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Items: 9

1.

Toward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin Resistant Staphylococcus aureus.

Reeve SM, Si D, Krucinska J, Yan Y, Viswanathan K, Wang S, Holt GT, Frenkel MS, Ojewole AA, Estrada A, Agabiti SS, Alverson JB, Gibson ND, Priestley ND, Wiemer AJ, Donald BR, Wright DL.

ACS Infect Dis. 2019 Nov 8;5(11):1896-1906. doi: 10.1021/acsinfecdis.9b00222. Epub 2019 Oct 15.

PMID:
31565920
2.

Structure-Guided In Vitro to In Vivo Pharmacokinetic Optimization of Propargyl-Linked Antifolates.

Lombardo MN, G-Dayanandan N, Keshipeddy S, Zhou W, Si D, Reeve SM, Alverson J, Barney P, Walker L, Hoody J, Priestley ND, Obach RS, Wright DL.

Drug Metab Dispos. 2019 Sep;47(9):995-1003. doi: 10.1124/dmd.119.086504. Epub 2019 Jun 14.

PMID:
31201212
3.

MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates.

Reeve SM, Scocchera EW, G-Dayanadan N, Keshipeddy S, Krucinska J, Hajian B, Ferreira J, Nailor M, Aeschlimann J, Wright DL, Anderson AC.

Cell Chem Biol. 2016 Dec 22;23(12):1458-1467. doi: 10.1016/j.chembiol.2016.11.007. Epub 2016 Dec 8.

4.

OSPREY Predicts Resistance Mutations Using Positive and Negative Computational Protein Design.

Ojewole A, Lowegard A, Gainza P, Reeve SM, Georgiev I, Anderson AC, Donald BR.

Methods Mol Biol. 2017;1529:291-306.

5.

Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens.

Scocchera E, Reeve SM, Keshipeddy S, Lombardo MN, Hajian B, Sochia AE, Alverson JB, Priestley ND, Anderson AC, Wright DL.

ACS Med Chem Lett. 2016 May 5;7(7):692-6. doi: 10.1021/acsmedchemlett.6b00120. eCollection 2016 Jul 14.

6.

Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations.

Reeve SM, Scocchera E, Ferreira JJ, G-Dayanandan N, Keshipeddy S, Wright DL, Anderson AC.

J Med Chem. 2016 Jul 14;59(13):6493-500. doi: 10.1021/acs.jmedchem.6b00688. Epub 2016 Jun 28.

7.

Understanding the structural mechanisms of antibiotic resistance sets the platform for new discovery.

Reeve SM, Lombardo MN, Anderson AC.

Future Microbiol. 2015;10(11):1727-33. doi: 10.2217/fmb.15.78. Epub 2015 Oct 30. Review.

8.

Nonracemic Antifolates Stereoselectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus.

Keshipeddy S, Reeve SM, Anderson AC, Wright DL.

J Am Chem Soc. 2015 Jul 22;137(28):8983-90. doi: 10.1021/jacs.5b01442. Epub 2015 Jul 8.

9.

Protein design algorithms predict viable resistance to an experimental antifolate.

Reeve SM, Gainza P, Frey KM, Georgiev I, Donald BR, Anderson AC.

Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):749-54. doi: 10.1073/pnas.1411548112. Epub 2014 Dec 31.

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