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Tailoring Hydrothermal Vent Biodiversity Toward Improved Biodiscovery Using a Novel in situ Enrichment Strategy.

Stokke R, Reeves EP, Dahle H, Fedøy AE, Viflot T, Lie Onstad S, Vulcano F, Pedersen RB, Eijsink VGH, Steen IH.

Front Microbiol. 2020 Feb 21;11:249. doi: 10.3389/fmicb.2020.00249. eCollection 2020.


Alpha-1 antitrypsin therapy modulates the neutrophil membrane proteome and secretome.

Murphy MP, McEnery T, McQuillan K, McElvaney OF, McElvaney OJ, Landers S, Coleman O, Bussayajirapong A, Hawkins P, Henry M, Meleady P, Reeves EP, McElvaney NG.

Eur Respir J. 2020 Feb 14. pii: 1901678. doi: 10.1183/13993003.01678-2019. [Epub ahead of print]


Activation of complement component 3 is associated with airways disease and pulmonary emphysema in alpha-1 antitrypsin deficiency.

O'Brien ME, Fee L, Browne N, Carroll TP, Meleady P, Henry M, McQuillan K, Murphy MP, Logan M, McCarthy C, McElvaney OJ, Reeves EP, McElvaney NG.

Thorax. 2020 Apr;75(4):321-330. doi: 10.1136/thoraxjnl-2019-214076. Epub 2020 Jan 20.


Targeting airway inflammation in cystic fibrosis.

McElvaney OJ, Wade P, Murphy M, Reeves EP, McElvaney NG.

Expert Rev Respir Med. 2019 Nov;13(11):1041-1055. doi: 10.1080/17476348.2019.1666715. Epub 2019 Oct 10.


Specific Inhibition of the NLRP3 Inflammasome as an Antiinflammatory Strategy in Cystic Fibrosis.

McElvaney OJ, Zaslona Z, Becker-Flegler K, Palsson-McDermott EM, Boland F, Gunaratnam C, Gulbins E, O'Neill LA, Reeves EP, McElvaney NG.

Am J Respir Crit Care Med. 2019 Dec 1;200(11):1381-1391. doi: 10.1164/rccm.201905-1013OC.


Pneumothorax and lung cysts: a family affair.

Hawkins P, Logan PM, Reeves EP, McElvaney NG.

Lancet. 2019 Jun 29;393(10191):2635. doi: 10.1016/S0140-6736(19)31283-8. Epub 2019 Jun 27. No abstract available.


Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity.

Reeves EP, Dunlea DM, McQuillan K, O'Dwyer CA, Carroll TP, Saldova R, Akepati PR, Wormald MR, McElvaney OJ, Shutchaidat V, Henry M, Meleady P, Keenan J, Liberti DC, Kotton DN, Rudd PM, Wilson AA, McElvaney NG.

J Immunol. 2019 Apr 15;202(8):2240-2253. doi: 10.4049/jimmunol.1801045. Epub 2019 Feb 22.


GDPR: an impediment to research?

Clarke N, Vale G, Reeves EP, Kirwan M, Smith D, Farrell M, Hurl G, McElvaney NG.

Ir J Med Sci. 2019 Nov;188(4):1129-1135. doi: 10.1007/s11845-019-01980-2. Epub 2019 Feb 8.


Emerging pharmacotherapies in cystic fibrosis.

McElvaney OJ, Gunaratnam C, McElvaney OF, Bagwe I, Reeves EP, McElvaney NG.

Expert Rev Respir Med. 2018 Oct;12(10):843-855. doi: 10.1080/17476348.2018.1512409. Epub 2018 Sep 19. Review.


Ataluren, a New Therapeutic for Alpha-1 Antitrypsin-Deficient Individuals with Nonsense Mutations.

Reeves EP, O'Dwyer CA, Dunlea DM, Wormald MR, Hawkins P, Alfares M, Kotton DN, Rowe SM, Wilson AA, McElvaney NG.

Am J Respir Crit Care Med. 2018 Oct 15;198(8):1099-1102. doi: 10.1164/rccm.201802-0338LE. No abstract available.


A specialized method of sputum collection and processing for therapeutic interventions in cystic fibrosis.

McElvaney OJ, Gunaratnam C, Reeves EP, McElvaney NG.

J Cyst Fibros. 2019 Mar;18(2):203-211. doi: 10.1016/j.jcf.2018.06.001. Epub 2018 Jun 28.


Hermansky-Pudlak syndrome with a novel genetic variant in HPS1 and subsequent accelerated pulmonary fibrosis: significance for phenocopy diseases.

McElvaney OJ, Huizing M, Gahl WA, O'Donovan P, Horan D, Logan PM, Reeves EP, McElvaney NG.

Thorax. 2018 Nov;73(11):1085-1088. doi: 10.1136/thoraxjnl-2018-211920. Epub 2018 Jun 25.


The Human Cathelicidin Antimicrobial Peptide LL-37 Promotes the Growth of the Pulmonary Pathogen Aspergillus fumigatus.

Sheehan G, Bergsson G, McElvaney NG, Reeves EP, Kavanagh K.

Infect Immun. 2018 Jun 21;86(7). pii: e00097-18. doi: 10.1128/IAI.00097-18. Print 2018 Jul.


The impact of alpha-1 antitrypsin augmentation therapy on neutrophil-driven respiratory disease in deficient individuals.

Dunlea DM, Fee LT, McEnery T, McElvaney NG, Reeves EP.

J Inflamm Res. 2018 Mar 26;11:123-134. doi: 10.2147/JIR.S156405. eCollection 2018. Review.


Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing.

Clancy DM, Sullivan GP, Moran HBT, Henry CM, Reeves EP, McElvaney NG, Lavelle EC, Martin SJ.

Cell Rep. 2018 Mar 13;22(11):2937-2950. doi: 10.1016/j.celrep.2018.02.062.


Glycosylation Repurposes Alpha-1 Antitrypsin for Resolution of Community-acquired Pneumonia.

McCarthy C, Dunlea DM, Saldova R, Henry M, Meleady P, McElvaney OJ, Marsh B, Rudd PM, Reeves EP, McElvaney NG.

Am J Respir Crit Care Med. 2018 May 15;197(10):1346-1349. doi: 10.1164/rccm.201709-1954LE. No abstract available.



McCarthy C, Reeves EP, Orr C, Fearon U, Veale DJ, McElvaney NG.

Arthritis Rheumatol. 2017 Dec;69(12):2404-2406. doi: 10.1002/art.40309. Epub 2017 Nov 8. No abstract available.


Neutrophil Membrane Cholesterol Content is a Key Factor in Cystic Fibrosis Lung Disease.

White MM, Geraghty P, Hayes E, Cox S, Leitch W, Alfawaz B, Lavelle GM, McElvaney OJ, Flannery R, Keenan J, Meleady P, Henry M, Clynes M, Gunaratnam C, McElvaney NG, Reeves EP.

EBioMedicine. 2017 Sep;23:173-184. doi: 10.1016/j.ebiom.2017.08.013. Epub 2017 Aug 16.


Brief Report: Genetic Variation of the α1 -Antitrypsin Gene Is Associated With Increased Autoantibody Production in Rheumatoid Arthritis.

McCarthy C, Orr C, Fee LT, Carroll TP, Dunlea DM, Hunt DJL, Dunne E, O'Connell P, McCarthy G, Kenny D, Fearon U, Veale DJ, Reeves EP, McElvaney NG.

Arthritis Rheumatol. 2017 Aug;69(8):1576-1579. doi: 10.1002/art.40127. Epub 2017 Jun 26.


5 Year Expression and Neutrophil Defect Repair after Gene Therapy in Alpha-1 Antitrypsin Deficiency.

Mueller C, Gernoux G, Gruntman AM, Borel F, Reeves EP, Calcedo R, Rouhani FN, Yachnis A, Humphries M, Campbell-Thompson M, Messina L, Chulay JD, Trapnell B, Wilson JM, McElvaney NG, Flotte TR.

Mol Ther. 2017 Jun 7;25(6):1387-1394. doi: 10.1016/j.ymthe.2017.03.029. Epub 2017 Apr 10.


The Role of Neutrophils in Alpha-1 Antitrypsin Deficiency.

McCarthy C, Reeves EP, McElvaney NG.

Ann Am Thorac Soc. 2016 Aug;13 Suppl 4:S297-304. doi: 10.1513/AnnalsATS.201509-634KV. Review.


Animal Models of Cystic Fibrosis Pathology: Phenotypic Parallels and Divergences.

Lavelle GM, White MM, Browne N, McElvaney NG, Reeves EP.

Biomed Res Int. 2016;2016:5258727. doi: 10.1155/2016/5258727. Epub 2016 Jun 1. Review.


Heterotrophic Proteobacteria in the vicinity of diffuse hydrothermal venting.

Meier DV, Bach W, Girguis PR, Gruber-Vodicka HR, Reeves EP, Richter M, Vidoudez C, Amann R, Meyerdierks A.

Environ Microbiol. 2016 Dec;18(12):4348-4368. doi: 10.1111/1462-2920.13304. Epub 2016 Apr 28.


Tumor necrosis factor-α driven inflammation in alpha-1 antitrypsin deficiency: a new model of pathogenesis and treatment.

Hurley K, Reeves EP, Carroll TP, McElvaney NG.

Expert Rev Respir Med. 2016 Feb;10(2):207-22. doi: 10.1586/17476348.2016.1127759. Epub 2015 Dec 18. Review.


The BLT1 Inhibitory Function of α-1 Antitrypsin Augmentation Therapy Disrupts Leukotriene B4 Neutrophil Signaling.

O'Dwyer CA, O'Brien ME, Wormald MR, White MM, Banville N, Hurley K, McCarthy C, McElvaney NG, Reeves EP.

J Immunol. 2015 Oct 15;195(8):3628-41. doi: 10.4049/jimmunol.1500038. Epub 2015 Sep 14.


Inhaled hypertonic saline for cystic fibrosis: Reviewing the potential evidence for modulation of neutrophil signalling and function.

Reeves EP, McCarthy C, McElvaney OJ, Vijayan MS, White MM, Dunlea DM, Pohl K, Lacey N, McElvaney NG.

World J Crit Care Med. 2015 Aug 4;4(3):179-91. doi: 10.5492/wjccm.v4.i3.179. eCollection 2015 Aug 4. Review.


The impact of smoke exposure on the clinical phenotype of alpha-1 antitrypsin deficiency in Ireland: exploiting a national registry to understand a rare disease.

O'Brien ME, Pennycooke K, Carroll TP, Shum J, Fee LT, O'Connor C, Logan PM, Reeves EP, McElvaney NG.

COPD. 2015 May;12 Suppl 1:2-9. doi: 10.3109/15412555.2015.1021913.


Methane cycling. Nonequilibrium clumped isotope signals in microbial methane.

Wang DT, Gruen DS, Lollar BS, Hinrichs KU, Stewart LC, Holden JF, Hristov AN, Pohlman JW, Morrill PL, Könneke M, Delwiche KB, Reeves EP, Sutcliffe CN, Ritter DJ, Seewald JS, McIntosh JC, Hemond HF, Kubo MD, Cardace D, Hoehler TM, Ono S.

Science. 2015 Apr 24;348(6233):428-31. doi: 10.1126/science.aaa4326. Epub 2015 Mar 5.


The effect of the decoy molecule PA401 on CXCL8 levels in bronchoalveolar lavage fluid of patients with cystic fibrosis.

McElvaney OJ, O'Reilly N, White M, Lacey N, Pohl K, Gerlza T, Bergin DA, Kerr H, McCarthy C, O'Brien ME, Adage T, Kungl AJ, Reeves EP, McElvaney NG.

Mol Immunol. 2015 Feb;63(2):550-8. doi: 10.1016/j.molimm.2014.10.013. Epub 2014 Nov 2.


Alpha-1 antitrypsin augmentation therapy corrects accelerated neutrophil apoptosis in deficient individuals.

Hurley K, Lacey N, O'Dwyer CA, Bergin DA, McElvaney OJ, O'Brien ME, McElvaney OF, Reeves EP, McElvaney NG.

J Immunol. 2014 Oct 15;193(8):3978-91. doi: 10.4049/jimmunol.1400132. Epub 2014 Sep 12.


A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy.

Pohl K, Hayes E, Keenan J, Henry M, Meleady P, Molloy K, Jundi B, Bergin DA, McCarthy C, McElvaney OJ, White MM, Clynes M, Reeves EP, McElvaney NG.

Blood. 2014 Aug 14;124(7):999-1009. doi: 10.1182/blood-2014-02-555268. Epub 2014 Jun 16.


Microbial lipids reveal carbon assimilation patterns on hydrothermal sulfide chimneys.

Reeves EP, Yoshinaga MY, Pjevac P, Goldenstein NI, Peplies J, Meyerdierks A, Amann R, Bach W, Hinrichs KU.

Environ Microbiol. 2014 Nov;16(11):3515-32. doi: 10.1111/1462-2920.12525. Epub 2014 Jul 7.


The role and importance of glycosylation of acute phase proteins with focus on alpha-1 antitrypsin in acute and chronic inflammatory conditions.

McCarthy C, Saldova R, Wormald MR, Rudd PM, McElvaney NG, Reeves EP.

J Proteome Res. 2014 Jul 3;13(7):3131-43. doi: 10.1021/pr500146y. Epub 2014 Jun 12. Review.


The origin of methanethiol in midocean ridge hydrothermal fluids.

Reeves EP, McDermott JM, Seewald JS.

Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5474-9. doi: 10.1073/pnas.1400643111. Epub 2014 Mar 27.


Galectin-9 signaling through TIM-3 is involved in neutrophil-mediated Gram-negative bacterial killing: an effect abrogated within the cystic fibrosis lung.

Vega-Carrascal I, Bergin DA, McElvaney OJ, McCarthy C, Banville N, Pohl K, Hirashima M, Kuchroo VK, Reeves EP, McElvaney NG.

J Immunol. 2014 Mar 1;192(5):2418-31. doi: 10.4049/jimmunol.1300711. Epub 2014 Jan 29.


The circulating proteinase inhibitor α-1 antitrypsin regulates neutrophil degranulation and autoimmunity.

Bergin DA, Reeves EP, Hurley K, Wolfe R, Jameel R, Fitzgerald S, McElvaney NG.

Sci Transl Med. 2014 Jan 1;6(217):217ra1. doi: 10.1126/scitranslmed.3007116.


Increased outer arm and core fucose residues on the N-glycans of mutated alpha-1 antitrypsin protein from alpha-1 antitrypsin deficient individuals.

McCarthy C, Saldova R, O'Brien ME, Bergin DA, Carroll TP, Keenan J, Meleady P, Henry M, Clynes M, Rudd PM, Reeves EP, McElvaney NG.

J Proteome Res. 2014 Feb 7;13(2):596-605. doi: 10.1021/pr400752t. Epub 2013 Dec 13.


Intracellular secretory leukoprotease inhibitor modulates inositol 1,4,5-triphosphate generation and exerts an anti-inflammatory effect on neutrophils of individuals with cystic fibrosis and chronic obstructive pulmonary disease.

Reeves EP, Banville N, Ryan DM, O'Reilly N, Bergin DA, Pohl K, Molloy K, McElvaney OJ, Alsaleh K, Aljorfi A, Kandalaft O, O'Flynn E, Geraghty P, O'Neill SJ, McElvaney NG.

Biomed Res Int. 2013;2013:560141. doi: 10.1155/2013/560141. Epub 2013 Aug 29.


Airway inflammatory markers in individuals with cystic fibrosis and non-cystic fibrosis bronchiectasis.

Bergin DA, Hurley K, Mehta A, Cox S, Ryan D, O'Neill SJ, Reeves EP, McElvaney NG.

J Inflamm Res. 2013;6:1-11. doi: 10.2147/JIR.S40081. Epub 2013 Jan 23.


Endothelial progenitor cells in mothers of low-birthweight infants: a link between defective placental vascularization and increased cardiovascular risk?

King TF, Bergin DA, Kent EM, Manning F, Reeves EP, Dicker P, McElvaney NG, Sreenan S, Malone FD, McDermott JH.

J Clin Endocrinol Metab. 2013 Jan;98(1):E33-9. doi: 10.1210/jc.2012-2793. Epub 2012 Nov 15.


H₂/CH₄ ratios cannot reliably distinguish abiotic vs. biotic methane in natural hydrothermal systems.

Lang SQ, Früh-Green GL, Kelley DS, Lilley MD, Proskurowski G, Reeves EP.

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):E3210; author reply E3211. doi: 10.1073/pnas.1213138109. Epub 2012 Sep 25. No abstract available.


The role of TIM-containing molecules in airway disease and their potential as therapeutic targets.

Vega-Carrascal I, Reeves EP, McElvaney NG.

J Inflamm Res. 2012;5:77-87. doi: 10.2147/JIR.S34225. Epub 2012 Aug 14.


The effect of Aspergillus fumigatus infection on vitamin D receptor expression in cystic fibrosis.

Coughlan CA, Chotirmall SH, Renwick J, Hassan T, Low TB, Bergsson G, Eshwika A, Bennett K, Dunne K, Greene CM, Gunaratnam C, Kavanagh K, Logan PM, Murphy P, Reeves EP, McElvaney NG.

Am J Respir Crit Care Med. 2012 Nov 15;186(10):999-1007. doi: 10.1164/rccm.201203-0478OC. Epub 2012 Aug 16.


Hypertonic saline in treatment of pulmonary disease in cystic fibrosis.

Reeves EP, Molloy K, Pohl K, McElvaney NG.

ScientificWorldJournal. 2012;2012:465230. doi: 10.1100/2012/465230. Epub 2012 May 3. Review.


The facilitating effect of hypertonic saline on resolution of airway inflammation in cystic fibrosis.

Reeves EP, McElvaney NG.

Am J Respir Crit Care Med. 2012 Jan 15;185(2):226-7. No abstract available.


Alpha-1 antitrypsin: a potent anti-inflammatory and potential novel therapeutic agent.

Bergin DA, Hurley K, McElvaney NG, Reeves EP.

Arch Immunol Ther Exp (Warsz). 2012 Apr;60(2):81-97. doi: 10.1007/s00005-012-0162-5. Epub 2012 Feb 15. Review.


Demodex-associated bacterial proteins induce neutrophil activation.

O'Reilly N, Bergin D, Reeves EP, McElvaney NG, Kavanagh K.

Br J Dermatol. 2012 Apr;166(4):753-60. doi: 10.1111/j.1365-2133.2011.10746.x. Epub 2012 Mar 2.


A novel neutrophil derived inflammatory biomarker of pulmonary exacerbation in cystic fibrosis.

Reeves EP, Bergin DA, Fitzgerald S, Hayes E, Keenan J, Henry M, Meleady P, Vega-Carrascal I, Murray MA, Low TB, McCarthy C, O'Brien E, Clynes M, Gunaratnam C, McElvaney NG.

J Cyst Fibros. 2012 Mar;11(2):100-7. doi: 10.1016/j.jcf.2011.09.010. Epub 2011 Oct 28.


Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α.

Afonina IS, Tynan GA, Logue SE, Cullen SP, Bots M, Lüthi AU, Reeves EP, McElvaney NG, Medema JP, Lavelle EC, Martin SJ.

Mol Cell. 2011 Oct 21;44(2):265-78. doi: 10.1016/j.molcel.2011.07.037.


The involvement of glycosaminoglycans in airway disease associated with cystic fibrosis.

Reeves EP, Bergin DA, Murray MA, McElvaney NG.

ScientificWorldJournal. 2011 Apr 19;11:959-71. doi: 10.1100/tsw.2011.81. Review.

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