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Items: 1 to 50 of 76

1.

TET2 haploinsufficiency alters reprogramming into induced pluripotent stem cells.

Secardin L, Limia CEG, di Stefano A, Bonamino MH, Saliba J, Kataoka K, Rehen SK, Raslova H, Marty C, Ogawa S, Vainchenker W, Monte-Mor BDCR, Plo I.

Stem Cell Res. 2020 Mar 6;44:101755. doi: 10.1016/j.scr.2020.101755. [Epub ahead of print]

2.

The cyanobacterial saxitoxin exacerbates neural cell death and brain malformations induced by Zika virus.

Pedrosa CDSG, Souza LRQ, Gomes TA, de Lima CVF, Ledur PF, Karmirian K, Barbeito-Andres J, Costa MDN, Higa LM, Rossi ÁD, Bellio M, Tanuri A, Prata-Barbosa A, Tovar-Moll F, Garcez PP, Lara FA, Molica RJR, Rehen SK.

PLoS Negl Trop Dis. 2020 Mar 12;14(3):e0008060. doi: 10.1371/journal.pntd.0008060. eCollection 2020 Mar.

3.

Short and long TNF-alpha exposure recapitulates canonical astrogliosis events in human-induced pluripotent stem cells-derived astrocytes.

Trindade P, Loiola EC, Gasparotto J, Ribeiro CT, Cardozo PL, Devalle S, Salerno JA, Ornelas IM, Ledur PF, Ribeiro FM, Ventura ALM, Moreira JCF, Gelain DP, Porciúncula LO, Rehen SK.

Glia. 2020 Jan 31. doi: 10.1002/glia.23786. [Epub ahead of print]

PMID:
32003513
4.

Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes.

Ledur PF, Karmirian K, Pedrosa CDSG, Souza LRQ, Assis-de-Lemos G, Martins TM, Ferreira JCCG, de Azevedo Reis GF, Silva ES, Silva D, Salerno JA, Ornelas IM, Devalle S, Madeiro da Costa RF, Goto-Silva L, Higa LM, Melo A, Tanuri A, Chimelli L, Murata MM, Garcez PP, Filippi-Chiela EC, Galina A, Borges HL, Rehen SK.

Sci Rep. 2020 Jan 27;10(1):1218. doi: 10.1038/s41598-020-57914-x.

5.

New tetrodotoxin analogs in Brazilian pufferfishes tissues and microbiome.

Tonon LAC, de Azevedo GPR, Monteiro AF, Bernardi DI, Gubiani JR, Ióca LP, Mattsson HK, Moreira APB, Gomes AF, Pires Junior OR, da S G Pedrosa C, Souza LRQ, Rehen SK, Thompson CC, Thompson FL, Berlinck RGS.

Chemosphere. 2020 Mar;242:125211. doi: 10.1016/j.chemosphere.2019.125211. Epub 2019 Oct 30.

PMID:
31896201
6.

Human Cerebral Organoids and Fetal Brain Tissue Share Proteomic Similarities.

Nascimento JM, Saia-Cereda VM, Sartore RC, da Costa RM, Schitine CS, Freitas HR, Murgu M, de Melo Reis RA, Rehen SK, Martins-de-Souza D.

Front Cell Dev Biol. 2019 Nov 28;7:303. doi: 10.3389/fcell.2019.00303. eCollection 2019.

7.

Computational fluid dynamic analysis of physical forces playing a role in brain organoid cultures in two different multiplex platforms.

Goto-Silva L, Ayad NME, Herzog IL, Silva NP, Lamien B, Orlande HRB, da Costa Souza A, Ribeiro S, Martins M, Domont GB, Junqueira M, Tovar-Moll F, Rehen SK.

BMC Dev Biol. 2019 Mar 7;19(1):3. doi: 10.1186/s12861-019-0183-y.

8.

Beyond Members of the Flaviviridae Family, Sofosbuvir Also Inhibits Chikungunya Virus Replication.

Ferreira AC, Reis PA, de Freitas CS, Sacramento CQ, Villas Bôas Hoelz L, Bastos MM, Mattos M, Rocha N, Gomes de Azevedo Quintanilha I, da Silva Gouveia Pedrosa C, Rocha Quintino Souza L, Correia Loiola E, Trindade P, Rangel Vieira Y, Barbosa-Lima G, de Castro Faria Neto HC, Boechat N, Rehen SK, Brüning K, Bozza FA, Bozza PT, Souza TML.

Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01389-18. doi: 10.1128/AAC.01389-18. Print 2019 Feb.

9.

Generation of iPSC-Derived Human Peripheral Sensory Neurons Releasing Substance P Elicited by TRPV1 Agonists.

Guimarães MZP, De Vecchi R, Vitória G, Sochacki JK, Paulsen BS, Lima I, Rodrigues da Silva F, da Costa RFM, Castro NG, Breton L, Rehen SK.

Front Mol Neurosci. 2018 Aug 22;11:277. doi: 10.3389/fnmol.2018.00277. eCollection 2018.

10.

Deformation of Mitochondrial Cristae in Human Neural Progenitor Cells Exposed to Valproic Acid.

Costa RMD, Karmirian K, Rehen SK.

An Acad Bras Cienc. 2018 Aug;90(2 suppl 1):2223-2232. doi: 10.1590/0001-3765201820170762. Epub 2018 Apr 23.

11.

Specific Cytostatic and Cytotoxic Effect of Dihydrochelerythrine in Glioblastoma Cells: Role of NF-κB/β-catenin and STAT3/IL-6 Pathways.

Silva TCC, de Faria Lopes GP, de J Menezes-Filho N, de Oliveira DM, Pereira E, Pitanga BPS, Dos Santos Costa R, da Silva Velozo E, Freire SM, Clarêncio J, Borges HL, Rehen SK, Moura-Neto V, Costa SL.

Anticancer Agents Med Chem. 2018;18(10):1386-1393. doi: 10.2174/1871520618666180412122101.

PMID:
29651966
12.

hiPSC-derived neural stem cells from patients with schizophrenia induce an impaired angiogenesis.

Casas BS, Vitória G, do Costa MN, Madeiro da Costa R, Trindade P, Maciel R, Navarrete N, Rehen SK, Palma V.

Transl Psychiatry. 2018 Feb 22;8(1):48. doi: 10.1038/s41398-018-0095-9.

13.

Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT.

Dakic V, Minardi Nascimento J, Costa Sartore R, Maciel RM, de Araujo DB, Ribeiro S, Martins-de-Souza D, Rehen SK.

Sci Rep. 2017 Oct 9;7(1):12863. doi: 10.1038/s41598-017-12779-5.

14.

Inhibition of pRB Pathway Differentially Modulates Apoptosis in Esophageal Cancer Cells.

Soletti RC, Biasoli D, Rodrigues NALV, Delou JMA, Maciel R, Chagas VLA, Martins RAP, Rehen SK, Borges HL.

Transl Oncol. 2017 Oct;10(5):726-733. doi: 10.1016/j.tranon.2017.06.008. Epub 2017 Jul 19.

15.

Corrigendum: The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication.

Sacramento CQ, de Melo GR, de Freitas CS, Rocha N, Hoelz LVB, Miranda M, Fintelman-Rodrigues N, Marttorelli A, Ferreira AC, Barbosa-Lima G, Abrantes JL, Vieira YR, Bastos MM, Volotão EM, Nunes EP, Tschoeke DA, Leomil L, Loiola EC, Trindade P, Rehen SK, Bozza FA, Bozza PT, Boechat N, Thompson FL, de Filippis AMB, Brüning K, Souza TML.

Sci Rep. 2017 Apr 24;7:46772. doi: 10.1038/srep46772. No abstract available.

16.

Combining Patient-Reprogrammed Neural Cells and Proteomics as a Model to Study Psychiatric Disorders.

Zuccoli GS, Martins-de-Souza D, Guest PC, Rehen SK, Nascimento JM.

Adv Exp Med Biol. 2017;974:279-287. doi: 10.1007/978-3-319-52479-5_26.

PMID:
28353247
17.

Derivation of Functional Human Astrocytes from Cerebral Organoids.

Dezonne RS, Sartore RC, Nascimento JM, Saia-Cereda VM, Romão LF, Alves-Leon SV, de Souza JM, Martins-de-Souza D, Rehen SK, Gomes FC.

Sci Rep. 2017 Mar 27;7:45091. doi: 10.1038/srep45091.

18.

Trace elements during primordial plexiform network formation in human cerebral organoids.

Sartore RC, Cardoso SC, Lages YV, Paraguassu JM, Stelling MP, Madeiro da Costa RF, Guimaraes MZ, Pérez CA, Rehen SK.

PeerJ. 2017 Feb 8;5:e2927. doi: 10.7717/peerj.2927. eCollection 2017.

19.

Zika virus disrupts molecular fingerprinting of human neurospheres.

Garcez PP, Nascimento JM, de Vasconcelos JM, Madeiro da Costa R, Delvecchio R, Trindade P, Loiola EC, Higa LM, Cassoli JS, Vitória G, Sequeira PC, Sochacki J, Aguiar RS, Fuzii HT, de Filippis AM, da Silva Gonçalves Vianez Júnior JL, Tanuri A, Martins-de-Souza D, Rehen SK.

Sci Rep. 2017 Jan 23;7:40780. doi: 10.1038/srep40780.

20.

The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication.

Sacramento CQ, de Melo GR, de Freitas CS, Rocha N, Hoelz LV, Miranda M, Fintelman-Rodrigues N, Marttorelli A, Ferreira AC, Barbosa-Lima G, Abrantes JL, Vieira YR, Bastos MM, de Mello Volotão E, Nunes EP, Tschoeke DA, Leomil L, Loiola EC, Trindade P, Rehen SK, Bozza FA, Bozza PT, Boechat N, Thompson FL, de Filippis AM, Brüning K, Souza TM.

Sci Rep. 2017 Jan 18;7:40920. doi: 10.1038/srep40920. Erratum in: Sci Rep. 2017 Apr 24;7:46772.

21.

Harmine stimulates proliferation of human neural progenitors.

Dakic V, Maciel RM, Drummond H, Nascimento JM, Trindade P, Rehen SK.

PeerJ. 2016 Dec 6;4:e2727. eCollection 2016.

22.

Zika virus impairs growth in human neurospheres and brain organoids.

Garcez PP, Loiola EC, Madeiro da Costa R, Higa LM, Trindade P, Delvecchio R, Nascimento JM, Brindeiro R, Tanuri A, Rehen SK.

Science. 2016 May 13;352(6287):816-8. doi: 10.1126/science.aaf6116. Epub 2016 Apr 10.

23.

Low oxygen alters mitochondrial function and response to oxidative stress in human neural progenitor cells.

Lages YM, Nascimento JM, Lemos GA, Galina A, Castilho LR, Rehen SK.

PeerJ. 2015 Dec 10;3:e1486. doi: 10.7717/peerj.1486. eCollection 2015.

24.

Stem cell research in Latin America: update, challenges and opportunities in a priority research area.

Palma V, Pitossi FJ, Rehen SK, Touriño C, Velasco I.

Regen Med. 2015;10(6):785-98. doi: 10.2217/rme.15.44. Epub 2015 Oct 6. Review.

25.

Mitomycin-treated undifferentiated embryonic stem cells as a safe and effective therapeutic strategy in a mouse model of Parkinson's disease.

Acquarone M, de Melo TM, Meireles F, Brito-Moreira J, Oliveira G, Ferreira ST, Castro NG, Tovar-Moll F, Houzel JC, Rehen SK.

Front Cell Neurosci. 2015 Apr 8;9:97. doi: 10.3389/fncel.2015.00097. eCollection 2015.

26.

Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains.

Bushman DM, Kaeser GE, Siddoway B, Westra JW, Rivera RR, Rehen SK, Yung YC, Chun J.

Elife. 2015 Feb 4;4. doi: 10.7554/eLife.05116.

27.

Accelerating neuronal aging in in vitro model brain disorders: a focus on reactive oxygen species.

Campos PB, Paulsen BS, Rehen SK.

Front Aging Neurosci. 2014 Oct 27;6:292. doi: 10.3389/fnagi.2014.00292. eCollection 2014. Review.

28.

Glioblastoma cells inhibit astrocytic p53-expression favoring cancer malignancy.

Biasoli D, Sobrinho MF, da Fonseca AC, de Matos DG, Romão L, de Moraes Maciel R, Rehen SK, Moura-Neto V, Borges HL, Lima FR.

Oncogenesis. 2014 Oct 20;3:e123. doi: 10.1038/oncsis.2014.36.

29.

LPA-primed astrocytes induce axonal outgrowth of cortical progenitors by activating PKA signaling pathways and modulating extracellular matrix proteins.

Spohr TC, Dezonne RS, Rehen SK, Gomes FC.

Front Cell Neurosci. 2014 Sep 25;8:296. doi: 10.3389/fncel.2014.00296. eCollection 2014.

30.

Valproate reverts zinc and potassium imbalance in schizophrenia-derived reprogrammed cells.

Paulsen Bda S, Cardoso SC, Stelling MP, Cadilhe DV, Rehen SK.

Schizophr Res. 2014 Apr;154(1-3):30-5. doi: 10.1016/j.schres.2014.02.007. Epub 2014 Mar 1.

PMID:
24593932
31.

2,4-Dinitrophenol induces neural differentiation of murine embryonic stem cells.

Freitas-Correa L, Lourenco MV, Acquarone M, da Costa RF, Galina A, Rehen SK, Ferreira ST.

Stem Cell Res. 2013 Nov;11(3):1407-16. doi: 10.1016/j.scr.2013.09.016. Epub 2013 Oct 6.

32.

Aneuploid cells are differentially susceptible to caspase-mediated death during embryonic cerebral cortical development.

Peterson SE, Yang AH, Bushman DM, Westra JW, Yung YC, Barral S, Mutoh T, Rehen SK, Chun J.

J Neurosci. 2012 Nov 14;32(46):16213-22. doi: 10.1523/JNEUROSCI.3706-12.2012.

33.

Pluripotent stem cells as a model to study oxygen metabolism in neurogenesis and neurodevelopmental disorders.

Paulsen Bda S, da Silveira MS, Galina A, Rehen SK.

Arch Biochem Biophys. 2013 Jun;534(1-2):3-10. doi: 10.1016/j.abb.2012.10.009. Epub 2012 Oct 27. Review.

PMID:
23111185
34.

Matrix-bound heparan sulfate is essential for the growth and pluripotency of human embryonic stem cells.

Stelling MP, Lages YM, Tovar AM, Mourão PA, Rehen SK.

Glycobiology. 2013 Mar;23(3):337-45. doi: 10.1093/glycob/cws133. Epub 2012 Sep 22.

PMID:
23002246
35.

Implications of aneuploidy for stem cell biology and brain therapeutics.

Devalle S, Sartore RC, Paulsen BS, Borges HL, Martins RA, Rehen SK.

Front Cell Neurosci. 2012 Sep 5;6:36. doi: 10.3389/fncel.2012.00036. eCollection 2012.

36.

Xeno-free production of human embryonic stem cells in stirred microcarrier systems using a novel animal/human-component-free medium.

Marinho PA, Vareschini DT, Gomes IC, Paulsen Bda S, Furtado DR, Castilho Ldos R, Rehen SK.

Tissue Eng Part C Methods. 2013 Feb;19(2):146-55. doi: 10.1089/ten.TEC.2012.0141. Epub 2012 Oct 16.

PMID:
22834864
37.

Sphingosine 1-phosphate-primed astrocytes enhance differentiation of neuronal progenitor cells.

Spohr TC, Dezonne RS, Nones J, Dos Santos Souza C, Einicker-Lamas M, Gomes FC, Rehen SK.

J Neurosci Res. 2012 Oct;90(10):1892-902. doi: 10.1002/jnr.23076. Epub 2012 May 15.

PMID:
22588662
38.

Cycle arrest and aneuploidy induced by zidovudine in murine embryonic stem cells.

Campos PB, Sartore RC, Ramalho BL, Costa ES, Rehen SK.

Mutagenesis. 2012 Jul;27(4):431-6. doi: 10.1093/mutage/ger093. Epub 2012 Jan 4.

PMID:
22217549
39.

Synchrotron radiation X-ray microfluorescence reveals polarized distribution of atomic elements during differentiation of pluripotent stem cells.

Cardoso SC, Stelling MP, Paulsen BS, Rehen SK.

PLoS One. 2011;6(12):e29244. doi: 10.1371/journal.pone.0029244. Epub 2011 Dec 16.

40.

Dynamic expression of synemin isoforms in mouse embryonic stem cells and neural derivatives.

de Souza Martins SC, Agbulut O, Diguet N, Larcher JC, Paulsen BS, Rehen SK, Moura-Neto V, Paulin D, Li Z, Xue Z.

BMC Cell Biol. 2011 Nov 23;12:51. doi: 10.1186/1471-2121-12-51.

41.

Altered oxygen metabolism associated to neurogenesis of induced pluripotent stem cells derived from a schizophrenic patient.

Paulsen Bda S, de Moraes Maciel R, Galina A, Souza da Silveira M, dos Santos Souza C, Drummond H, Nascimento Pozzatto E, Silva H Jr, Chicaybam L, Massuda R, Setti-Perdigão P, Bonamino M, Belmonte-de-Abreu PS, Castro NG, Brentani H, Rehen SK.

Cell Transplant. 2012;21(7):1547-59.

PMID:
21975034
42.

Normal human pluripotent stem cell lines exhibit pervasive mosaic aneuploidy.

Peterson SE, Westra JW, Rehen SK, Young H, Bushman DM, Paczkowski CM, Yung YC, Lynch CL, Tran HT, Nickey KS, Wang YC, Laurent LC, Loring JF, Carpenter MK, Chun J.

PLoS One. 2011;6(8):e23018. doi: 10.1371/journal.pone.0023018. Epub 2011 Aug 16.

43.

Astrocytes treated by lysophosphatidic acid induce axonal outgrowth of cortical progenitors through extracellular matrix protein and epidermal growth factor signaling pathway.

E Spohr TC, Dezonne RS, Rehen SK, Gomes FC.

J Neurochem. 2011 Oct;119(1):113-23. doi: 10.1111/j.1471-4159.2011.07421.x. Epub 2011 Sep 1.

44.

Retinoic acid-treated pluripotent stem cells undergoing neurogenesis present increased aneuploidy and micronuclei formation.

Sartore RC, Campos PB, Trujillo CA, Ramalho BL, Negraes PD, Paulsen BS, Meletti T, Costa ES, Chicaybam L, Bonamino MH, Ulrich H, Rehen SK.

PLoS One. 2011;6(6):e20667. doi: 10.1371/journal.pone.0020667. Epub 2011 Jun 6.

45.

Human dental pulp cells: a new source of cell therapy in a mouse model of compressive spinal cord injury.

de Almeida FM, Marques SA, Ramalho Bdos S, Rodrigues RF, Cadilhe DV, Furtado D, Kerkis I, Pereira LV, Rehen SK, Martinez AM.

J Neurotrauma. 2011 Sep;28(9):1939-49. doi: 10.1089/neu.2010.1317. Epub 2011 Aug 8.

PMID:
21609310
46.

Agathisflavone enhances retinoic acid-induced neurogenesis and its receptors α and β in pluripotent stem cells.

Paulsen BS, Souza CS, Chicaybam L, Bonamino MH, Bahia M, Costa SL, Borges HL, Rehen SK.

Stem Cells Dev. 2011 Oct;20(10):1711-21. doi: 10.1089/scd.2010.0446. Epub 2011 Mar 18.

PMID:
21281018
47.

Analysis of pluripotent stem cells by using cryosections of embryoid bodies.

Gomes IC, Acquarone M, Maciel Rde M, Erlich RB, Rehen SK.

J Vis Exp. 2010 Dec 8;(46). pii: 2344. doi: 10.3791/2344.

48.

Predifferentiated embryonic stem cells promote functional recovery after spinal cord compressive injury.

Marques SA, Almeida FM, Fernandes AM, dos Santos Souza C, Cadilhe DV, Rehen SK, Martinez AM.

Brain Res. 2010 Aug 19;1349:115-28. doi: 10.1016/j.brainres.2010.06.028. Epub 2010 Jun 18.

PMID:
20599835
49.

Murine model for Parkinson's disease: from 6-OH dopamine lesion to behavioral test.

da Conceição FS, Ngo-Abdalla S, Houzel JC, Rehen SK.

J Vis Exp. 2010 Jan 15;(35). pii: 1376. doi: 10.3791/1376.

50.

Worldwide survey of published procedures to culture human embryonic stem cells.

Fernandes AM, Meletti T, Guimarães R, Stelling MP, Marinho PA, Valladão AS, Rehen SK.

Cell Transplant. 2010;19(5):509-23. doi: 10.3727/096368909X485067. Epub 2010 Jan 6. Review.

PMID:
20053319

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