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Items: 22

1.

Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases.

Hemmerling M, Nilsson S, Edman K, Eirefelt S, Russell W, Hendrickx R, Johnsson E, Kärrman Mårdh C, Berger M, Rehwinkel H, Abrahamsson A, Dahmén J, Eriksson AR, Gabos B, Henriksson K, Hossain N, Ivanova S, Jansson AH, Jensen TJ, Jerre A, Johansson H, Klingstedt T, Lepistö M, Lindsjö M, Mile I, Nikitidis G, Steele J, Tehler U, Wissler L, Hansson T.

J Med Chem. 2017 Oct 26;60(20):8591-8605. doi: 10.1021/acs.jmedchem.7b01215. Epub 2017 Oct 12.

PMID:
28937774
2.

Pan-mutant-IDH1 inhibitor BAY1436032 is highly effective against human IDH1 mutant acute myeloid leukemia in vivo.

Chaturvedi A, Herbst L, Pusch S, Klett L, Goparaju R, Stichel D, Kaulfuss S, Panknin O, Zimmermann K, Toschi L, Neuhaus R, Haegebarth A, Rehwinkel H, Hess-Stumpp H, Bauser M, Bochtler T, Struys EA, Sharma A, Bakkali A, Geffers R, Araujo-Cruz MM, Thol F, Gabdoulline R, Ganser A, Ho AD, von Deimling A, Rippe K, Heuser M, Krämer A.

Leukemia. 2017 Oct;31(10):2020-2028. doi: 10.1038/leu.2017.46. Epub 2017 Jan 31.

3.

Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo.

Pusch S, Krausert S, Fischer V, Balss J, Ott M, Schrimpf D, Capper D, Sahm F, Eisel J, Beck AC, Jugold M, Eichwald V, Kaulfuss S, Panknin O, Rehwinkel H, Zimmermann K, Hillig RC, Guenther J, Toschi L, Neuhaus R, Haegebart A, Hess-Stumpp H, Bauser M, Wick W, Unterberg A, Herold-Mende C, Platten M, von Deimling A.

Acta Neuropathol. 2017 Apr;133(4):629-644. doi: 10.1007/s00401-017-1677-y. Epub 2017 Jan 25.

PMID:
28124097
4.

Discovery of new selective glucocorticoid receptor agonist leads.

Berger M, Rehwinkel H, Schmees N, Schäcke H, Edman K, Wissler L, Reichel A, Jaroch S.

Bioorg Med Chem Lett. 2017 Feb 1;27(3):437-442. doi: 10.1016/j.bmcl.2016.12.047. Epub 2016 Dec 23.

PMID:
28043796
5.

Discovery of indazole ethers as novel, potent, non-steroidal glucocorticoid receptor modulators.

Hemmerling M, Edman K, Lepistö M, Eriksson A, Ivanova S, Dahmén J, Rehwinkel H, Berger M, Hendrickx R, Dearman M, Jensen TJ, Wissler L, Hansson T.

Bioorg Med Chem Lett. 2016 Dec 1;26(23):5741-5748. doi: 10.1016/j.bmcl.2016.10.052. Epub 2016 Oct 19.

PMID:
27810243
6.

Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876.

Siebeneicher H, Cleve A, Rehwinkel H, Neuhaus R, Heisler I, Müller T, Bauser M, Buchmann B.

ChemMedChem. 2016 Oct 19;11(20):2261-2271. doi: 10.1002/cmdc.201600276. Epub 2016 Aug 23.

7.

Identification of novel GLUT inhibitors.

Siebeneicher H, Bauser M, Buchmann B, Heisler I, Müller T, Neuhaus R, Rehwinkel H, Telser J, Zorn L.

Bioorg Med Chem Lett. 2016 Apr 1;26(7):1732-7. doi: 10.1016/j.bmcl.2016.02.050. Epub 2016 Feb 19.

PMID:
26949183
8.

Discovery of quinolines as selective glucocorticoid receptor agonists.

Jaroch S, Berger M, Huwe C, Krolikiewicz K, Rehwinkel H, Schäcke H, Schmees N, Skuballa W.

Bioorg Med Chem Lett. 2010 Oct 1;20(19):5835-8. doi: 10.1016/j.bmcl.2010.07.125. Epub 2010 Aug 3.

PMID:
20727743
9.

Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases.

Schäcke H, Zollner TM, Döcke WD, Rehwinkel H, Jaroch S, Skuballa W, Neuhaus R, May E, Zügel U, Asadullah K.

Br J Pharmacol. 2009 Oct;158(4):1088-103. doi: 10.1111/j.1476-5381.2009.00238.x. Epub 2009 May 6.

10.

Selective glucocorticoid receptor agonists (SEGRAs): novel ligands with an improved therapeutic index.

Schäcke H, Berger M, Rehwinkel H, Asadullah K.

Mol Cell Endocrinol. 2007 Sep 15;275(1-2):109-17. Epub 2007 May 31. Review.

PMID:
17630119
11.

GR ligands: can we improve the established drugs?

Rehwinkel H, Schäcke H.

ChemMedChem. 2006 Aug;1(8):803-5. Review. No abstract available.

PMID:
16902932
12.
13.

Dissociated glucocorticoid receptor ligands: compounds with an improved therapeutic index.

Schäcke H, Rehwinkel H, Asadullah K.

Curr Opin Investig Drugs. 2005 May;6(5):503-7. Review.

PMID:
15912964
14.

Dissociated glucocorticoid receptor ligands.

Schäcke H, Rehwinkel H.

Curr Opin Investig Drugs. 2004 May;5(5):524-8. Review.

PMID:
15202726
15.

Fluorinated dihydroquinolines as potent n-NOS inhibitors.

Jaroch S, Rehwinkel H, Hölscher P, Sülzle D, Burton G, Hillmann M, McDonald FM, Miklautz H.

Bioorg Med Chem Lett. 2004 Feb 9;14(3):743-6.

PMID:
14741281
16.

Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects.

Schäcke H, Schottelius A, Döcke WD, Strehlke P, Jaroch S, Schmees N, Rehwinkel H, Hennekes H, Asadullah K.

Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):227-32. Epub 2003 Dec 23.

17.

Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors.

Jaroch S, Hölscher P, Rehwinkel H, Sülzle D, Burton G, Hillmann M, McDonald FM.

Bioorg Med Chem Lett. 2003 Jun 16;13(12):1981-4.

PMID:
12781178
18.

SEGRAs: a novel class of anti-inflammatory compounds.

Schäcke H, Hennekes H, Schottelius A, Jaroch S, Lehmann M, Schmees N, Rehwinkel H, Asadullah K.

Ernst Schering Res Found Workshop. 2002;(40):357-71. Review.

PMID:
12355726
19.

Dihydroquinolines as novel n-NOS inhibitors.

Jaroch S, Hölscher P, Rehwinkel H, Sülzle D, Burton G, Hillmann M, McDonald FM.

Bioorg Med Chem Lett. 2002 Sep 16;12(18):2561-4.

PMID:
12182860
20.

Novel prostanoid thromboxane A2 agonists.

Joachim KD, Klar U, Pletsch A, Rehwinkel H, Skuballa W.

Prostaglandins. 1995 Aug;50(2):57-63.

PMID:
8588073
21.

Stable 9 beta- or 11 alpha-halogen-15-cyclohexyl-prostaglandins with high affinity to the PGD2-receptor.

Thierauch KH, Stürzebecher CS, Schillinger E, Rehwinkel H, Radüchel B, Skuballa W, Vorbrüggen H.

Adv Prostaglandin Thromboxane Leukot Res. 1989;19:655-8. No abstract available.

PMID:
2526554
22.

Stable 9 beta- or 11 alpha-halogen-15-cyclohexyl-prostaglandins with high affinity to the PGD2-receptor.

Thierauch KH, Stürzebecher CS, Schillinger E, Rehwinkel H, Radüchel B, Skuballa W, Vorbrüggen H.

Prostaglandins. 1988 Jun;35(6):855-68.

PMID:
2847246

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