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Items: 46

1.

Neddylation regulates excitatory synaptic transmission and plasticity.

Brockmann MM, Döngi M, Einsfelder U, Körber N, Refojo D, Stein V.

Sci Rep. 2019 Nov 29;9(1):17935. doi: 10.1038/s41598-019-54182-2.

2.

Neuroimmune and Inflammatory Signals in Complex Disorders of the Central Nervous System.

Liberman AC, Trias E, da Silva Chagas L, Trindade P, Dos Santos Pereira M, Refojo D, Hedin-Pereira C, Serfaty CA.

Neuroimmunomodulation. 2018;25(5-6):246-270. doi: 10.1159/000494761. Epub 2018 Dec 5. Review.

3.

Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety.

Dedic N, Kühne C, Jakovcevski M, Hartmann J, Genewsky AJ, Gomes KS, Anderzhanova E, Pöhlmann ML, Chang S, Kolarz A, Vogl AM, Dine J, Metzger MW, Schmid B, Almada RC, Ressler KJ, Wotjak CT, Grinevich V, Chen A, Schmidt MV, Wurst W, Refojo D, Deussing JM.

Nat Neurosci. 2018 Jun;21(6):803-807. doi: 10.1038/s41593-018-0151-z. Epub 2018 May 21.

4.

Automated quantification of protein periodic nanostructures in fluorescence nanoscopy images: abundance and regularity of neuronal spectrin membrane-associated skeleton.

Barabas FM, Masullo LA, Bordenave MD, A Giusti S, Unsain N, Refojo D, Cáceres A, Stefani FD.

Sci Rep. 2017 Nov 22;7(1):16029. doi: 10.1038/s41598-017-16280-x.

5.

Heterozygosity for the Mood Disorder-Associated Variant Gln460Arg Alters P2X7 Receptor Function and Sleep Quality.

Metzger MW, Walser SM, Dedic N, Aprile-Garcia F, Jakubcakova V, Adamczyk M, Webb KJ, Uhr M, Refojo D, Schmidt MV, Friess E, Steiger A, Kimura M, Chen A, Holsboer F, Arzt E, Wurst W, Deussing JM.

J Neurosci. 2017 Nov 29;37(48):11688-11700. doi: 10.1523/JNEUROSCI.3487-16.2017. Epub 2017 Oct 27.

6.

Co-Expression of Wild-Type P2X7R with Gln460Arg Variant Alters Receptor Function.

Aprile-Garcia F, Metzger MW, Paez-Pereda M, Stadler H, Acuña M, Liberman AC, Senin SA, Gerez J, Hoijman E, Refojo D, Mitkovski M, Panhuysen M, Stühmer W, Holsboer F, Deussing JM, Arzt E.

PLoS One. 2016 Mar 17;11(3):e0151862. doi: 10.1371/journal.pone.0151862. eCollection 2016.

7.

Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed.

Rybak-Wolf A, Stottmeister C, Glažar P, Jens M, Pino N, Giusti S, Hanan M, Behm M, Bartok O, Ashwal-Fluss R, Herzog M, Schreyer L, Papavasileiou P, Ivanov A, Öhman M, Refojo D, Kadener S, Rajewsky N.

Mol Cell. 2015 Jun 4;58(5):870-85. doi: 10.1016/j.molcel.2015.03.027. Epub 2015 Apr 23.

8.

Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition.

Vogl AM, Brockmann MM, Giusti SA, Maccarrone G, Vercelli CA, Bauder CA, Richter JS, Roselli F, Hafner AS, Dedic N, Wotjak CT, Vogt-Weisenhorn DM, Choquet D, Turck CW, Stein V, Deussing JM, Refojo D.

Nat Neurosci. 2015 Feb;18(2):239-51. doi: 10.1038/nn.3912. Epub 2015 Jan 12.

PMID:
25581363
9.

MicroRNA-9 controls dendritic development by targeting REST.

Giusti SA, Vogl AM, Brockmann MM, Vercelli CA, Rein ML, Trümbach D, Wurst W, Cazalla D, Stein V, Deussing JM, Refojo D.

Elife. 2014 Nov 18;3. doi: 10.7554/eLife.02755.

10.

Behavioral phenotyping of Nestin-Cre mice: implications for genetic mouse models of psychiatric disorders.

Giusti SA, Vercelli CA, Vogl AM, Kolarz AW, Pino NS, Deussing JM, Refojo D.

J Psychiatr Res. 2014 Aug;55:87-95. doi: 10.1016/j.jpsychires.2014.04.002. Epub 2014 Apr 12.

PMID:
24768109
11.

MicroRNA-9 promotes the switch from early-born to late-born motor neuron populations by regulating Onecut transcription factor expression.

Luxenhofer G, Helmbrecht MS, Langhoff J, Giusti SA, Refojo D, Huber AB.

Dev Biol. 2014 Feb 15;386(2):358-70. doi: 10.1016/j.ydbio.2013.12.023. Epub 2013 Dec 24.

12.

B-Raf and CRHR1 internalization mediate biphasic ERK1/2 activation by CRH in hippocampal HT22 Cells.

Bonfiglio JJ, Inda C, Senin S, Maccarrone G, Refojo D, Giacomini D, Turck CW, Holsboer F, Arzt E, Silberstein S.

Mol Endocrinol. 2013 Mar;27(3):491-510. doi: 10.1210/me.2012-1359. Epub 2013 Jan 31.

13.

Underlying mechanisms of cAMP- and glucocorticoid-mediated inhibition of FasL expression in activation-induced cell death.

Liberman AC, Refojo D, Antunica-Noguerol M, Holsboer F, Arzt E.

Mol Immunol. 2012 Apr;50(4):220-35. doi: 10.1016/j.molimm.2012.01.008. Epub 2012 Feb 17.

PMID:
22341864
14.

Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1.

Refojo D, Schweizer M, Kuehne C, Ehrenberg S, Thoeringer C, Vogl AM, Dedic N, Schumacher M, von Wolff G, Avrabos C, Touma C, Engblom D, Schütz G, Nave KA, Eder M, Wotjak CT, Sillaber I, Holsboer F, Wurst W, Deussing JM.

Science. 2011 Sep 30;333(6051):1903-7. doi: 10.1126/science.1202107. Epub 2011 Sep 1.

15.

The corticotropin-releasing hormone network and the hypothalamic-pituitary-adrenal axis: molecular and cellular mechanisms involved.

Bonfiglio JJ, Inda C, Refojo D, Holsboer F, Arzt E, Silberstein S.

Neuroendocrinology. 2011;94(1):12-20. doi: 10.1159/000328226. Epub 2011 May 13. Review.

16.

CRH signaling. Molecular specificity for drug targeting in the CNS.

Refojo D, Holsboer F.

Ann N Y Acad Sci. 2009 Oct;1179:106-19. doi: 10.1111/j.1749-6632.2009.04983.x. Review.

PMID:
19906235
17.

Amygdaloid pERK1/2 in corticotropin-releasing hormone overexpressing mice under basal and acute stress conditions.

Silberstein S, Vogl AM, Refojo D, Senin SA, Wurst W, Holsboer F, Deussing JM, Arzt E.

Neuroscience. 2009 Mar 17;159(2):610-7. doi: 10.1016/j.neuroscience.2009.01.014.

PMID:
19361479
18.

Immunology, signal transduction, and behavior in hypothalamic-pituitary-adrenal axis-related genetic mouse models.

Silberstein S, Vogl AM, Bonfiglio JJ, Wurst W, Holsboer F, Arzt E, Deussing JM, Refojo D.

Ann N Y Acad Sci. 2009 Feb;1153:120-30. doi: 10.1111/j.1749-6632.2008.03967.x. Review.

PMID:
19236335
19.

[Molecular mechanisms of action of some immunosuppressive drugs].

Liberman AC, Druker J, Refojo D, Arzt E.

Medicina (B Aires). 2008;68(6):455-64. Spanish.

PMID:
19147430
20.

Glucocorticoids inhibit GATA-3 phosphorylation and activity in T cells.

Liberman AC, Druker J, Refojo D, Holsboer F, Arzt E.

FASEB J. 2009 May;23(5):1558-71. doi: 10.1096/fj.08-121236. Epub 2009 Jan 5.

PMID:
19124555
21.

Conditional CRH overexpressing mice: an animal model for stress-elicited pathologies and treatments that target the central CRH system.

Lu A, Steiner MA, Whittle N, Vogl AM, Walser SM, Ableitner M, Refojo D, Ekker M, Rubenstein JL, Stalla GK, Singewald N, Holsboer F, Wotjak CT, Wurst W, Deussing JM.

Mol Psychiatry. 2008 Nov;13(11):989. doi: 10.1038/mp.2008.107. No abstract available.

PMID:
18936754
22.

Interferon-gamma inhibits cellular proliferation and ACTH production in corticotroph tumor cells through a novel janus kinases-signal transducer and activator of transcription 1/nuclear factor-kappa B inhibitory signaling pathway.

Labeur M, Refojo D, Wölfel B, Stalla J, Vargas V, Theodoropoulou M, Buchfelder M, Paez-Pereda M, Arzt E, Stalla GK.

J Endocrinol. 2008 Nov;199(2):177-89. doi: 10.1677/JOE-08-0011. Epub 2008 Aug 20.

PMID:
18715881
23.

Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior.

Lu A, Steiner MA, Whittle N, Vogl AM, Walser SM, Ableitner M, Refojo D, Ekker M, Rubenstein JL, Stalla GK, Singewald N, Holsboer F, Wotjak CT, Wurst W, Deussing JM.

Mol Psychiatry. 2008 Nov;13(11):1028-42. doi: 10.1038/mp.2008.51. Epub 2008 May 13.

PMID:
18475271
24.

The activated glucocorticoid receptor inhibits the transcription factor T-bet by direct protein-protein interaction.

Liberman AC, Refojo D, Druker J, Toscano M, Rein T, Holsboer F, Arzt E.

FASEB J. 2007 Apr;21(4):1177-88. Epub 2007 Jan 10.

PMID:
17215482
25.

Molecular understanding of cytokine-steroid hormone dialogue: implications for human diseases.

Druker J, Liberman AC, Acuña M, Giacomini D, Refojo D, Silberstein S, Pereda MP, Stalla GK, Holsboer F, Arzt E.

Ann N Y Acad Sci. 2006 Nov;1088:297-306. Review.

PMID:
17192575
26.

Development of a species-specific RNA polymerase I-based shRNA expression vector.

Brenz Verca MS, Weber P, Mayer C, Graf C, Refojo D, Kühn R, Grummt I, Lutz B.

Nucleic Acids Res. 2007;35(2):e10. Epub 2006 Dec 7.

27.

Bone morphogenetic protein-4 control of pituitary pathophysiology.

Giacomini D, Páez-Pereda M, Theodoropoulou M, Gerez J, Nagashima AC, Chervin A, Berner S, Labeur M, Refojo D, Renner U, Stalla GK, Arzt E.

Front Horm Res. 2006;35:22-31. doi: 10.1159/000094262. Review.

PMID:
16809920
28.

Bone morphogenetic protein-4 inhibits corticotroph tumor cells: involvement in the retinoic acid inhibitory action.

Giacomini D, Páez-Pereda M, Theodoropoulou M, Labeur M, Refojo D, Gerez J, Chervin A, Berner S, Losa M, Buchfelder M, Renner U, Stalla GK, Arzt E.

Endocrinology. 2006 Jan;147(1):247-56. Epub 2005 Sep 29.

PMID:
16195406
29.

Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas.

Refojo D, Echenique C, Müller MB, Reul JM, Deussing JM, Wurst W, Sillaber I, Paez-Pereda M, Holsboer F, Arzt E.

Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6183-8. Epub 2005 Apr 15.

30.

Cytokine signaling/transcription factor cross-talk in T cell activation and Th1-Th2 differentiation.

Liberman AC, Refojo D, Arzt E.

Arch Immunol Ther Exp (Warsz). 2003;51(6):351-65. Review.

PMID:
14692657
31.

Integrating systemic information at the molecular level: cross-talk between steroid receptors and cytokine signaling on different target cells.

Refojo D, Liberman AC, Giacomini D, Carbia Nagashima A, Graciarena M, Echenique C, Paez Pereda M, Stalla G, Holsboer F, Arzt E.

Ann N Y Acad Sci. 2003 May;992:196-204. Review.

PMID:
12794059
32.

[New mechanisms involved in the pathogenesis of pituitary adenomas].

Giacomini D, Páez-Pereda M, Refojo D, Carbia Nagashima A, Chervin A, Goldberg V, Arzt E.

Medicina (B Aires). 2003;63(2):147-50. Spanish.

PMID:
12793085
33.

Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk.

Paez-Pereda M, Giacomini D, Refojo D, Nagashima AC, Hopfner U, Grubler Y, Chervin A, Goldberg V, Goya R, Hentges ST, Low MJ, Holsboer F, Stalla GK, Arzt E.

Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1034-9. Epub 2003 Jan 27.

34.

Increased splenocyte proliferative response and cytokine production in beta-endorphin-deficient mice.

Refojo D, Kovalovsky D, Young JI, Rubinstein M, Holsboer F, Reul JM, Low MJ, Arzt E.

J Neuroimmunol. 2002 Oct;131(1-2):126-34.

PMID:
12458044
35.

Activation and induction of NUR77/NURR1 in corticotrophs by CRH/cAMP: involvement of calcium, protein kinase A, and MAPK pathways.

Kovalovsky D, Refojo D, Liberman AC, Hochbaum D, Pereda MP, Coso OA, Stalla GK, Holsboer F, Arzt E.

Mol Endocrinol. 2002 Jul;16(7):1638-51.

PMID:
12089357
36.
37.

Transcription factor-mediated molecular mechanisms involved in the functional cross-talk between cytokines and glucocorticoids.

Refojo D, Liberman AC, Holsboer F, Arzt E.

Immunol Cell Biol. 2001 Aug;79(4):385-94. Review.

PMID:
11488986
38.

Functional cross-talk among cytokines, T-cell receptor, and glucocorticoid receptor transcriptional activity and action.

Arzt E, Kovalovsky D, Igaz LM, Costas M, Plazas P, Refojo D, Páez-Pereda M, Reul JM, Stalla G, Holsboer F.

Ann N Y Acad Sci. 2000;917:672-7. Review.

PMID:
11268396
39.

Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production.

Kovalovsky D, Refojo D, Holsboer F, Arzt E.

J Neuroimmunol. 2000 Sep 1;109(1):23-9. Review.

PMID:
10969177
41.

Interleukin-1 inhibits NMDA-stimulated GnRH secretion: associated effects on the release of hypothalamic inhibitory amino acid neurotransmitters.

Feleder C, Arias P, Refojo D, Nacht S, Moguilevsky J.

Neuroimmunomodulation. 2000;7(1):46-50.

PMID:
10601818
42.

Arrest of pulsatile luteinizing hormone (LH) secretion during insulin-induced hypoglycemia (IIH): improvement by intrahypothalamic perfusion with glucose.

Rodríguez M, Arias P, Refojo D, Feleder C, Moguilevsky J.

Exp Clin Endocrinol Diabetes. 1999;107(4):257-61.

PMID:
10433065
43.

Interleukin-1 stimulates hypothalamic inhibitory amino acid neurotransmitter release.

Feleder C, Refojo D, Nacht S, Moguilevsky JA.

Neuroimmunomodulation. 1998 Jan-Apr;5(1-2):1-4.

PMID:
9698251
44.

Effect of bacterial endotoxin on in vivo pulsatile gonadotropin secretion in adult male rats.

Refojo D, Arias P, Moguilevsky JA, Feleder C.

Neuroendocrinology. 1998 Apr;67(4):275-81.

PMID:
9588697
45.
46.

Repeated intracerebroventricular administration of taurine lowers LH levels and postpones vaginal opening in peripubertal female rats.

Arias P, Feleder C, Rodríguez M, Ginzburg M, Refojo D, Szwarcfarb B, Moguilevsky JA.

Brain Res Dev Brain Res. 1995 Mar 16;85(1):137-9.

PMID:
7781160

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