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Items: 1 to 50 of 53

1.

The Emergence of Universal Chromatographic Methods in the Research and Development of New Drug Substances.

Regalado EL, Haidar Ahmad IA, Bennett R, D'Atri V, Makarov AA, Humphrey GR, Mangion I, Guillarme D.

Acc Chem Res. 2019 Jul 16;52(7):1990-2002. doi: 10.1021/acs.accounts.9b00068. Epub 2019 Jun 14.

PMID:
31198042
2.

Revealing the inner workings of the power function algorithm in Charged Aerosol Detection: A simple and effective approach to optimizing power function value for quantitative analysis.

Haidar Ahmad IA, Blasko A, Tam J, Variankaval N, Halsey HM, Hartman R, Regalado EL.

J Chromatogr A. 2019 Apr 27. pii: S0021-9673(19)30385-1. doi: 10.1016/j.chroma.2019.04.017. [Epub ahead of print]

PMID:
31196588
3.

Multi-column ultra-high performance liquid chromatography screening with chaotropic agents and computer-assisted separation modeling enables process development of new drug substances.

Haidar Ahmad IA, Chen W, Halsey HM, Klapars A, Limanto J, Pirrone GF, Nowak T, Bennett R, Hartman R, Makarov AA, Mangion I, Regalado EL.

Analyst. 2019 Apr 23;144(9):2872-2880. doi: 10.1039/c8an02499e.

PMID:
30830135
4.

Enhanced fluidity liquid chromatography: A guide to scaling up from analytical to preparative separations.

Bennett R, Biba M, Liu J, Haidar Ahmad IA, Hicks MB, Regalado EL.

J Chromatogr A. 2019 Jun 21;1595:190-198. doi: 10.1016/j.chroma.2019.02.017. Epub 2019 Feb 7.

PMID:
30803788
5.

Evaluation of global conformational changes in peptides and proteins following purification by supercritical fluid chromatography.

Schiavone NM, Bennett R, Hicks MB, Pirrone GF, Regalado EL, Mangion I, Makarov AA.

J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Mar 15;1110-1111:94-100. doi: 10.1016/j.jchromb.2019.02.012. Epub 2019 Feb 13.

PMID:
30785083
6.

Generic anion-exchange chromatography method for analytical and preparative separation of nucleotides in the development and manufacture of drug substances.

Tsay FR, Haidar Ahmad IA, Henderson D, Schiavone N, Liu Z, Makarov AA, Mangion I, Regalado EL.

J Chromatogr A. 2019 Feb 22;1587:129-135. doi: 10.1016/j.chroma.2018.12.018. Epub 2018 Dec 11.

PMID:
30591245
7.

Generic gas chromatography flame ionization detection method using hydrogen as the carrier gas for the analysis of solvents in pharmaceuticals.

Bernardoni F, Halsey HM, Hartman R, Nowak T, Regalado EL.

J Pharm Biomed Anal. 2019 Feb 20;165:366-373. doi: 10.1016/j.jpba.2018.12.006. Epub 2018 Dec 7.

PMID:
30580085
8.

First inter-laboratory study of a Supercritical Fluid Chromatography method for the determination of pharmaceutical impurities.

Dispas A, Marini R, Desfontaine V, Veuthey JL, Kotoni D, Losacco LG, Clarke A, Muscat Galea C, Mangelings D, Jocher BM, Regalado EL, Plachká K, Nováková L, Wuyts B, François I, Gray M, Aubin AJ, Tarafder A, Cazes M, Desvignes C, Villemet L, Sarrut M, Raimbault A, Lemasson E, Lesellier E, West C, Leek T, Wong M, Dai L, Zhang K, Grand-Guillaume Perrenoud A, Brunelli C, Hennig P, Bertin S, Mauge F, Da Costa N, Farrell WP, Hill M, Desphande N, Grangrade M, Sadaphule S, Yadav R, Rane S, Shringare S, Iguiniz M, Heinisch S, Lefevre J, Corbel E, Roques N, Heyden YV, Guillarme D, Hubert P.

J Pharm Biomed Anal. 2018 Nov 30;161:414-424. doi: 10.1016/j.jpba.2018.08.042. Epub 2018 Aug 23.

PMID:
30216790
9.

Visualizing and studying frictional heating effects in reversed-phase liquid chromatography using infrared thermal imaging.

Makarov AA, Mann BF, Regalado EL, Pirrone GF, Sun C, Sun S, Nowak T, Wang H, Mangion I.

Anal Chim Acta. 2018 Aug 14;1018:1-6. doi: 10.1016/j.aca.2018.02.061. Epub 2018 Mar 9.

PMID:
29605126
10.

Supercritical fluid chromatography-photodiode array detection-electrospray ionization mass spectrometry as a framework for impurity fate mapping in the development and manufacture of drug substances.

Pirrone GF, Mathew RM, Makarov AA, Bernardoni F, Klapars A, Hartman R, Limanto J, Regalado EL.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Mar 30;1080:42-49. doi: 10.1016/j.jchromb.2018.02.006. Epub 2018 Feb 8.

PMID:
29477066
11.

Macrocyclic glycopeptide chiral selectors bonded to core-shell particles enables enantiopurity analysis of the entire verubecestat synthetic route.

Barhate CL, Lopez DA, Makarov AA, Bu X, Morris WJ, Lekhal A, Hartman R, Armstrong DW, Regalado EL.

J Chromatogr A. 2018 Mar 2;1539:87-92. doi: 10.1016/j.chroma.2018.01.042. Epub 2018 Jan 31.

PMID:
29397980
12.

Generic gas chromatography-flame ionization detection method for quantitation of volatile amines in pharmaceutical drugs and synthetic intermediates.

Graffius GC, Jocher BM, Zewge D, Halsey HM, Lee G, Bernardoni F, Bu X, Hartman R, Regalado EL.

J Chromatogr A. 2017 Oct 6;1518:70-77. doi: 10.1016/j.chroma.2017.08.048. Epub 2017 Aug 23.

PMID:
28882339
13.

Palladium-Catalyzed Enantioselective Arylation of Aryl Sulfenate Anions: A Combined Experimental and Computational Study.

Jia T, Zhang M, McCollom SP, Bellomo A, Montel S, Mao J, Dreher SD, Welch CJ, Regalado EL, Williamson RT, Manor BC, Tomson NC, Walsh PJ.

J Am Chem Soc. 2017 Jun 21;139(24):8337-8345. doi: 10.1021/jacs.7b03623. Epub 2017 Jun 7.

PMID:
28537724
14.

Overcoming "speed limits" in high throughput chromatographic analysis.

Zawatzky K, Barhate CL, Regalado EL, Mann BF, Marshall N, Moore JC, Welch CJ.

J Chromatogr A. 2017 May 26;1499:211-216. doi: 10.1016/j.chroma.2017.04.002. Epub 2017 Apr 4.

PMID:
28416217
15.

Ultrafast Chiral Chromatography as the Second Dimension in Two-Dimensional Liquid Chromatography Experiments.

Barhate CL, Regalado EL, Contrella ND, Lee J, Jo J, Makarov AA, Armstrong DW, Welch CJ.

Anal Chem. 2017 Mar 21;89(6):3545-3553. doi: 10.1021/acs.analchem.6b04834. Epub 2017 Jan 23.

PMID:
28192943
16.

Ultrafast chiral separations for high throughput enantiopurity analysis.

Barhate CL, Joyce LA, Makarov AA, Zawatzky K, Bernardoni F, Schafer WA, Armstrong DW, Welch CJ, Regalado EL.

Chem Commun (Camb). 2017 Jan 3;53(3):509-512. doi: 10.1039/c6cc08512a.

PMID:
27872920
17.

Hydroxypyridyl Imines: Enhancing Chromatographic Separation and Stereochemical Analysis of Chiral Amines via Circular Dichroism.

Joyce LA, Regalado EL, Welch CJ.

J Org Chem. 2016 Sep 16;81(18):8199-205. doi: 10.1021/acs.joc.6b01162. Epub 2016 Sep 1.

PMID:
27529785
18.

Are fluorine-rich pharmaceuticals lost by partition into fluorous phases?

Sun S, Zawatzky K, Regalado EL, Mangion IK, Welch CJ.

J Pharm Biomed Anal. 2016 Sep 5;128:106-110. doi: 10.1016/j.jpba.2016.05.025. Epub 2016 May 17.

PMID:
27239759
19.

MISER chiral supercritical fluid chromatography for high throughput analysis of enantiopurity.

Zawatzky K, Biba M, Regalado EL, Welch CJ.

J Chromatogr A. 2016 Jan 15;1429:374-9. doi: 10.1016/j.chroma.2015.12.057. Epub 2015 Dec 23.

PMID:
26747691
20.

Ultrafast separation of fluorinated and desfluorinated pharmaceuticals using highly efficient and selective chiral selectors bonded to superficially porous particles.

Barhate CL, Breitbach ZS, Pinto EC, Regalado EL, Welch CJ, Armstrong DW.

J Chromatogr A. 2015 Dec 24;1426:241-7. doi: 10.1016/j.chroma.2015.11.056. Epub 2015 Nov 28.

PMID:
26643720
21.

Development of a Direct Photocatalytic C-H Fluorination for the Preparative Synthesis of Odanacatib.

Halperin SD, Kwon D, Holmes M, Regalado EL, Campeau LC, DiRocco DA, Britton R.

Org Lett. 2015 Nov 6;17(21):5200-3. doi: 10.1021/acs.orglett.5b02532. Epub 2015 Oct 20.

PMID:
26484983
22.

Supercritical fluid chromatography for GMP analysis in support of pharmaceutical development and manufacturing activities.

Hicks MB, Regalado EL, Tan F, Gong X, Welch CJ.

J Pharm Biomed Anal. 2016 Jan 5;117:316-24. doi: 10.1016/j.jpba.2015.09.014. Epub 2015 Sep 15.

PMID:
26412720
23.

Pushing the speed limit in enantioselective supercritical fluid chromatography.

Regalado EL, Welch CJ.

J Sep Sci. 2015 Aug;38(16):2826-32. doi: 10.1002/jssc.201500270. Epub 2015 Jul 17.

PMID:
26075564
24.

Search for improved fluorinated stationary phases for separation of fluorine-containing pharmaceuticals from their desfluoro analogs.

Regalado EL, Makarov AA, McClain R, Przybyciel M, Welch CJ.

J Chromatogr A. 2015 Feb 6;1380:45-54. doi: 10.1016/j.chroma.2014.12.025. Epub 2014 Dec 17.

PMID:
25595532
25.

Organic chemistry. Nanomole-scale high-throughput chemistry for the synthesis of complex molecules.

Buitrago Santanilla A, Regalado EL, Pereira T, Shevlin M, Bateman K, Campeau LC, Schneeweis J, Berritt S, Shi ZC, Nantermet P, Liu Y, Helmy R, Welch CJ, Vachal P, Davies IW, Cernak T, Dreher SD.

Science. 2015 Jan 2;347(6217):49-53. doi: 10.1126/science.1259203. Epub 2014 Nov 20.

26.

Investigation of two-dimensional high performance liquid chromatography approaches for reversed phase resolution of warfarin and hydroxywarfarin isomers.

Regalado EL, Schariter JA, Welch CJ.

J Chromatogr A. 2014 Oct 10;1363:200-6. doi: 10.1016/j.chroma.2014.08.025. Epub 2014 Aug 14.

PMID:
25160950
27.

Effect of particle size on the speed and resolution of chiral separations using supercritical fluid chromatography.

Biba M, Regalado EL, Wu N, Welch CJ.

J Chromatogr A. 2014 Oct 10;1363:250-6. doi: 10.1016/j.chroma.2014.07.010. Epub 2014 Jul 12.

PMID:
25082525
28.

Estimating optimal time for fast chromatographic separations.

Welch CJ, Regalado EL.

J Sep Sci. 2014 Sep;37(18):2552-8. doi: 10.1002/jssc.201400508. Epub 2014 Aug 8.

PMID:
24995384
29.

Effect of pressure on the chromatographic separation of enantiomers under reversed-phase conditions.

Makarov AA, Regalado EL, Welch CJ, Schafer WA.

J Chromatogr A. 2014 Jul 25;1352:87-92. doi: 10.1016/j.chroma.2014.05.044. Epub 2014 May 28.

PMID:
24928149
30.

Chromatographic resolution of closely related species: drug metabolites and analogs.

Regalado EL, Helmy R, Green MD, Welch CJ.

J Sep Sci. 2014 May;37(9-10):1094-102. doi: 10.1002/jssc.201400038. Epub 2014 Apr 10.

PMID:
24596023
31.

Support of academic synthetic chemistry using separation technologies from the pharmaceutical industry.

Regalado EL, Kozlowski MC, Curto JM, Ritter T, Campbell MG, Mazzotti AR, Hamper BC, Spilling CD, Mannino MP, Wan L, Yu JQ, Liu J, Welch CJ.

Org Biomol Chem. 2014 Apr 14;12(14):2161-6. doi: 10.1039/c3ob42195c. Review.

PMID:
24589831
32.

Detection of dehalogenation impurities in organohalogenated pharmaceuticals by UHPLC-DAD-HRESIMS.

Regalado EL, Dermenjian RK, Joyce LA, Welch CJ.

J Pharm Biomed Anal. 2014 Apr;92:1-5. doi: 10.1016/j.jpba.2013.12.043. Epub 2014 Jan 7.

PMID:
24469094
33.

Chromatographic resolution of closely related species in pharmaceutical chemistry: dehalogenation impurities and mixtures of halogen isomers.

Regalado EL, Zhuang P, Chen Y, Makarov AA, Schafer WA, McGachy N, Welch CJ.

Anal Chem. 2014 Jan 7;86(1):805-13. doi: 10.1021/ac403376h. Epub 2013 Dec 20.

PMID:
24359254
34.

Chromatographic separation and assignment of absolute configuration of hydroxywarfarin isomers.

Regalado EL, Sherer EC, Green MD, Hendersonl DW, Thomas Williamson R, Joyce LA, Welch CJ.

Chirality. 2014 Feb;26(2):95-101. doi: 10.1002/chir.22274. Epub 2013 Dec 13.

PMID:
24339228
35.

In vitro antiplasmodial activity, cytotoxicity and chemical profiles of sponge species of Cuban coasts.

Mendiola J, Regalado EL, Díaz-García A, Thomas OP, Fernández-Calienes A, Rodríguez H, Laguna A, Valdés O.

Nat Prod Res. 2014;28(5):312-7. doi: 10.1080/14786419.2013.861835. Epub 2013 Dec 4.

PMID:
24304347
36.

Chromatographic resolution of closely related species: separation of warfarin and hydroxylated isomers.

Regalado EL, Schafer W, McClain R, Welch CJ.

J Chromatogr A. 2013 Nov 1;1314:266-75. doi: 10.1016/j.chroma.2013.07.092. Epub 2013 Jul 30.

PMID:
24055230
37.

Improved chiral SFC screening for analytical method development.

Schafer W, Chandrasekaran T, Pirzada Z, Zhang C, Gong X, Biba M, Regalado EL, Welch CJ.

Chirality. 2013 Nov;25(11):799-804. doi: 10.1002/chir.22218. Epub 2013 Aug 15.

PMID:
23946148
38.

Extending the range of supercritical fluid chromatography by use of water-rich modifiers.

Liu J, Regalado EL, Mergelsberg I, Welch CJ.

Org Biomol Chem. 2013 Aug 14;11(30):4925-9. doi: 10.1039/c3ob41121d. Epub 2013 Jun 24.

PMID:
23793077
39.

Phytochemical analysis and antioxidant capacity of BM-21, a bioactive extract rich in polyphenolic metabolites from the sea Grass Thalassia testudinum.

Regalado EL, Menendez R, Valdés O, Morales RA, Laguna A, Thomas OP, Hernandez Y, Nogueiras C, Kijjoa A.

Nat Prod Commun. 2012 Jan;7(1):47-50.

PMID:
22428242
40.

Furfuran lignans and a flavone from Artemisia gorgonum Webb and their in vitro activity against Plasmodium falciparum.

Ortet R, Prado S, Regalado EL, Valeriote FA, Media J, Mendiola J, Thomas OP.

J Ethnopharmacol. 2011 Nov 18;138(2):637-40. doi: 10.1016/j.jep.2011.09.039. Epub 2011 Sep 29.

PMID:
21982788
41.

Chemical composition and antioxidant activities of the essential oil from Tornabenea bischoffii (Apiaceae).

Ortet R, Regalado EL, Thomas OP, Pino JA, Fernández MD.

Nat Prod Commun. 2011 Aug;6(8):1179-82.

PMID:
21922930
42.

Isolation and identification of phenolic compounds from rum aged in oak barrels by high-speed countercurrent chromatography/high-performance liquid chromatography-diode array detection-electrospray ionization mass spectrometry and screening for antioxidant activity.

Regalado EL, Tolle S, Pino JA, Winterhalter P, Menendez R, Morales AR, Rodríguez JL.

J Chromatogr A. 2011 Oct 14;1218(41):7358-64. doi: 10.1016/j.chroma.2011.08.068. Epub 2011 Aug 25.

PMID:
21907994
43.

Cytotoxic and haemolytic steroidal glycosides from the Caribbean sponge Pandaros acanthifolium.

Regalado EL, Turk T, Tasdemir D, Gorjanc M, Kaiser M, Thomas OP, Fernández R, Amade P.

Steroids. 2011 Nov;76(12):1389-96. doi: 10.1016/j.steroids.2011.07.010. Epub 2011 Jul 26.

PMID:
21820457
44.

Photoprotecting action and phytochemical analysis of a multiple radical scavenger lipophilic fraction obtained from the leaf of the seagrass Thalassia testudinum.

Regalado EL, Rodríguez M, Menéndez R, Fernandez X, Hernández I, Morales RA, Fernández MD, Thomas OP, Pino JA, Concepción AR, Laguna A.

Photochem Photobiol. 2011 Sep-Oct;87(5):1058-66. doi: 10.1111/j.1751-1097.2011.00945.x. Epub 2011 Jul 7.

PMID:
21615743
45.

Antinociception produced by Thalassia testudinum extract BM-21 is mediated by the inhibition of acid sensing ionic channels by the phenolic compound thalassiolin B.

Garateix A, Salceda E, Menéndez R, Regalado EL, López O, García T, Morales RA, Laguna A, Thomas OP, Soto E.

Mol Pain. 2011 Jan 24;7:10. doi: 10.1186/1744-8069-7-10.

46.

Phytochemical analysis and in vitro free-radical-scavenging activities of the essential oils from leaf and fruit of Melaleuca leucadendra L.

Pino JA, Regalado EL, Rodríguez JL, Fernández MD.

Chem Biodivers. 2010 Sep;7(9):2281-8. doi: 10.1002/cbdv.200900162.

PMID:
20860029
47.

Polar alkaloids from the Caribbean marine sponge Niphates digitalis.

Regalado EL, Mendiola J, Laguna A, Nogueiras C, Thomas OP.

Nat Prod Commun. 2010 Aug;5(8):1187-90.

PMID:
20839615
48.

Antiprotozoal steroidal saponins from the marine sponge Pandaros acanthifolium.

Regalado EL, Tasdemir D, Kaiser M, Cachet N, Amade P, Thomas OP.

J Nat Prod. 2010 Aug 27;73(8):1404-10. doi: 10.1021/np100348x.

PMID:
20614907
49.

Composition and biological properties of the volatile oil of Artemisia gorgonum Webb.

Ortet R, Thomas OP, Regalado EL, Pino JA, Filippi JJ, Fernández MD.

Chem Biodivers. 2010 May;7(5):1325-32. doi: 10.1002/cbdv.200900111.

PMID:
20491086
50.

Composition and antioxidant properties of the essential oil of the endemic Cape Verdean Satureja forbesii.

Ortet R, Regalado EL, Thomas OP, Pino JA, Fernández MD, Filippi JJ.

Nat Prod Commun. 2009 Sep;4(9):1277-80.

PMID:
19831044

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