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Items: 1 to 50 of 100

1.

Patients with CD3G mutations reveal a role for human CD3γ in Treg diversity and suppressive function.

Rowe JH, Delmonte OM, Keles S, Stadinski BD, Dobbs AK, Henderson LA, Yamazaki Y, Allende LM, Bonilla FA, Gonzalez-Granado LI, Celikbilek Celik S, Guner SN, Kapakli H, Yee C, Pai SY, Huseby ES, Reisli I, Regueiro JR, Notarangelo LD.

Blood. 2018 May 24;131(21):2335-2344. doi: 10.1182/blood-2018-02-835561. Epub 2018 Apr 13.

2.

Complement in leucocyte development and function.

Regueiro JR, Fernández FJ, Vega MC.

Semin Cell Dev Biol. 2019 Jan;85:84-85. doi: 10.1016/j.semcdb.2018.02.024. Epub 2018 Mar 7. No abstract available.

PMID:
29499387
3.

Lymphocyte integration of complement cues.

Marin AV, Cárdenas PP, Jiménez-Reinoso A, Muñoz-Ruiz M, Regueiro JR.

Semin Cell Dev Biol. 2019 Jan;85:132-142. doi: 10.1016/j.semcdb.2018.02.005. Epub 2018 Mar 8. Review.

PMID:
29438807
4.

New human combined immunodeficiency caused by interferon regulatory factor 4 (IRF4) deficiency inherited by uniparental isodisomy.

Bravo García-Morato M, Aracil Santos FJ, Briones AC, Blázquez Moreno A, Del Pozo Maté Á, Domínguez-Soto Á, Beato Merino MJ, Del Pino Molina L, Torres Canizales J, Marin AV, Vallespín García E, Feito Rodríguez M, Plaza López Sabando D, Jiménez-Reinoso A, Mozo Del Castillo Y, Sanz Santaeufemia FJ, de Lucas-Laguna R, Cárdenas PP, Casamayor Polo L, Coronel Díaz M, Valés-Gómez M, Roldán Santiago E, Ferreira Cerdán A, Nevado Blanco J, Corbí ÁL, Reyburn HT, Regueiro JR, López-Granados E, Rodríguez Pena R.

J Allergy Clin Immunol. 2018 May;141(5):1924-1927.e18. doi: 10.1016/j.jaci.2017.12.995. Epub 2018 Mar 2. No abstract available.

PMID:
29408330
5.

Complement as a diagnostic tool in immunopathology.

López-Lera A, Corvillo F, Nozal P, Regueiro JR, Sánchez-Corral P, López-Trascasa M.

Semin Cell Dev Biol. 2019 Jan;85:86-97. doi: 10.1016/j.semcdb.2017.12.017. Epub 2018 Jan 12. Review.

PMID:
29292221
6.

Human plasma C3 is essential for the development of memory B, but not T, lymphocytes.

Jiménez-Reinoso A, Marin AV, Subias M, López-Lera A, Román-Ortiz E, Payne K, Ma CS, Arbore G, Kolev M, Freeley SJ, Kemper C, Tangye SG, Fernández-Malavé E, Rodríguez de Córdoba S, López-Trascasa M, Regueiro JR.

J Allergy Clin Immunol. 2018 Mar;141(3):1151-1154.e14. doi: 10.1016/j.jaci.2017.09.037. Epub 2017 Nov 4. No abstract available.

PMID:
29113906
7.

Analysis of the recovery of CD247 expression in a PID patient: insights into the spontaneous repair of defective genes.

Blázquez-Moreno A, Pérez-Portilla A, Agúndez-Llaca M, Dukovska D, Valés-Gómez M, Aydogmus C, Ikinciogullari A, Regueiro JR, Reyburn HT.

Blood. 2017 Sep 7;130(10):1205-1208. doi: 10.1182/blood-2017-01-762864. Epub 2017 Jul 25.

8.

Human Invariant Natural Killer T Cells Respond to Antigen-Presenting Cells Exposed to Lipids from Olea europaea Pollen.

Abos Gracia B, López Relaño J, Revilla A, Castro L, Villalba M, Martín Adrados B, Regueiro JR, Fernández-Malavé E, Martínez Naves E, Gómez Del Moral M.

Int Arch Allergy Immunol. 2017;173(1):12-22. doi: 10.1159/000467394. Epub 2017 May 10.

9.

The Behçet's disease-associated variant of the aminopeptidase ERAP1 shapes a low-affinity HLA-B*51 peptidome by differential subpeptidome processing.

Guasp P, Barnea E, González-Escribano MF, Jiménez-Reinoso A, Regueiro JR, Admon A, López de Castro JA.

J Biol Chem. 2017 Jun 9;292(23):9680-9689. doi: 10.1074/jbc.M117.789180. Epub 2017 Apr 26.

10.

Crystal Structure of Glyceraldehyde-3-Phosphate Dehydrogenase from the Gram-Positive Bacterial Pathogen A. vaginae, an Immunoevasive Factor that Interacts with the Human C5a Anaphylatoxin.

Querol-García J, Fernández FJ, Marin AV, Gómez S, Fullà D, Melchor-Tafur C, Franco-Hidalgo V, Albertí S, Juanhuix J, Rodríguez de Córdoba S, Regueiro JR, Vega MC.

Front Microbiol. 2017 Apr 10;8:541. doi: 10.3389/fmicb.2017.00541. eCollection 2017.

11.

Complement in basic processes of the cell.

Jiménez-Reinoso A, Marin AV, Regueiro JR.

Mol Immunol. 2017 Apr;84:10-16. doi: 10.1016/j.molimm.2016.11.011. Epub 2016 Dec 3. Review.

PMID:
27919436
12.

Gain-of-function mutation in PIK3R1 in a patient with a narrow clinical phenotype of respiratory infections.

Martínez-Saavedra MT, García-Gomez S, Domínguez Acosta A, Mendoza Quintana JJ, Páez JP, García-Reino EJ, Camps G, Martinez-Barricarte R, Itan Y, Boisson B, Sánchez-Ramón S, Regueiro JR, Casanova JL, Rodríguez-Gallego C, Pérez de Diego R.

Clin Immunol. 2016 Dec;173:117-120. doi: 10.1016/j.clim.2016.09.011. Epub 2016 Sep 28.

PMID:
27693481
13.

Primary T-cell immunodeficiency with functional revertant somatic mosaicism in CD247.

Marin AV, Jiménez-Reinoso A, Briones AC, Muñoz-Ruiz M, Aydogmus C, Pasick LJ, Couso J, Mazariegos MS, Alvarez-Prado AF, Blázquez-Moreno A, Cipe FE, Haskologlu S, Dogu F, Morín M, Moreno-Pelayo MA, García-Sánchez F, Gil-Herrera J, Fernández-Malavé E, Reyburn HT, Ramiro AR, Ikinciogullari A, Recio MJ, Regueiro JR, Garcillán B.

J Allergy Clin Immunol. 2017 Jan;139(1):347-349.e8. doi: 10.1016/j.jaci.2016.06.020. Epub 2016 Aug 21. No abstract available.

PMID:
27555457
14.

TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets.

Muñoz-Ruiz M, Ribot JC, Grosso AR, Gonçalves-Sousa N, Pamplona A, Pennington DJ, Regueiro JR, Fernández-Malavé E, Silva-Santos B.

Nat Immunol. 2016 Jun;17(6):721-727. doi: 10.1038/ni.3424. Epub 2016 Apr 4.

15.

Natural killer cell hyporesponsiveness and impaired development in a CD247-deficient patient.

Valés-Gómez M, Esteso G, Aydogmus C, Blázquez-Moreno A, Marín AV, Briones AC, Garcillán B, García-Cuesta EM, López Cobo S, Haskologlu S, Moraru M, Cipe F, Dobbs K, Dogu F, Parolini S, Notarangelo LD, Vilches C, Recio MJ, Regueiro JR, Ikinciogullari A, Reyburn HT.

J Allergy Clin Immunol. 2016 Mar;137(3):942-5.e4. doi: 10.1016/j.jaci.2015.07.051. Epub 2015 Nov 2. No abstract available.

PMID:
26542031
16.

Spanish Immunology on the move.

Sancho D, Villar LM, Regueiro JR, de Andrés B.

Eur J Immunol. 2015 Jun;45(6):1580-3. doi: 10.1002/eji.201570064. No abstract available.

17.

γδ T Lymphocytes in the Diagnosis of Human T Cell Receptor Immunodeficiencies.

Garcillán B, Marin AV, Jiménez-Reinoso A, Briones AC, Muñoz-Ruiz M, García-León MJ, Gil J, Allende LM, Martínez-Naves E, Toribio ML, Regueiro JR.

Front Immunol. 2015 Jan 29;6:20. doi: 10.3389/fimmu.2015.00020. eCollection 2015. Review. No abstract available.

18.

A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells.

López-Cotarelo P, Escribano-Díaz C, González-Bethencourt IL, Gómez-Moreira C, Deguiz ML, Torres-Bacete J, Gómez-Cabañas L, Fernández-Barrera J, Delgado-Martín C, Mellado M, Regueiro JR, Miranda-Carús ME, Rodríguez-Fernández JL.

J Biol Chem. 2015 Jan 9;290(2):827-40. doi: 10.1074/jbc.M114.596551. Epub 2014 Nov 25.

19.

Inherited BCL10 deficiency impairs hematopoietic and nonhematopoietic immunity.

Torres JM, Martinez-Barricarte R, García-Gómez S, Mazariegos MS, Itan Y, Boisson B, Rholvarez R, Jiménez-Reinoso A, del Pino L, Rodríguez-Pena R, Ferreira A, Hernández-Jiménez E, Toledano V, Cubillos-Zapata C, Díaz-Almirón M, López-Collazo E, Unzueta-Roch JL, Sánchez-Ramón S, Regueiro JR, López-Granados E, Casanova JL, Pérez de Diego R.

J Clin Invest. 2014 Dec;124(12):5239-48. doi: 10.1172/JCI77493. Epub 2014 Nov 3.

20.

The CD3 conformational change in the γδ T cell receptor is not triggered by antigens but can be enforced to enhance tumor killing.

Dopfer EP, Hartl FA, Oberg HH, Siegers GM, Yousefi OS, Kock S, Fiala GJ, Garcillán B, Sandstrom A, Alarcón B, Regueiro JR, Kabelitz D, Adams EJ, Minguet S, Wesch D, Fisch P, Schamel WWA.

Cell Rep. 2014 Jun 12;7(5):1704-1715. doi: 10.1016/j.celrep.2014.04.049. Epub 2014 May 22.

21.

Enrichment of the rare CD4⁺ γδ T-cell subset in patients with atypical CD3δ deficiency.

Garcillán B, Mazariegos MS, Fisch P, Res PC, Muñoz-Ruiz M, Gil J, López-Granados E, Fernández-Malavé E, Regueiro JR.

J Allergy Clin Immunol. 2014 Apr;133(4):1205-8. doi: 10.1016/j.jaci.2013.10.002. Epub 2013 Nov 28. No abstract available.

PMID:
24290291
22.

Human CD3γ, but not CD3δ, haploinsufficiency differentially impairs γδ versus αβ surface TCR expression.

Muñoz-Ruiz M, Pérez-Flores V, Garcillán B, Guardo AC, Mazariegos MS, Takada H, Allende LM, Kilic SS, Sanal O, Roifman CM, López-Granados E, Recio MJ, Martínez-Naves E, Fernández-Malavé E, Regueiro JR.

BMC Immunol. 2013 Jan 21;14:3. doi: 10.1186/1471-2172-14-3.

23.

New tools in regenerative medicine: gene therapy.

Muñoz Ruiz M, Regueiro JR.

Adv Exp Med Biol. 2012;741:254-75. doi: 10.1007/978-1-4614-2098-9_17.

PMID:
22457115
24.

A leaky mutation in CD3D differentially affects αβ and γδ T cells and leads to a Tαβ-Tγδ+B+NK+ human SCID.

Gil J, Busto EM, Garcillán B, Chean C, García-Rodríguez MC, Díaz-Alderete A, Navarro J, Reiné J, Mencía A, Gurbindo D, Beléndez C, Gordillo I, Duchniewicz M, Höhne K, García-Sánchez F, Fernández-Cruz E, López-Granados E, Schamel WW, Moreno-Pelayo MA, Recio MJ, Regueiro JR.

J Clin Invest. 2011 Oct;121(10):3872-6. doi: 10.1172/JCI44254. Epub 2011 Sep 19.

25.

CD3γ-independent pathways in TCR-mediated signaling in mature T and iNKT lymphocytes.

Reiné J, Busto EM, Muñoz-Ruiz M, Rossi NE, Rodríguez-Fernández JL, Martínez-Naves E, Regueiro JR, Recio MJ.

Cell Immunol. 2011;271(1):62-6. doi: 10.1016/j.cellimm.2011.06.009. Epub 2011 Jun 22.

PMID:
21764047
26.

Hematopoietic stem cell transplantation for CD3δ deficiency.

Marcus N, Takada H, Law J, Cowan MJ, Gil J, Regueiro JR, Plaza Lopez de Sabando D, Lopez-Granados E, Dalal J, Friedrich W, Manfred H, Hanson IC, Grunebaum E, Shearer WT, Roifman CM.

J Allergy Clin Immunol. 2011 Nov;128(5):1050-7. doi: 10.1016/j.jaci.2011.05.031. Epub 2011 Jul 16. Erratum in: J Allergy Clin Immunol. 2013 Nov;132(5):1259.

27.

SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages.

Berger SB, Romero X, Ma C, Wang G, Faubion WA, Liao G, Compeer E, Keszei M, Rameh L, Wang N, Boes M, Regueiro JR, Reinecker HC, Terhorst C.

Nat Immunol. 2010 Oct;11(10):920-7. doi: 10.1038/ni.1931. Epub 2010 Sep 5.

28.

GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells.

Liao G, Nayak S, Regueiro JR, Berger SB, Detre C, Romero X, de Waal Malefyt R, Chatila TA, Herzog RW, Terhorst C.

Int Immunol. 2010 Apr;22(4):259-70. doi: 10.1093/intimm/dxq001. Epub 2010 Feb 5.

29.

The MHC-related protein 1 (MR1) is expressed by a subpopulation of CD38+, IgA+ cells in the human intestinal mucosa.

Gozalbo-López B, Gómez del Moral M, Campos-Martín Y, Setién F, Martín P, Bellas C, Regueiro JR, Martínez-Naves E.

Histol Histopathol. 2009 Nov;24(11):1439-49. doi: 10.14670/HH-24.1439.

PMID:
19760593
30.

Differential antibody binding to the surface alphabetaTCR.CD3 complex of CD4+ and CD8+ T lymphocytes is conserved in mammals and associated with differential glycosylation.

Rossi NE, Reiné J, Pineda-Lezamit M, Pulgar M, Meza NW, Swamy M, Risueno R, Schamel WW, Bonay P, Fernández-Malavé E, Regueiro JR.

Int Immunol. 2008 Oct;20(10):1247-58. doi: 10.1093/intimm/dxn081. Epub 2008 Jul 24.

PMID:
18653700
31.

Critical involvement of the ATM-dependent DNA damage response in the apoptotic demise of HIV-1-elicited syncytia.

Perfettini JL, Nardacci R, Bourouba M, Subra F, Gros L, Séror C, Manic G, Rosselli F, Amendola A, Masdehors P, Chessa L, Novelli G, Ojcius DM, Siwicki JK, Chechlinska M, Auclair C, Regueiro JR, de Thé H, Gougeon ML, Piacentini M, Kroemer G.

PLoS One. 2008 Jun 18;3(6):e2458. doi: 10.1371/journal.pone.0002458.

32.

Different composition of the human and the mouse gammadelta T cell receptor explains different phenotypes of CD3gamma and CD3delta immunodeficiencies.

Siegers GM, Swamy M, Fernández-Malavé E, Minguet S, Rathmann S, Guardo AC, Pérez-Flores V, Regueiro JR, Alarcón B, Fisch P, Schamel WW.

J Exp Med. 2007 Oct 29;204(11):2537-44. Epub 2007 Oct 8. Erratum in: J Exp Med. 2007 Nov 26;204(12):3049.

33.

Differential biological role of CD3 chains revealed by human immunodeficiencies.

Recio MJ, Moreno-Pelayo MA, Kiliç SS, Guardo AC, Sanal O, Allende LM, Pérez-Flores V, Mencía A, Modamio-Høybjør S, Seoane E, Regueiro JR.

J Immunol. 2007 Feb 15;178(4):2556-64.

34.

Herpesvirus saimiri-transformed CD8+ T cells as a tool to study Chediak-Higashi syndrome cytolytic lymphocytes.

Martín-Fernández JM, Cabanillas JA, Rivero-Carmena M, Lacasa E, Pardo J, Anel A, Ramírez-Duque PR, Merino F, Rodríguez-Gallego C, Regueiro JR.

J Leukoc Biol. 2005 May;77(5):661-8. Epub 2005 Feb 22.

PMID:
15728247
35.

Biochemical differences in the alphabeta T cell receptor.CD3 surface complex between CD8+ and CD4+ human mature T lymphocytes.

Zapata DA, Schamel WW, Torres PS, Alarcón B, Rossi NE, Navarro MN, Toribio ML, Regueiro JR.

J Biol Chem. 2004 Jun 4;279(23):24485-92. Epub 2004 Apr 1.

36.

Toward gene therapy for human CD3 deficiencies.

Pacheco-Castro A, Martín-Fernández JM, Millán R, Sanal O, Allende L, Regueiro JR.

Hum Gene Ther. 2003 Nov 20;14(17):1653-61.

PMID:
14633407
37.

TCR dynamics in human mature T lymphocytes lacking CD3 gamma.

Torres PS, Alcover A, Zapata DA, Arnaud J, Pacheco A, Martín-Fernández JM, Villasevil EM, Sanal O, Regueiro JR.

J Immunol. 2003 Jun 15;170(12):5947-55.

38.

Direct genetic correction as a new method for diagnosis and molecular characterization of MHC class II deficiency.

Matheux F, Ikinciogullari A, Zapata DA, Barras E, Zufferey M, Dogu F, Regueiro JR, Reith W, Villard J.

Mol Ther. 2002 Dec;6(6):824-9.

39.

Contribution of CD3 gamma to TCR regulation and signaling in human mature T lymphocytes.

Torres PS, Zapata DA, Pacheco-Castro A, Rodríguez-Fernández JL, Cabañas C, Regueiro JR.

Int Immunol. 2002 Nov;14(11):1357-67.

PMID:
12407027
40.

Characterization of Herpesvirus saimiri-transformed T lymphocytes from common variable immunodeficiency patients.

Cabanillas JA, Cambronero R, Pacheco-Castro A, García-Rodríguez MC, Martín-Fernández JM, Fontán G, Regueiro JR.

Clin Exp Immunol. 2002 Feb;127(2):366-73.

41.

Apparent genotype-phenotype correlation in childhood, adolescent, and adult Chediak-Higashi syndrome.

Karim MA, Suzuki K, Fukai K, Oh J, Nagle DL, Moore KJ, Barbosa E, Falik-Borenstein T, Filipovich A, Ishida Y, Kivrikko S, Klein C, Kreuz F, Levin A, Miyajima H, Regueiro JR, Russo C, Uyama E, Vierimaa O, Spritz RA.

Am J Med Genet. 2002 Feb 15;108(1):16-22.

PMID:
11857544
42.

Membrane and transmembrane signaling in Herpesvirus saimiri-transformed human CD4(+) and CD8(+) T lymphocytes is ATM-independent.

Rivero-Carmena M, Porras O, Pelaez B, Pacheco-Castro A, Gatti RA, Regueiro JR.

Int Immunol. 2000 Jun;12(6):927-35.

PMID:
10837420
43.

Conformational and biochemical differences in the TCR.CD3 complex of CD8(+) versus CD4(+) mature lymphocytes revealed in the absence of CD3gamma.

Zapata DA, Pacheco-Castro A, Torres PS, Ramiro AR, San José E, Alarcón B, Alibaud L, Rubin B, Toribio ML, Regueiro JR.

J Biol Chem. 1999 Dec 3;274(49):35119-28.

44.

[Physiopathogenesis and molecular bases of the primary immunodeficiencies].

García Cabanillas JA, Pacheco A, Regueiro JR.

Sangre (Barc). 1999 Apr;44(2):107-22. Review. Spanish. No abstract available.

PMID:
10382320
45.

Functional integrity of the CD28 co-stimulatory pathway in T lymphocytes from elderly subjects.

Vidán MT, Fernández-Gutiérrez B, Hernández-García C, Serra JA, Ribera JM, Pérez-Blas M, Regueiro JR, Bañares A, Jover JA.

Age Ageing. 1999 Mar;28(2):221-7.

PMID:
10350423
46.

Signaling through a CD3 gamma-deficient TCR/CD3 complex in immortalized mature CD4+ and CD8+ T lymphocytes.

Pacheco-Castro A, Alvarez-Zapata D, Serrano-Torres P, Regueiro JR.

J Immunol. 1998 Sep 15;161(6):3152-60.

47.

A model for ATM heterozygote identification in a large population: four founder-effect ATM mutations identify most of Costa Rican patients with ataxia telangiectasia.

Telatar M, Wang S, Castellvi-Bel S, Tai LQ, Sheikhavandi S, Regueiro JR, Porras O, Gatti RA.

Mol Genet Metab. 1998 May;64(1):36-43.

PMID:
9682216
48.

Phenotypical and functional characterization of Herpesvirus saimiri-immortalized human major histocompatibility complex class II-deficient T lymphocytes.

Alvarez-Zapata D, de Miguel Olalla S, Fontán G, Ferreira A, García-Rodríguez MC, Madero L, van den Elsen P, Regueiro JR.

Tissue Antigens. 1998 Mar;51(3):250-7.

PMID:
9550325
49.
50.

Herpes virus saimiri transformation of T cells in CD3 gamma immunodeficiency: phenotypic and functional characterization.

Rodríguez-Gallego C, Corell A, Pacheco A, Timón M, Regueiro JR, Allende LM, Madroño A, Arnaiz-Villena A.

J Immunol Methods. 1996 Nov 13;198(2):177-86.

PMID:
8946013

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