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Items: 31

1.

Antifibrotic effects of hypocalcemic vitamin D analogs in murine and human hepatic stellate cells and in the CCl4 mouse model.

Reiter FP, Ye L, Bösch F, Wimmer R, Artmann R, Ziesch A, Kanitz V, Mayr D, Steib CJ, Trauner M, Regel I, Gerbes AL, Mayerle J, Hohenester S, de Toni EN, Denk G.

Lab Invest. 2019 Aug 29. doi: 10.1038/s41374-019-0310-1. [Epub ahead of print]

PMID:
31467426
2.

Ring1b-dependent epigenetic remodelling is an essential prerequisite for pancreatic carcinogenesis.

Benitz S, Straub T, Mahajan UM, Mutter J, Czemmel S, Unruh T, Wingerath B, Deubler S, Fahr L, Cheng T, Nahnsen S, Bruns P, Kong B, Raulefs S, Ceyhan GO, Mayerle J, Steiger K, Esposito I, Kleeff J, Michalski CW, Regel I.

Gut. 2019 Apr 6. pii: gutjnl-2018-317208. doi: 10.1136/gutjnl-2018-317208. [Epub ahead of print]

PMID:
30954952
3.

Loss of TLR3 and its downstream signaling accelerates acinar cell damage in the acute phase of pancreatitis.

Regel I, Raulefs S, Benitz S, Mihaljevic C, Rieder S, Leinenkugel G, Steiger K, Schlitter AM, Esposito I, Mayerle J, Kong B, Kleeff J, Michalski CW.

Pancreatology. 2019 Jan;19(1):149-157. doi: 10.1016/j.pan.2018.12.005. Epub 2018 Dec 15.

PMID:
30583980
4.

Immune Cell and Stromal Signature Associated With Progression-Free Survival of Patients With Resected Pancreatic Ductal Adenocarcinoma.

Mahajan UM, Langhoff E, Goni E, Costello E, Greenhalf W, Halloran C, Ormanns S, Kruger S, Boeck S, Ribback S, Beyer G, Dombroswki F, Weiss FU, Neoptolemos JP, Werner J, D'Haese JG, Bazhin A, Peterhansl J, Pichlmeier S, Büchler MW, Kleeff J, Ganeh P, Sendler M, Palmer DH, Kohlmann T, Rad R, Regel I, Lerch MM, Mayerle J.

Gastroenterology. 2018 Nov;155(5):1625-1639.e2. doi: 10.1053/j.gastro.2018.08.009. Epub 2018 Aug 6.

PMID:
30092175
5.

Molecular, morphological and survival analysis of 177 resected pancreatic ductal adenocarcinomas (PDACs): Identification of prognostic subtypes.

Schlitter AM, Segler A, Steiger K, Michalski CW, Jäger C, Konukiewitz B, Pfarr N, Endris V, Bettstetter M, Kong B, Regel I, Kleeff J, Klöppel G, Esposito I.

Sci Rep. 2017 Feb 1;7:41064. doi: 10.1038/srep41064.

6.

In vivo functional dissection of a context-dependent role for Hif1α in pancreatic tumorigenesis.

Cheng T, Jian Z, Li K, Raulefs S, Regel I, Shen S, Zou X, Ruland J, Ceyhan GO, Friess H, Michalski CW, Kleeff J, Kong B.

Oncogenesis. 2016 Dec 12;5(12):e278. doi: 10.1038/oncsis.2016.78.

7.

Periostin and tumor-stroma interactions in non-small cell lung cancer.

Nitsche U, Stangel D, Pan Z, Schlitter AM, Esposito I, Regel I, Raulefs S, Friess H, Kleeff J, Erkan M.

Oncol Lett. 2016 Nov;12(5):3804-3810. Epub 2016 Sep 14.

8.

Dynamic landscape of pancreatic carcinogenesis reveals early molecular networks of malignancy.

Kong B, Bruns P, Behler NA, Chang L, Schlitter AM, Cao J, Gewies A, Ruland J, Fritzsche S, Valkovskaya N, Jian Z, Regel I, Raulefs S, Irmler M, Beckers J, Friess H, Erkan M, Mueller NS, Roth S, Hackert T, Esposito I, Theis FJ, Kleeff J, Michalski CW.

Gut. 2018 Jan;67(1):146-156. doi: 10.1136/gutjnl-2015-310913. Epub 2016 Sep 19.

PMID:
27646934
9.

Polycomb repressor complex 1 promotes gene silencing through H2AK119 mono-ubiquitination in acinar-to-ductal metaplasia and pancreatic cancer cells.

Benitz S, Regel I, Reinhard T, Popp A, Schäffer I, Raulefs S, Kong B, Esposito I, Michalski CW, Kleeff J.

Oncotarget. 2016 Mar 8;7(10):11424-33. doi: 10.18632/oncotarget.6717.

10.

Intraductal tubulopapillary neoplasms of the bile ducts: clinicopathologic, immunohistochemical, and molecular analysis of 20 cases.

Schlitter AM, Jang KT, Klöppel G, Saka B, Hong SM, Choi H, Offerhaus GJ, Hruban RH, Zen Y, Konukiewitz B, Regel I, Allgäuer M, Balci S, Basturk O, Reid MD, Esposito I, Adsay V.

Mod Pathol. 2016 Jan;29(1):93. doi: 10.1038/modpathol.2015.106. No abstract available.

11.

Pancreas-specific activation of mTOR and loss of p53 induce tumors reminiscent of acinar cell carcinoma.

Kong B, Cheng T, Qian C, Wu W, Steiger K, Cao J, Schlitter AM, Regel I, Raulefs S, Friess H, Erkan M, Esposito I, Kleeff J, Michalski CW.

Mol Cancer. 2015 Dec 18;14:212. doi: 10.1186/s12943-015-0483-1.

12.

Pathobiology of pancreatic cancer: implications on therapy.

Regel I, Hausmann S, Benitz S, Esposito I, Kleeff J.

Expert Rev Anticancer Ther. 2016;16(2):219-27. doi: 10.1586/14737140.2016.1129276. Epub 2016 Jan 11. Review.

PMID:
26652651
13.

Loss of Periostin Results in Impaired Regeneration and Pancreatic Atrophy after Cerulein-Induced Pancreatitis.

Hausmann S, Regel I, Steiger K, Wagner N, Thorwirth M, Schlitter AM, Esposito I, Michalski CW, Friess H, Kleeff J, Erkan M.

Am J Pathol. 2016 Jan;186(1):24-31. doi: 10.1016/j.ajpath.2015.09.022. Epub 2015 Nov 27.

PMID:
26632158
14.

Loss of Ifnar1 in Pancreatic Acinar Cells Ameliorates the Disease Course of Acute Pancreatitis.

Miller KJ, Raulefs S, Kong B, Steiger K, Regel I, Gewies A, Kleeff J, Michalski CW.

PLoS One. 2015 Nov 30;10(11):e0143735. doi: 10.1371/journal.pone.0143735. eCollection 2015.

15.

Hypoxia-induced endoplasmic reticulum stress characterizes a necrotic phenotype of pancreatic cancer.

Kong B, Cheng T, Wu W, Regel I, Raulefs S, Friess H, Erkan M, Esposito I, Kleeff J, Michalski CW.

Oncotarget. 2015 Oct 13;6(31):32154-60. doi: 10.18632/oncotarget.5168.

16.

Erratum to: Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer.

Müller S, Raulefs S, Bruns P, Afonso-Grunz F, Plötner A, Thermann R, Jäger C, Schlitter AM, Kong B, Regel I, Roth WK, Rotter B, Hoffmeier K, Kahl G, Koch I, Theis FJ, Kleeff J, Winter P, Michalski CW.

Mol Cancer. 2015 Jul 31;14:144. doi: 10.1186/s12943-015-0401-6. No abstract available.

17.

Intraductal tubulopapillary neoplasms of the bile ducts: clinicopathologic, immunohistochemical, and molecular analysis of 20 cases.

Schlitter AM, Jang KT, Klöppel G, Saka B, Hong SM, Choi H, Offerhaus GJ, Hruban RH, Zen Y, Konukiewitz B, Regel I, Allgäuer M, Balci S, Basturk O, Reid MD, Esposito I, Adsay V.

Mod Pathol. 2015 Sep;28(9):1249-64. doi: 10.1038/modpathol.2015.61. Epub 2015 Jun 26. Erratum in: Mod Pathol. 2016 Jan;29(1):93.

18.

Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer.

Müller S, Raulefs S, Bruns P, Afonso-Grunz F, Plötner A, Thermann R, Jäger C, Schlitter AM, Kong B, Regel I, Roth WK, Rotter B, Hoffmeier K, Kahl G, Koch I, Theis FJ, Kleeff J, Winter P, Michalski CW.

Mol Cancer. 2015 Apr 25;14:94. doi: 10.1186/s12943-015-0358-5. Erratum in: Mol Cancer. 2015;14:144.

19.

RSPO2 Enhances Canonical Wnt Signaling to Confer Stemness-Associated Traits to Susceptible Pancreatic Cancer Cells.

Ilmer M, Boiles AR, Regel I, Yokoi K, Michalski CW, Wistuba II, Rodriguez J, Alt E, Vykoukal J.

Cancer Res. 2015 May 1;75(9):1883-96. doi: 10.1158/0008-5472.CAN-14-1327. Epub 2015 Mar 13.

20.

A subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras/Mek/Erk-induced hyperactive mTOR signalling.

Kong B, Wu W, Cheng T, Schlitter AM, Qian C, Bruns P, Jian Z, Jäger C, Regel I, Raulefs S, Behler N, Irmler M, Beckers J, Friess H, Erkan M, Siveke JT, Tannapfel A, Hahn SA, Theis FJ, Esposito I, Kleeff J, Michalski CW.

Gut. 2016 Apr;65(4):647-57. doi: 10.1136/gutjnl-2014-307616. Epub 2015 Jan 19.

PMID:
25601637
21.

Complexity of molecular alterations impacts pancreatic cancer prognosis.

Regel I, Kong B, Bruns P, Michalski CW, Kleeff J.

World J Gastrointest Oncol. 2013 Jan 15;5(1):1-3. doi: 10.4251/wjgo.v5.i1.1.

22.

Pan-histone deacetylase inhibitor panobinostat sensitizes gastric cancer cells to anthracyclines via induction of CITED2.

Regel I, Merkl L, Friedrich T, Burgermeister E, Zimmermann W, Einwächter H, Herrmann K, Langer R, Röcken C, Hofheinz R, Schmid R, Ebert MP.

Gastroenterology. 2012 Jul;143(1):99-109.e10. doi: 10.1053/j.gastro.2012.03.035. Epub 2012 Mar 27.

PMID:
22465428
23.

Energy metabolism and proliferation in pancreatic carcinogenesis.

Regel I, Kong B, Raulefs S, Erkan M, Michalski CW, Hartel M, Kleeff J.

Langenbecks Arch Surg. 2012 Apr;397(4):507-12. doi: 10.1007/s00423-012-0933-9. Epub 2012 Mar 20. Review.

PMID:
22430298
24.

IGFBP3 impedes aggressive growth of pediatric liver cancer and is epigenetically silenced in vascular invasive and metastatic tumors.

Regel I, Eichenmüller M, Joppien S, Liebl J, Häberle B, Müller-Höcker J, Vollmar A, von Schweinitz D, Kappler R.

Mol Cancer. 2012 Mar 8;11:9. doi: 10.1186/1476-4598-11-9.

25.

WNT6 is a novel target gene of caveolin-1 promoting chemoresistance to epirubicin in human gastric cancer cells.

Yuan G, Regel I, Lian F, Friedrich T, Hitkova I, Hofheinz RD, Ströbel P, Langer R, Keller G, Röcken C, Zimmermann W, Schmid RM, Ebert MP, Burgermeister E.

Oncogene. 2013 Jan 17;32(3):375-87. doi: 10.1038/onc.2012.40. Epub 2012 Feb 27.

PMID:
22370641
26.

Transcription factor NF-κB regulates expression of pore-forming Ca2+ channel unit, Orai1, and its activator, STIM1, to control Ca2+ entry and affect cellular functions.

Eylenstein A, Schmidt S, Gu S, Yang W, Schmid E, Schmidt EM, Alesutan I, Szteyn K, Regel I, Shumilina E, Lang F.

J Biol Chem. 2012 Jan 20;287(4):2719-30. doi: 10.1074/jbc.M111.275925. Epub 2011 Nov 21.

27.

Hydration-sensitive gene expression in brain.

Tang C, Zelenak C, Völkl J, Eichenmüller M, Regel I, Fröhlich H, Kempe D, Jimenez L, Le Bellego L, Vergne S, Lang F.

Cell Physiol Biochem. 2011;27(6):757-68. doi: 10.1159/000330084. Epub 2011 Jun 17.

28.

The Ras inhibitors caveolin-1 and docking protein 1 activate peroxisome proliferator-activated receptor γ through spatial relocalization at helix 7 of its ligand-binding domain.

Burgermeister E, Friedrich T, Hitkova I, Regel I, Einwächter H, Zimmermann W, Röcken C, Perren A, Wright MB, Schmid RM, Seger R, Ebert MP.

Mol Cell Biol. 2011 Aug;31(16):3497-510. doi: 10.1128/MCB.01421-10. Epub 2011 Jun 20.

29.

Stimulation of Ca2+-channel Orai1/STIM1 by serum- and glucocorticoid-inducible kinase 1 (SGK1).

Eylenstein A, Gehring EM, Heise N, Shumilina E, Schmidt S, Szteyn K, Münzer P, Nurbaeva MK, Eichenmüller M, Tyan L, Regel I, Föller M, Kuhl D, Soboloff J, Penner R, Lang F.

FASEB J. 2011 Jun;25(6):2012-21. doi: 10.1096/fj.10-178210. Epub 2011 Mar 8.

30.

[Questionnaire on professional satisfaction with psychiatric emergency services: the professionals' opinion].

Robin M, Waddington A, Pochard F, Regel I, Mauriac F, Devynck C, Kannas S.

Encephale. 1999 May-Jun;25(3):195-200. French.

PMID:
10434144
31.

[Security and home emergency psychiatric interventions].

Pochard F, Robin M, Regel I, Mauriac F, Waddington A, Kannas S.

Encephale. 1998 Jul-Aug;24(4):324-9. French.

PMID:
9809237

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