: center stage in DNA sensing.

Goubau D, Rehwinkel J, Reis e Sousa C.

Nat Immunol. 2010 Nov;11(11):984-6. doi: 10.1038/ni1110-984. No abstract available.

PMID:
20959802
28.

Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity.

Schulz O, Pichlmair A, Rehwinkel J, Rogers NC, Scheuner D, Kato H, Takeuchi O, Akira S, Kaufman RJ, Reis e Sousa C.

Cell Host Microbe. 2010 May 20;7(5):354-61. doi: 10.1016/j.chom.2010.04.007.

29.

Exposing viruses: RNA patterns sensed by RIG-I-like receptors.

Rehwinkel J.

J Clin Immunol. 2010 Jul;30(4):491-5. doi: 10.1007/s10875-010-9384-7. Epub 2010 Mar 31. Review.

PMID:
20354786
30.

RIG-I detects viral genomic RNA during negative-strand RNA virus infection.

Rehwinkel J, Tan CP, Goubau D, Schulz O, Pichlmair A, Bier K, Robb N, Vreede F, Barclay W, Fodor E, Reis e Sousa C.

Cell. 2010 Feb 5;140(3):397-408. doi: 10.1016/j.cell.2010.01.020.

31.

RIGorous detection: exposing virus through RNA sensing.

Rehwinkel J, Reis e Sousa C.

Science. 2010 Jan 15;327(5963):284-6. doi: 10.1126/science.1185068.

PMID:
20075242
32.

Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity.

Crow YJ, Rehwinkel J.

Hum Mol Genet. 2009 Oct 15;18(R2):R130-6. doi: 10.1093/hmg/ddp293. Review.

33.

Activation of MDA5 requires higher-order RNA structures generated during virus infection.

Pichlmair A, Schulz O, Tan CP, Rehwinkel J, Kato H, Takeuchi O, Akira S, Way M, Schiavo G, Reis e Sousa C.

J Virol. 2009 Oct;83(20):10761-9. doi: 10.1128/JVI.00770-09. Epub 2009 Aug 5.

34.

Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila.

Hansen KD, Lareau LF, Blanchette M, Green RE, Meng Q, Rehwinkel J, Gallusser FL, Izaurralde E, Rio DC, Dudoit S, Brenner SE.

PLoS Genet. 2009 Jun;5(6):e1000525. doi: 10.1371/journal.pgen.1000525. Epub 2009 Jun 19.

35.

Deadenylation is a widespread effect of miRNA regulation.

Eulalio A, Huntzinger E, Nishihara T, Rehwinkel J, Fauser M, Izaurralde E.

RNA. 2009 Jan;15(1):21-32. doi: 10.1261/rna.1399509. Epub 2008 Nov 24.

36.

Exploring the economics of motorcycle helmet laws--implications for low and middle-income countries.

Hyder AA, Waters H, Phillips T, Rehwinkel J.

Asia Pac J Public Health. 2007;19(2):16-22. Review.

PMID:
18050559
37.

Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing.

Eulalio A, Rehwinkel J, Stricker M, Huntzinger E, Yang SF, Doerks T, Dorner S, Bork P, Boutros M, Izaurralde E.

Genes Dev. 2007 Oct 15;21(20):2558-70. Epub 2007 Sep 27.

38.

mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons.

Behm-Ansmant I, Kashima I, Rehwinkel J, Saulière J, Wittkopp N, Izaurralde E.

FEBS Lett. 2007 Jun 19;581(15):2845-53. Epub 2007 May 21. Review.

39.

MicroRNAs silence gene expression by repressing protein expression and/or by promoting mRNA decay.

Behm-Ansmant I, Rehwinkel J, Izaurralde E.

Cold Spring Harb Symp Quant Biol. 2006;71:523-30. Review.

PMID:
17381335
40.

A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay.

Behm-Ansmant I, Gatfield D, Rehwinkel J, Hilgers V, Izaurralde E.

EMBO J. 2007 Mar 21;26(6):1591-601. Epub 2007 Feb 22.

41.

Nonsense-mediated mRNA decay: Target genes and functional diversification of effectors.

Rehwinkel J, Raes J, Izaurralde E.

Trends Biochem Sci. 2006 Nov;31(11):639-46. Epub 2006 Sep 28.

PMID:
17010613
42.

mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes.

Behm-Ansmant I, Rehwinkel J, Doerks T, Stark A, Bork P, Izaurralde E.

Genes Dev. 2006 Jul 15;20(14):1885-98. Epub 2006 Jun 30.

43.

Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogaster.

Rehwinkel J, Natalin P, Stark A, Brennecke J, Cohen SM, Izaurralde E.

Mol Cell Biol. 2006 Apr;26(8):2965-75.

44.

Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets.

Rehwinkel J, Letunic I, Raes J, Bork P, Izaurralde E.

RNA. 2005 Oct;11(10):1530-44.

45.

A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing.

Rehwinkel J, Behm-Ansmant I, Gatfield D, Izaurralde E.

RNA. 2005 Nov;11(11):1640-7. Epub 2005 Sep 21.

46.

The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha.

Jínek M, Rehwinkel J, Lazarus BD, Izaurralde E, Hanover JA, Conti E.

Nat Struct Mol Biol. 2004 Oct;11(10):1001-7. Epub 2004 Sep 12.

PMID:
15361863
47.

Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster.

Rehwinkel J, Herold A, Gari K, Köcher T, Rode M, Ciccarelli FL, Wilm M, Izaurralde E.

Nat Struct Mol Biol. 2004 Jun;11(6):558-66. Epub 2004 May 9.

PMID:
15133499
48.

Economic evaluation of Mectizan distribution.

Waters HR, Rehwinkel JA, Burnham G.

Trop Med Int Health. 2004 Apr;9(4):A16-25. Review.

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