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The phospholipase C inhibitor U73122 is a potent agonist of the polymodal transient receptor potential ankyrin type 1 (TRPA1) receptor channel.

Neacsu C, Sauer SK, Reeh PW, Babes A.

Naunyn Schmiedebergs Arch Pharmacol. 2019 Sep 3. doi: 10.1007/s00210-019-01722-2. [Epub ahead of print]


Etomidate and propylene glycol activate nociceptive TRP ion channels.

Niedermirtl F, Eberhardt M, Namer B, Leffler A, Nau C, Reeh PW, Kistner K.

Mol Pain. 2018 Jan-Dec;14:1744806918811699. doi: 10.1177/1744806918811699. Epub 2018 Oct 22.


Local NGF and GDNF levels modulate morphology and function of porcine DRG neurites, In Vitro.

Klusch A, Gorzelanny C, Reeh PW, Schmelz M, Petersen M, Sauer SK.

PLoS One. 2018 Sep 27;13(9):e0203215. doi: 10.1371/journal.pone.0203215. eCollection 2018.


Heat-resistant action potentials require TTX-resistant sodium channels NaV1.8 and NaV1.9.

Touska F, Turnquist B, Vlachova V, Reeh PW, Leffler A, Zimmermann K.

J Gen Physiol. 2018 Aug 6;150(8):1125-1144. doi: 10.1085/jgp.201711786. Epub 2018 Jul 3.


New mechanism underlying IL-31-induced atopic dermatitis.

Meng J, Moriyama M, Feld M, Buddenkotte J, Buhl T, Szöllösi A, Zhang J, Miller P, Ghetti A, Fischer M, Reeh PW, Shan C, Wang J, Steinhoff M.

J Allergy Clin Immunol. 2018 May;141(5):1677-1689.e8. doi: 10.1016/j.jaci.2017.12.1002. Epub 2018 Feb 7.


The roles of TRPV1, TRPA1 and TRPM8 channels in chemical and thermal sensitivity of the mouse oral mucosa.

Kichko TI, Neuhuber W, Kobal G, Reeh PW.

Eur J Neurosci. 2018 Feb;47(3):201-210. doi: 10.1111/ejn.13799. Epub 2018 Jan 11.


NaV1.7 and pain: contribution of peripheral nerves.

Hoffmann T, Sharon O, Wittmann J, Carr RW, Vyshnevska A, Col R, Nassar MA, Reeh PW, Weidner C.

Pain. 2018 Mar;159(3):496-506. doi: 10.1097/j.pain.0000000000001119.


TRPA1 and TRPV1 are required for lidocaine-evoked calcium influx and neuropeptide release but not cytotoxicity in mouse sensory neurons.

Eberhardt M, Stueber T, de la Roche J, Herzog C, Leffler A, Reeh PW, Kistner K.

PLoS One. 2017 Nov 15;12(11):e0188008. doi: 10.1371/journal.pone.0188008. eCollection 2017.


Photosensitization of TRPA1 and TRPV1 by 7-dehydrocholesterol: implications for the Smith-Lemli-Opitz syndrome.

Babes A, Ciotu CI, Hoffmann T, Kichko TI, Selescu T, Neacsu C, Sauer SK, Reeh PW, Fischer MJM.

Pain. 2017 Dec;158(12):2475-2486. doi: 10.1097/j.pain.0000000000001056.


Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes NaV1.9, NaV1.7 and NaV1.1.

Touska F, Sattler S, Malsch P, Lewis RJ, Reeh PW, Zimmermann K.

Mar Drugs. 2017 Aug 30;15(9). pii: E269. doi: 10.3390/md15090269.


Inflammatory pain control by blocking oxidized phospholipid-mediated TRP channel activation.

Oehler B, Kistner K, Martin C, Schiller J, Mayer R, Mohammadi M, Sauer RS, Filipovic MR, Nieto FR, Kloka J, Pflücke D, Hill K, Schaefer M, Malcangio M, Reeh PW, Brack A, Blum R, Rittner HL.

Sci Rep. 2017 Jul 14;7(1):5447. doi: 10.1038/s41598-017-05348-3.


Sodium Channel Nav1.8 Underlies TTX-Resistant Axonal Action Potential Conduction in Somatosensory C-Fibers of Distal Cutaneous Nerves.

Klein AH, Vyshnevska A, Hartke TV, De Col R, Mankowski JL, Turnquist B, Bosmans F, Reeh PW, Schmelz M, Carr RW, Ringkamp M.

J Neurosci. 2017 May 17;37(20):5204-5214. doi: 10.1523/JNEUROSCI.3799-16.2017. Epub 2017 Apr 27.


Activity and connectivity changes of central projection areas revealed by functional magnetic resonance imaging in NaV1.8-deficient mice upon cold signaling.

Heindl-Erdmann C, Zimmermann K, Reeh P, Brune K, Hess A.

Sci Rep. 2017 Apr 3;7(1):543. doi: 10.1038/s41598-017-00524-x.


TRPA1 and TRPV1 Antagonists Do Not Inhibit Human Acidosis-Induced Pain.

Schwarz MG, Namer B, Reeh PW, Fischer MJM.

J Pain. 2017 May;18(5):526-534. doi: 10.1016/j.jpain.2016.12.011. Epub 2017 Jan 3.


Lactate is a potent inhibitor of the capsaicin receptor TRPV1.

de la Roche J, Walther I, Leonow W, Hage A, Eberhardt M, Fischer M, Reeh PW, Sauer S, Leffler A.

Sci Rep. 2016 Nov 9;6:36740. doi: 10.1038/srep36740.


Reduced excitability and impaired nociception in peripheral unmyelinated fibers from Nav1.9-null mice.

Hoffmann T, Kistner K, Carr RW, Nassar MA, Reeh PW, Weidner C.

Pain. 2017 Jan;158(1):58-67.


Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia.

Bressan E, Touska F, Vetter I, Kistner K, Kichko TI, Teixeira NB, Picolo G, Cury Y, Lewis RJ, Fischer MJ, Zimmermann K, Reeh PW.

Pain. 2016 Nov;157(11):2504-2516.


Systemic desensitization through TRPA1 channels by capsazepine and mustard oil - a novel strategy against inflammation and pain.

Kistner K, Siklosi N, Babes A, Khalil M, Selescu T, Zimmermann K, Wirtz S, Becker C, Neurath MF, Reeh PW, Engel MA.

Sci Rep. 2016 Jun 30;6:28621. doi: 10.1038/srep28621.


Human TRPA1 is a heat sensor displaying intrinsic U-shaped thermosensitivity.

Moparthi L, Kichko TI, Eberhardt M, Högestätt ED, Kjellbom P, Johanson U, Reeh PW, Leffler A, Filipovic MR, Zygmunt PM.

Sci Rep. 2016 Jun 28;6:28763. doi: 10.1038/srep28763.


Photosensitization in Porphyrias and Photodynamic Therapy Involves TRPA1 and TRPV1.

Babes A, Sauer SK, Moparthi L, Kichko TI, Neacsu C, Namer B, Filipovic M, Zygmunt PM, Reeh PW, Fischer MJ.

J Neurosci. 2016 May 11;36(19):5264-78. doi: 10.1523/JNEUROSCI.4268-15.2016.


Use dependence of peripheral nociceptive conduction in the absence of tetrodotoxin-resistant sodium channel subtypes.

Hoffmann T, Kistner K, Nassar M, Reeh PW, Weidner C.

J Physiol. 2016 Oct 1;594(19):5529-41. doi: 10.1113/JP272082. Epub 2016 Jun 12.


Functional and structural characterization of axonal opioid receptors as targets for analgesia.

Mambretti EM, Kistner K, Mayer S, Massotte D, Kieffer BL, Hoffmann C, Reeh PW, Brack A, Asan E, Rittner HL.

Mol Pain. 2016 Mar 1;12. pii: 1744806916628734. doi: 10.1177/1744806916628734. Print 2016.


Transient receptor potential melastatin 8 ion channel in macrophages modulates colitis through a balance-shift in TNF-alpha and interleukin-10 production.

Khalil M, Babes A, Lakra R, Försch S, Reeh PW, Wirtz S, Becker C, Neurath MF, Engel MA.

Mucosal Immunol. 2016 Nov;9(6):1500-1513. doi: 10.1038/mi.2016.16. Epub 2016 Mar 16.


Taurolidine and congeners activate hTRPA1 but not hTRPV1 channels and stimulate CGRP release from mouse tracheal sensory nerves.

Kichko TI, Pfirrmann RW, Reeh PW.

Pharmacol Res Perspect. 2016 Feb 1;4(1):e00204. doi: 10.1002/prp2.204. eCollection 2016 Feb.


The prokineticin Bv8 sensitizes cutaneous terminals of female mice to heat.

Hoffmann T, Negri L, Maftei D, Lattanzi R, Reeh PW.

Eur J Pain. 2016 Sep;20(8):1326-34. doi: 10.1002/ejp.857. Epub 2016 Feb 23.


Quaternary Lidocaine Derivative QX-314 Activates and Permeates Human TRPV1 and TRPA1 to Produce Inhibition of Sodium Channels and Cytotoxicity.

Stueber T, Eberhardt MJ, Hadamitzky C, Jangra A, Schenk S, Dick F, Stoetzer C, Kistner K, Reeh PW, Binshtok AM, Leffler A.

Anesthesiology. 2016 May;124(5):1153-65. doi: 10.1097/ALN.0000000000001050.


Cigarette smoke has sensory effects through nicotinic and TRPA1 but not TRPV1 receptors on the isolated mouse trachea and larynx.

Kichko TI, Kobal G, Reeh PW.

Am J Physiol Lung Cell Mol Physiol. 2015 Oct 15;309(8):L812-20. doi: 10.1152/ajplung.00164.2015. Epub 2015 Aug 21.


Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice.

Mueller-Tribbensee SM, Karna M, Khalil M, Neurath MF, Reeh PW, Engel MA.

PLoS One. 2015 Jul 24;10(7):e0128242. doi: 10.1371/journal.pone.0128242. eCollection 2015.


Vitamin B complex attenuated heat hyperalgesia following infraorbital nerve constriction in rats and reduced capsaicin in vivo and in vitro effects.

Kopruszinski CM, Reis RC, Bressan E, Reeh PW, Chichorro JG.

Eur J Pharmacol. 2015 Sep 5;762:326-32. doi: 10.1016/j.ejphar.2015.05.063. Epub 2015 Jun 3.


Streptozotocin Stimulates the Ion Channel TRPA1 Directly: INVOLVEMENT OF PEROXYNITRITE.

Andersson DA, Filipović MR, Gentry C, Eberhardt M, Vastani N, Leffler A, Reeh P, Bevan S.

J Biol Chem. 2015 Jun 12;290(24):15185-96. doi: 10.1074/jbc.M115.644476. Epub 2015 Apr 22.


Formalin evokes calcium transients from the endoplasmatic reticulum.

Fischer MJ, Soller KJ, Sauer SK, Kalucka J, Veglia G, Reeh PW.

PLoS One. 2015 Apr 15;10(4):e0123762. doi: 10.1371/journal.pone.0123762. eCollection 2015.


Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release.

Held K, Kichko T, De Clercq K, Klaassen H, Van Bree R, Vanherck JC, Marchand A, Reeh PW, Chaltin P, Voets T, Vriens J.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1363-72. doi: 10.1073/pnas.1419845112. Epub 2015 Mar 2.


Mice and rats differ with respect to activity-dependent slowing of conduction velocity in the saphenous peripheral nerve.

Hoffmann T, De Col R, Messlinger K, Reeh PW, Weidner C.

Neurosci Lett. 2015 Apr 10;592:12-6. doi: 10.1016/j.neulet.2015.02.057. Epub 2015 Feb 27.


Irritant volatile anesthetics induce neurogenic inflammation through TRPA1 and TRPV1 channels in the isolated mouse trachea.

Kichko TI, Niedermirtl F, Leffler A, Reeh PW.

Anesth Analg. 2015 Feb;120(2):467-71. doi: 10.1213/ANE.0000000000000568.


H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway.

Eberhardt M, Dux M, Namer B, Miljkovic J, Cordasic N, Will C, Kichko TI, de la Roche J, Fischer M, Suárez SA, Bikiel D, Dorsch K, Leffler A, Babes A, Lampert A, Lennerz JK, Jacobi J, Martí MA, Doctorovich F, Högestätt ED, Zygmunt PM, Ivanovic-Burmazovic I, Messlinger K, Reeh P, Filipovic MR.

Nat Commun. 2014 Jul 15;5:4381. doi: 10.1038/ncomms5381.


Direct evidence for functional TRPV1/TRPA1 heteromers.

Fischer MJ, Balasuriya D, Jeggle P, Goetze TA, McNaughton PA, Reeh PW, Edwardson JM.

Pflugers Arch. 2014 Dec;466(12):2229-41. doi: 10.1007/s00424-014-1497-z. Epub 2014 Mar 19.


A new paradigm to understand and treat diabetic neuropathy.

Hidmark A, Fleming T, Vittas S, Mendler M, Deshpande D, Groener JB, Müller BP, Reeh PW, Sauer SK, Pham M, Muckenthaler MU, Bendszus M, Nawroth PP.

Exp Clin Endocrinol Diabetes. 2014 Apr;122(4):201-7. doi: 10.1055/s-0034-1367023. Epub 2014 Mar 12. Review.


Receptors, cells and circuits involved in pruritus of systemic disorders.

Kremer AE, Feramisco J, Reeh PW, Beuers U, Oude Elferink RP.

Biochim Biophys Acta. 2014 Jul;1842(7):869-92. doi: 10.1016/j.bbadis.2014.02.007. Epub 2014 Feb 22. Review.


HCN2 channels account for mechanical (but not heat) hyperalgesia during long-standing inflammation.

Schnorr S, Eberhardt M, Kistner K, Rajab H, Käßer J, Hess A, Reeh P, Ludwig A, Herrmann S.

Pain. 2014 Jun;155(6):1079-90. doi: 10.1016/j.pain.2014.02.006. Epub 2014 Feb 10.


TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins.

Meseguer V, Alpizar YA, Luis E, Tajada S, Denlinger B, Fajardo O, Manenschijn JA, Fernández-Peña C, Talavera A, Kichko T, Navia B, Sánchez A, Señarís R, Reeh P, Pérez-García MT, López-López JR, Voets T, Belmonte C, Talavera K, Viana F.

Nat Commun. 2014;5:3125. doi: 10.1038/ncomms4125.


The interphase of the formalin test.

Fischer M, Carli G, Raboisson P, Reeh P.

Pain. 2014 Mar;155(3):511-21. doi: 10.1016/j.pain.2013.11.015. Epub 2013 Nov 27.


Amplified cold transduction in native nociceptors by M-channel inhibition.

Vetter I, Hein A, Sattler S, Hessler S, Touska F, Bressan E, Parra A, Hager U, Leffler A, Boukalova S, Nissen M, Lewis RJ, Belmonte C, Alzheimer C, Huth T, Vlachova V, Reeh PW, Zimmermann K.

J Neurosci. 2013 Oct 16;33(42):16627-41. doi: 10.1523/JNEUROSCI.1473-13.2013.


Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block.

Brenneis C, Kistner K, Puopolo M, Jo S, Roberson D, Sisignano M, Segal D, Cobos EJ, Wainger BJ, Labocha S, Ferreirós N, von Hehn C, Tran J, Geisslinger G, Reeh PW, Bean BP, Woolf CJ.

Br J Pharmacol. 2014 Jan;171(2):438-51. doi: 10.1111/bph.12466.


Bimodal concentration-response of nicotine involves the nicotinic acetylcholine receptor, transient receptor potential vanilloid type 1, and transient receptor potential ankyrin 1 channels in mouse trachea and sensory neurons.

Kichko TI, Lennerz J, Eberhardt M, Babes RM, Neuhuber W, Kobal G, Reeh PW.

J Pharmacol Exp Ther. 2013 Nov;347(2):529-39. doi: 10.1124/jpet.113.205971. Epub 2013 Aug 7.


Analgesic treatment of ciguatoxin-induced cold allodynia.

Zimmermann K, Deuis JR, Inserra MC, Collins LS, Namer B, Cabot PJ, Reeh PW, Lewis RJ, Vetter I.

Pain. 2013 Oct;154(10):1999-2006. doi: 10.1016/j.pain.2013.06.015. Epub 2013 Jun 15.


TRPA1 and TRPV1 are differentially involved in heat nociception of mice.

Hoffmann T, Kistner K, Miermeister F, Winkelmann R, Wittmann J, Fischer MJ, Weidner C, Reeh PW.

Eur J Pain. 2013 Nov;17(10):1472-82. doi: 10.1002/j.1532-2149.2013.00331.x. Epub 2013 May 29.


The molecular basis for species-specific activation of human TRPA1 protein by protons involves poorly conserved residues within transmembrane domains 5 and 6.

de la Roche J, Eberhardt MJ, Klinger AB, Stanslowsky N, Wegner F, Koppert W, Reeh PW, Lampert A, Fischer MJ, Leffler A.

J Biol Chem. 2013 Jul 12;288(28):20280-92. doi: 10.1074/jbc.M113.479337. Epub 2013 May 24.


Dynamic multivalency for carbohydrate-protein recognition through dynamic combinatorial libraries based on Fe(II)-bipyridine complexes.

Reeh P, de Mendoza J.

Chemistry. 2013 Apr 22;19(17):5259-62. doi: 10.1002/chem.201300464. Epub 2013 Mar 11.


The anti-diabetic drug glibenclamide is an agonist of the transient receptor potential Ankyrin 1 (TRPA1) ion channel.

Babes A, Fischer MJ, Filipovic M, Engel MA, Flonta ML, Reeh PW.

Eur J Pharmacol. 2013 Mar 15;704(1-3):15-22. doi: 10.1016/j.ejphar.2013.02.018. Epub 2013 Feb 24.


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