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Novel Adult-Onset Systolic Cardiomyopathy Due to MYH7 E848G Mutation in Patient-Derived Induced Pluripotent Stem Cells.

Yang KC, Breitbart A, De Lange WJ, Hofsteen P, Futakuchi-Tsuchida A, Xu J, Schopf C, Razumova MV, Jiao A, Boucek R, Pabon L, Reinecke H, Kim DH, Ralphe JC, Regnier M, Murry CE.

JACC Basic Transl Sci. 2018 Dec 31;3(6):728-740. doi: 10.1016/j.jacbts.2018.08.008. eCollection 2018 Dec.


Restoring LINC00673 expression triggers cellular senescence in lung cancer.

Roth A, Boulay K, Groß M, Polycarpou-Schwarz M, Mallette FA, Regnier M, Bida O, Ginsberg D, Warth A, Schnabel PA, Muley T, Meister M, Zabeck H, Hoffmann H, Diederichs S.

RNA Biol. 2018 Nov 30. doi: 10.1080/15476286.2018.1553481. [Epub ahead of print]


The protective role of liver X receptor (LXR) during fumonisin B1-induced hepatotoxicity.

Régnier M, Polizzi A, Lukowicz C, Smati S, Lasserre F, Lippi Y, Naylies C, Laffitte J, Bétoulières C, Montagner A, Ducheix S, Gourbeyre P, Ellero-Simatos S, Menard S, Bertrand-Michel J, Al Saati T, Lobaccaro JM, Burger HM, Gelderblom WC, Guillou H, Oswald IP, Loiseau N.

Arch Toxicol. 2018 Nov 17. doi: 10.1007/s00204-018-2345-2. [Epub ahead of print]


Sphingolipid metabolism in non-alcoholic fatty liver diseases.

Régnier M, Polizzi A, Guillou H, Loiseau N.

Biochimie. 2018 Jul 31. pii: S0300-9084(18)30216-5. doi: 10.1016/j.biochi.2018.07.021. [Epub ahead of print] Review.


Mechanistic complexity of contractile dysfunction in hypertrophic cardiomyopathy.

Regnier M.

J Gen Physiol. 2018 Aug 6;150(8):1051-1053. doi: 10.1085/jgp.201812091. Epub 2018 Jul 23. No abstract available.


Metabolic Effects of a Chronic Dietary Exposure to a Low-Dose Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor.

Lukowicz C, Ellero-Simatos S, Régnier M, Polizzi A, Lasserre F, Montagner A, Lippi Y, Jamin EL, Martin JF, Naylies C, Canlet C, Debrauwer L, Bertrand-Michel J, Al Saati T, Théodorou V, Loiseau N, Mselli-Lakhal L, Guillou H, Gamet-Payrastre L.

Environ Health Perspect. 2018 Jun 25;126(6):067007. doi: 10.1289/EHP2877. eCollection 2018 Jun.


A Spatially Explicit Model Shows How Titin Stiffness Modulates Muscle Mechanics and Energetics.

Powers JD, Williams CD, Regnier M, Daniel TL.

Integr Comp Biol. 2018 Aug 1;58(2):186-193. doi: 10.1093/icb/icy055.


Afterload promotes maturation of human induced pluripotent stem cell derived cardiomyocytes in engineered heart tissues.

Leonard A, Bertero A, Powers JD, Beussman KM, Bhandari S, Regnier M, Murry CE, Sniadecki NJ.

J Mol Cell Cardiol. 2018 May;118:147-158. doi: 10.1016/j.yjmcc.2018.03.016. Epub 2018 Mar 28.


Fast and sensitive HPLC-MS/MS method for direct quantification of intracellular deoxyribonucleoside triphosphates from tissue and cells.

Olafsson S, Whittington D, Murray J, Regnier M, Moussavi-Harami F.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Nov 15;1068-1069:90-97. doi: 10.1016/j.jchromb.2017.10.008. Epub 2017 Oct 5.


A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response.

Iroz A, Montagner A, Benhamed F, Levavasseur F, Polizzi A, Anthony E, Régnier M, Fouché E, Lukowicz C, Cauzac M, Tournier E, Do-Cruzeiro M, Daujat-Chavanieu M, Gerbal-Chalouin S, Fauveau V, Marmier S, Burnol AF, Guilmeau S, Lippi Y, Girard J, Wahli W, Dentin R, Guillou H, Postic C.

Cell Rep. 2017 Oct 10;21(2):403-416. doi: 10.1016/j.celrep.2017.09.065.


Gene Therapy for Nonischemic Cardiomyopathy: Moving Forward by Learning From Lessons of the Past.

Regnier M, Moussavi-Harami F.

J Am Coll Cardiol. 2017 Oct 3;70(14):1757-1759. doi: 10.1016/j.jacc.2017.08.042. No abstract available.


Identification of Signaling Pathways Targeted by the Food Contaminant FB1: Transcriptome and Kinome Analysis of Samples from Pig Liver and Intestine.

Régnier M, Gourbeyre P, Pinton P, Napper S, Laffite J, Cossalter AM, Bailly JD, Lippi Y, Bertrand-Michel J, Bracarense APFRL, Guillou H, Loiseau N, Oswald IP.

Mol Nutr Food Res. 2017 Dec;61(12). doi: 10.1002/mnfr.201700433. Epub 2017 Oct 17.


Insights into the role of hepatocyte PPARα activity in response to fasting.

Régnier M, Polizzi A, Lippi Y, Fouché E, Michel G, Lukowicz C, Smati S, Marrot A, Lasserre F, Naylies C, Batut A, Viars F, Bertrand-Michel J, Postic C, Loiseau N, Wahli W, Guillou H, Montagner A.

Mol Cell Endocrinol. 2018 Aug 15;471:75-88. doi: 10.1016/j.mce.2017.07.035. Epub 2017 Jul 31.


Dietary oleic acid regulates hepatic lipogenesis through a liver X receptor-dependent signaling.

Ducheix S, Montagner A, Polizzi A, Lasserre F, Régnier M, Marmugi A, Benhamed F, Bertrand-Michel J, Mselli-Lakhal L, Loiseau N, Martin PG, Lobaccaro JM, Ferrier L, Postic C, Guillou H.

PLoS One. 2017 Jul 21;12(7):e0181393. doi: 10.1371/journal.pone.0181393. eCollection 2017.


Translation of Cardiac Myosin Activation with 2-deoxy-ATP to Treat Heart Failure via an Experimental Ribonucleotide Reductase-Based Gene Therapy.

Thomson KS, Odom GL, Murry CE, Mahairas GG, Moussavi-Harami F, Teichman SL, Chen X, Hauschka SD, Chamberlain JS, Regnier M.

JACC Basic Transl Sci. 2016 Dec;1(7):666-679. doi: 10.1016/j.jacbts.2016.07.006.


Eye bank prepared versus surgeon cut endothelial graft tissue for Descemet membrane endothelial keratoplasty: An observational study.

Regnier M, Auxenfans C, Maucort-Boulch D, Marty AS, Damour O, Burillon C, Kocaba V.

Medicine (Baltimore). 2017 May;96(19):e6885. doi: 10.1097/MD.0000000000006885.


Outcome of patients with septic shock and high-dose vasopressor therapy.

Auchet T, Regnier MA, Girerd N, Levy B.

Ann Intensive Care. 2017 Dec;7(1):43. doi: 10.1186/s13613-017-0261-x. Epub 2017 Apr 20.


Insights and Challenges of Multi-Scale Modeling of Sarcomere Mechanics in cTn and Tm DCM Mutants-Genotype to Cellular Phenotype.

Dewan S, McCabe KJ, Regnier M, McCulloch AD.

Front Physiol. 2017 Mar 14;8:151. doi: 10.3389/fphys.2017.00151. eCollection 2017. Review.


High-throughput sequencing reveals circular substrates for an archaeal RNA ligase.

Becker HF, Héliou A, Djaout K, Lestini R, Regnier M, Myllykallio H.

RNA Biol. 2017 Aug 3;14(8):1075-1085. doi: 10.1080/15476286.2017.1302640. Epub 2017 Mar 9.


A postnatal role for embryonic myosin revealed by MYH3 mutations that alter TGFβ signaling and cause autosomal dominant spondylocarpotarsal synostosis.

Zieba J, Zhang W, Chong JX, Forlenza KN, Martin JH, Heard K, Grange DK, Butler MG, Kleefstra T, Lachman RS, Nickerson D, Regnier M, Cohn DH, Bamshad M, Krakow D.

Sci Rep. 2017 Feb 16;7:41803. doi: 10.1038/srep41803.


Molecular mechanisms underlying deoxy-ADP.Pi activation of pre-powerstroke myosin.

Nowakowski SG, Regnier M, Daggett V.

Protein Sci. 2017 Apr;26(4):749-762. doi: 10.1002/pro.3121. Epub 2017 Mar 21.


Mechanical Stress Conditioning and Electrical Stimulation Promote Contractility and Force Maturation of Induced Pluripotent Stem Cell-Derived Human Cardiac Tissue.

Ruan JL, Tulloch NL, Razumova MV, Saiget M, Muskheli V, Pabon L, Reinecke H, Regnier M, Murry CE.

Circulation. 2016 Nov 15;134(20):1557-1567. Epub 2016 Oct 13.


Cardiac Myosin Activation with Gene Therapy Produces Sustained Inotropic Effects and May Treat Heart Failure with Reduced Ejection Fraction.

Teichman SL, Thomson KS, Regnier M.

Handb Exp Pharmacol. 2017;243:447-464. doi: 10.1007/164_2016_31. Review.


Accurate Prediction of the Statistics of Repetitions in Random Sequences: A Case Study in Archaea Genomes.

Régnier M, Chassignet P.

Front Bioeng Biotechnol. 2016 Jun 8;4:35. doi: 10.3389/fbioe.2016.00035. eCollection 2016.


Isolation and Mechanical Measurements of Myofibrils from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Pioner JM, Racca AW, Klaiman JM, Yang KC, Guan X, Pabon L, Muskheli V, Zaunbrecher R, Macadangdang J, Jeong MY, Mack DL, Childers MK, Kim DH, Tesi C, Poggesi C, Murry CE, Regnier M.

Stem Cell Reports. 2016 Jun 14;6(6):885-896. doi: 10.1016/j.stemcr.2016.04.006. Epub 2016 May 5.


Effects of Cardiac Troponin I Mutation P83S on Contractile Properties and the Modulation by PKA-Mediated Phosphorylation.

Cheng Y, Lindert S, Oxenford L, Tu AY, McCulloch AD, Regnier M.

J Phys Chem B. 2016 Aug 25;120(33):8238-53. doi: 10.1021/acs.jpcb.6b01859. Epub 2016 May 18.


Molecular Effects of cTnC DCM Mutations on Calcium Sensitivity and Myofilament Activation-An Integrated Multiscale Modeling Study.

Dewan S, McCabe KJ, Regnier M, McCulloch AD, Lindert S.

J Phys Chem B. 2016 Aug 25;120(33):8264-75. doi: 10.1021/acs.jpcb.6b01950. Epub 2016 May 6.


A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy.

Davis J, Davis LC, Correll RN, Makarewich CA, Schwanekamp JA, Moussavi-Harami F, Wang D, York AJ, Wu H, Houser SR, Seidman CE, Seidman JG, Regnier M, Metzger JM, Wu JC, Molkentin JD.

Cell. 2016 May 19;165(5):1147-1159. doi: 10.1016/j.cell.2016.04.002. Epub 2016 Apr 21.


Stromal Cells in Dense Collagen Promote Cardiomyocyte and Microvascular Patterning in Engineered Human Heart Tissue.

Roberts MA, Tran D, Coulombe KL, Razumova M, Regnier M, Murry CE, Zheng Y.

Tissue Eng Part A. 2016 Apr;22(7-8):633-44. doi: 10.1089/ten.TEA.2015.0482. Epub 2016 Mar 31.


Nanotopography-Induced Structural Anisotropy and Sarcomere Development in Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells.

Carson D, Hnilova M, Yang X, Nemeth CL, Tsui JH, Smith AS, Jiao A, Regnier M, Murry CE, Tamerler C, Kim DH.

ACS Appl Mater Interfaces. 2016 Aug 31;8(34):21923-32. doi: 10.1021/acsami.5b11671. Epub 2016 Feb 11.


Cardiac troponin structure-function and the influence of hypertrophic cardiomyopathy associated mutations on modulation of contractility.

Cheng Y, Regnier M.

Arch Biochem Biophys. 2016 Jul 1;601:11-21. doi: 10.1016/ Epub 2016 Feb 4. Review.


Finally, We Can Relax: A New Generation of Muscle Models that Incorporate Sarcomere Compliance.

Regnier M, Cheng Y.

Biophys J. 2016 Feb 2;110(3):521-522. doi: 10.1016/j.bpj.2015.12.025. No abstract available.


Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD.

Montagner A, Polizzi A, Fouché E, Ducheix S, Lippi Y, Lasserre F, Barquissau V, Régnier M, Lukowicz C, Benhamed F, Iroz A, Bertrand-Michel J, Al Saati T, Cano P, Mselli-Lakhal L, Mithieux G, Rajas F, Lagarrigue S, Pineau T, Loiseau N, Postic C, Langin D, Wahli W, Guillou H.

Gut. 2016 Jul;65(7):1202-14. doi: 10.1136/gutjnl-2015-310798. Epub 2016 Feb 1.


SV-Bay: structural variant detection in cancer genomes using a Bayesian approach with correction for GC-content and read mappability.

Iakovishina D, Janoueix-Lerosey I, Barillot E, Regnier M, Boeva V.

Bioinformatics. 2016 Apr 1;32(7):984-92. doi: 10.1093/bioinformatics/btv751. Epub 2016 Jan 6.


2-Deoxyadenosine triphosphate restores the contractile function of cardiac myofibril from adult dogs with naturally occurring dilated cardiomyopathy.

Cheng Y, Hogarth KA, O'Sullivan ML, Regnier M, Pyle WG.

Am J Physiol Heart Circ Physiol. 2016 Jan 1;310(1):H80-91. doi: 10.1152/ajpheart.00530.2015. Epub 2015 Oct 23.


Contractile properties of developing human fetal cardiac muscle.

Racca AW, Klaiman JM, Pioner JM, Cheng Y, Beck AE, Moussavi-Harami F, Bamshad MJ, Regnier M.

J Physiol. 2016 Jan 15;594(2):437-52. doi: 10.1113/JP271290. Epub 2015 Dec 7.


Troponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation.

Cheng Y, Rao V, Tu AY, Lindert S, Wang D, Oxenford L, McCulloch AD, McCammon JA, Regnier M.

J Biol Chem. 2015 Nov 13;290(46):27749-66. doi: 10.1074/jbc.M115.683045. Epub 2015 Sep 21.


AAV6-mediated Cardiac-specific Overexpression of Ribonucleotide Reductase Enhances Myocardial Contractility.

Kolwicz SC Jr, Odom GL, Nowakowski SG, Moussavi-Harami F, Chen X, Reinecke H, Hauschka SD, Murry CE, Mahairas GG, Regnier M.

Mol Ther. 2016 Feb;24(2):240-250. doi: 10.1038/mt.2015.176. Epub 2015 Sep 21.


MMP-10 Regulates Collagenolytic Activity of Alternatively Activated Resident Macrophages.

Rohani MG, McMahan RS, Razumova MV, Hertz AL, Cieslewicz M, Pun SH, Regnier M, Wang Y, Birkland TP, Parks WC.

J Invest Dermatol. 2015 Oct;135(10):2377-2384. doi: 10.1038/jid.2015.167. Epub 2015 Apr 30.


Ribonucleotide reductase-mediated increase in dATP improves cardiac performance via myosin activation in a large animal model of heart failure.

Kadota S, Carey J, Reinecke H, Leggett J, Teichman S, Laflamme MA, Murry CE, Regnier M, Mahairas GG.

Eur J Heart Fail. 2015 Aug;17(8):772-81. doi: 10.1002/ejhf.270. Epub 2015 Apr 15.


Mechanical Stress Promotes Maturation of Human Myocardium From Pluripotent Stem Cell-Derived Progenitors.

Ruan JL, Tulloch NL, Saiget M, Paige SL, Razumova MV, Regnier M, Tung KC, Keller G, Pabon L, Reinecke H, Murry CE.

Stem Cells. 2015 Jul;33(7):2148-57. doi: 10.1002/stem.2036. Epub 2015 May 11.


The embryonic myosin R672C mutation that underlies Freeman-Sheldon syndrome impairs cross-bridge detachment and cycling in adult skeletal muscle.

Racca AW, Beck AE, McMillin MJ, Korte FS, Bamshad MJ, Regnier M.

Hum Mol Genet. 2015 Jun 15;24(12):3348-58. doi: 10.1093/hmg/ddv084. Epub 2015 Mar 3.


Phosphorylation of Ser283 enhances the stiffness of the tropomyosin head-to-tail overlap domain.

Lehman W, Medlock G, Li XE, Suphamungmee W, Tu AY, Schmidtmann A, Ujfalusi Z, Fischer S, Moore JR, Geeves MA, Regnier M.

Arch Biochem Biophys. 2015 Apr 1;571:10-5. doi: 10.1016/ Epub 2015 Feb 26.


Analysis of pattern overlaps and exact computation of P-values of pattern occurrences numbers: case of Hidden Markov Models.

Régnier M, Furletova E, Yakovlev V, Roytberg M.

Algorithms Mol Biol. 2014 Dec 16;9(1):25. doi: 10.1186/s13015-014-0025-1. eCollection 2014.


Effects of HCM cTnI mutation R145G on troponin structure and modulation by PKA phosphorylation elucidated by molecular dynamics simulations.

Lindert S, Cheng Y, Kekenes-Huskey P, Regnier M, McCammon JA.

Biophys J. 2015 Jan 20;108(2):395-407. doi: 10.1016/j.bpj.2014.11.3461.


2-Deoxy adenosine triphosphate improves contraction in human end-stage heart failure.

Moussavi-Harami F, Razumova MV, Racca AW, Cheng Y, Stempien-Otero A, Regnier M.

J Mol Cell Cardiol. 2015 Feb;79:256-63. doi: 10.1016/j.yjmcc.2014.12.002. Epub 2014 Dec 10.


Impact of tropomyosin isoform composition on fast skeletal muscle thin filament regulation and force development.

Scellini B, Piroddi N, Flint GV, Regnier M, Poggesi C, Tesi C.

J Muscle Res Cell Motil. 2015 Feb;36(1):11-23. doi: 10.1007/s10974-014-9394-9. Epub 2014 Nov 8.


Computational studies of the effect of the S23D/S24D troponin I mutation on cardiac troponin structural dynamics.

Cheng Y, Lindert S, Kekenes-Huskey P, Rao VS, Solaro RJ, Rosevear PR, Amaro R, McCulloch AD, McCammon JA, Regnier M.

Biophys J. 2014 Oct 7;107(7):1675-85. doi: 10.1016/j.bpj.2014.08.008.


miRAFinder and GeneAFinder scripts: large-scale searching for miRNA and related information in indexed literature abstracts.

Berillo O, Régnier M, Ivashchenko A.

Bioinformation. 2014 Aug 30;10(8):539-43. doi: 10.6026/97320630010539. eCollection 2014.

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