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Items: 40

1.

Meningeal γδ T cell-derived IL-17 controls synaptic plasticity and short-term memory.

Ribeiro M, Brigas HC, Temido-Ferreira M, Pousinha PA, Regen T, Santa C, Coelho JE, Marques-Morgado I, Valente CA, Omenetti S, Stockinger B, Waisman A, Manadas B, Lopes LV, Silva-Santos B, Ribot JC.

Sci Immunol. 2019 Oct 11;4(40). pii: eaay5199. doi: 10.1126/sciimmunol.aay5199.

PMID:
31604844
2.

Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation.

Garg G, Muschaweckh A, Moreno H, Vasanthakumar A, Floess S, Lepennetier G, Oellinger R, Zhan Y, Regen T, Hiltensperger M, Peter C, Aly L, Knier B, Palam LR, Kapur R, Kaplan MH, Waisman A, Rad R, Schotta G, Huehn J, Kallies A, Korn T.

Cell Rep. 2019 Feb 12;26(7):1854-1868.e5. doi: 10.1016/j.celrep.2019.01.070.

3.

IL-17A/F in Leishmania major-resistant C57BL/6 mice.

Dietze-Schwonberg K, Lopez Kostka S, Lorenz B, Regen T, Waisman A, von Stebut E.

Exp Dermatol. 2019 Mar;28(3):321-323. doi: 10.1111/exd.13896.

PMID:
30703249
4.

Alternative Splice Forms of CYLD Mediate Ubiquitination of SMAD7 to Prevent TGFB Signaling and Promote Colitis.

Tang Y, Reissig S, Glasmacher E, Regen T, Wanke F, Nikolaev A, Gerlach K, Popp V, Karram K, Fantini MC, Schattenberg JM, Galle PR, Neurath MF, Weigmann B, Kurschus FC, Hövelmeyer N, Waisman A.

Gastroenterology. 2019 Feb;156(3):692-707.e7. doi: 10.1053/j.gastro.2018.10.023. Epub 2018 Oct 10.

PMID:
30315770
5.

Expression of IL-17F is associated with non-pathogenic Th17 cells.

Wanke F, Tang Y, Gronke K, Klebow S, Moos S, Hauptmann J, Shanmugavadivu A, Regen T, Mufazalov IA, Gabriel LA, Reißig S, Diefenbach A, Kurschus FC, Waisman A.

J Mol Med (Berl). 2018 Aug;96(8):819-829. doi: 10.1007/s00109-018-1662-5. Epub 2018 Jun 29.

PMID:
29959474
6.

RNase H2 Loss in Murine Astrocytes Results in Cellular Defects Reminiscent of Nucleic Acid-Mediated Autoinflammation.

Bartsch K, Damme M, Regen T, Becker L, Garrett L, Hölter SM, Knittler K, Borowski C, Waisman A, Glatzel M, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Rabe B.

Front Immunol. 2018 Mar 29;9:587. doi: 10.3389/fimmu.2018.00587. eCollection 2018.

7.

IL-4 Receptor Alpha Signaling through Macrophages Differentially Regulates Liver Fibrosis Progression and Reversal.

Weng SY, Wang X, Vijayan S, Tang Y, Kim YO, Padberg K, Regen T, Molokanova O, Chen T, Bopp T, Schild H, Brombacher F, Crosby JR, McCaleb ML, Waisman A, Bockamp E, Schuppan D.

EBioMedicine. 2018 Mar;29:92-103. doi: 10.1016/j.ebiom.2018.01.028. Epub 2018 Feb 17.

8.

Interferon-γ-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever.

Remy MM, Sahin M, Flatz L, Regen T, Xu L, Kreutzfeldt M, Fallet B, Doras C, Rieger T, Bestmann L, Hanisch UK, Kaufmann BA, Merkler D, Pinschewer DD.

Cell Host Microbe. 2017 Sep 13;22(3):354-365.e5. doi: 10.1016/j.chom.2017.07.008. Epub 2017 Aug 17.

9.

A presumed antagonistic LPS identifies distinct functional organization of TLR4 in mouse microglia.

Döring C, Regen T, Gertig U, van Rossum D, Winkler A, Saiepour N, Brück W, Hanisch UK, Janova H.

Glia. 2017 Jul;65(7):1176-1185. doi: 10.1002/glia.23151. Epub 2017 May 4.

PMID:
28471051
10.

Corrigendum: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells.

Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T.

Nat Immunol. 2017 Mar 22;18(4):474. doi: 10.1038/ni0417-474b. No abstract available.

PMID:
28323263
11.

TGF-β inhibitor Smad7 regulates dendritic cell-induced autoimmunity.

Lukas D, Yogev N, Kel JM, Regen T, Mufazalov IA, Tang Y, Wanke F, Reizis B, Müller W, Kurschus FC, Prinz M, Kleiter I, Clausen BE, Waisman A.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1480-E1489. doi: 10.1073/pnas.1615065114. Epub 2017 Feb 6.

12.

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells.

Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T.

Nat Immunol. 2017 Jan;18(1):74-85. doi: 10.1038/ni.3632. Epub 2016 Nov 28. Erratum in: Nat Immunol. 2017 Mar 22;18(4):474.

13.

IL-1 signaling is critical for expansion but not generation of autoreactive GM-CSF+ Th17 cells.

Mufazalov IA, Schelmbauer C, Regen T, Kuschmann J, Wanke F, Gabriel LA, Hauptmann J, Müller W, Pinteaux E, Kurschus FC, Waisman A.

EMBO J. 2017 Jan 4;36(1):102-115. doi: 10.15252/embj.201694615. Epub 2016 Nov 8.

14.

Generation of a Novel T Cell Specific Interleukin-1 Receptor Type 1 Conditional Knock Out Mouse Reveals Intrinsic Defects in Survival, Expansion and Cytokine Production of CD4 T Cells.

Mufazalov IA, Regen T, Schelmbauer C, Kuschmann J, Muratova AM, Nikolaev A, Müller W, Pinteaux E, Waisman A.

PLoS One. 2016 Aug 23;11(8):e0161505. doi: 10.1371/journal.pone.0161505. eCollection 2016.

15.

TLR4-activated microglia require IFN-γ to induce severe neuronal dysfunction and death in situ.

Papageorgiou IE, Lewen A, Galow LV, Cesetti T, Scheffel J, Regen T, Hanisch UK, Kann O.

Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):212-7. doi: 10.1073/pnas.1513853113. Epub 2015 Dec 22.

16.

CD14 is a key organizer of microglial responses to CNS infection and injury.

Janova H, Böttcher C, Holtman IR, Regen T, van Rossum D, Götz A, Ernst AS, Fritsche C, Gertig U, Saiepour N, Gronke K, Wrzos C, Ribes S, Rolfes S, Weinstein J, Ehrenreich H, Pukrop T, Kopatz J, Stadelmann C, Salinas-Riester G, Weber MS, Prinz M, Brück W, Eggen BJ, Boddeke HW, Priller J, Hanisch UK.

Glia. 2016 Apr;64(4):635-49. doi: 10.1002/glia.22955. Epub 2015 Dec 18.

PMID:
26683584
17.

Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System.

Bruttger J, Karram K, Wörtge S, Regen T, Marini F, Hoppmann N, Klein M, Blank T, Yona S, Wolf Y, Mack M, Pinteaux E, Müller W, Zipp F, Binder H, Bopp T, Prinz M, Jung S, Waisman A.

Immunity. 2015 Jul 21;43(1):92-106. doi: 10.1016/j.immuni.2015.06.012. Epub 2015 Jul 7.

18.

Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism.

Menzfeld C, John M, van Rossum D, Regen T, Scheffel J, Janova H, Götz A, Ribes S, Nau R, Borisch A, Boutin P, Neumann K, Bremes V, Wienands J, Reichardt HM, Lühder F, Tischner D, Waetzig V, Herdegen T, Teismann P, Greig I, Müller M, Pukrop T, Mildner A, Kettenmann H, Brück W, Prinz M, Rotshenker S, Weber MS, Hanisch UK.

Glia. 2015 Jun;63(6):1083-99. doi: 10.1002/glia.22803. Epub 2015 Mar 2.

PMID:
25731696
19.

The role of IL-17 in CNS diseases.

Waisman A, Hauptmann J, Regen T.

Acta Neuropathol. 2015 May;129(5):625-37. doi: 10.1007/s00401-015-1402-7. Epub 2015 Feb 26. Review.

PMID:
25716179
20.

IFN-γ-producing CD4+ T cells promote generation of protective germinal center-derived IgM+ B cell memory against Salmonella Typhi.

Perez-Shibayama C, Gil-Cruz C, Pastelin-Palacios R, Cervantes-Barragan L, Hisaki E, Chai Q, Onder L, Scandella E, Regen T, Waisman A, Isibasi A, Lopez-Macias C, Ludewig B.

J Immunol. 2014 Jun 1;192(11):5192-200. doi: 10.4049/jimmunol.1302526. Epub 2014 Apr 28.

21.

A new model for primary-progressive multiple sclerosis?

Waisman A, Regen T.

Acta Neuropathol. 2013 Oct;126(4):519-21. doi: 10.1007/s00401-013-1179-5. Epub 2013 Sep 15. No abstract available.

PMID:
24036552
22.

Empty liposomes induce antitumoral effects associated with macrophage responses distinct from those of the TLR1/2 agonist Pam3CSK 4 (BLP).

König S, Regen T, Dittmann K, Engelke M, Wienands J, Schwendener R, Hanisch UK, Pukrop T, Hahn H.

Cancer Immunol Immunother. 2013 Oct;62(10):1587-97. doi: 10.1007/s00262-013-1444-4. Epub 2013 Aug 6.

23.

Histone deacetylase inhibitors suppress immune activation in primary mouse microglia.

Kannan V, Brouwer N, Hanisch UK, Regen T, Eggen BJ, Boddeke HW.

J Neurosci Res. 2013 Sep;91(9):1133-42. doi: 10.1002/jnr.23221. Epub 2013 May 17.

PMID:
23686642
24.

Resistance of the brain to Escherichia coli K1 infection depends on MyD88 signaling and the contribution of neutrophils and monocytes.

Ribes S, Regen T, Meister T, Tauber SC, Schütze S, Mildner A, Mack M, Hanisch UK, Nau R.

Infect Immun. 2013 May;81(5):1810-9. doi: 10.1128/IAI.01349-12. Epub 2013 Mar 11.

25.

Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia.

Scheffel J, Regen T, Van Rossum D, Seifert S, Ribes S, Nau R, Parsa R, Harris RA, Boddeke HW, Chuang HN, Pukrop T, Wessels JT, Jürgens T, Merkler D, Brück W, Schnaars M, Simons M, Kettenmann H, Hanisch UK.

Glia. 2012 Dec;60(12):1930-43. doi: 10.1002/glia.22409. Epub 2012 Aug 21.

PMID:
22911652
26.

The nucleotide-binding oligomerization domain-containing-2 ligand muramyl dipeptide enhances phagocytosis and intracellular killing of Escherichia coli K1 by Toll-like receptor agonists in microglial cells.

Ribes S, Adam N, Schütze S, Regen T, Redlich S, Janova H, Borisch A, Hanisch UK, Nau R.

J Neuroimmunol. 2012 Nov 15;252(1-2):16-23. doi: 10.1016/j.jneuroim.2012.07.012. Epub 2012 Aug 11.

PMID:
22889567
27.

Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination.

Brück W, Pförtner R, Pham T, Zhang J, Hayardeny L, Piryatinsky V, Hanisch UK, Regen T, van Rossum D, Brakelmann L, Hagemeier K, Kuhlmann T, Stadelmann C, John GR, Kramann N, Wegner C.

Acta Neuropathol. 2012 Sep;124(3):411-24. doi: 10.1007/s00401-012-1009-1. Epub 2012 Jul 6.

28.

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis.

Fitzner D, Schnaars M, van Rossum D, Krishnamoorthy G, Dibaj P, Bakhti M, Regen T, Hanisch UK, Simons M.

J Cell Sci. 2011 Feb 1;124(Pt 3):447-58. doi: 10.1242/jcs.074088.

29.

CD14 and TRIF govern distinct responsiveness and responses in mouse microglial TLR4 challenges by structural variants of LPS.

Regen T, van Rossum D, Scheffel J, Kastriti ME, Revelo NH, Prinz M, Brück W, Hanisch UK.

Brain Behav Immun. 2011 Jul;25(5):957-70. doi: 10.1016/j.bbi.2010.10.009. Epub 2010 Oct 15.

PMID:
20951794
30.

Inflammatory cytokine release of astrocytes in vitro is reduced by all-trans retinoic acid.

van Neerven S, Nemes A, Imholz P, Regen T, Denecke B, Johann S, Beyer C, Hanisch UK, Mey J.

J Neuroimmunol. 2010 Dec 15;229(1-2):169-79. doi: 10.1016/j.jneuroim.2010.08.005. Epub 2010 Sep 9.

PMID:
20826012
31.

The viral TLR3 agonist poly(I:C) stimulates phagocytosis and intracellular killing of Escherichia coli by microglial cells.

Ribes S, Adam N, Ebert S, Regen T, Bunkowski S, Hanisch UK, Nau R.

Neurosci Lett. 2010 Sep 20;482(1):17-20. doi: 10.1016/j.neulet.2010.06.078. Epub 2010 Jul 3.

PMID:
20599470
32.

Inflammatory chemokine release of astrocytes in vitro is reduced by all-trans retinoic acid.

van Neerven S, Regen T, Wolf D, Nemes A, Johann S, Beyer C, Hanisch UK, Mey J.

J Neurochem. 2010 Sep 1;114(5):1511-26. doi: 10.1111/j.1471-4159.2010.06867.x. Epub 2010 Jun 16.

33.

Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way.

Pukrop T, Dehghani F, Chuang HN, Lohaus R, Bayanga K, Heermann S, Regen T, Van Rossum D, Klemm F, Schulz M, Siam L, Hoffmann A, Trümper L, Stadelmann C, Bechmann I, Hanisch UK, Binder C.

Glia. 2010 Sep;58(12):1477-89. doi: 10.1002/glia.21022.

PMID:
20549749
34.

T cell-dependence of Lassa fever pathogenesis.

Flatz L, Rieger T, Merkler D, Bergthaler A, Regen T, Schedensack M, Bestmann L, Verschoor A, Kreutzfeldt M, Brück W, Hanisch UK, Günther S, Pinschewer DD.

PLoS Pathog. 2010 Mar 26;6(3):e1000836. doi: 10.1371/journal.ppat.1000836.

35.

Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine.

Heneka MT, Nadrigny F, Regen T, Martinez-Hernandez A, Dumitrescu-Ozimek L, Terwel D, Jardanhazi-Kurutz D, Walter J, Kirchhoff F, Hanisch UK, Kummer MP.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):6058-63. doi: 10.1073/pnas.0909586107. Epub 2010 Mar 15.

36.

Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia.

Ribes S, Ebert S, Regen T, Agarwal A, Tauber SC, Czesnik D, Spreer A, Bunkowski S, Eiffert H, Hanisch UK, Hammerschmidt S, Nau R.

Infect Immun. 2010 Feb;78(2):865-71. doi: 10.1128/IAI.01110-09. Epub 2009 Nov 23.

37.

Fibronectin stimulates Escherichia coli phagocytosis by microglial cells.

Ribes S, Ebert S, Regen T, Czesnik D, Scheffel J, Zeug A, Bunkowski S, Eiffert H, Hanisch UK, Hammerschmidt S, Nau R.

Glia. 2010 Feb;58(3):367-76. doi: 10.1002/glia.20929.

PMID:
19780198
38.

Toll-like receptor prestimulation increases phagocytosis of Escherichia coli DH5alpha and Escherichia coli K1 strains by murine microglial cells.

Ribes S, Ebert S, Czesnik D, Regen T, Zeug A, Bukowski S, Mildner A, Eiffert H, Hanisch UK, Hammerschmidt S, Nau R.

Infect Immun. 2009 Jan;77(1):557-64. doi: 10.1128/IAI.00903-08. Epub 2008 Nov 3.

39.

Manipulation of host hepatocytes by the malaria parasite for delivery into liver sinusoids.

Sturm A, Amino R, van de Sand C, Regen T, Retzlaff S, Rennenberg A, Krueger A, Pollok JM, Menard R, Heussler VT.

Science. 2006 Sep 1;313(5791):1287-90. Epub 2006 Aug 3.

40.

A new clinically relevant approach to expand myelin specific T cells.

Arbour N, Lapointe R, Saikali P, McCrea E, Regen T, Antel JP.

J Immunol Methods. 2006 Mar 20;310(1-2):53-61. Epub 2006 Jan 19.

PMID:
16464465

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