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Correction: Discovery of O-glycans on atrial natriuretic peptide (ANP) that affect both its proteolytic degradation and potency at its cognate receptor.

Hansen LH, Madsen TD, Goth CK, Clausen H, Chen Y, Dzoyashvili N, Iyer SR, Sangaralingham SJ, Burnett JC Jr, Rehfeld JF, Vakhrushev SY, Schjoldager KT, Goetze JP.

J Biol Chem. 2019 Nov 29;294(48):18516. doi: 10.1074/jbc.AAC119.011661. No abstract available.


Dairy products influence gut hormone secretion and appetite differently: A randomized controlled crossover trial.

Hansson P, Holven KB, Øyri LKL, Brekke HK, Gjevestad GO, Rehfeld JF, Raza GS, Herzig KH, Ulven SM.

J Dairy Sci. 2019 Nov 20. pii: S0022-0302(19)31029-X. doi: 10.3168/jds.2019-16863. [Epub ahead of print]


Intestinal sensing and handling of dietary lipids in gastric bypass-operated patients and matched controls.

Martinussen C, Dirksen C, Bojsen-Møller KN, Svane MS, Carlsson ER, Hartmann B, Clausen TR, Veedfald S, Kristiansen VB, Rehfeld JF, Hansen HS, Holst JJ, Madsbad S.

Am J Clin Nutr. 2019 Nov 19. pii: nqz272. doi: 10.1093/ajcn/nqz272. [Epub ahead of print]


Gastrin secretion in normal subjects and diabetes patients is inhibited by glucagon-like peptide 1: a role in the gastric side effects of GLP-1-derived drugs?

Rehfeld JF, Knop FK, Asmar M.

Scand J Gastroenterol. 2019 Nov 14:1-4. doi: 10.1080/00365521.2019.1690673. [Epub ahead of print]


Gastric cancer and gastrin: on the interaction of Helicobacter pylori gastritis and acid inhibitory induced hypergastrinemia.

Waldum HL, Rehfeld JF.

Scand J Gastroenterol. 2019 Sep;54(9):1118-1123. doi: 10.1080/00365521.2019.1663446. Epub 2019 Sep 14.


Discovery of O-glycans on atrial natriuretic peptide (ANP) that affect both its proteolytic degradation and potency at its cognate receptor.

Hansen LH, Madsen TD, Goth CK, Clausen H, Chen Y, Dzhoyashvili N, Iyer SR, Sangaralingham SJ, Burnett JC Jr, Rehfeld JF, Vakhrushev SY, Schjoldager KT, Goetze JP.

J Biol Chem. 2019 Aug 23;294(34):12567-12578. doi: 10.1074/jbc.RA119.008102. Epub 2019 Jun 11. Erratum in: J Biol Chem. 2019 Nov 29;294(48):18516.


Investigating the effect of sex and ketosis on weight-loss-induced changes in appetite.

Lyngstad A, Nymo S, Coutinho SR, Rehfeld JF, Truby H, Kulseng B, Martins C.

Am J Clin Nutr. 2019 Jun 1;109(6):1511-1518. doi: 10.1093/ajcn/nqz002.


Physiological Predictors of Weight Regain at 1-Year Follow-Up in Weight-Reduced Adults with Obesity.

Nymo S, Coutinho SR, Rehfeld JF, Truby H, Kulseng B, Martins C.

Obesity (Silver Spring). 2019 Jun;27(6):925-931. doi: 10.1002/oby.22476. Epub 2019 Apr 20.


Fructose malabsorption induces cholecystokinin expression in the ileum and cecum by changing microbiota composition and metabolism.

Zhang X, Grosfeld A, Williams E, Vasiliauskas D, Barretto S, Smith L, Mariadassou M, Philippe C, Devime F, Melchior C, Gourcerol G, Dourmap N, Lapaque N, Larraufie P, Blottière HM, Herberden C, Gerard P, Rehfeld JF, Ferraris RP, Fritton JC, Ellero-Simatos S, Douard V.

FASEB J. 2019 Jun;33(6):7126-7142. doi: 10.1096/fj.201801526RR. Epub 2019 Apr 2.


Postprandial Nutrient Handling and Gastrointestinal Hormone Secretion After Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy.

Svane MS, Bojsen-Møller KN, Martinussen C, Dirksen C, Madsen JL, Reitelseder S, Holm L, Rehfeld JF, Kristiansen VB, van Hall G, Holst JJ, Madsbad S.

Gastroenterology. 2019 May;156(6):1627-1641.e1. doi: 10.1053/j.gastro.2019.01.262. Epub 2019 Feb 8.


Effects of active commuting and leisure-time exercise on appetite in individuals with overweight and obesity.

Quist JS, Blond MB, Gram AS, Steenholt CB, Janus C, Holst JJ, Rehfeld JF, Sjödin A, Stallknecht B, Rosenkilde M.

J Appl Physiol (1985). 2019 Apr 1;126(4):941-951. doi: 10.1152/japplphysiol.00239.2018. Epub 2019 Jan 3.


Energy intake, gastrointestinal transit, and gut hormone release in response to oral triglycerides and fatty acids in men with and without severe obesity.

Dirksen C, Graff J, Fuglsang S, Rehfeld JF, Holst JJ, Madsen JL.

Am J Physiol Gastrointest Liver Physiol. 2019 Mar 1;316(3):G332-G337. doi: 10.1152/ajpgi.00310.2018. Epub 2018 Dec 6.


Metformin-induced glucagon-like peptide-1 secretion contributes to the actions of metformin in type 2 diabetes.

Bahne E, Sun EWL, Young RL, Hansen M, Sonne DP, Hansen JS, Rohde U, Liou AP, Jackson ML, de Fontgalland D, Rabbitt P, Hollington P, Sposato L, Due S, Wattchow DA, Rehfeld JF, Holst JJ, Keating DJ, Vilsbøll T, Knop FK.

JCI Insight. 2018 Dec 6;3(23). pii: 93936. doi: 10.1172/jci.insight.93936.


The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones.

Rudenko O, Shang J, Munk A, Ekberg JP, Petersen N, Engelstoft MS, Egerod KL, Hjorth SA, Wu M, Feng Y, Zhou YP, Mokrosinski J, Thams P, Reimann F, Gribble F, Rehfeld JF, Holst JJ, Treebak JT, Howard AD, Schwartz TW.

Mol Metab. 2019 Jan;19:49-64. doi: 10.1016/j.molmet.2018.10.012. Epub 2018 Nov 5.


PYY(3-36) and exendin-4 reduce food intake and activate neuronal circuits in a synergistic manner in mice.

Kjaergaard M, Salinas CBG, Rehfeld JF, Secher A, Raun K, Wulff BS.

Neuropeptides. 2019 Feb;73:89-95. doi: 10.1016/j.npep.2018.11.004. Epub 2018 Nov 19.


Cholecystokinin secretion is suppressed by glucagon-like peptide-1: clue to the mechanism of the adverse gallbladder events of GLP-1-derived drugs.

Rehfeld JF, Knop FK, Asmar A, Madsbad S, Holst JJ, Asmar M.

Scand J Gastroenterol. 2018 Dec;53(12):1429-1432. doi: 10.1080/00365521.2018.1530297. Epub 2018 Nov 19.


Acute Effects of Dietary Carbohydrate Restriction on Glycemia, Lipemia and Appetite Regulating Hormones in Normal-Weight to Obese Subjects.

Samkani A, Skytte MJ, Thomsen MN, Astrup A, Deacon CF, Holst JJ, Madsbad S, Rehfeld JF, Krarup T, Haugaard SB.

Nutrients. 2018 Sep 12;10(9). pii: E1285. doi: 10.3390/nu10091285.


Cardiac procholecystokinin expression during haemodynamic changes in the mammalian heart.

Goetze JP, Hunter I, Zois NE, Terzic D, Valeur N, Olsen LH, Smith J, Plomgaard P, Hansen LH, Rehfeld JF, Balling L, Gustafsson F.

Peptides. 2018 Oct;108:7-13. doi: 10.1016/j.peptides.2018.08.004. Epub 2018 Aug 16.


RYGB increases the satiating effect of intrajejunal lipid infusions in female rats.

Bächler T, Geary N, Bueter M, Leeners B, Rehfeld JF, Lutz TA, Asarian L.

Appetite. 2018 Dec 1;131:94-99. doi: 10.1016/j.appet.2018.08.020. Epub 2018 Aug 14.


The Origin and Understanding of the Incretin Concept.

Rehfeld JF.

Front Endocrinol (Lausanne). 2018 Jul 16;9:387. doi: 10.3389/fendo.2018.00387. eCollection 2018. Review.


Hyperosmolar Duodenal Saline Infusion Lowers Circulating Ghrelin and Stimulates Intestinal Hormone Release in Young Men.

Veedfald S, Wu T, Bound M, Grivell J, Hartmann B, Rehfeld JF, Deacon CF, Horowitz M, Holst JJ, Rayner CK.

J Clin Endocrinol Metab. 2018 Dec 1;103(12):4409-4418. doi: 10.1210/jc.2018-00699.


Commentary: measurement of biomarkers in medicine.

Goetze JP, Hansen LH, Terzic D, Mark PD, Wewer Albrechtsen NJ, Plomgaard P, Rehfeld JF.

Biomark Med. 2018 Sep;12(9):941-944. doi: 10.2217/bmm-2018-0210. Epub 2018 Jul 25. No abstract available.


Investigation of the long-term sustainability of changes in appetite after weight loss.

Nymo S, Coutinho SR, Eknes PH, Vestbostad I, Rehfeld JF, Truby H, Kulseng B, Martins C.

Int J Obes (Lond). 2018 Aug;42(8):1489-1499. doi: 10.1038/s41366-018-0119-9. Epub 2018 Jun 21.


Procholecystokinin expression and processing in cardiac myocytes.

Goetze JP, Rehfeld JF.

Peptides. 2019 Jan;111:71-76. doi: 10.1016/j.peptides.2018.06.001. Epub 2018 Jun 11. Review.


Restoration of enteroendocrine and pancreatic function after internal hernia and short bowel syndrome in a young woman with gastric bypass - a 2-year follow-up.

Borghede M, Vinter-Jensen L, Rasmussen HH, Veedfald S, Rehfeld JF, Hartmann B, Holst JJ, Knop FK, Sonne DP.

Physiol Rep. 2018 May;6(9):e13686. doi: 10.14814/phy2.13686.


Effects of caloric and noncaloric sweeteners on antroduodenal motility, gastrointestinal hormone secretion and appetite-related sensations in healthy subjects.

Meyer-Gerspach AC, Biesiekierski JR, Deloose E, Clevers E, Rotondo A, Rehfeld JF, Depoortere I, Van Oudenhove L, Tack J.

Am J Clin Nutr. 2018 May 1;107(5):707-716. doi: 10.1093/ajcn/nqy004.


A carbohydrate-reduced high-protein diet acutely decreases postprandial and diurnal glucose excursions in type 2 diabetes patients.

Samkani A, Skytte MJ, Kandel D, Kjaer S, Astrup A, Deacon CF, Holst JJ, Madsbad S, Rehfeld JF, Haugaard SB, Krarup T.

Br J Nutr. 2018 Apr;119(8):910-917. doi: 10.1017/S0007114518000521.


Effects of Smoking Versus Nonsmoking on Postprandial Glucose Metabolism in Heavy Smokers Compared With Nonsmokers.

Grøndahl MF, Bagger JI, Lund A, Faurschou A, Rehfeld JF, Holst JJ, Vilsbøll T, Knop FK.

Diabetes Care. 2018 Jun;41(6):1260-1267. doi: 10.2337/dc17-1818. Epub 2018 Mar 30.


Comparison of Glycomacropeptide with Phenylalanine Free-Synthetic Amino Acids in Test Meals to PKU Patients: No Significant Differences in Biomarkers, Including Plasma Phe Levels.

Ahring KK, Lund AM, Jensen E, Jensen TG, Brøndum-Nielsen K, Pedersen M, Bardow A, Holst JJ, Rehfeld JF, Møller LB.

J Nutr Metab. 2018 Jan 8;2018:6352919. doi: 10.1155/2018/6352919. eCollection 2018.


Glucose-lowering effects and mechanisms of the bile acid-sequestering resin sevelamer.

Brønden A, Mikkelsen K, Sonne DP, Hansen M, Våben C, Gabe MN, Rosenkilde M, Tremaroli V, Wu H, Bäckhed F, Rehfeld JF, Holst JJ, Vilsbøll T, Knop FK.

Diabetes Obes Metab. 2018 Jul;20(7):1623-1631. doi: 10.1111/dom.13272. Epub 2018 Mar 26.


Differences in the Postprandial Release of Appetite-Related Hormones Between Active and Inactive Men.

Bøhler L, Coutinho SR, Rehfeld JF, Morgan L, Martins C.

Int J Sport Nutr Exerc Metab. 2018 Nov 1;28(6):602-610. doi: 10.1123/ijsnem.2017-0303. Epub 2018 Aug 3.


Impact of weight loss achieved through a multidisciplinary intervention on appetite in patients with severe obesity.

Coutinho SR, Rehfeld JF, Holst JJ, Kulseng B, Martins C.

Am J Physiol Endocrinol Metab. 2018 Jul 1;315(1):E91-E98. doi: 10.1152/ajpendo.00322.2017. Epub 2018 Jan 23.


Comparing olive oil and C4-dietary oil, a prodrug for the GPR119 agonist, 2-oleoyl glycerol, less energy intake of the latter is needed to stimulate incretin hormone secretion in overweight subjects with type 2 diabetes.

Mandøe MJ, Hansen KB, Windeløv JA, Knop FK, Rehfeld JF, Rosenkilde MM, Holst JJ, Hansen HS.

Nutr Diabetes. 2018 Jan 12;8(1):2. doi: 10.1038/s41387-017-0011-z.


Three of a (Peptic) Kind!

Zimmer V, Rehfeld JF, Lammert F.

Am J Med. 2018 Apr;131(4):e139-e140. doi: 10.1016/j.amjmed.2017.10.055. Epub 2017 Nov 22. No abstract available.


Single-Dose Metformin Enhances Bile Acid-Induced Glucagon-Like Peptide-1 Secretion in Patients With Type 2 Diabetes.

Brønden A, Albér A, Rohde U, Rehfeld JF, Holst JJ, Vilsbøll T, Knop FK.

J Clin Endocrinol Metab. 2017 Nov 1;102(11):4153-4162. doi: 10.1210/jc.2017-01091.


The Changing Concept of Gut Endocrinology.

Rehfeld JF.

Endocr Dev. 2017;32:8-19. doi: 10.1159/000475728. Epub 2017 Aug 15.


The bile acid-sequestering resin sevelamer eliminates the acute GLP-1 stimulatory effect of endogenously released bile acids in patients with type 2 diabetes.

Brønden A, Albér A, Rohde U, Gasbjerg LS, Rehfeld JF, Holst JJ, Vilsbøll T, Knop FK.

Diabetes Obes Metab. 2018 Feb;20(2):362-369. doi: 10.1111/dom.13080. Epub 2017 Sep 24.


Cholecystokininoma syndrome, calcitonin and diarrhea.

Rehfeld JF, Federspiel B, Agersnap M, Knigge U, Bardram L.

Scand J Gastroenterol. 2017 Nov;52(11):1304-1305. doi: 10.1080/00365521.2017.1357752. Epub 2017 Jul 25. No abstract available.


The impact of rate of weight loss on body composition and compensatory mechanisms during weight reduction: A randomized control trial.

Coutinho SR, With E, Rehfeld JF, Kulseng B, Truby H, Martins C.

Clin Nutr. 2018 Aug;37(4):1154-1162. doi: 10.1016/j.clnu.2017.04.008. Epub 2017 Apr 25.


Cholecystokinin-From Local Gut Hormone to Ubiquitous Messenger.

Rehfeld JF.

Front Endocrinol (Lausanne). 2017 Apr 13;8:47. doi: 10.3389/fendo.2017.00047. eCollection 2017. Review.


Compensatory mechanisms activated with intermittent energy restriction: A randomized control trial.

Coutinho SR, Halset EH, Gåsbakk S, Rehfeld JF, Kulseng B, Truby H, Martins C.

Clin Nutr. 2018 Jun;37(3):815-823. doi: 10.1016/j.clnu.2017.04.002. Epub 2017 Apr 7.


Timeline of changes in appetite during weight loss with a ketogenic diet.

Nymo S, Coutinho SR, Jørgensen J, Rehfeld JF, Truby H, Kulseng B, Martins C.

Int J Obes (Lond). 2017 Aug;41(8):1224-1231. doi: 10.1038/ijo.2017.96. Epub 2017 Apr 25.


Distribution and characterisation of CCK containing enteroendocrine cells of the mouse small and large intestine.

Fakhry J, Wang J, Martins P, Fothergill LJ, Hunne B, Prieur P, Shulkes A, Rehfeld JF, Callaghan B, Furness JB.

Cell Tissue Res. 2017 Aug;369(2):245-253. doi: 10.1007/s00441-017-2612-1. Epub 2017 Apr 17.


Serum gastrin and cholecystokinin are associated with subsequent development of gastric cancer in a prospective cohort of Finnish smokers.

Murphy G, Abnet CC, Choo-Wosoba H, Vogtmann E, Weinstein SJ, Taylor PR, Männistö S, Albanes D, Dawsey SM, Rehfeld JF, Freedman ND.

Int J Epidemiol. 2017 Jun 1;46(3):914-923. doi: 10.1093/ije/dyx030.


Acute effects of N-terminal progastrin fragments on gastric acid secretion in man.

Goetze JP, Hansen CP, Rehfeld JF.

Physiol Rep. 2017 Mar;5(5). pii: e13164. doi: 10.14814/phy2.13164.


The impact of Roux-en-Y gastric bypass surgery on normal metabolism in a porcine model.

Lindqvist A, Ekelund M, Garcia-Vaz E, Ståhlman M, Pierzynowski S, Gomez MF, Rehfeld JF, Groop L, Hedenbro J, Wierup N, Spégel P.

PLoS One. 2017 Mar 3;12(3):e0173137. doi: 10.1371/journal.pone.0173137. eCollection 2017.


The Dynamics of Gastric Emptying and Self-Reported Feelings of Satiation Are Better Predictors Than Gastrointestinal Hormones of the Effects of Lipid Emulsion Structure on Fat Digestion in Healthy Adults-A Bayesian Inference Approach.

Steingoetter A, Buetikofer S, Curcic J, Menne D, Rehfeld JF, Fried M, Schwizer W, Wooster TJ.

J Nutr. 2017 Apr;147(4):706-714. doi: 10.3945/jn.116.237800. Epub 2017 Feb 22.


Chenodeoxycholic acid stimulates glucagon-like peptide-1 secretion in patients after Roux-en-Y gastric bypass.

Nielsen S, Svane MS, Kuhre RE, Clausen TR, Kristiansen VB, Rehfeld JF, Holst JJ, Madsbad S, Bojsen-Moller KN.

Physiol Rep. 2017 Feb;5(3). pii: e13140. doi: 10.14814/phy2.13140. Epub 2017 Feb 14.


Mechanism-Based Modeling of Gastric Emptying Rate and Gallbladder Emptying in Response to Caloric Intake.

Guiastrennec B, Sonne DP, Hansen M, Bagger JI, Lund A, Rehfeld JF, Alskär O, Karlsson MO, Vilsbøll T, Knop FK, Bergstrand M.

CPT Pharmacometrics Syst Pharmacol. 2016 Dec;5(12):692-700. doi: 10.1002/psp4.12152.


Effect of L-Tryptophan and L-Leucine on Gut Hormone Secretion, Appetite Feelings and Gastric Emptying Rates in Lean and Non-Diabetic Obese Participants: A Randomized, Double-Blind, Parallel-Group Trial.

Meyer-Gerspach AC, Häfliger S, Meili J, Doody A, Rehfeld JF, Drewe J, Beglinger C, Wölnerhanssen B.

PLoS One. 2016 Nov 22;11(11):e0166758. doi: 10.1371/journal.pone.0166758. eCollection 2016.

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