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Micro(RNA) Management and Mismanagement of the Islet.

Eliasson L, Regazzi R.

J Mol Biol. 2019 Oct 16. pii: S0022-2836(19)30572-8. doi: 10.1016/j.jmb.2019.09.017. [Epub ahead of print] Review.


Circulating miRNA-150-5p is associated with immune-mediated early β-cell loss in a humanized mouse model.

Roat R, Hossain MM, Christopherson J, Free C, Guay C, Regazzi R, Guo Z.

Xenotransplantation. 2019 Mar;26(2):e12474. doi: 10.1111/xen.12474. Epub 2018 Nov 21.


Lymphocyte-Derived Exosomal MicroRNAs Promote Pancreatic β Cell Death and May Contribute to Type 1 Diabetes Development.

Guay C, Kruit JK, Rome S, Menoud V, Mulder NL, Jurdzinski A, Mancarella F, Sebastiani G, Donda A, Gonzalez BJ, Jandus C, Bouzakri K, Pinget M, Boitard C, Romero P, Dotta F, Regazzi R.

Cell Metab. 2019 Feb 5;29(2):348-361.e6. doi: 10.1016/j.cmet.2018.09.011. Epub 2018 Oct 11.


MicroRNAs and histone deacetylase inhibition-mediated protection against inflammatory β-cell damage.

Lindeløv Vestergaard A, Heiner Bang-Berthelsen C, Fløyel T, Lucien Stahl J, Christen L, Taheri Sotudeh F, de Hemmer Horskjær P, Stensgaard Frederiksen K, Greek Kofod F, Bruun C, Adrian Berchtold L, Størling J, Regazzi R, Kaur S, Pociot F, Mandrup-Poulsen T.

PLoS One. 2018 Sep 27;13(9):e0203713. doi: 10.1371/journal.pone.0203713. eCollection 2018.


Contribution of the Long Noncoding RNA H19 to β-Cell Mass Expansion in Neonatal and Adult Rodents.

Sanchez-Parra C, Jacovetti C, Dumortier O, Lee K, Peyot ML, Guay C, Prentki M, Laybutt DR, Van Obberghen E, Regazzi R.

Diabetes. 2018 Nov;67(11):2254-2267. doi: 10.2337/db18-0201. Epub 2018 Aug 16.


Na+/Ca2+ Exchanger a Druggable Target to Promote β-Cell Proliferation and Function.

Papin J, Zummo FP, Pachera N, Guay C, Regazzi R, Cardozo AK, Herchuelz A.

J Endocr Soc. 2018 May 25;2(7):631-645. doi: 10.1210/js.2017-00370. eCollection 2018 Jul 1.


Identification of Differential Transcriptional Patterns in Primary and Secondary Hyperparathyroidism.

Sadowski SM, Pusztaszeri M, Brulhart-Meynet MC, Petrenko V, De Vito C, Sobel J, Delucinge-Vivier C, Kebebew E, Regazzi R, Philippe J, Triponez F, Dibner C.

J Clin Endocrinol Metab. 2018 Jun 1;103(6):2189-2198. doi: 10.1210/jc.2017-02506.


Circular RNAs as novel regulators of β-cell functions in normal and disease conditions.

Stoll L, Sobel J, Rodriguez-Trejo A, Guay C, Lee K, Venø MT, Kjems J, Laybutt DR, Regazzi R.

Mol Metab. 2018 Mar;9:69-83. doi: 10.1016/j.molmet.2018.01.010. Epub 2018 Jan 31.


MicroRNAs as therapeutic targets for the treatment of diabetes mellitus and its complications.

Regazzi R.

Expert Opin Ther Targets. 2018 Feb;22(2):153-160. doi: 10.1080/14728222.2018.1420168. Epub 2017 Dec 22. Review.


Identification of islet-enriched long non-coding RNAs contributing to β-cell failure in type 2 diabetes.

Motterle A, Gattesco S, Peyot ML, Esguerra JLS, Gomez-Ruiz A, Laybutt DR, Gilon P, Burdet F, Ibberson M, Eliasson L, Prentki M, Regazzi R.

Mol Metab. 2017 Nov;6(11):1407-1418. doi: 10.1016/j.molmet.2017.08.005. Epub 2017 Aug 18.


Exosomes as new players in metabolic organ cross-talk.

Guay C, Regazzi R.

Diabetes Obes Metab. 2017 Sep;19 Suppl 1:137-146. doi: 10.1111/dom.13027. Review.


PIWI-interacting RNAs as novel regulators of pancreatic beta cell function.

Henaoui IS, Jacovetti C, Guerra Mollet I, Guay C, Sobel J, Eliasson L, Regazzi R.

Diabetologia. 2017 Oct;60(10):1977-1986. doi: 10.1007/s00125-017-4368-2. Epub 2017 Jul 16.


MicroRNAs modulate core-clock gene expression in pancreatic islets during early postnatal life in rats.

Jacovetti C, Rodriguez-Trejo A, Guay C, Sobel J, Gattesco S, Petrenko V, Saini C, Dibner C, Regazzi R.

Diabetologia. 2017 Oct;60(10):2011-2020. doi: 10.1007/s00125-017-4348-6. Epub 2017 Jul 4.


Fatty acid metabolism regulates cell survival in specific niches.

Regazzi R, Widmann C.

Curr Opin Lipidol. 2017 Jun;28(3):284-285. doi: 10.1097/MOL.0000000000000418. Review. No abstract available.


MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells.

Grieco FA, Sebastiani G, Juan-Mateu J, Villate O, Marroqui L, Ladrière L, Tugay K, Regazzi R, Bugliani M, Marchetti P, Dotta F, Eizirik DL.

Diabetes. 2017 Jan;66(1):100-112. doi: 10.2337/db16-0592. Epub 2016 Oct 13.


Identification and Characterization of microRNAs Associated With Human β-Cell Loss in a Mouse Model.

Roat R, Hossain MM, Christopherson J, Free C, Jain S, Guay C, Regazzi R, Guo Z.

Am J Transplant. 2017 Apr;17(4):992-1007. doi: 10.1111/ajt.14073. Epub 2016 Nov 7.


Role of long non-coding RNAs in the determination of β-cell identity.

Motterle A, Sanchez-Parra C, Regazzi R.

Diabetes Obes Metab. 2016 Sep;18 Suppl 1:41-50. doi: 10.1111/dom.12714. Review.


New emerging tasks for microRNAs in the control of β-cell activities.

Guay C, Regazzi R.

Biochim Biophys Acta. 2016 Dec;1861(12 Pt B):2121-2129. doi: 10.1016/j.bbalip.2016.05.003. Epub 2016 May 10. Review.


Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice.

Jalabert A, Vial G, Guay C, Wiklander OP, Nordin JZ, Aswad H, Forterre A, Meugnier E, Pesenti S, Regazzi R, Danty-Berger E, Ducreux S, Vidal H, El-Andaloussi S, Rieusset J, Rome S.

Diabetologia. 2016 May;59(5):1049-58. doi: 10.1007/s00125-016-3882-y. Epub 2016 Feb 6.


Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets.

Tugay K, Guay C, Marques AC, Allagnat F, Locke JM, Harries LW, Rutter GA, Regazzi R.

Diabetologia. 2016 Jan;59(1):161-169. doi: 10.1007/s00125-015-3783-5.


Insulin secretion in health and disease: nutrients dictate the pace.

Regazzi R, Rodriguez-Trejo A, Jacovetti C.

Proc Nutr Soc. 2016 Feb;75(1):19-29. Epub 2015 Oct 16.


Autocrine Action of IGF2 Regulates Adult β-Cell Mass and Function.

Modi H, Jacovetti C, Tarussio D, Metref S, Madsen OD, Zhang FP, Rantakari P, Poutanen M, Nef S, Gorman T, Regazzi R, Thorens B.

Diabetes. 2015 Dec;64(12):4148-57. doi: 10.2337/db14-1735. Epub 2015 Sep 17.


Postnatal β-cell maturation is associated with islet-specific microRNA changes induced by nutrient shifts at weaning.

Jacovetti C, Matkovich SJ, Rodriguez-Trejo A, Guay C, Regazzi R.

Nat Commun. 2015 Sep 2;6:8084. doi: 10.1038/ncomms9084.


Involvement of long non-coding RNAs in beta cell failure at the onset of type 1 diabetes in NOD mice.

Motterle A, Gattesco S, Caille D, Meda P, Regazzi R.

Diabetologia. 2015 Aug;58(8):1827-35. doi: 10.1007/s00125-015-3641-5. Epub 2015 Jun 3.


Therapeutic potential of miRNAs in diabetes mellitus.

Henaoui I, Stoll L, Tugay K, Regazzi R.

Expert Rev Endocrinol Metab. 2015 May;10(3):285-296. doi: 10.1586/17446651.2015.996131. Epub 2014 Dec 25.


MicroRNAs and the functional β cell mass: For better or worse.

Guay C, Regazzi R.

Diabetes Metab. 2015 Nov;41(5):369-77. doi: 10.1016/j.diabet.2015.03.006. Epub 2015 Apr 22. Review.


Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells.

Guay C, Menoud V, Rome S, Regazzi R.

Cell Commun Signal. 2015 Mar 19;13:17. doi: 10.1186/s12964-015-0097-7.


Contribution of Intronic miR-338-3p and Its Hosting Gene AATK to Compensatory β-Cell Mass Expansion.

Jacovetti C, Jimenez V, Ayuso E, Laybutt R, Peyot ML, Prentki M, Bosch F, Regazzi R.

Mol Endocrinol. 2015 May;29(5):693-702. doi: 10.1210/me.2014-1299. Epub 2015 Mar 9.


Role of islet microRNAs in diabetes: which model for which question?

Guay C, Regazzi R.

Diabetologia. 2015 Mar;58(3):456-63. doi: 10.1007/s00125-014-3471-x. Epub 2014 Dec 16. Review.


Out of darkness: long non-coding RNAs come of age.

Huang Y, Regazzi R, Cho WC.

Front Genet. 2014 Nov 7;5:388. doi: 10.3389/fgene.2014.00388. eCollection 2014. No abstract available.


Compensatory mechanisms of pancreatic beta cells: insights into the therapeutic perspectives for diabetes.

Regazzi R, Dalle S, Abderrahmani A.

J Diabetes Res. 2014;2014:217387. doi: 10.1155/2014/217387. Epub 2014 Jul 17. No abstract available.


Role of microRNAs in islet beta-cell compensation and failure during diabetes.

Plaisance V, Waeber G, Regazzi R, Abderrahmani A.

J Diabetes Res. 2014;2014:618652. doi: 10.1155/2014/618652. Epub 2014 Mar 5. Review.


Analysis of synaptic-like microvesicle exocytosis of B-cells using a live imaging technique.

Bergeron A, Pucci L, Bezzi P, Regazzi R.

PLoS One. 2014 Feb 4;9(2):e87758. doi: 10.1371/journal.pone.0087758. eCollection 2014.


Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes.

Nesca V, Guay C, Jacovetti C, Menoud V, Peyot ML, Laybutt DR, Prentki M, Regazzi R.

Diabetologia. 2013 Oct;56(10):2203-12. doi: 10.1007/s00125-013-2993-y. Epub 2013 Jul 11.


The GTPase Rab37 Participates in the Control of Insulin Exocytosis.

Ljubicic S, Bezzi P, Brajkovic S, Nesca V, Guay C, Ohbayashi N, Fukuda M, Abderrhamani A, Regazzi R.

PLoS One. 2013 Jun 27;8(6):e68255. doi: 10.1371/journal.pone.0068255. Print 2013.


Circulating microRNAs as novel biomarkers for diabetes mellitus.

Guay C, Regazzi R.

Nat Rev Endocrinol. 2013 Sep;9(9):513-21. doi: 10.1038/nrendo.2013.86. Epub 2013 Apr 30. Review.


Rab3D is critical for secretory granule maturation in PC12 cells.

Kögel T, Rudolf R, Hodneland E, Copier J, Regazzi R, Tooze SA, Gerdes HH.

PLoS One. 2013;8(3):e57321. doi: 10.1371/journal.pone.0057321. Epub 2013 Mar 19.


Compensatory β-cell mass expansion: a big role for a tiny actor.

Jacovetti C, Regazzi R.

Cell Cycle. 2013 Jan 15;12(2):197-8. doi: 10.4161/cc.23378. Epub 2012 Jan 15. No abstract available.


MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity.

Jacovetti C, Abderrahmani A, Parnaud G, Jonas JC, Peyot ML, Cornu M, Laybutt R, Meugnier E, Rome S, Thorens B, Prentki M, Bosco D, Regazzi R.

J Clin Invest. 2012 Oct;122(10):3541-51. doi: 10.1172/JCI64151. Epub 2012 Sep 10.


MyRIP interaction with MyoVa on secretory granules is controlled by the cAMP-PKA pathway.

Brozzi F, Lajus S, Diraison F, Rajatileka S, Hayward K, Regazzi R, Molnár E, Váradi A.

Mol Biol Cell. 2012 Nov;23(22):4444-55. doi: 10.1091/mbc.E12-05-0369. Epub 2012 Sep 19.


Emerging roles of non-coding RNAs in pancreatic β-cell function and dysfunction.

Guay C, Jacovetti C, Nesca V, Motterle A, Tugay K, Regazzi R.

Diabetes Obes Metab. 2012 Oct;14 Suppl 3:12-21. doi: 10.1111/j.1463-1326.2012.01654.x. Review.


Changes in microRNA expression contribute to pancreatic β-cell dysfunction in prediabetic NOD mice.

Roggli E, Gattesco S, Caille D, Briet C, Boitard C, Meda P, Regazzi R.

Diabetes. 2012 Jul;61(7):1742-51. doi: 10.2337/db11-1086. Epub 2012 Apr 26.


Genetics and molecular biology: miRNAs take the HDL ride.

Regazzi R, Widmann C.

Curr Opin Lipidol. 2012 Apr;23(2):165-6. doi: 10.1097/MOL.0b013e32835135aa. No abstract available.


Involvement of the RNA-binding protein ARE/poly(U)-binding factor 1 (AUF1) in the cytotoxic effects of proinflammatory cytokines on pancreatic beta cells.

Roggli E, Gattesco S, Pautz A, Regazzi R.

Diabetologia. 2012 Jun;55(6):1699-708. doi: 10.1007/s00125-011-2399-7. Epub 2011 Dec 13.


Impaired expression of the inducible cAMP early repressor accounts for sustained adipose CREB activity in obesity.

Favre D, Le Gouill E, Fahmi D, Verdumo C, Chinetti-Gbaguidi G, Staels B, Caiazzo R, Pattou F, Lê KA, Tappy L, Regazzi R, Giusti V, Vollenweider P, Waeber G, Abderrahmani A.

Diabetes. 2011 Dec;60(12):3169-74. doi: 10.2337/db10-1743. Epub 2011 Oct 12.


Molecular mechanism of myosin Va recruitment to dense core secretory granules.

Brozzi F, Diraison F, Lajus S, Rajatileka S, Philips T, Regazzi R, Fukuda M, Verkade P, Molnár E, Váradi A.

Traffic. 2012 Jan;13(1):54-69. doi: 10.1111/j.1600-0854.2011.01301.x. Epub 2011 Nov 14.


A role for glutamate transporters in the regulation of insulin secretion.

Gammelsaeter R, Coppola T, Marcaggi P, Storm-Mathisen J, Chaudhry FA, Attwell D, Regazzi R, Gundersen V.

PLoS One. 2011;6(8):e22960. doi: 10.1371/journal.pone.0022960. Epub 2011 Aug 11.


Role for inducible cAMP early repressor in promoting pancreatic beta cell dysfunction evoked by oxidative stress in human and rat islets.

Favre D, Niederhauser G, Fahmi D, Plaisance V, Brajkovic S, Beeler N, Allagnat F, Haefliger JA, Regazzi R, Waeber G, Abderrahmani A.

Diabetologia. 2011 Sep;54(9):2337-46. doi: 10.1007/s00125-011-2165-x. Epub 2011 May 6.


Diabetes mellitus, a microRNA-related disease?

Guay C, Roggli E, Nesca V, Jacovetti C, Regazzi R.

Transl Res. 2011 Apr;157(4):253-64. doi: 10.1016/j.trsl.2011.01.009. Epub 2011 Feb 4. Review.


Diabetes mellitus reveals its micro-signature.

Regazzi R.

Circ Res. 2010 Sep 17;107(6):686-8. doi: 10.1161/CIRCRESAHA.110.228841. No abstract available.


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