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Redox signals at the ER-mitochondria interface control melanoma progression.

Zhang X, Gibhardt CS, Will T, Stanisz H, Körbel C, Mitkovski M, Stejerean I, Cappello S, Pacheu-Grau D, Dudek J, Tahbaz N, Mina L, Simmen T, Laschke MW, Menger MD, Schön MP, Helms V, Niemeyer BA, Rehling P, Vultur A, Bogeski I.

EMBO J. 2019 Aug 1;38(15):e100871. doi: 10.15252/embj.2018100871. Epub 2019 Jul 15.


Guarding the gate for mitochondrial entry.

Callegari S, Rehling P.

Nature. 2019 May;569(7758):635-637. doi: 10.1038/d41586-019-01588-7. No abstract available.


Neuronal Redox-Imbalance in Rett Syndrome Affects Mitochondria as Well as Cytosol, and Is Accompanied by Intensified Mitochondrial O 2 Consumption and ROS Release.

Can K, Menzfeld C, Rinne L, Rehling P, Kügler S, Golubiani G, Dudek J, Müller M.

Front Physiol. 2019 Apr 30;10:479. doi: 10.3389/fphys.2019.00479. eCollection 2019.


A MICOS-TIM22 Association Promotes Carrier Import into Human Mitochondria.

Callegari S, Müller T, Schulz C, Lenz C, Jans DC, Wissel M, Opazo F, Rizzoli SO, Jakobs S, Urlaub H, Rehling P, Deckers M.

J Mol Biol. 2019 Jul 12;431(15):2835-2851. doi: 10.1016/j.jmb.2019.05.015. Epub 2019 May 17.


Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7.

Mohanraj K, Wasilewski M, Benincá C, Cysewski D, Poznanski J, Sakowska P, Bugajska Z, Deckers M, Dennerlein S, Fernandez-Vizarra E, Rehling P, Dadlez M, Zeviani M, Chacinska A.

EMBO Mol Med. 2019 May;11(5). pii: e9561. doi: 10.15252/emmm.201809561.


The role of mitochondrial cardiolipin in heart function and its implication in cardiac disease.

Dudek J, Hartmann M, Rehling P.

Biochim Biophys Acta Mol Basis Dis. 2019 Apr 1;1865(4):810-821. doi: 10.1016/j.bbadis.2018.08.025. Epub 2018 Aug 26. Review.


O2 affects mitochondrial functionality ex vivo.

Nanadikar MS, Vergel Leon AM, Borowik S, Hillemann A, Zieseniss A, Belousov VV, Bogeski I, Rehling P, Dudek J, Katschinski DM.

Redox Biol. 2019 Apr;22:101152. doi: 10.1016/j.redox.2019.101152. Epub 2019 Feb 23.


Overexpression of branched-chain amino acid aminotransferases rescues the growth defects of cells lacking the Barth syndrome-related gene TAZ1.

Antunes D, Chowdhury A, Aich A, Saladi S, Harpaz N, Stahl M, Schuldiner M, Herrmann JM, Rehling P, Rapaport D.

J Mol Med (Berl). 2019 Feb;97(2):269-279. doi: 10.1007/s00109-018-1728-4. Epub 2019 Jan 3.


ROMO1 is a constituent of the human presequence translocase required for YME1L protease import.

Richter F, Dennerlein S, Nikolov M, Jans DC, Naumenko N, Aich A, MacVicar T, Linden A, Jakobs S, Urlaub H, Langer T, Rehling P.

J Cell Biol. 2019 Feb 4;218(2):598-614. doi: 10.1083/jcb.201806093. Epub 2018 Dec 31.


Combined Use of Unnatural Amino Acids Enables Dual-Color Super-Resolution Imaging of Proteins via Click Chemistry.

Saal KA, Richter F, Rehling P, Rizzoli SO.

ACS Nano. 2018 Dec 26;12(12):12247-12254. doi: 10.1021/acsnano.8b06047. Epub 2018 Dec 13.


Mutations of the mitochondrial carrier translocase channel subunit TIM22 cause early-onset mitochondrial myopathy.

Pacheu-Grau D, Callegari S, Emperador S, Thompson K, Aich A, Topol SE, Spencer EG, McFarland R, Ruiz-Pesini E, Torkamani A, Taylor RW, Montoya J, Rehling P.

Hum Mol Genet. 2018 Dec 1;27(23):4135-4144. doi: 10.1093/hmg/ddy305.


The codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain.

Mandad S, Rahman RU, Centeno TP, Vidal RO, Wildhagen H, Rammner B, Keihani S, Opazo F, Urban I, Ischebeck T, Kirli K, Benito E, Fischer A, Yousefi RY, Dennerlein S, Rehling P, Feussner I, Urlaub H, Bonn S, Rizzoli SO, Fornasiero EF.

Sci Rep. 2018 Nov 15;8(1):16913. doi: 10.1038/s41598-018-35277-8.


Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia.

Chowdhury A, Aich A, Jain G, Wozny K, Lüchtenborg C, Hartmann M, Bernhard O, Balleiniger M, Alfar EA, Zieseniss A, Toischer K, Guan K, Rizzoli SO, Brügger B, Fischer A, Katschinski DM, Rehling P, Dudek J.

Cell Rep. 2018 Oct 16;25(3):561-570.e6. doi: 10.1016/j.celrep.2018.09.057.


Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions.

Fornasiero EF, Mandad S, Wildhagen H, Alevra M, Rammner B, Keihani S, Opazo F, Urban I, Ischebeck T, Sakib MS, Fard MK, Kirli K, Centeno TP, Vidal RO, Rahman RU, Benito E, Fischer A, Dennerlein S, Rehling P, Feussner I, Bonn S, Simons M, Urlaub H, Rizzoli SO.

Nat Commun. 2018 Oct 12;9(1):4230. doi: 10.1038/s41467-018-06519-0.


Motor recruitment to the TIM23 channel's lateral gate restricts polypeptide release into the inner membrane.

Schendzielorz AB, Bragoszewski P, Naumenko N, Gomkale R, Schulz C, Guiard B, Chacinska A, Rehling P.

Nat Commun. 2018 Oct 2;9(1):4028. doi: 10.1038/s41467-018-06492-8.


COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis.

Aich A, Wang C, Chowdhury A, Ronsör C, Pacheu-Grau D, Richter-Dennerlein R, Dennerlein S, Rehling P.

Elife. 2018 Jan 30;7. pii: e32572. doi: 10.7554/eLife.32572.


The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis.

Lorenzi I, Oeljeklaus S, Aich A, Ronsör C, Callegari S, Dudek J, Warscheid B, Dennerlein S, Rehling P.

Biochim Biophys Acta Mol Cell Res. 2018 Feb;1865(2):323-333. doi: 10.1016/j.bbamcr.2017.11.010. Epub 2017 Nov 16.


Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy.

Richter KN, Revelo NH, Seitz KJ, Helm MS, Sarkar D, Saleeb RS, D'Este E, Eberle J, Wagner E, Vogl C, Lazaro DF, Richter F, Coy-Vergara J, Coceano G, Boyden ES, Duncan RR, Hell SW, Lauterbach MA, Lehnart SE, Moser T, Outeiro TF, Rehling P, Schwappach B, Testa I, Zapiec B, Rizzoli SO.

EMBO J. 2018 Jan 4;37(1):139-159. doi: 10.15252/embj.201695709. Epub 2017 Nov 16.


INA complex liaises the F1Fo-ATP synthase membrane motor modules.

Naumenko N, Morgenstern M, Rucktäschel R, Warscheid B, Rehling P.

Nat Commun. 2017 Nov 1;8(1):1237. doi: 10.1038/s41467-017-01437-z.


Cation selectivity of the presequence translocase channel Tim23 is crucial for efficient protein import.

Denkert N, Schendzielorz AB, Barbot M, Versemann L, Richter F, Rehling P, Meinecke M.

Elife. 2017 Aug 31;6. pii: e28324. doi: 10.7554/eLife.28324.


Plasticity of Mitochondrial Translation.

Dennerlein S, Wang C, Rehling P.

Trends Cell Biol. 2017 Oct;27(10):712-721. doi: 10.1016/j.tcb.2017.05.004. Epub 2017 Jun 9. Review.


Two distinct membrane potential-dependent steps drive mitochondrial matrix protein translocation.

Schendzielorz AB, Schulz C, Lytovchenko O, Clancy A, Guiard B, Ieva R, van der Laan M, Rehling P.

J Cell Biol. 2017 Jan 2;216(1):83-92. doi: 10.1083/jcb.201607066. Epub 2016 Dec 23.


Phospho-ubiquitin-PARK2 complex as a marker for mitophagy defects.

Callegari S, Oeljeklaus S, Warscheid B, Dennerlein S, Thumm M, Rehling P, Dudek J.

Autophagy. 2017 Jan 2;13(1):201-211. doi: 10.1080/15548627.2016.1254852. Epub 2016 Nov 15.


PHD2 Is a Regulator for Glycolytic Reprogramming in Macrophages.

Guentsch A, Beneke A, Swain L, Farhat K, Nagarajan S, Wielockx B, Raithatha K, Dudek J, Rehling P, Zieseniss A, Jatho A, Chong M, Santos CXC, Shah AM, Katschinski DM.

Mol Cell Biol. 2016 Dec 19;37(1). pii: e00236-16. doi: 10.1128/MCB.00236-16. Print 2017 Jan 1.


TIM29 is a subunit of the human carrier translocase required for protein transport.

Callegari S, Richter F, Chojnacka K, Jans DC, Lorenzi I, Pacheu-Grau D, Jakobs S, Lenz C, Urlaub H, Dudek J, Chacinska A, Rehling P.

FEBS Lett. 2016 Dec;590(23):4147-4158. doi: 10.1002/1873-3468.12450. Epub 2016 Oct 26.


Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein.

Richter-Dennerlein R, Oeljeklaus S, Lorenzi I, Ronsör C, Bareth B, Schendzielorz AB, Wang C, Warscheid B, Rehling P, Dennerlein S.

Cell. 2016 Oct 6;167(2):471-483.e10. doi: 10.1016/j.cell.2016.09.003. Epub 2016 Sep 29.


Ribosome-Associated Mba1 Escorts Cox2 from Insertion Machinery to Maturing Assembly Intermediates.

Lorenzi I, Oeljeklaus S, Ronsör C, Bareth B, Warscheid B, Rehling P, Dennerlein S.

Mol Cell Biol. 2016 Oct 28;36(22):2782-2793. doi: 10.1128/MCB.00361-16. Print 2016 Nov 15.


NSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translation.

Haag S, Sloan KE, Ranjan N, Warda AS, Kretschmer J, Blessing C, Hübner B, Seikowski J, Dennerlein S, Rehling P, Rodnina MV, Höbartner C, Bohnsack MT.

EMBO J. 2016 Oct 4;35(19):2104-2119. Epub 2016 Aug 5.


Cox26 is a novel stoichiometric subunit of the yeast cytochrome c oxidase.

Levchenko M, Wuttke JM, Römpler K, Schmidt B, Neifer K, Juris L, Wissel M, Rehling P, Deckers M.

Biochim Biophys Acta. 2016 Jul;1863(7 Pt A):1624-32. doi: 10.1016/j.bbamcr.2016.04.007. Epub 2016 Apr 12.


Oms1 associates with cytochrome c oxidase assembly intermediates to stabilize newly synthesized Cox1.

Bareth B, Nikolov M, Lorenzi I, Hildenbeutel M, Mick DU, Helbig C, Urlaub H, Ott M, Rehling P, Dennerlein S.

Mol Biol Cell. 2016 May 15;27(10):1570-80. doi: 10.1091/mbc.E15-12-0811. Epub 2016 Mar 30.


Protein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways.

Heininger AU, Hackert P, Andreou AZ, Boon KL, Memet I, Prior M, Clancy A, Schmidt B, Urlaub H, Schleiff E, Sloan KE, Deckers M, Lührmann R, Enderlein J, Klostermeier D, Rehling P, Bohnsack MT.

RNA Biol. 2016;13(3):320-30. doi: 10.1080/15476286.2016.1142038. Epub 2016 Jan 29.


Cardiac-specific succinate dehydrogenase deficiency in Barth syndrome.

Dudek J, Cheng IF, Chowdhury A, Wozny K, Balleininger M, Reinhold R, Grunau S, Callegari S, Toischer K, Wanders RJ, Hasenfuß G, Brügger B, Guan K, Rehling P.

EMBO Mol Med. 2016 Feb 1;8(2):139-54. doi: 10.15252/emmm.201505644.


Integrating mitochondrial translation into the cellular context.

Richter-Dennerlein R, Dennerlein S, Rehling P.

Nat Rev Mol Cell Biol. 2015 Oct;16(10):586-92. Review.


MITRAC7 Acts as a COX1-Specific Chaperone and Reveals a Checkpoint during Cytochrome c Oxidase Assembly.

Dennerlein S, Oeljeklaus S, Jans D, Hellwig C, Bareth B, Jakobs S, Deckers M, Warscheid B, Rehling P.

Cell Rep. 2015 Sep 8;12(10):1644-55. doi: 10.1016/j.celrep.2015.08.009. Epub 2015 Aug 28.


Cooperation between COA6 and SCO2 in COX2 maturation during cytochrome c oxidase assembly links two mitochondrial cardiomyopathies.

Pacheu-Grau D, Bareth B, Dudek J, Juris L, Vögtle FN, Wissel M, Leary SC, Dennerlein S, Rehling P, Deckers M.

Cell Metab. 2015 Jun 2;21(6):823-33. doi: 10.1016/j.cmet.2015.04.012. Epub 2015 May 7.


A presequence-binding groove in Tom70 supports import of Mdl1 into mitochondria.

Melin J, Kilisch M, Neumann P, Lytovchenko O, Gomkale R, Schendzielorz A, Schmidt B, Liepold T, Ficner R, Jahn O, Rehling P, Schulz C.

Biochim Biophys Acta. 2015 Aug;1853(8):1850-9. doi: 10.1016/j.bbamcr.2015.04.021. Epub 2015 May 7.


Human mitochondrial COX1 assembly into cytochrome c oxidase at a glance.

Dennerlein S, Rehling P.

J Cell Sci. 2015 Mar 1;128(5):833-7. doi: 10.1242/jcs.161729. Epub 2015 Feb 6. Review.


Unlocking the presequence import pathway.

Schulz C, Schendzielorz A, Rehling P.

Trends Cell Biol. 2015 May;25(5):265-75. doi: 10.1016/j.tcb.2014.12.001. Epub 2014 Dec 23. Review.


Cell biology. Powering the cell cycle.

Schulz C, Rehling P.

Science. 2014 Nov 28;346(6213):1059-60. doi: 10.1126/science.aaa2313. No abstract available.


A discrete pathway for the transfer of intermembrane space proteins across the outer membrane of mitochondria.

Gornicka A, Bragoszewski P, Chroscicki P, Wenz LS, Schulz C, Rehling P, Chacinska A.

Mol Biol Cell. 2014 Dec 15;25(25):3999-4009. doi: 10.1091/mbc.E14-06-1155. Epub 2014 Oct 15.


Remodelling of the active presequence translocase drives motor-dependent mitochondrial protein translocation.

Schulz C, Rehling P.

Nat Commun. 2014 Jul 10;5:4349. doi: 10.1038/ncomms5349.


Presequence recognition by the tom40 channel contributes to precursor translocation into the mitochondrial matrix.

Melin J, Schulz C, Wrobel L, Bernhard O, Chacinska A, Jahn O, Schmidt B, Rehling P.

Mol Cell Biol. 2014 Sep 15;34(18):3473-85. doi: 10.1128/MCB.00433-14. Epub 2014 Jul 7.


The INA complex facilitates assembly of the peripheral stalk of the mitochondrial F1Fo-ATP synthase.

Lytovchenko O, Naumenko N, Oeljeklaus S, Schmidt B, von der Malsburg K, Deckers M, Warscheid B, van der Laan M, Rehling P.

EMBO J. 2014 Aug 1;33(15):1624-38. doi: 10.15252/embj.201488076. Epub 2014 Jun 18.


Uniform nomenclature for the mitochondrial contact site and cristae organizing system.

Pfanner N, van der Laan M, Amati P, Capaldi RA, Caudy AA, Chacinska A, Darshi M, Deckers M, Hoppins S, Icho T, Jakobs S, Ji J, Kozjak-Pavlovic V, Meisinger C, Odgren PR, Park SK, Rehling P, Reichert AS, Sheikh MS, Taylor SS, Tsuchida N, van der Bliek AM, van der Klei IJ, Weissman JS, Westermann B, Zha J, Neupert W, Nunnari J.

J Cell Biol. 2014 Mar 31;204(7):1083-6. doi: 10.1083/jcb.201401006.


The heme a synthase Cox15 associates with cytochrome c oxidase assembly intermediates during Cox1 maturation.

Bareth B, Dennerlein S, Mick DU, Nikolov M, Urlaub H, Rehling P.

Mol Cell Biol. 2013 Oct;33(20):4128-37. doi: 10.1128/MCB.00747-13. Epub 2013 Aug 26.


Uth1 is a mitochondrial inner membrane protein dispensable for post-log-phase and rapamycin-induced mitophagy.

Welter E, Montino M, Reinhold R, Schlotterhose P, Krick R, Dudek J, Rehling P, Thumm M.

FEBS J. 2013 Oct;280(20):4970-82. doi: 10.1111/febs.12468. Epub 2013 Sep 2.


Cardiolipin deficiency affects respiratory chain function and organization in an induced pluripotent stem cell model of Barth syndrome.

Dudek J, Cheng IF, Balleininger M, Vaz FM, Streckfuss-Bömeke K, Hübscher D, Vukotic M, Wanders RJ, Rehling P, Guan K.

Stem Cell Res. 2013 Sep;11(2):806-19. doi: 10.1016/j.scr.2013.05.005. Epub 2013 May 28.


STED super-resolution microscopy reveals an array of MINOS clusters along human mitochondria.

Jans DC, Wurm CA, Riedel D, Wenzel D, Stagge F, Deckers M, Rehling P, Jakobs S.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):8936-41. doi: 10.1073/pnas.1301820110. Epub 2013 May 15.


Signal recognition initiates reorganization of the presequence translocase during protein import.

Lytovchenko O, Melin J, Schulz C, Kilisch M, Hutu DP, Rehling P.

EMBO J. 2013 Mar 20;32(6):886-98. doi: 10.1038/emboj.2013.23. Epub 2013 Feb 12.


MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation.

Mick DU, Dennerlein S, Wiese H, Reinhold R, Pacheu-Grau D, Lorenzi I, Sasarman F, Weraarpachai W, Shoubridge EA, Warscheid B, Rehling P.

Cell. 2012 Dec 21;151(7):1528-41. doi: 10.1016/j.cell.2012.11.053.

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